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                       SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549


                                    FORM 8-K


                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                        Securities Exchange Act of 1934



Date of Report: December 3, 1997                Commission File No. 0-27352
                ----------------                                    -------
(Date of earliest event reported)



                                 HYBRIDON, INC.
                                 --------------
             (Exact name of registrant as specified in its Charter)


          Delaware                                       04-3072298
          --------                                       ----------
(State or other jurisdiction of              (IRS Employer Identification No.)
incorporation or organization)


620 Memorial Drive, Cambridge, Massachusetts               02139
- --------------------------------------------               -----
(Address of principal executive offices)                 (Zip Code)



                                 (617) 528-7000
                                 --------------
              (Registrant's telephone number, including area code)
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ITEM 5. OTHER EVENTS

     On December 3, 1997, Hybridon, Inc. (the "Company") issued a press release
announcing that, effective as of the close of business on December 2, 1997, the
Company's Common Stock was delisted from the Nasdaq National Market and that the
Company's Common Stock would be quoted on the OTC Bulletin Board under the
symbol "HYBN" commencing on December 3, 1997. A copy of the press release has
been filed with this Current Report on Form 8-K as Exhibit 99.1 and is
incorporated herein by reference.


ITEM 7. EXHIBITS

99.1 Press release dated December 3, 1997.
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                                   SIGNATURES


     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.




Dated: December 3, 1997              HYBRIDON, INC.


                                     /s/ E. Andrews Grinstead, III
                                     ---------------------------------------
                                     E. Andrews Grinstead, III
                                     Chairman, President and Chief Executive
                                     Officer   
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                               INDEX TO EXHIBITS




Exhibit
  No.              Description
- -------            -----------

  99.1        Press release dated December 3, 1997.
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                                                    Exhibit 99.1

                             [HYBRIDON LETTERHEAD]

                                  NEWS RELEASE

FOR IMMEDIATE RELEASE

               HYBRIDON STOCK TO BE QUOTED ON OTC BULLETIN BOARD

     CAMBRIDGE, Mass., December 3 -- Hybridon, Inc., today announced that,
effective as of the close of business on December 2, 1997, the Company's Common
Stock was delisted from The Nasdaq National Market. The Company's Common Stock
will be quoted on the OTC Bulletin Board under the "HYBN" commencing today.  

     "Our current level of net tangible assets disqualified us from continued
listing on the Nasdaq National Market, given our capital structure, including
the $50.0 million of 9% Convertible Subordinated Notes currently outstanding,"
said E. Andrews Grinstead, III, the Company's Chairman, President and Chief
Executive Officer. "The Company is exploring a range of financing options."

     As previously announced, the Company intends to effect the proposed
five-for-one reverse stock split of its Common Stock as of December 10, 1997.

     Hybridon, headquartered in Cambridge, Massachusetts, is a leader in the
discovery and development of novel genetic medicines for the treatment of
important diseases, based primarily on antisense technology. Antisense
technology involves the use of synthetic segments of DNA and RNA to stop the
production of disease-associated proteins by interacting at the genetic level
with target strands of messenger RNA.

                                     # # #

     This press release contains forward-looking statements that involve a
number of risks and uncertainties. There can be no assurance that the Company
will consummate any of the financing options it is exploring or as to the term
of any such financing options.

                    Leadership in Genetic Antisense Medicine