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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    FORM 8-K


                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                        Securities Exchange Act of 1934


Date of Report: September 23, 1997          Commission File No. 0-27352
                ------------------                              -------
(Date of earliest event reported)



                                 HYBRIDON, INC.
                                 --------------
             (Exact name of registrant as specified in its Charter)


           Delaware                                    04-3072298
           --------                                    ----------
(State or other jurisdiction of             (IRS Employer Identification No.)
incorporation or organization)


620 Memorial Drive, Cambridge, Massachusetts             02139
- --------------------------------------------           ----------
(Address of principal executive offices)               (Zip Code)


                                 (617) 528-7000
                                 --------------
              (Registrant's telephone number, including area code)
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ITEM 5. OTHER EVENTS

        On September 23, 1997, Hybridon, Inc. (the "Company") issued a press
release announcing that (i) the Company is moving forward with the appeal
process with The Nasdaq Stock Market Inc., in response to the notification of
delisting that the Company announced last week; and (ii) the Company's common
stock, $.001 par value per share, will continue to trade on the Nasdaq National
Market until the appeal is resolved. A copy of the press release has been filed
with this Current Report on Form 8-K as Exhibit 99.1 and is incorporated herein
by reference.

ITEM 7. EXHIBITS

99.1    Press release dated September 23, 1997.
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                                   SIGNATURES


        Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


Dated: September 24, 1997            HYBRIDON, INC.






                                     /s/ E. Andrews Grinstead, III
                                     ---------------------------------------
                                     E. Andrews Grinstead, III
                                     Chairman, President and Chief Executive
                                     Officer
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                               INDEX TO EXHIBITS

EXHIBIT
  NO.                   DESCRIPTION
- -------                 -----------

 99.1       Press release dated September 23, 1997.
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                                                                    EXHIBIT 99.1

[HYBRIDON LOGO]          NEWS RELEASE



Hybridon, Inc. Tel: 617.528.7000 Fax: 617.528.7001 620 Memorial Drive www.hybridon.com FOR IMMEDIATE RELEASE Cambridge, MA 02139 Contact: Douglas J. Jensen Vice President, Administration and Corporate Development 617.528.7523 Noonan Russo Communications, Inc. 212.695.4455 Stephanie Seiler, PhD. (Investor) ext. 212 Renee Solano (media) ext.227
HYBRIDON TO CONTINUE TRADING PENDING NASDAQ APPEAL PROCESS Cambridge, Mass. - September 23, 1997 - Hybridon, Inc. (Nasdaq: HYBN) today announced that the Company is moving forward with the appeal process with The Nasdaq Stock Market Inc. ("NASDAQ"), in response to a notification of delisting which the Company announced last week. Hybridon received a letter from NASDAQ indicating that the Company was no longer in compliance with listing requirements and would be delisted. Hybridon has filed an appeal with NASDAQ, and the Company's stock will continue to trade on the Nasdaq National Market until the appeal is resolved. "We are examining our options for addressing NASDAQ's concerns and moving forward with our appeal process," said E. Andrews Grinstead, Chief Executive Officer of Hybridon. "There are a number of possible approaches to resolving our non-compliance issues, in addition to complying with alternative listing requirements on the NASDAQ National Market which we are exploring. Hybridon stock will continue to trade during the appeal process." Hybridon, headquartered in Cambridge, Massachusetts, is a leader in the discovery and development of novel genetic medicines for the treatment of important diseases, based primarily on antisense technology. Antisense technology involves the use of synthetic segments of DNA and RNA to stop the production of disease-associated proteins by interacting at the genetic level with target strands of messenger RNA. # # # Leadership in Genetic Antisense Medicine