1




                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    FORM 8-K


                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934


Date of Report:  APRIL 2, 1997                      Commission File No. 0-27352
                 -------------                                          -------
(Date of earliest event reported)                                       



                                 HYBRIDON, INC.
                                 --------------
             (Exact name of registrant as specified in its Charter)


         DELAWARE                                       04-3072298
         --------                                       ----------
(State of other jurisdiction of               (IRS Employer Identification No.)
incorporation or organization)

620 MEMORIAL DRIVE, CAMBRIDGE, MASSACHUSETTS                           02139
- --------------------------------------------                           -----
(Address of principal executive offices)                             (Zip Code)

                                 (617) 528-7000
                                 -------------- 
             (Registrant's telephone number, including area code)


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ITEM 5.  OTHER EVENTS

     On April 2, 1997, Hybridon, Inc. (the "Company") completed the sale of
$50,000,000 aggregate principal amount of 9% Convertible Subordinated Notes Due
2004 (the "Notes"). Interest on the Notes will be payable semi-annually in
arrears on April 1 and October 1 of each year, commencing October 1, 1997. The
Notes are convertible at the option of the holder at any time prior to maturity,
unless previously redeemed or repurchased, into shares of Common Stock, $.001
par value per share (the "Common Stock"), of the Company at a conversion price
of $7.0125 per share, subject to adjustment under certain circumstances (the
"Conversion Price").

     The Notes are unsecured and subordinate to all Senior Indebtedness (as
defined). The indenture under which the Notes were issued does not restrict the
incurrence of additional indebtedness by the Company or any of its subsidiaries.
The Notes are not redeemable prior to April 1, 2000. Thereafter, the Notes are
redeemable at any time, in whole or in part, at the Company's option, at
specified redemption prices, in each case, plus accrued dividends to the date of
repurchase; provided that from April 1, 2000 to March 31, 2001, the Notes may
not be redeemed unless the closing market price of the Common Stock equals or
exceeds 150% of the Conversion Price for a period of at least 20 out of 30
consecutive trading days and the Notes are redeemed within 60 days after such
trading period.

     Upon a Change of Control (as defined), the Company will offer to repurchase
each holder's Notes at a purchase price equal to 150% of the principal amount
thereof, plus accrued and unpaid interest to the date of repurchase.

     The Notes have been accepted for inclusion in the Private Offerings,
Resales and Trading through Automated Linkages ("PORTAL") Market. Pursuant to a
Registration Rights Agreement dated as of March 26, 1997, the Company has agreed
to file a Shelf Registration Statement (as defined) relating to the Notes and
the shares of Common Stock issuable upon conversion of the Notes.

ITEM 7.  EXHIBITS

1.   Purchase Agreement dated as of March 26, 1997 between Forum Capital
     Markets L.P. ("Forum") and the Company.

4.   Indenture dated as of March 26, 1997 between State Street Bank and Trust
     Company and the Company.

10.1 Registration Rights Agreement dated as of March 26, 1997 between Forum and
     the Company.


                                      -2-


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10.2 Warrant Agreement dated as of March 26, 1997 between Forum and the Company.

99.1 Press release dated March 27, 1997.

99.2 Press release dated April 2, 1997.


                                      -3-


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                                   SIGNATURES




     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


Dated:  April 9, 1997     HYBRIDON, INC.
             

                          /s/ E. Andrews Grinstead, III
                          ------------------------------
                          E. Andrews Grinstead, III
                          Chairman, President and Chief Executive 
                          Officer





                                      -4-



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                                INDEX TO EXHIBITS

EXHIBIT NO. DESCRIPTION ------- ----------- 1 Purchase Agreement dated as of March 26, 1997 between Forum Capital Markets L.P. ("Forum") and the Company. 4 Indenture dated as of March 26, 1997 between State Street Bank and Trust Company and the Company. 10.1 Registration Rights Agreement dated as of March 26, 1997 between Forum and the Company. 10.2 Warrant Agreement dated as of March 26, 1997 between Forum and the Company. 99.1 Press release dated March 27, 1997. 99.2 Press release dated April 2, 1997.
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                                                                     Exhibit 1

                                   $60,000,000
                   9% CONVERTIBLE SUBORDINATED NOTES DUE 2004

                                 HYBRIDON, INC.

                               PURCHASE AGREEMENT
                               ------------------

                                                            New York, New York
                                                                March 26, 1997

Forum Capital Markets L.P.
53 Forest Avenue
Old Greenwich, Connecticut 06870


Ladies and Gentlemen:

     Hybridon, Inc., a Delaware corporation (the "Company"), proposes to issue
and sell to Forum Capital Markets L.P. (the "Initial Purchaser") $50,000,000
aggregate principal amount of its 9% Convertible Subordinated Notes due 2004
(the "Notes") to be issued pursuant to the provisions of an indenture dated as
of the date hereof (the "Indenture") between the Company and State Street Bank
and Trust Company, as trustee (the "Trustee"). Such $50,000,000 aggregate
principal amount of Notes are hereafter referred to as the "Firm Notes." Upon
the request of the Initial Purchaser, as provided in Section 2(b) of this
Agreement, the Company shall also issue and sell to the Initial Purchaser up to
an additional $10,000,000 aggregate principal amount of Notes for the purpose of
covering over-allotments, if any. Such $10,000,000 aggregate principal amount of
Notes are hereinafter referred to as the "Option Notes." The Firm Notes and the
Option Notes collectively constitute all of the Notes. The shares of the
Company's common stock, par value $.001 per share (the "Common Stock"), issuable
upon conversion of the Notes are hereinafter referred to as the "Conversion
Shares."

     The Company also proposes to sell to the Initial Purchaser, for nominal
consideration, warrants (the "Warrants") pursuant to a warrant agreement (the
"Warrant Agreement") for the purchase of an aggregate of up to 427,807 shares of
Common Stock (the "Warrant Shares") at an exercise price per share of $7.0125,
subject to adjustment as provided in the Warrant Agreement. The Notes, the
Conversion Shares, the Warrants and the Warrant Shares are hereinafter referred
to collectively as the "Securities."

     The Notes will be offered and sold to the Initial Purchaser without being
registered under the Securities Act of 1933, as amended (the "Securities Act"),
in reliance on an exemption therefrom. The Company has prepared a preliminary
offering circular dated March 12, 1997 (the "Preliminary Offering Circular"),
and a final offering circular dated March 26, 1997 (the "Offering Circular"),
setting forth information regarding the Company and the Securities. The Company
hereby confirms that it has authorized the use of the Preliminary Offering
Circular and the Offering Circular in connection with the offering and sale of
the Notes (the "Offering").

     Holders (including subsequent transferees) of the Notes and Conversion
Shares will have the registration rights set forth in the Registration Rights
Agreement (the "Registration Rights Agreement") between the Initial Purchaser
and the Company, dated concurrently herewith. Pursuant to the Registration
Rights Agreement, the Company has agreed to file with the Securities and
Exchange Commission (the "Commission") a shelf registration statement pursuant
to Rule 415 under the Securities Act (the "Shelf Registration Statement") to
cover public resales of the Notes and the Conversion Shares by the holders
thereof.

     Capitalized terms used herein without definition have the respective
meanings specified therefor in the Offering Circular. For purposes hereof,
"Rules and Regulations" means the rules and regulations adopted by the
Commission under the Securities Act, the Securities Exchange Act of 1934, as
amended (the "Exchange Act"), or the Trust Indenture Act of 1939, as amended
(the "Trust Indenture Act"), as applicable.


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     1. REPRESENTATIONS AND WARRANTIES OF THE COMPANY. The Company represents
and warrants to, and agrees with, the Initial Purchaser as of the date hereof,
and as of the Closing Date and each Option Closing Date (as defined in Section
2(b) hereof), if any, as follows:

          (a) The Offering Circular does not, and at the Closing Date and any
Option Closing Date will not, and any amendment or supplement thereto, if any,
as of its date, will not, contain any untrue statement of a material fact or
omit to state any material fact required to be stated therein or necessary in
order to make the statements therein, in light of the circumstances under which
they were made, not misleading. The preceding sentence does not apply to
information contained in or omitted from the Preliminary Offering Circular or
the Offering Circular (or any supplement or amendment thereto) in reliance upon
and in conformity with written information furnished to the Company by or on
behalf of the Initial Purchaser specifically for use therein (the "Initial
Purchaser's Information"). The parties acknowledge and agree that the Initial
Purchaser's Information consists solely of the last paragraph at the bottom of
the front cover page concerning the terms of the offering by the Initial
Purchaser, the legends concerning over-allotment and trading activities of the
Initial Purchaser and its affiliates on page 3 and the paragraphs under the
caption "Plan of Distribution" in the Offering Circular. No order suspending or
preventing the sale of the Securities in any jurisdiction has been issued or
threatened or, to the knowledge of the Company, is contemplated.

          (b) The Company is subject to Section 13 or 15(d) of the Exchange Act.
The documents incorporated by reference into the Offering Circular (the
"Incorporated Documents"), when they were filed with the Commission (or, if any
amendment with respect to any such document was filed, when such amendment was
filed), complied in all material respects with the applicable requirements of
the Exchange Act and when read together with the Incorporated Documents and the
Offering Circular did not, as of such date, contain an untrue statement of a
material fact or omit to state a material fact required to be stated therein or
necessary in order to make the statements therein not misleading; and any
Incorporated Documents filed subsequent to the date of the Offering Circular
shall, when filed with the Commission, conform in all material respects to the
applicable requirements of the Securities Act, the Rules and Regulations and the
Exchange Act, as applicable. All reports and statements required to be filed by
the Company under the Securities Act and the Exchange Act have been filed,
together with all exhibits required to be filed therewith. The documents and
agreements so filed which are described in the Offering Circular are in full
force and effect on the date hereof (unless noted otherwise in the Offering
Circular) and neither the Company nor any of its direct and indirect
subsidiaries identified on Annex I hereto (collectively, the "Subsidiaries"),
nor, to the knowledge of the Company, any other party thereto is in breach of or
default under a material provision of any such document or agreement, which
breach or default, if left uncured, would have a material adverse effect on the
condition, financial or otherwise, results of operations, business or prospects
of the Company and the Subsidiaries, taken as a whole (a "Material Adverse
Effect"). The descriptions in the Offering Circular of agreements, contracts and
other documents to which the Company or any of the Subsidiaries is a party or by
which any of them is bound fairly present in all material respects the
information that would be required to be presented with respect thereto under
United States federal securities laws.

          (c) The Company and each of the Subsidiaries has been duly organized
and is validly existing as a corporation in good standing under the laws of the
jurisdiction of its incorporation, except to the extent such concept is
inapplicable in such jurisdiction. Each of the Company and the Subsidiaries is
duly qualified and licensed and in good standing as a foreign corporation in
each jurisdiction in which its ownership or leasing of any properties or the
character of its operations require such qualification or licensing (each of
which jurisdictions is designated on Annex I hereto), except where the failure
to be so qualified or licensed would not have a Material Adverse Effect or where
such concept is inapplicable in such jurisdiction. Each Subsidiary which
accounted for more than 5% of the Company's consolidated assets at December 31,
1996 or more than 10% of the Company's consolidated revenues during the 12
months then ended or which is reasonably expected to exceed such percentages
with respect to the Company's next four fiscal quarters ending after the date
hereof are indicated on Annex I hereto, and all such Subsidiaries are
hereinafter referred to collectively as the "Significant Subsidiaries." The
Company does not own or control, directly or indirectly, any corporation,
association or other


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entity. Except as set forth on Annex I, the Company owns, either directly or 
through other Subsidiaries, all of the outstanding capital stock of each 
Subsidiary, in each case free and clear of all liens, charges, claims, 
encumbrances, pledges, security interests, defects or other restrictions or 
equities of any kind whatsoever; and all outstanding capital stock of the 
Subsidiaries has been duly authorized and validly issued and is fully paid and 
non-assessable and not issued in violation of any preemptive rights or 
applicable securities laws. Each of the Company and the Subsidiaries has all 
requisite power and authority (corporate and other), and has obtained any and 
all requisite authorizations, approvals, orders, licenses, certificates, 
franchises and permits of and from all governmental or regulatory officials and
bodies, to own or lease its properties and conduct its business as described in
the Offering Circular, except where the failure to have any such power, 
authority, authorization, approval, order license, certificate, franchise or 
permit would not have a Material Adverse Effect; each of the Company and the 
Subsidiaries is and has been doing business in compliance with all such 
authorizations, approvals, orders, licenses, certificates, franchises and 
permits and all federal, foreign, state and local laws, rules and regulations, 
except where the failure to be in compliance would not have a Material Adverse 
Effect; and neither the Company nor any of the Subsidiaries has received any 
notice of proceedings relating to the revocation or modification of any such 
authorization, approval, order, license, certificate, franchise or permit 
which, singly or in the aggregate, if the subject of an unfavorable decision, 
ruling or finding, would have a Material Adverse Effect.

          (d) The Company has an authorized capitalization as set forth in the
Offering Circular and will have the adjusted capitalization as of the period
indicated therein, based upon the assumptions set forth therein. Neither the
Company nor any of the Subsidiaries is a party to or bound by any instrument,
agreement or other arrangement, including, but not limited to, any voting trust
agreement, stockholders' agreement or other agreement or instrument, affecting
the securities or rights or obligations of securityholders of the Company or any
of the Subsidiaries or providing for any of them to issue, sell, transfer or
acquire any capital stock, rights, warrants, options or other securities of the
Company or any of the Subsidiaries, except for this Agreement, the Indenture,
the Warrant Agreement and as set forth in the Offering Circular (including the
notes to the financial statements set forth therein). The Company's capital
stock and the Securities conform in all material respects to all statements with
respect thereto contained in the Offering Circular. All issued and outstanding
equity securities of the Company have been duly authorized and validly issued
and are fully paid and non-assessable, as applicable; the holders thereof have
no rights of rescission with respect thereto and are not subject to personal
liability by reason of being such holders; and none of such securities were
issued in violation of the preemptive rights of any securityholder of the
Company or any of the Subsidiaries or similar contractual rights granted by the
Company or any of the Subsidiaries.

          (e) The Notes will be issued pursuant to the terms and conditions of
the Indenture, and the Indenture and the Registration Rights Agreement each
conform to the description thereof contained in the Offering Circular. At the
Closing Date, the Indenture will conform in all material respects to the
requirements of the Trust Indenture Act and the Rules and Regulations applicable
to an indenture which is qualified thereunder. The Notes have been duly
authorized and, when validly authenticated, issued, delivered and paid for in
the manner contemplated by the Indenture, will be duly authorized, validly
issued and outstanding obligations of the Company entitled to the benefits of
the Indenture. The Warrant Agreement will conform in all material respects to
the description thereof set forth in the Offering Circular. The Warrants have
been duly authorized and when validly issued, delivered and paid for in the
manner contemplated by the Warrant Agreement, will be duly authorized, validly
issued and outstanding obligations of the Company entitled to the benefits of
the Warrant Agreement. The Conversion Shares issuable upon conversion of the
Notes and the Warrant Shares issuable upon exercise of the Warrants will, upon
payment and issuance in accordance with the terms of the Warrant Agreement, be
duly authorized, fully-paid and non-assessable, and the Company has duly
authorized and reserved the Conversion Shares for issuance upon conversion of
the Notes and the Warrant Shares for issuance upon exercise of the Warrants. The
Securities are not and will not be subject to any preemptive or other similar
rights of any securityholder of the Company or any of the Subsidiaries; all
corporate action required to be taken on behalf of the Company for the
authorization, issue and sale of the Securities has been duly and validly taken;
and the certificates representing the any Conversion Shares or Warrant Shares
will comply with the requirements of the Delaware General Corporation Law. Upon
the issuance and delivery pursuant to the terms of this Agreement, the Indenture
and the Warrant Agreement of the Notes and the Warrants, the Initial Purchaser
will acquire good and marketable title thereto


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(subject to restrictions imposed by applicable federal and state securities
laws) free and clear of any lien, charge, claim, encumbrance, pledge, security
interest, defect or other restriction or equity of any kind whatsoever (other
than restrictions created by the Initial Purchaser).

          (f) The consolidated financial statements of the Company and the
Subsidiaries together with the related notes thereto included in the Preliminary
Offering Circular and the Offering Circular fairly present the financial
position, income, changes in stockholders' equity, cash flow and results of
operations of the Company and the Subsidiaries at the respective dates and for
the respective periods to which they apply and such financial statements have
been prepared in conformity with generally accepted accounting principles and
the Rules and Regulations, consistently applied throughout the periods involved.
Except as described in or contemplated by the Offering Circular, (i) there has
been no material adverse change or development involving a prospective material
change in the condition, financial or otherwise, or in the earnings, business,
prospects or results of operations of the Company and the Subsidiaries, taken as
a whole, whether or not arising in the ordinary course of business, since the
date of the latest financial statements included in the Offering Circular (other
than the continued incurrence of losses by the Company in the ordinary course of
business) and (ii) the outstanding debt, the property, both tangible and
intangible, and the businesses of each of the Company and the Subsidiaries
conform in all material respects to the descriptions thereof contained in the
Offering Circular. Financial information set forth in the Offering Circular
under the headings "Summary Consolidated Financial Data," "Selected Consolidated
Financial Data," "Capitalization" and "Management's Discussion and Analysis of
Financial Condition and Results of Operations" fairly present, on the basis
stated in the Offering Circular, the information set forth therein and have been
derived from or compiled on a basis consistent with that of the audited
financial statements included in the Offering Circular.

          (g) Each of the Company and the Subsidiaries has filed all income and
franchise tax returns required to be filed (after giving effect to all
permissible extensions) through the date hereof by it in any jurisdiction, and
has paid all taxes shown to be due on such returns or claimed to be due from
such entities, other than those being contested in good faith, except where the
failure to so file or pay would not have a Material Adverse Effect. All tax
liabilities, including those being contested by the Company or the Subsidiaries
are adequately reserved for in the Company's financial statements (in accordance
with generally accepted accounting principles). No tax deficiency has been
asserted and no tax proceedings are pending or, to the knowledge of the Company,
is threatened against the Company or any of the Subsidiaries which, if adversely
determined would have a Material Adverse Effect, and to the knowledge of the
Company, no such deficiency or proceeding is contemplated.

          (h) No transfer tax, stamp duty or other similar tax is payable by or
on behalf of the Initial Purchaser in connection with (i) the issuance by the
Company of the Securities, (ii) the purchase by the Initial Purchaser of the
Notes or the Warrants from the Company or (iii) the consummation by the Company
of any of its obligations under this Agreement, the Indenture or the Warrant
Agreement.

          (i) Each of the Company and the Subsidiaries maintains liability,
casualty and other insurance (subject to customary deductions and retentions)
against such risk of the types and in the amounts customarily maintained by
companies of comparable size to the Company engaged in similar businesses in
similar industries, all of which insurance is in full force and effect.

          (j) There is no action, suit, proceeding, litigation or governmental
proceeding pending or, to the knowledge of the Company, threatened or
contemplated against (or circumstances that are reasonably likely to give rise
to the same), or involving the properties or businesses of, the Company or any
of the Subsidiaries which (i) questions the validity of the capital stock of the
Company or any of the Subsidiaries, this Agreement, the Indenture, the Warrant
Agreement, the Registration Rights Agreement or of any action taken or to be
taken by the Company or any of the Subsidiaries pursuant to or in connection
with this Agreement, the Indenture, the Warrant Agreement or the Registration
Rights Agreement or (ii) except as disclosed in or contemplated by the Offering
Circular, would have a Material Adverse Effect.


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          (k) The Company has the legal right and corporate power and authority
to authorize, issue, deliver and sell the Securities, to enter into this
Agreement, the Indenture, the Warrant Agreement and the Registration Rights
Agreement and to consummate the transactions provided for in such agreements;
and this Agreement has been duly and properly authorized, executed and delivered
by the Company and when the Company has duly executed and delivered the Warrant
Agreement and the Registration Rights Agreement (assuming the due execution and
delivery thereof by the Initial Purchaser) and the Indenture (assuming the due
execution and delivery thereof by the Trustee), this Agreement, the Warrant
Agreement, the Registration Rights Agreement and the Indenture each will
constitute a legal, valid and binding agreement of the Company enforceable
against the Company in accordance with its terms, except as rights to
indemnification may be limited by federal or state securities laws and except
for the effect of bankruptcy, insolvency, reorganization, moratorium and other
similar laws relating to or affecting the rights of creditors generally. None of
the Company's issue and sale of the Securities, the execution or delivery of
this Agreement, the Indenture, the Warrant Agreement and the Registration Rights
Agreement, its performance hereunder and thereunder or its consummation of the
transactions contemplated herein and therein conflicts or will conflict with or
results or will result in any breach or violation of any of the terms or
provisions of, or constitutes or will constitute a default under, or results or
will result in the creation or imposition of any lien, charge, claim,
encumbrance, pledge, security interest, defect or other restriction or equity of
any kind whatsoever upon any property or assets of the Company or any of the
Subsidiaries pursuant to the terms of, (i) the certificate of incorporation or
by-laws of the Company or any of the Subsidiaries, (ii) any license, contract,
indenture, mortgage, deed of trust, voting trust agreement, stockholders'
agreement, note, loan or credit agreement or other agreement or instrument to
which the Company or any of the Subsidiaries is a party or by which it or any
Subsidiary is or may be bound or to which its or any of the Subsidiaries'
properties or assets is or may be subject, or any indebtedness, or (iii) any
statute, judgment, decree, order, rule or regulation directly applicable to the
Company or any of the Subsidiaries of any arbitrator, court, regulatory body or
administrative agency or other governmental agency or body, having jurisdiction
over the Company or any of the Subsidiaries or any of their respective
activities or properties, which, with respect to the foregoing clauses (ii) and
(iii) only, breach, violation or default would have a Material Adverse Effect.

          (l) Neither the Company nor any of the Subsidiaries (i) is in
violation of its certificate of incorporation or by-laws, (ii) is in default in
the performance of any obligation, agreement or condition contained in any
license, contract, indenture, mortgage, installment sale agreement, lease, deed
of trust, voting trust agreement, stockholders' agreement, note, loan or credit
agreement, purchase order, agreement or instrument evidencing an obligation for
borrowed money or other material agreement or instrument to which the Company or
any of the Subsidiaries is a party or by which the Company or any of the
Subsidiaries may be bound or to which the property or assets of the Company or
any of the Subsidiaries is subject or affected or (iii) is in violation in any
respect of any law, ordinance, governmental rule, regulation or court decree to
which it or its property or assets may be subject, except any violation or
default under the foregoing clauses (ii) or (iii) as would not have a Material
Adverse Effect.

          (m) No consent, approval, authorization or order of, and no filing
with, any court, arbitrator, regulatory body, government agency or other body,
domestic or foreign, is required for the execution, delivery or performance of
this Agreement, the Indenture, the Warrant Agreement, the Registration Rights
Agreement or the transactions contemplated hereby or thereby, except such as
have been or may be obtained under the Securities Act (including the filing of
registration statements and filings to list the Notes on the Private Offerings,
Resale and Trading through Automated Linkages Market ("Portal") and the
Conversion Shares on the Nasdaq National Market) or may be required under state
securities or Blue Sky laws.

          (n) Subsequent to the respective dates as of which information is set
forth in the Offering Circular, and except as may otherwise be indicated or
contemplated herein or therein, neither the Company nor any of the Subsidiaries
has (i) issued any securities (other than upon the issuance or exercise of
options pursuant to the Company's Stock Option Plan and Stock Purchase Plan or
the exercise of warrants outstanding on such respective dates, or incurred any
material liability or obligation, direct or contingent, for borrowed money not
in the ordinary course of business, (ii) entered into any material transaction
other than in the ordinary course of business or 


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(iii) declared or paid any dividend or made any other distribution on or in
respect of its capital stock of any class and there has not been any change in
the capital stock (excluding changes contemplated by clause (i) hereof) or long
term debt of the Company and the Subsidiaries taken as a whole.

          (o) The Company and the Subsidiaries are in compliance in all material
respects with all applicable federal, state, local and foreign laws and
regulations respecting employment and employment practices, terms and conditions
of employment and wages and hours. To the knowledge of the Company, there are no
pending investigations involving the Company or any of the Subsidiaries by the
U.S. Department of Labor or any other governmental agency responsible for the
enforcement of such federal, state, local or foreign laws and regulations. To
the knowledge of the Company, there is no unfair labor practice charge or
complaint against the Company or any of the Subsidiaries pending before the
National Labor Relations Board or any strike, picketing, boycott, dispute,
slowdown or stoppage pending or threatened against or involving the Company or
any of the Subsidiaries. Neither the Company nor any of the Subsidiaries is or
ever have been a party to any collective bargaining agreement, and no collective
bargaining agreement is currently being negotiated by the Company or any of the
Subsidiaries. No material labor dispute with the employees of the Company or any
of the Subsidiaries exists or, to the knowledge of the Company, is imminent.

          (p) No "employee pension benefit plan," "employee welfare benefit
plan" or "multi- employer plan" of the Company ("ERISA Plans") as such terms are
defined in Sections 3(2), 3(1) and 3(37), respectively, of the Employee
Retirement Income Security Act of 1974, as amended ("ERISA"), or any trust
created thereunder has engaged in a "prohibited transaction" within the meaning
of Section 406 of ERISA or Section 4975 of the Internal Revenue Code of 1986, as
amended (the "Code") which could subject the Company to any material tax penalty
on prohibited transactions and which has not adequately been corrected. No
"accumulated funding deficiency" (as defined in Section 302 of ERISA) or any of
the events set forth in Section 4043(b) of ERISA (other than events with respect
to which the 30-day notice under Section 4043 of ERISA has been waived) has
occurred with respect to any employee benefit plan which might reasonably be
expected to have a Material Adverse Effect.

          (q) Neither the Company or any of the Subsidiaries, nor any of its
affiliates has taken or will take, directly or indirectly, any action designed
to or which has constituted or which might be expected to cause or result in,
under the Exchange Act or otherwise, stabilization or manipulation of the price
of any security of the Company to facilitate the sale or resale of the
Securities or otherwise.

          (r) Except as described in or contemplated by the Offering Circular,
each of the Company and the Subsidiaries (i) owns or has the right to use all
patents, trademarks, service marks, trade names, copyrights, technology, and all
licenses and rights with respect to the foregoing, used in the conduct of its
business without, to the knowledge of the Company and the Subsidiaries,
infringing upon the right of any person, corporation or other entity, except
where the failure to so own or have such right would not, in the aggregate, have
a Material Adverse Effect and (ii) has no reason to believe, and has not
received any written notice, that the conduct of their respective businesses
infringe or conflict with any such rights of others with respect to any of the
foregoing.

          (s) Each of the Company and the Subsidiaries has good and marketable
title to, or valid and enforceable leasehold estates in, all items of real and
personal property which are material to its business and/or reflected as owned
by it in the financial statements included in the Offering Circular, in each
case free and clear of all liens, charges, claims, encumbrances, pledges,
security interests, defects and other restrictions except those disclosed in the
Offering Circular or those which are not material in amount and do not
materially adversely affect the use made or proposed to be made of such
property.

          (t) Arthur Andersen LLP are independent certified public accountants
of the Company as required by the Securities Act and the Rules and Regulations.

          (u) The Notes satisfy the eligibility requirements of Rule 144A(d)(3)
under the Securities Act. The Common Stock is registered pursuant to Section
12(g) of the Exchange Act, and is approved for listing


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on the Nasdaq National Market under the symbol "HYBN." The Company has taken 
no action that was designed to terminate, or that is likely to have the affect 
of terminating, trading of the Common Stock on the Nasdaq National Market, nor 
has the Company received any notification that the Commission or the Nasdaq 
National Market is contemplating terminating such trading.

          (v) Neither the Company nor any of the Subsidiaries has, nor, to the
knowledge of the Company, has any officer, director or employee of the Company
or any of the Subsidiaries or any other person acting on behalf of the Company
or any of the Subsidiaries, for the benefit of the Company or any such
Subsidiaries at any time during the last five years, (i) made any unlawful gift
or contribution to any candidate for federal, state, local or foreign political
office, or failed to disclose fully any such gift or contribution in violation
of law, or (ii) made any payment to any federal, state, local or foreign
governmental officer or official, which would be reasonably likely to subject
the Company or any of the Subsidiaries to any damage or penalty in any civil,
criminal or governmental litigation or proceeding (domestic or foreign). Each of
the Company's and the Subsidiaries' internal accounting controls are sufficient
to cause the Company and the Subsidiaries to comply in all material respects
with the Foreign Corrupt Practices Act of 1977, as amended.

          (w) [Intentionally omitted]

          (x) The minute books of each of the Company and the Subsidiaries have
been made available to the Initial Purchaser, summarize in all material respects
all meetings and actions of the directors and stockholders of each of the
Company and the Subsidiaries since the time of their respective incorporation.

          (y) Neither the Company nor any of the Subsidiaries has been notified
in writing that it is liable with respect to obligations under the Comprehensive
Environmental Response, Compensation and Liability Act of 1980, as amended, or
any similar law ("Environmental Laws"), except for any liability as would not
have a Material Adverse Effect, and it is not aware of any facts or
circumstances which could reasonably be expected to result in any such
liability. The Company and the Subsidiaries are in substantial compliance with
all applicable existing Environmental Laws, except for such instances of
non-compliance which would not have a Material Adverse Effect. The term
"Hazardous Material" means (i) any "hazardous substance" as defined by the
Comprehensive Environmental Response, Compensation and Liability Act of 1980, as
amended, (ii) any "hazardous waste" as defined by the Resource Conservation and
Recovery Act, as amended, (iii) any petroleum or petroleum product, (iv) any
polychlorinated biphenyl and (v) any pollutant or contaminant or hazardous,
dangerous or toxic chemical, material, waste or substance regulation under or
within the meaning of any other Environmental Law. To the Company's knowledge,
no disposal, release or discharge of "Hazardous Material" has occurred on, in,
at or about any of the facilities or properties of the Company or any of the
Subsidiaries, except for any such disposal, release or discharge which is in
compliance with Environmental Laws or which would not have a Material Adverse
Effect. Except as described in the Offering Circular, to the Company's
knowledge: (i) there has been no storage, disposal, generation, transportation,
handling or treatment of hazardous substances or solid wastes by the Company or
any of the Subsidiaries (or to the knowledge of the Company, any of its
predecessors in interest) at, upon or from any of the property now or previously
owned or leased by the Company or any of the Subsidiaries in violation of any
applicable law, ordinance, rule, regulation, order, judgment, decree or permit
or which would require remedial action which has not been taken, under any
applicable law, ordinance, rule, regulation, order, judgment, decree or permit,
except for such violations and failures to take remedial action which would not
result in, singularly or in the aggregate, a Material Adverse Effect; and (ii)
there has been no material spill, discharge, leak, emission, injection, escape,
dumping or release of any kind onto such property or into the environment
surrounding such property by the Company or any of the Subsidiaries of any solid
waste or Hazardous Materials, except for such spills, discharges, leaks,
emissions, injections, escapes, dumping or releases which would not result in,
singularly or in the aggregate, a Material Adverse Effect.

          (z) The Company is not an "investment company" or a company controlled
by an "investment company" or, to the Company's knowledge, an "affiliated
person" of, or "promoter" or "principal


                                       7


   8


underwriter" for, an "investment company" as such terms are defined in the
Investment Company Act of 1940, as amended.

          (aa) Neither the Company nor any affiliate (as such term is defined in
Rule 501(b) under the Securities Act) of the Company has, directly or through
any agent, sold, offered for sale, solicited offers to buy or otherwise
negotiated in respect of, any "security" (as defined in the Securities Act),
which is or will be integrated with the sale of the Notes in a manner that would
require the registration of the Notes under the Securities Act.

          (bb) None of the Company, any affiliate (as such term is defined in
Rule 501(b) under the Securities Act) of the Company and any other person acting
on its or their behalf has engaged, in connection with the Offering, in any form
of general solicitation or general advertising within the meaning of Rule 502(c)
under the Securities Act.

          (cc) Assuming (A) the accuracy of the representations, warranties and
agreements of the Initial Purchaser contained in Section 2 hereof and those
contained in any Purchase Letter, (B) the due performance by the Initial
Purchaser of the agreements set forth in Section 3 of this Agreement, (C)
compliance by the Initial Purchaser with the offering and transfer procedures
and restrictions described in the Offering Circular, (D) the accuracy of the
representations and warranties made in accordance with this Agreement and the
Offering Circular by purchasers to whom the Initial Purchaser initially resells
Notes and (E) that purchasers to whom the Initial Purchaser initially resells
Notes receive a copy of the Offering Circular prior to such sale, it is not
necessary, in connection with the issuance and sale of the Notes and the offer,
resale and delivery of the Notes in the manner contemplated by this Agreement
and the Offering Circular, to register the Notes or the Conversion Shares under
the Securities Act or to qualify the Indenture under the Trust Indenture Act.

     2. Purchase by the Initial Purchaser.
        ----------------------------------

          (a) On the basis of the representations, warranties and agreements
contained herein, and subject to the terms and conditions set forth herein, the
Company agrees to issue and sell to the Initial Purchaser, and the Initial
Purchaser agrees to purchase from the Company, the Firm Notes at a purchase
price equal to 95% of the principal amount thereof.

          (b) In addition, on the basis of the representations, warranties and
agreements contained herein, and subject to the terms and conditions set forth
herein, the Company hereby grants an option to the Initial Purchaser to purchase
any or all of the Option Notes at a price equal to 95% of the principal amount
thereof plus accrued interest from the Closing Date to the applicable Option
Closing Date. Such option will expire 60 days after the date hereof, and may be
exercised in whole or in part from time to time only for the purpose of covering
over-allotments which may be made in connection with the offering and
distribution of the Firm Notes upon written notice by the Initial Purchaser to
the Company setting forth the aggregate principal amount of Option Notes as to
which the Initial Purchaser is then exercising the option and the time and date
of delivery and payment therefor. Any such time and date of delivery and payment
(an "Option Closing Date") shall be determined by the Initial Purchaser, but
shall not be later than five full business days after the exercise of such
option unless otherwise agreed by the Company and the Initial Purchaser;
provided that the Option Closing Date may not occur prior to the Closing Date.

          (c) The Initial Purchaser has advised the Company that it intends, as
promptly as it deems appropriate after the Company shall have furnished the
Initial Purchaser with copies of the Offering Circular, to resell the Notes
pursuant to the procedures and upon the terms set forth in the Offering Circular
and in compliance with applicable securities laws, including not to solicit any
offer to buy or offer to sell the Notes by means of any form of general
solicitation or general advertising (within the meaning of Regulation D under
the Securities Act) or in any manner involving a public offering within the
meaning of Section 4(2) of the Securities Act. The Initial Purchaser warrants
and agrees with the Company that it has solicited and will solicit offers (the
"Exempt Resales") for Notes only in compliance with applicable securities laws
and only from, and will offer Notes only to, persons


                                       8


   9


that it reasonably believes to be (i) "qualified institutional buyers" (as
defined in Rule 144A under the Securities Act ("QIBs")) in transactions that
meet the requirements for an exemption from the registration requirements of the
Securities Act under Rule 144A or (ii) to a limited number of "institutional
accredited investors" (as defined in Regulation D under the Securities Act and
of the types described in the Offering Circular ("Institutional Accredited
Investors")) that execute and deliver a letter containing certain
representations and agreements in the form attached as Annex A of the Offering
Circular. The QIBs and the Institutional Accredited Investors are referred to
herein as "Eligible Purchasers." The Initial Purchaser represents and warrants
that it is an Institutional Accredited Investor with such knowledge and
experience in financial and business matters as are necessary to evaluate the
merits and risks of an investment in the Notes, and is acquiring its interest in
the Notes not with a view to the distribution or resale thereof, except resales
in compliance with the registration requirements or exemption provisions of the
Securities Act and that neither it, nor anyone acting on its behalf, will offer
the Notes so as to bring the issuance and sale of the Notes within the
provisions of Section 5 of the Securities Act. The Company acknowledges and
agrees that the Initial Purchaser may sell Notes to any of its affiliates and
any such affiliate may sell Notes purchased by it to the Initial Purchaser. The
Initial Purchaser agrees that, prior to or simultaneously with the confirmation
of sale by it to any purchaser of any of the Notes purchased from the Company
pursuant hereto, such Initial Purchaser shall furnish to that purchaser a copy
of the Offering Circular (and any amendment thereof or supplement thereto that
the Company shall have furnished to the Initial Purchaser prior to the date of
such confirmation of sale).

          (d) On the Closing Date, the Company shall in consideration of the
payment to it by the Initial Purchaser of $.0001 per Warrant, issue to the
Initial Purchaser the Warrants pursuant to the Warrant Agreement.

     3. DELIVERY OF AND PAYMENT FOR THE NOTES. Delivery of, and payment for, the
Firm Notes shall be made at 10:00 a.m., New York City time, on April 2, 1997, or
at such other date or time as shall be agreed by the Initial Purchaser and the
Company (such date and time being referred to herein as the "Closing Date").
Delivery of, and payment for, the Firm Notes and the Option Notes shall be made
at the offices of Hale and Dorr LLP, 60 State Street, Boston, Massachusetts, or
any such other place as shall be agreed by the Initial Purchaser and the
Company. On the Closing Date, the Company shall deliver or cause to be delivered
to the Initial Purchaser certificates for the Firm Notes against payment to or
upon the order of the Company of the purchase price by wire or book-entry
transfer of immediately available funds. On each Option Closing Date, the
Company shall deliver or cause to be delivered to the Initial Purchaser
certificates for the Option Notes purchased thereat against payment to or upon
the order of the Company of the purchase price by wire or book-entry transfer of
immediately available funds. Upon delivery, the Notes shall be in global form,
in such denominations and registered in such names, or otherwise, as the Initial
Purchaser shall have requested in writing not less than two full business days
prior to the Closing Date. The Company shall make the certificates for the Notes
available for inspection by the Initial Purchaser in New York, New York, not
later than one full business day prior to the Closing Date.

     4. COVENANTS AND AGREEMENTS OF THE COMPANY. The Company covenants and
agrees with the Initial Purchaser as follows:

          (a) During the period ending upon the completion of the distribution
of the Securities to advise the Initial Purchaser promptly and, if requested,
confirm such advice in writing, of the happening of any event of which the
Company is aware which makes any statement of a material fact made in the
Offering Circular untrue or that requires the making of any additions to or
changes in the Offering Circular (as amended or supplemented from time to time)
in order to make the statements therein, in light of the circumstances under
which they were made, not misleading; to advise the Initial Purchaser promptly
upon learning of any order preventing or suspending the use of the Preliminary
Offering Circular or the Offering Circular, of the suspension of the
qualification of the Notes for offering or sale in any jurisdiction and of
learning of the initiation or threatening of any proceeding for any such
purpose; and to use its reasonable best efforts to prevent the issuance of any
such order preventing or suspending the use of the Preliminary Offering Circular
or of the Offering Circular or suspending any 


                                       9


   10


such qualification and, if any such suspension is issued, to use its reasonable
best efforts to obtain the lifting thereof at the earliest possible time.

          (b) To furnish promptly to the Initial Purchaser and counsel for the
Initial Purchaser, without charge, as many copies of the Preliminary Offering
Circular and the Offering Circular (and of any amendments or supplements
thereto) as may be reasonably requested; to furnish to the Initial Purchaser on
the date hereof a copy of the independent accountants' report included in the
Offering Circular signed by the accountants rendering such report; and the
Company hereby consents to the use of the Preliminary Offering Circular and the
Offering Circular, and any amendments and supplements thereto, in connection
with Exempt Resales of the Notes.

          (c) If the delivery of the Offering Circular is required at any time
in connection with the sale of the Notes and if at such time the Company becomes
aware of any events that have occurred as a result of which the Offering
Circular as then amended or supplemented would include an untrue statement of a
material fact or omit to state any material fact necessary in order to make the
statements therein, in the light of the circumstances under which they were made
when the Offering Circular is delivered, not misleading, or if for any other
reason it shall be necessary at such time to amend or supplement the Offering
Circular in order to comply with any law, to notify the Initial Purchaser
immediately after learning thereof, and to promptly prepare and furnish to the
Initial Purchaser an amended Offering Circular or a supplement to the Offering
Circular so that statements in the Offering Circular, as so amended or
supplemented, will not, in light of the circumstances under which they were made
when it is so delivered, be misleading, or so that the Offering Circular will
comply with applicable law. The Initial Purchaser's delivery of any such
amendment or supplement shall not constitute a waiver of any of the conditions
set forth in Section 6 hereof.

          (d) During the five-year period following the Closing Date, provided
any of the Notes remain outstanding, to furnish to the Initial Purchaser all
reports, documents, information and financial statements filed by the Company
with the Commission pursuant to the Trust Indenture Act, the Exchange Act or the
Rules and Regulations.

          (e) During the two-year period following the Closing Date or the last
Option Closing Date, if any, for so long as and at any time that it is not
subject to Section 13 or 15(d) of the Exchange Act, upon request of any holder
of the Notes, to furnish to such holder, and to any prospective purchaser or
purchasers of the Notes designated by such holder, information satisfying the
requirements of subsection (d)(4) of Rule 144(A) under the Securities Act. This
covenant is intended to be for the benefit of the holders from time to time of
the Notes, and prospective purchasers of the Notes designated by such holders.

          (f) To use the proceeds from the sale of the Notes in the manner
described in the Offering Circular under the caption "Use of Proceeds."

          (g) [intentionally omitted]

          (h) To use reasonable efforts to do and perform all things required to
be done and performed under this Agreement by it that are within its control
prior to or after the Closing Date and to use reasonable efforts to satisfy all
conditions precedent on its part to the delivery of the Securities.

          (i) Except following the effectiveness of the Shelf Registration
Statement, to not authorize or knowingly permit any person acting on its behalf
to solicit any offer to buy or offer to sell the Notes by means of any form of
general solicitation or general advertising (as such terms are used in
Regulation D under the Securities Act) or in any manner involving a public
offering within the meaning of Section 4(2) of the Securities Act; provided,
however, that nothing in this Section 4(i) shall impute any liability on the
Company for any actions of the Initial Purchaser.


                                       10


   11


          (j) To not, and to use reasonable efforts to ensure that no affiliate
(as such term is defined in Rule 501(b) under the Securities Act) of the Company
will, offer, sell or solicit offers to buy or otherwise negotiate in respect of
any "security" (as defined in the Securities Act) which could be integrated with
the sale of the Notes in a manner that would require the registration of the
Notes under the Securities Act.

          (k) To not, so long as the Notes are outstanding, be or become (and
use its best efforts not to be or become owned by) an open-end investment
company, unit investment trust or face-amount certificate company that is or is
required to be registered under Section 8 of the Investment Company Act, and to
not be or become (and use its best efforts not to be or become owned by) a
closed-end investment company required to be registered, but not registered
thereunder.

          (l) To cooperate with the Initial Purchaser and counsel for the
Initial Purchaser to qualify the Notes for offering and sale under the
securities laws of such jurisdictions as the Initial Purchaser may reasonably
request and to comply with such laws so as to permit the continuance of sales
and dealings therein in such jurisdictions for as long as may be necessary to
complete the distribution of the Notes; provided, however, that in connection
therewith the Company shall not be required to qualify as a foreign corporation
or to file a general consent to service of process or to subject it to taxation
in any jurisdiction where it is not so qualified or so subject.

          (m) To comply with the Registration Rights Agreement and all
agreements set forth in the representation letters of the Company to The
Depository Trust Company relating to the approval of the Notes for "book-entry"
transfers.

          (n) In connection with the Offering, until the Initial Purchaser shall
have notified the Company of the completion of the resale of the Notes, to not
and use reasonable efforts to not permit any affiliated purchasers (as defined
in Rule 10b-6 under the Exchange Act), either alone or with one or more other
persons, to bid for or purchase, for any account in which it or any of its
affiliated purchasers has a beneficial interest, any Notes or Common Stock, or
attempt to induce any person to purchase any Notes; and to not and use
reasonable efforts to not permit any of its affiliated purchasers to make bids
or purchases for the purpose of creating actual, or apparent, active trading in
or of raising the price of the Notes.

          (o) Prior to the Closing Date, to not issue any press release or other
communication directly or indirectly or hold any press conference with respect
to the Company, its condition, financial or otherwise, or earnings, business
affairs or business prospects, without prior consultation with the Initial
Purchaser, unless in the judgment of the Company and its counsel, and after
notification to the Initial Purchaser, such press release or communication is
required by law.

          (p) To not take any action after the date hereof and prior to the
execution and delivery of the Indenture which, if taken after such execution and
delivery, would have violated any of the covenants contained in the Indenture.

          (q) To not take any action prior to the Closing Date which in the
Company's reasonable judgment would require the Offering Circular to be amended
or supplemented pursuant to Section 4(c) hereof.

          (r) Until April 1, 2005, to maintain a transfer agent and, if
necessary under the laws of the jurisdiction of incorporation of the Company, a
registrar (which may be the same entity as the transfer agent) for the Common
Stock.

          (s) For a period ending on the earlier of five (5) years from the date
hereof or the date on which the aggregate principal amount of Notes outstanding
is less than $1,000,000, to use its best efforts to maintain the Portal (or
after the Shelf Registration Statement, Nasdaq Stock Market (or another national
securities exchange listing, if the Company is then listed thereon) listing of
the Notes, to the extent outstanding, and the


                                       11


   12


Nasdaq National Market (or another national securities exchange or other Nasdaq
Stock Market, if the Common Stock is then listed thereon) listing of the Common
Stock.

          (t) For three years from the date of issuance of the Notes, to not
issue any security that is directly or indirectly convertible into or
exchangeable for equity securities of the Company (or any security itself
convertible into or exchangeable for equity securities of the Company) which
provides for a conversion or exchange price which is calculated based upon the
future market value of the Common Stock unless at the time of the issuance of
the security an initial conversion or exchange price is established and the
formula for calculating an adjusted conversion or exchange price expressly
provides that such conversion or exchange price shall not be less than the
initial conversion or exchange price other than as a result of anti-dilution
adjustments to the conversion or the exchange price resulting from issuance of
equity securities by the Company.

     5. Payment of Expenses.
        -------------------

               (a) The Company hereby agrees to pay all of the following
expenses and fees incident to the performance of the obligations of the Company
under this Agreement, the Indenture, the Warrant Agreement and the Registration
Rights Agreement, including, regardless of whether any sale of the Notes to the
Initial Purchaser is consummated: (i) the fees and expenses of accountants and
counsel for the Company, (ii) all costs and expenses incurred in connection with
the preparation, duplication, printing (including mailing and handling charges),
delivery and mailing (including the payment of postage with respect thereto) of
each Preliminary Offering Circular and the Offering Circular and any amendments
and supplements thereto, in quantities as hereinabove stated, (iii) the
printing, engraving, issuance and delivery of the certificates representing the
Notes, (iv) costs and expenses of travel, food and lodging of Company personnel
in connection with the "road show," information meetings and presentations, (v)
fees and expenses of the transfer agent and registrar, (vi) fees and expenses of
the Trustee, including the Trustee's counsel, in connection with the Indenture
and the Notes, (vii) the fees payable to the NASD, CUSIP Service Bureau and DTC
incurred in connection with the listing of the Notes and the Conversion Shares
for trading in the PORTAL Market, (viii) the fees payable to the Commission and
the Nasdaq National Market in connection with the filing of a registration
statement with respect to the Notes and the Conversion Shares and the listing of
the Conversion Shares on the Nasdaq National Market, (ix) all costs of placing
tombstone advertisements in The New York Times, The Wall Street Journal and The
Investment Dealers Digest and (x) all other costs and expenses incident to the
performance of its obligations hereunder which are not specifically otherwise
provided for in this Section. In addition, at the Closing, the Company will pay
or reimburse the Initial Purchaser for its reasonable and accountable
out-of-pocket expenses in connection with the Offering of up to $200,000,
provided, the Initial Purchaser will not incur any such expenses in excess of
$15,000 (other than legal fees and expenses) without the Company's prior
consent.

               (b) If this Agreement is terminated for any reason, the Company
shall reimburse and indemnify the Initial Purchaser for its actual accountable
out-of-pocket expenses, up to the limits and subject to the conditions set forth
in the preceding paragraph.

     6. CONDITIONS OF THE INITIAL PURCHASER'S OBLIGATIONS. The obligations of
the Initial Purchaser hereunder shall be subject to the continuing accuracy of
the representations and warranties of the Company herein as of the date hereof
and as of the Closing Date and each Option Closing Date, if any, as if they had
been made on and as of the Closing Date or each Option Closing Date, as the case
may be; and the performance by the Company on and as of the Closing Date and
each Option Closing Date, if any, of its covenants and obligations hereunder and
to the following further conditions:

               (a) The Initial Purchaser shall not have advised the Company that
the Offering Circular, or any supplement or amendment thereto, contains an
untrue statement of fact which, in the opinion of Kelley Drye & Warren LLP,
counsel for the Initial Purchaser, is material, or omits to state a fact which,
in the opinion of Kelley Drye & Warren LLP, counsel for the Initial Purchaser,
is material and is required to be stated therein or is


                                       12


   13


necessary to make the statements, in light of the circumstances under which they
were made, not misleading. No order suspending the sale of the Securities in any
jurisdiction shall have been issued on either the Closing Date or the relevant
Option Closing Date, if any, and no proceedings for that purpose shall have been
instituted or shall be contemplated.

               (b) On or prior to the Closing Date and each Option Closing Date,
if any, the Initial Purchaser shall have received from Kelley Drye & Warren LLP
such opinion or opinions with respect to the organization of the Company, the
validity of the Securities, the Offering Circular and other related matters as
the Initial Purchaser may request and Kelley Drye & Warren LLP shall have
received such papers and information as they may reasonably request to enable it
to pass upon such matters.

               (c) On the Closing Date and each Option Closing Date, if any, the
Initial Purchaser shall have received an opinion of Hale and Dorr LLP, counsel
to the Company, dated the Closing Date, or such Option Closing Date, as the case
may be, addressed to the Initial Purchaser and in form and substance
satisfactory to the Initial Purchaser and Kelley Drye & Warren LLP, to the
effect that:

               i) (A) the Company has been duly incorporated and is validly
          existing as a corporation in corporate and tax good standing under the
          laws of its jurisdiction of incorporation, (B) the Company is duly
          qualified to do business and in good standing as a foreign corporation
          in the Commonwealth of Massachusetts and (C) the Company has all
          requisite corporate power and authority necessary to own or lease its
          properties and conduct its business as described in the Offering
          Circular;

               ii) the Company's authorized capital stock as of December 31,
          1996 is as set forth under the heading "Capitalization" in the
          Offering Circular;

               iii the Securities and all other securities issued or issuable by
          the Company which are described in the Offering Circular conform or,
          when issued and paid for, will conform in all material respects to the
          descriptions thereof contained in the Offering Circular; all issued
          and outstanding capital stock of the Company has been duly authorized
          and validly issued and is fully paid and non-assessable; to such
          counsel's knowledge, none of such securities were issued in violation
          of the preemptive rights of any securityholder of the Company or
          similar contractual rights granted by the Company or applicable
          securities laws; the Notes have been duly authorized and, when validly
          issued, delivered and paid for by the Initial Purchaser in the manner
          contemplated by this Agreement, will be duly authorized and
          outstanding obligations of the Company and enforceable against the
          Company in accordance with their terms, except to the extent that
          enforceability thereof may be limited by (1) bankruptcy, insolvency,
          reorganization, fraudulent transfer, moratorium or similar laws now or
          hereafter in effect relating to creditors' rights generally; or (2)
          general principles of equity (regardless of whether enforceability is
          considered in a proceeding at law or in equity); the Warrants have
          been duly authorized and, when validly issued, delivered and paid for
          in the manner contemplated by the Warrant Agreement, will be duly
          authorized, validly issued and outstanding obligations of the Company;
          the shares of Common Stock issuable upon conversion of the Notes and
          exercise of the Warrants have been duly authorized and reserved for
          issuance upon conversion of the Notes and exercise of the Warrants, as
          the case may be, and, when issued, delivered and paid for, will be
          validly issued, fully paid and nonassessable; and the holders of
          outstanding securities of the Company are not entitled to any
          preemptive rights with respect to the Securities pursuant to the
          Company's Certificate of Incorporation or By-laws, as amended, or any
          other instrument known to such counsel; all corporate action required
          to be taken for the authorization, issue and sale of the Securities
          has been duly and validly taken;


                                       13


   14


               iv) to such counsel's knowledge, there is no action, arbitration,
          suit, or other proceeding pending or threatened in writing or any
          judgments outstanding against the Company or involving the properties
          or business of the Company which (A) questions the validity of the
          capital stock of the Company or of this Agreement, the Indenture, the
          Warrant Agreement, the Registration Rights Agreement or of any action
          taken or to be taken by the Company pursuant to or in connection with
          any of the foregoing or (B) is not disclosed in the Offering Circular;

               v) the Company has the corporate power and authority to execute,
          deliver and perform each of this Agreement, the Indenture, the Warrant
          Agreement and the Registration Rights Agreement and to consummate the
          transactions provided for herein and therein; the execution and
          delivery of this Agreement, the Indenture, the Warrant Agreement and
          the Registration Rights Agreement have been duly authorized by all
          requisite corporate action on the part of the Company and each of this
          Agreement, the Indenture, the Warrant Agreement and the Registration
          Rights Agreement has been duly executed and delivered by the Company;

               vi) the execution and delivery by the Company of this Agreement,
          the Indenture, the Warrant Agreement and the Registration Rights
          Agreement, the performance by the Company hereunder or thereunder, the
          compliance by the Company with the provisions thereof and the
          consummation by the Company of the transactions contemplated hereby
          and thereby, do not and will not conflict with or result in any breach
          or violation of, constitute a default under or result in the creation
          or imposition of any lien, charge, claim, pledge, security interest or
          other encumbrance upon any property or assets of the Company pursuant
          to the terms of (A) the charter or by-laws of the Company, (B) any
          license, contract, indenture, mortgage, deed of trust, voting trust
          agreement, stockholders' agreement, note, loan or credit agreement or
          other agreement or instrument listed as an exhibit to any of the
          Incorporated Documents or (C) any statute, rule or regulation (other
          than federal or state securities laws) or, to the best of such
          counsel's knowledge, any judgment, decree or order specifically naming
          the Company of any arbitrator, court, regulatory body or
          administrative agency or other governmental agency or body having
          jurisdiction over the Company or any of its activities or properties.
          Such counsel need express no opinion in this paragraph (vi) as to (A)
          state securities or Blue Sky laws or (B) with respect to matters of
          fact relating to compliance with any financial covenants, ratios or
          tests or any aspect of the financial condition or results of
          operations of the Company;

               vii) to the knowledge of such counsel, based solely upon a review
          of the exhibits to the Incorporated Documents and a certificate of the
          Chief Executive Officer of the Company, the Company is not a party to
          or bound by any instrument, agreement or other arrangement providing
          for it to issue any capital stock, rights, warrants, options or other
          securities of the Company, except for this Agreement and as described
          in or contemplated by the Offering Circular, the Indenture and the
          Warrant Agreement;

               viii) Based in so far as factual matters are concerned solely up
          on a certificate of the Company, no consent, approval, authorization 
          or order of, and no filing with, any court, regulatory body, 
          government agency or other body (other than such as have been or may 
          be made or obtained under the Securities Act (including the filing of
          registration statements) and such as may be required under state
          securities or Blue Sky laws and such as may be required in order to
          list the Notes on Portal or the Conversion Shares on the Nasdaq
          National Market, as to which no opinion need be rendered) is required
          in connection with the issuance of the Securities as contemplated by
          the Offering Circular or in connection with the performance of this
          Agreement, the Indenture, the Warrant Agreement and the Registration
          Rights Agreement, and the transactions contemplated hereby and
          thereby;


                                       14


   15


               ix) the statements in the Offering Circular under the captions
          "Description of Capital Stock" and "Certain United States Federal
          Income Tax Considerations" have been reviewed by such counsel, and
          insofar as they refer to statements of law, or descriptions of
          statutes, licenses, rules or regulations or legal conclusions, are
          correct in all material respects;

               x) assuming the (A) accuracy of the representations, warranties
          and agreements of the Company contained in Sections 1(x) and (y) of
          this Agreement and of the Initial Purchaser in Section 2 of this
          Agreement and those contained in any Purchase Letter, (B) the due
          performance by the Company of the agreements set forth in Section 4 of
          this Agreement and of the Initial Purchaser in Section 3 this
          Agreement, (C) compliance by the Initial Purchaser with the offering
          and transfer procedures and restrictions described in the Offering
          Circular, (D) the accuracy of the representations and warranties made
          in accordance with this Agreement and the Offering Circular by
          purchasers to whom the Initial Purchaser initially resells Notes and
          (E) that purchasers to whom the Initial Purchaser initially resells
          Notes receive a copy of the Offering Circular prior to such sale, the
          offer and sale of the Notes to the Initial Purchaser and the initial
          resale of the Notes by the Initial Purchaser to Eligible Purchasers in
          the manner contemplated by this Agreement and the Offering Circular,
          are exempt from the registration requirements of the Securities Act,
          it being understood that such counsel need express no opinion as to
          any subsequent resale of any of the Securities, and the Indenture need
          not be qualified under the Trust Indenture Act with respect to such
          offer and sale; and

               xi) the Company is not an "investment company," within the
          meaning of, is not registered or otherwise required to be registered
          under, and is not "controlled" by a company which is required to be
          registered under, the Investment Company Act of 1940, as amended.

In rendering such opinion, such counsel may: (A) state that its opinion is
limited to matters governed by the federal laws of the United States of America,
the state laws of the Commonwealth of Massachusetts and General Corporation Law
Statute of the State of Delaware and (B) rely as to matters of fact solely on
certificates and written statements of officers of the Company and certificates
or other written statements of officers of departments of various jurisdictions
having custody of documents respecting the corporate existence or good standing
of the Company, provided, that copies of any such statements or certificates
shall be delivered to the Initial Purchaser and Kelley Drye & Warren LLP, if
requested.

               (d) Hale and Dorr shall state in the opinion letter contemplated
by Section 6(c) that such counsel has participated in conferences with officers
and other representatives of the Company, representatives of the independent
public accountants for the Company and representatives of Initial Purchaser, at
which conferences the contents of the Offering Circular and related matters were
discussed, and, although such counsel is not passing upon, and does not assume
any responsibility for, the accuracy, completeness or fairness of the statements
contained in the Offering Circular, subject to the foregoing and based on such
participation, inquiries and discussions, no facts have come to the attention of
such counsel which has caused them to believe that the Offering Circular, as of
its date, contained an untrue statement of a material fact or omitted to state a
material fact required to be stated therein or necessary to make the statements
therein not misleading, except that such counsel need express no opinion or
belief with respect to the financial statements and related notes, the pro forma
financial information, or any other financial, statistical or accounting data,
or any information relating to the Initial Purchaser or the method of
distribution of the Notes by the Initial Purchaser included in the Offering
Circular or excluded therefrom or the matters in the Offering Circular relating
to intellectual property to which McDonnell, Boehman, Hulbert & Berghoff has
provided to you a separate legal opinion);

               (e) On or prior to the Closing Date and each Option Closing Date,
if any, Kelley Drye & Warren LLP shall have been furnished such documents and
certificates as they may reasonably require for the purpose of enabling them to
review or pass upon the matters referred to in subsection (c) of this Section 6
or in


                                       15


   16


order to evidence the accuracy, completeness or satisfaction of any of the
representations, warranties or conditions of the Company herein contained.

               (f) On and as of the Closing Date and each Option Closing Date,
if any: (i) there shall have been no material adverse change involving a
prospective change in the condition, financial or otherwise, prospects,
stockholders' equity or the business activities of the Company and the
Subsidiaries taken as a whole, whether or not in the ordinary course of
business, from the latest dates as of which such condition is set forth in the
Offering Circular, other than the continued incurrence of losses by the Company
in the ordinary course of business; (ii) there shall have been no transaction,
not in the ordinary course of business, entered into by the Company or any of
the Subsidiaries, from the latest date as of which the financial condition of
the Company and the Subsidiaries is set forth in the Offering Circular which is
materially adverse to the Company and the Subsidiaries taken as a whole; (iii)
neither the Company nor any of the Subsidiaries shall be in default under any
provision of any instrument relating to any material outstanding indebtedness;
(iv) no material amount of the assets of the Company or any of the Subsidiaries
shall have been pledged or mortgaged, except as set forth in the Offering
Circular; (v) no action, suit or proceeding, at law or in equity, shall have
been pending or, to the knowledge of the Company, threatened or contemplated
against the Company or any of the Subsidiaries, or affecting any of their
respective properties or businesses, before or by any court or federal, state or
foreign commission, board or other administrative agency wherein an unfavorable
decision, ruling or finding may have a Material Adverse Effect, except as set
forth in the Offering Circular; and (vi) no order suspending or preventing the
sale of the Securities shall have been issued under the Securities Act and no
proceedings therefor shall have been initiated or threatened or, to the
knowledge of the Company, contemplated by the Commission or any state regulatory
authority.

               (g) On the Closing Date and each Option Closing Date, if any, the
Initial Purchaser shall have received a certificate of the Company signed on
behalf of the Company by the principal executive officer and by the chief
financial or chief accounting officer of the Company, in their capacities as
such, dated the Closing Date or such Option Closing Date, as the case may be, to
the effect that each of such persons has carefully examined the Offering
Circular, this Agreement, the Indenture and the Registration Rights Agreement,
and that:

               i) the representations and warranties of the Company in this
          Agreement, the Indenture, the Warrant Agreement and the Registration
          Rights Agreement are true and correct, as if made on and as of the
          Closing Date or such Option Closing Date, as the case may be, and the
          Company has complied with all agreements and covenants and satisfied
          all conditions contained in this Agreement, the Indenture, the Warrant
          Agreement and the Registration Rights Agreement on its part to be
          performed or satisfied at or prior to the Closing Date or Option
          Closing Date, as the case may be;

               ii) no stop order suspending the qualification or exemption from
          qualification of the Securities shall have been issued and no
          proceedings for that purpose shall have been commenced or, to the
          knowledge of the Company, be contemplated;

               iii since the date of the most recent financial statements
          included in the Offering Circular, there has been no material adverse
          change in the condition, financial or otherwise, business, prospects
          or results of operation of the Company and the Subsidiaries, taken as
          a whole, except as set forth in the Offering Circular;

               iv) none of the Offering Circular or any amendment or supplement
          thereto includes any untrue statement of a material fact or omits to
          state any material fact required to be stated therein or necessary to
          make the statements therein, in light of the circumstances under which
          they were made, not misleading; and

               v) subsequent to the respective dates as of which information is
          given in the Offering Circular: (a) neither the Company nor any of the
          Subsidiaries has incurred up to and including


                                       16


   17


          the Closing Date or the Option Closing Date, as the case may be, other
          than in the ordinary course of its business, any material liabilities
          or obligations, direct or contingent, except as disclosed in the
          Offering Circular; (b) neither the Company nor any of the Subsidiaries
          has paid or declared any dividends or other distributions on its
          capital stock; (c) neither the Company nor any of the Subsidiaries has
          entered into any material transactions not in the ordinary course of
          business, except as disclosed in the Offering Circular; (d) there has
          not been any change in the capital stock (other than pursuant to the
          Company's stock option plan or stock purchase plan or the exercise of
          warrants outstanding on such respective dates) or the long term debt
          of the Company or any of the Subsidiaries; (e) neither the Company nor
          any of the Subsidiaries has sustained any material loss or damage to
          its property or assets, whether or not insured; (f) there is no
          litigation which is pending or, to the Company's knowledge, threatened
          or contemplated against the Company, any of the Subsidiaries or any
          affiliated party of any of the foregoing which would, if decided
          adversely, have a Material Adverse Effect and which is required to be
          set forth in an amended or supplemented Offering Circular which has
          not been set forth; and (g) there has occurred no event which would be
          required to be set forth in an amended or supplemented prospectus if
          the Offering Circular were a prospectus included in a registration
          statement on Form S-3, which has not been set forth in an amendment or
          supplement to the Offering Circular.

               (h) On or before the date hereof the Initial Purchaser shall have
received a letter, dated such date, addressed to the Initial Purchaser in form
and substance satisfactory in all respects to the Initial Purchaser and Kelley
Drye & Warren LLP, from Arthur Andersen LLP:

               i) confirming that they are independent certified public
          accountants with respect to the Company within the meaning of the
          Securities Act and the Exchange Act and the applicable Rules and
          Regulations;

               ii) stating that it is their opinion that the consolidated
          financial statements and supporting schedules of the Company and the
          Subsidiaries included in the Offering Circular or incorporated by
          reference therein comply as to form in all material respects with the
          applicable accounting requirements of the Securities Act;

               iii) stating that, on the basis of procedures which included a
          reading of the latest available unaudited interim consolidated
          financial statements of the Company and the Subsidiaries (with an
          indication of the date of the latest available unaudited interim
          consolidated financial statements of the Company and the
          Subsidiaries), a reading of the latest available minutes of the
          stockholders and board of directors and the various committees of the
          board of directors of each of the Company and the Subsidiaries,
          consultations with officers and other employees of each of the Company
          and the Subsidiaries responsible for financial and accounting matters
          and other procedures specified by the American Institute of Certified
          Public Accountants for a review of interim financial information as
          described in SAS No. 71, Interim Financial Information, nothing has
          come to their attention which would lead them to believe that (A) at
          February 28, 1997, there has been any change in the stockholder's
          equity or long-term debt of the Company, or any decrease in the
          stockholders' equity or net current assets or net assets of the
          Company, as compared with amounts shown in the December 31, 1996
          balance sheet included in the Offering Circular, other than as set
          forth in or contemplated by the Offering Circular, or, if there was
          any change or decrease, setting forth the amount of such change or
          decrease, (B) during the period from January 1, 1997 to February 28,
          1997, there was any decrease in net revenues or net earnings, or net
          earnings per common share of the Company, in each case as compared
          with the corresponding period beginning January 1, 1996, other than as
          set forth in or contemplated by the Offering Circular, or, if there
          was any such decrease, setting forth the amount of such decrease, (C)
          at a specified date not more than five (5) days prior to the later of
          the date of this Agreement or the Offering Circular, there has been
          any change in the stockholders' equity or long-term debt


                                       17


   18


          of the Company, or any decrease in the stockholders' equity or net
          current assets or net assets of the Company, as compared with amounts
          shown in the December 31, 1996 balance sheet included in the Offering
          Circular, other than as set forth in or contemplated by the Offering
          Circular, or, if there was any change or decrease, setting forth the
          amount of such change or decrease, and (D) during the period from
          January 1, 1997 to a specified date not more than five (5) days prior
          to the later of the date of this Agreement, there was any decrease in
          net revenues or net earnings or net earnings per common share of the
          Company, in each case as compared with the corresponding period
          beginning January 1, 1996, other than as set forth in or contemplated
          by the Offering Circular, or, if there was any such decrease, setting
          forth the amount of such decrease;

               iv) stating that they have compared specific dollar amounts,
          numbers of shares, percentages of revenues and earnings, statements
          and/or other financial information pertaining to the Company and the
          Subsidiaries set forth in the Offering Circular in each case to the
          extent that such amounts, numbers, percentages, statements and
          information may be derived from the general accounting records,
          including work sheets, of the Company and/or the Subsidiaries and
          excluding any questions requiring an interpretation by legal counsel,
          with the results obtained from the application of specified readings,
          inquiries and other appropriate procedures (which procedures need not
          constitute an examination in accordance with generally accepted
          auditing standards) set forth in the letter and found them to be in
          agreement; and

               v) statements as to such other matters incident to the
          transaction contemplated hereby as the Initial Purchaser may
          reasonably request.

               (i) On the Closing Date and each Option Closing Date, if any, the
Initial Purchaser shall have received from Arthur Andersen LLP a letter, dated
as of the Closing Date or such Option Closing Date, as the case may be, to the
effect that they reaffirm that statements made in the letter furnished pursuant
to subsection (h) of this Section 6, except that the specified date referred to
shall be a date not more than five (5) days prior to the Closing Date or such
Option Closing Date, as the case may be, to the further effect that they have
carried out procedures as specified in clause (iii) of subsection (h) of this
Section 6 with respect to certain amounts, percentages and financial information
as specified by the Initial Purchaser and deemed to be a part of the Offering
Circular and have found such amounts, percentages and financial information to
be in agreement with the records specified in such clause (iii). If there is
more than one Option Closing, the obligations of the Company pursuant to this
Section 6(i) shall be conditioned upon the payment by the Initial Purchaser of
the fees and expenses of Arthur Andersen LLP incurred to provide the foregoing
letter at any Option Closing after the initial Option Closing.

               (j) On the Closing Date and each Option Closing Date, if any,
there shall have been duly tendered to the Initial Purchaser the appropriate
principal amount of Notes.

               (k) The Notes shall have been approved by the National
Association of Securities Dealers, Inc. for trading in the PORTAL market.

               (l) Trading in the Common Stock shall not have been suspended by
the Nasdaq National Market at any time after February 28, 1996 (other than for a
period not in excess of one hour as a result of announcing the transaction
contemplated by this Agreement).

               (m) Subsequent to the execution and delivery of this Agreement
there shall not have occurred any of the following: (i) trading in securities
generally on the New York Stock Exchange, the American Stock Exchange or the
over-the-counter market shall have been suspended, or minimum prices shall have
been established on either of such exchanges or such market by the Commission,
by such exchange or by any other regulatory body or governmental authority
having jurisdiction, or trading in securities of the Company on any exchange or
in the over-the-counter market shall have been suspended or (ii) any moratorium
on commercial banking activities shall have been declared by Federal or New York
State authorities or (iii) an outbreak or


                                       18


   19


escalation of hostilities or a declaration by the United States of a national
emergency or war or such a material adverse change in general economic,
political or financial conditions (or the effect of international conditions on
the financial markets in the United States shall be such) as to make it, in the
judgment of the Initial Purchaser, impracticable or inadvisable to proceed with
the offering or the delivery of the Notes on the terms and in the manner
contemplated in the Offering Circular.

               (n) The Company and the Initial Purchaser shall have executed and
delivered the Warrant Agreement and the Registration Rights Agreement on the
date of this Agreement.

               (o) The Indenture shall have been duly executed and delivered by
the Company and the Trustee, and the Notes shall have been duly executed and
delivered by the Company and authenticated by the Trustee.

               (p) If any event shall have occurred that requires the Company
under Section 4(c) hereof to prepare an amendment or supplement to the Offering
Circular, such amendment or supplement shall have been prepared, the Initial
Purchaser shall have been given a reasonable opportunity to comment thereon, and
copies thereof delivered to the Initial Purchaser.

               (q) There shall not have occurred any invalidation of Rule 144A
under the Securities Act by any court or any withdrawal or proposed withdrawal
of any rule or regulation under the Securities Act or the Exchange Act by the
Commission or any amendment or proposed amendment thereof by the Commission
which in the reasonable and good faith judgment of the Initial Purchaser would
materially impair the ability of the Initial Purchaser to purchase, hold or
effect resales of the Notes as contemplated hereby.

               (r) On or prior to the Closing Date and each Option Closing Date,
if any, the Initial Purchaser shall have received a certificate signed on behalf
of the Company by the secretary of the Company, in his capacity as such, dated
the Closing Date or such Option Closing Date, as the case may be, as to:

               i) the absence of any contemplated proceeding for the merger,
          consolidation, liquidation or dissolution of the Company or any
          Subsidiary, as the case may be, or the sale of all or substantially
          all of its assets;

               ii) the due adoption and full force and effect of the By-laws of
          the Company (with a copy of the By-laws attached);

               iii) resolutions adopted by the Board of Directors of the Company
          and/or a committee thereof authorizing the Offering and the
          consummation of the transactions contemplated by this Agreement, the
          Indenture, the Warrant Agreement and the Registration Rights Agreement
          (with copies of such resolutions attached); and

               iv) the incumbency, authorization and signatures of those
          officers of the company signing this Agreement, the Indenture, the
          Warrant Agreement, the Registration Rights Agreement and/or any
          certificate delivered at Closing.

               (s) On the Closing Date and each Option Closing Date, if any, the
Initial Purchaser shall have received an opinion of McDonnell, Boehman, Hulbert
& Berghoff, United States patent counsel for the Company, dated the Closing Date
or such Option Closing Date, as the case may be, addressed to the Initial
Purchaser and in form and substance satisfactory to the Initial Purchaser and
Kelley Drye & Warren LLP to the effect that:

               i) Such counsel has reviewed the statements in the Offering
          Circular, set forth in the penultimate paragraph under the caption
          "Offering Circular Summary--The Company," in the


                                       19


   20

          eighth paragraph under the caption "Business" and under the captions
          "Risk Factors--Patent and Proprietary Rights" and "Business--Patents,
          Trade Secrets and Licenses" (other than the statements set forth in
          paragraphs 12 and 13 thereof), and insofar as such statements concern
          patents, patent applications or other intellectual property, such
          counsel does not believe that, the above-referenced paragraphs contain
          any untrue statement of a material fact or omit to state any material
          fact necessary to make the statements therein, in light of the
          circumstances in which they were made, not misleading. Further,
          insofar as such statements constitute summaries of matters of law,
          those statements are accurate statements or summaries of the matters
          set forth therein in all material respects.

               ii) Such counsel has no knowledge of any facts that would form a
          basis for the belief that the Company or any of the Subsidiaries lack
          any rights or licenses to use all patents and know-how necessary to
          conduct the business as proposed to be conducted in the United States
          by the Company and the Subsidiaries as described in the Offering
          Circular.

               iii) No facts have come to the attention of such counsel that
          would form a basis for the belief that any of the United States
          patents owned by the Company or any of the Subsidiaries is
          unenforceable or invalid. Such counsel is not aware of any patents of
          others which are or would be infringed by specific, current or
          proposed products or processes referred to in the Offering Circular in
          such manner as to materially and adversely affect the Company or any
          of the Subsidiaries; such counsel has no knowledge of any pending or
          threatened action, suit, proceeding or claim by others that the
          Company or any of the Subsidiaries is infringing any patent, trade
          secret or other intellectual property which could result in a Material
          Adverse Effect.

               iv) Other than as described in the Offering Circular, such
          counsel has no knowledge of any legal or governmental proceedings
          pending relating to the United States patent rights of the Company,
          other than U.S. Patent and Trademark Office ("PTO") review of pending
          applications for patents, including appeal proceedings, and no such
          proceedings are threatened or contemplated by United States
          governmental authorities or others, except that Hybridon has received
          a co- exclusive license from the NIH under NIH's patents related to
          certain oligonucleotide phosphorothioates, and pre-existing licensees
          have appealed NIH's decision to grant this license.

               v) Prior to filing the patent applications referred to in the
          Offering Circular, such counsel conducted investigations of the
          published prior art relating to the inventions claimed in such
          applications. Based on the information obtained in such
          investigations, such patent applications disclosed all pertinent prior
          art references known to such counsel. To the best of such counsel's
          knowledge, all information submitted to the PTO in such patent
          applications, and in connection with the prosecution thereof, was
          complete and accurate. Each of the patents and patent applications
          referred to in the Offering Circular as being owned by the Company has
          been assigned to the Company by the inventors named therein; each of
          such patent applications has been filed with the PTO in accordance
          with the rules and regulations of the PTO, except for such failures as
          will not individually or in the aggregate result in a Material Adverse
          Effect, and substantially all of such applications have been awarded a
          filing date by the PTO.

In rendering such opinion, such counsel shall state the it has no reason to
believe that the Company's pending patent applications will not eventuate in
issued patents or that the patents issued to the Company or any patents to be
issued in respect of the pending patent applications of the Company will not be
valid or will not afford the Company reasonable patent protection relative to
the subject matter thereof.

               (t) On the Closing Date, Arthur Andersen LLP shall have delivered
to the Initial Purchaser an unqualified Report of Independent Public Accountants
with respect to the Company's December 31, 1996 financial statements, which
shall contain no reference to the Company's ability to continue as a going
concern.


                                       20

   21


               (u) On the Closing Date and each Option Closing Date, if any, the
Initial Purchaser shall have received an opinion of Brobeck, Phleger & Harrison
LLP, counsel to the Company, dated the Closing Date, or such Option Closing
Date, as the case may be, addressed to the Initial Purchaser and in form and
substance satisfactory to the Initial Purchaser and Kelley Drye & Warren LLP, to
the effect that assuming each of this Agreement, the Indenture, the Warrant
Agreement and the Registration Rights Agreement has been duly authorized,
executed and delivered by the Company and by each other party thereto, the same
constitutes a legal, valid and binding agreement of the Company enforceable
against the Company in accordance with its terms; except as enforceability
thereof may be limited by applicable bankruptcy, insolvency, reorganization,
fraudulent transfer, moratorium or other similar laws now or hereafter in effect
relating to or affecting creditors' rights generally or by general equitable
principles and except that such counsel need express no opinion as to the
enforceability of any rights to indemnification, contribution or liquidated
damages, or any provisions relating to consent to jurisdiction or choice of
forum contained in this Agreement, the Indenture, the Warrant Agreement or the
Registration Rights Agreement.

               All opinions, letters, evidence and certificates mentioned above
or elsewhere in this Agreement shall be deemed to be in compliance with the
provisions hereof only if they are in form and substance reasonably satisfactory
to the Initial Purchaser.

               If any condition to the Initial Purchaser's obligations hereunder
to be fulfilled prior to or at the Closing Date or the relevant Option Closing
Date, as the case may be, is not so fulfilled, the Initial Purchaser may
terminate its obligations pursuant to Section 9 or, if the Initial Purchaser so
elects, it may waive any such conditions which have not been fulfilled or extend
the time for their fulfillment.

               7. Indemnification.
                  ----------------

               (a) The Company agrees to indemnify and hold harmless the Initial
Purchaser (for purposes of this Section 7, "Initial Purchaser" shall include the
officers, directors, partners, employees and agents, and each person, if any,
who controls the Initial Purchaser ("controlling person") within the meaning of
Section 15 of the Securities Act or Section 20(a) of the Exchange Act, from and
against any and all losses, claims, damages, expenses or liabilities, joint or
several (and actions, proceedings, suits and litigation in respect thereof),
whatsoever, as the same are incurred, to which the Initial Purchaser or any such
controlling person may become subject, under the Securities Act, the Exchange
Act or any other statute or at common law or otherwise insofar as such losses,
claims, damages, expenses or liabilities arise out of or are based upon any
untrue statement or alleged untrue statement of a material fact contained in any
Preliminary Offering Circular or the Offering Circular (as from time to time
amended and supplemented) or arise out of or are based upon the omission or
alleged omission therefrom of a material fact required to be stated therein or
necessary to make the statements therein in the light of the circumstances under
which they were made, not misleading; provided, however, that the Company shall
not be liable in any such case to the extent that any such loss, claim, damage,
expense or liability arises out of or is based upon any untrue statement or
alleged untrue statement or omission or alleged omission made in any Preliminary
Offering Circular or the Offering Circular or any such amendment or supplement
in reliance upon and in conformity with Initial Purchaser's Information and
provided, further, that the Company shall not be liable to the Initial Purchaser
under the indemnity agreement in this subsection (a) (i) with respect to any
Preliminary Offering Circular to the extent that any such loss, liability,
claim, damage or expense of the Initial Purchaser arises out of a sale of the
Notes by the Initial Purchaser to a person to whom there was not sent or given,
at or prior to the written confirmation of such sale, a copy of the Offering
Circular (or of the Offering Circular as then amended or supplemented) if the
Company has previously furnished copies thereof to the Initial Purchaser a
reasonable time in advance and the loss, liability, claim, damage or expense of
the Initial Purchaser results from an untrue statement or alleged untrue
statement or omission or alleged omission of a material fact contained in the
Preliminary Offering Circular which was corrected in the Offering Circular (or
the Offering Circular as amended or supplemented) or (ii) to the extent that any
such loss, claim, damage, expense or liability arises out of or is based upon
any action or failure to act by the Initial Purchaser that is found in a final
judicial determination (or a settlement tantamount thereto) to constitute


                                       21

   22


bad faith, willful misconduct or gross negligence on the part of the Initial
Purchaser. The indemnity agreement in this subsection (a) shall be in addition
to any liability which the Company may have at common law or otherwise.

               (b) The Initial Purchaser agrees to indemnify and hold harmless
the Company, each of its directors, each of its officers and each other person,
if any, who controls the Company within the meaning of the Securities Act, to
the same extent as the foregoing indemnity from the Company to the Initial
Purchaser, but only with respect to statements or omissions, if any, made in
conformity with the Initial Purchaser's Information in any Preliminary Offering
Circular or the Offering Circular or any amendment thereof or supplement
thereto.

               (c) Promptly after receipt by an indemnified party under this
Section 7 of notice of the commencement of any action, suit or proceeding, such
indemnified party shall, if a claim in respect thereof is to be made against one
or more indemnifying parties under this Section 7, notify each party against
whom indemnification is to be sought in writing of the commencement thereof (but
the failure to notify an indemnifying party shall not relieve it from any
liability which it may have under Sections 7(a) or (b) unless and to the extent
that it has been prejudiced in a material respect by such failure or from the
forfeiture of substantial rights and defenses). In case any such action, suit or
proceeding is brought against any indemnified party, and it notifies an
indemnifying party or parties of the commencement thereof, the indemnifying
party or parties will be entitled to participate therein, and to the extent it
may elect by written notice delivered to the indemnified party promptly after
receiving the aforesaid notice from such indemnified party, to assume the
defense thereof with counsel reasonably satisfactory to such indemnified party,
which may be the same counsel as counsel to the indemnifying party.
Notwithstanding the foregoing, the indemnified party or parties shall have the
right to employ its or their own counsel in any such case but the fees and
expenses of such counsel shall be at the expense of such indemnified party or
parties unless (i) the employment of such counsel shall have been authorized in
writing by the indemnifying parties in connection with the defense of such
action at the expense of the indemnifying party, (ii) the indemnifying parties
shall not have employed counsel reasonably satisfactory to such indemnified
party to take charge of the defense of such action within a reasonable time
after notice of commencement of the action or (iii) such indemnified party or
parties shall have reasonably concluded, after consultation with counsel to such
indemnified party or parties, that a conflict of interest exists which makes
representation by counsel chosen by the indemnifying party not advisable (in
which case the indemnifying parties shall not have the right to direct the
defense of such action on behalf of the indemnified party or parties), in any of
which events such fees and expenses of one additional counsel shall be borne by
the indemnifying parties. In no event shall the indemnifying parties be liable
for fees and expenses of more than one counsel (in addition to any local
counsel) separate from their own counsel for all indemnified parties in
connection with any one action or separate but similar or related actions in the
same jurisdiction arising out of the same general allegations or circumstances.
Anything in this Section 7 to the contrary notwithstanding, an indemnifying
party shall not be liable for any settlement of any claim or action effected
without its written consent.

               (d) In order to provide for just and equitable contribution in
any case in which (i) an indemnified party makes claim for indemnification
pursuant to this Section 7, but it is judicially determined (by the entry of a
final judgment or decree by a court of competent jurisdiction and the expiration
of time to appeal or the denial of the last right of appeal) that such
indemnification may not be enforced in such case notwithstanding the fact that
the express provisions of this Section 7 provide for indemnification in such
case, or (ii) contribution under the Securities Act may be required, then each
indemnifying party, in lieu of indemnifying such indemnified party, shall
contribute to the amount paid as a result of such losses, claims, damages,
expenses or liabilities (or actions, suits, proceedings or litigation in respect
thereof) (A) in such proportion as is appropriate to reflect the relative
benefits received by each of the contributing parties, on the one hand, and the
party to be indemnified on the other hand, from the offering of the Notes or (B)
if the allocation provided by clause (A) above is not permitted by applicable
law, in such proportion as is appropriate to reflect not only the relative
benefits referred to in clause (i) above but also the relative fault of each of
the contributing parties, on the one hand, and the party to be indemnified, on
the other hand, in connection with the statements or omissions that resulted in
such losses, claims, damages, expenses or liabilities, as well as any other
relevant equitable considerations. The relative benefits received by the
Company, on the one hand, and the Initial Purchaser, on the other, shall be
deemed to be in the same proportion as the total net proceeds from the offering
of the Notes (before deducting expenses) bear to the total discounts


                                       22


   23


received by the Initial Purchaser hereunder, in each case as set forth in the
table on the Cover Page of the Offering Circular. Relative fault shall be
determined by reference to, among other things, whether the untrue or alleged
untrue statement of a material fact or the omission or alleged omission to state
a material fact relates to information supplied by the Company or by the Initial
Purchaser, and the parties' relative intent, knowledge, access to information
and opportunity to correct or prevent such untrue statement or omission. The
amount paid or payable by an indemnified party as a result of the losses,
claims, damages, expenses or liabilities (or actions, suits, proceedings or
litigation in respect thereof) referred to above in this subsection (d) shall be
deemed to include any legal or other expenses reasonably incurred by such
indemnified party in connection with investigating, preparing or defending any
such action, claim, suit, proceeding or litigation. Notwithstanding the
provisions of this subsection (d), the Initial Purchaser shall not be required
to contribute any amount in excess of the discount applicable to the Notes
purchased by the Initial Purchaser hereunder. No person guilty of fraudulent
misrepresentation (within the meaning of Section 12(f) of the Securities Act)
shall be entitled to contribution from any person who was not guilty of such
fraudulent misrepresentation. For purposes of this Section 7, each person, if
any, who controls the Company within the meaning of the Securities Act, each
executive officer of the Company and each director of the Company shall have the
same rights to contribution as the Company, subject in each case to this
subsection (d). Any party entitled to contribution will, promptly after receipt
of notice of commencement of any action, suit, proceeding or litigation against
such party in respect to which a claim for contribution may be made against
another party or parties under this subsection (d), notify such party or parties
from whom contribution may be sought, but the omission so to notify such party
or parties shall not relieve the party or parties from whom contribution may be
sought from any obligation it or they may have hereunder or otherwise than under
this subsection (d), or to the extent that such party or parties were not
adversely affected by such omission. The contribution agreement set forth above
shall be in addition to any liabilities which any indemnifying party may have at
common law or otherwise.

               8. REPRESENTATIONS AND AGREEMENTS TO SURVIVE DELIVERY. All
representations, warranties and agreements contained in this Agreement or
contained in certificates of officers of the Company submitted pursuant hereto
shall be deemed to be representations, warranties and agreements at the Closing
Date and each Option Closing Date, as the case may be, and the agreements of the
Company and the provisions with respect to the payment of expenses contained in
Sections 5 and 9 and the respective indemnity agreements contained in Section 7
hereof shall remain operative and in full force and effect regardless of any
investigation made by or on behalf of the Initial Purchaser, the Company, any of
the Subsidiaries or any controlling person, and shall survive termination of
this Agreement or the issuance and delivery of the Notes to the Initial
Purchaser.

               9. Termination.
                  -----------

               (a) Subject to subsection (b) of this Section 9, the Initial
Purchaser shall have the right to terminate this Agreement (i) if any domestic
or international event or act or occurrence has disrupted, or in the Initial
Purchaser's reasonable and good faith opinion will in the immediate future
disrupt the United States financial markets; or (ii) if any material adverse
change in the United States financial markets shall have occurred; or (iii) if
trading on the New York Stock Exchange, the American Stock Exchange or in the
over-the-counter market shall have been suspended, or minimum or maximum prices
for trading shall have been fixed, or maximum ranges for prices for securities
shall have been required on the over-the-counter market by the NASD or by order
of the Commission or any other government authority having jurisdiction; or (iv)
if the United States shall have become involved in a war or major hostilities,
or there shall have been an escalation in an existing war or major hostilities,
or a national emergency shall have been declared in the United States; or (v) if
a banking moratorium has been declared by a state or federal authority; or (vi)
if a moratorium in foreign exchange trading has been declared; or (vii) if the
Company shall have sustained a loss material to the Company by fire, flood,
accident, hurricane, earthquake, theft, sabotage or other calamity or malicious
act which, whether or not such loss shall have been insured, will, in the
Initial Purchaser's reasonable and good faith opinion, make it inadvisable to
proceed with the delivery of the Securities; or (viii) if there shall have been
such a material adverse change in the general market, political or economic
conditions in the United States or elsewhere, as in the Initial Purchaser's
reasonable and good faith judgment would make it inadvisable to proceed with the
offering, sale and/or delivery of the Notes.


                                       23


   24


               (b) If this Agreement is terminated by the Initial Purchaser in
accordance with the provisions of Section 9(a) or 10 hereof or if this Agreement
shall not be carried out within the time specified herein, or any extension
thereof granted to the Initial Purchaser, by reason of any failure on the part
of the Company to perform any undertaking or satisfy any condition of this
Agreement by it to be performed or satisfied (including, without limitation,
pursuant to Section 6, 9 or 10 hereof), then the Company shall promptly
reimburse and indemnify the Initial Purchaser for all of its out-of-pocket
expenses, including the fees and disbursements of counsel for the Initial
Purchaser (less amounts previously paid pursuant to Section 5), up to $200,000.
Notwithstanding any contrary provision contained in this Agreement, any election
hereunder or any termination of this Agreement (including, without limitation,
pursuant to Sections 6, 9 and 10 hereof), and whether or not this Agreement is
otherwise carried out, the provisions of Section 5 and Section 7 shall not be in
any way affected by such election or termination or failure to carry out the
terms of this Agreement or any part hereof.

               10. DEFAULT BY THE COMPANY. If the Company shall fail at the
Closing Date or any Option Closing Date, as applicable, to sell and deliver the
number of Securities which it is obligated to sell hereunder on such date, then
the obligations of the Initial Purchaser under this Agreement shall terminate
(or, if such default shall occur with respect to any Option Securities to be
purchased on an Option Closing Date, the Initial Purchaser may, at its option,
by notice from the Initial Purchaser to the Company, terminate the Initial
Purchaser's obligation to purchase Option Notes from the Company on such date)
without any liability on the part of any non-defaulting party other than
pursuant to Sections 5, 7 and 9 hereof. No action taken pursuant to this Section
10 shall relieve the Company from liability, if any, in respect of such default.

               11. NOTICES. All notices and communications hereunder, except as
herein otherwise specifically provided, shall be given in writing and shall be
deemed to have been duly given if mailed or transmitted by any standard form of
telecommunication and shall be effective upon actual receipt. Notices to the
Initial Purchaser shall be directed to it at Forum Capital Markets L.P., 53
Forest Avenue, Old Greenwich, Connecticut 06870, Attention: Mr. C. Keith
Hartley, with a copy to Kelley Drye & Warren LLP, Two Stamford Plaza, 281
Tresser Boulevard, Stamford, Connecticut 06901, Attention: Jay R. Schifferli,
Esq. Notices to the Company shall be directed to the Company at 620 Memorial
Drive, Cambridge, Massachusetts 02139, Attention: President, with a copy to Hale
and Dorr LLP, 60 State Street, Boston, Massachusetts 02109, Attention: David E.
Redlick, Esq.

               12. PARTIES. This Agreement shall inure solely to the benefit of
and shall be binding upon the Initial Purchaser, the Company and the controlling
persons, directors and officers referred to in Section 7 hereof, and their
respective successors, legal representatives and assigns, and no other person
shall have or be construed to have any legal or equitable right, remedy or claim
under or in respect of or by virtue of this Agreement or any provisions herein
contained. No purchaser of Notes from the Initial Purchaser shall be deemed to
be a successor by reason merely of such purchase.

               13. CONSTRUCTION. This Agreement shall be governed by and
construed and enforced in accordance with the laws of the State of New York
without giving effect to choice of law or conflict of laws principles.

               14. COUNTERPARTS. This Agreement may be executed in any number of
counterparts, each of which shall be deemed to be an original, and all of which
taken together shall be deemed to be one and the same instrument.


                                       24


   25



               15. ENTIRE AGREEMENT; AMENDMENTS. This Agreement constitutes the
entire agreement of the parties hereto and supersedes all prior written or oral
agreements, understandings and negotiations with respect to the subject matter
hereof, including, without limitation, the Letter of Intent between the parties
dated March 13, 1997. This Agreement may not be amended except in a writing
signed by the Initial Purchaser and the Company.

               If the foregoing correctly sets forth the understanding between
the Initial Purchaser and the Company, please so indicate in the space provided
below for that purpose, whereupon this letter shall constitute a binding
agreement among us.


                                       Very truly yours,

                                       HYBRIDON, INC.



                                       By: /s/ E. Andrews Grinstead, III
                                          ---------------------------------
                                          Name: E. Andrews Grinstead, III
                                          Title: Chairman, President and Chief
                                                 Executive Officer
Confirmed and accepted as of
  the date first above written.

FORUM CAPITAL MARKETS L.P.



By: /s/ C. Keith Hartley
   -------------------------------------
   Name:  C. Keith Hartley
   Title:  Senior Managing Director




                                       25


   26


                                     ANNEX I


                                  Subsidiaries
                                  ------------

Jurisdictions in Ownership which Qualified to Name Jurisdiction Of Incorporation Percentage Conduct Business - ---------------- ----------------------------- ---------- -------------------
26
   1
================================================================================

                                 HYBRIDON, INC.,

                         Company

                                       and

                       STATE STREET BANK AND TRUST COMPANY

                         Trustee


                                    INDENTURE


                           Dated as of March 26, 1997


                           ==========================


                                  $60,000,000


                   9% Convertible Subordinated Notes Due 2004











================================================================================

   2



                                TABLE OF CONTENTS


                                                                          Page


ARTICLE 1.     DEFINITIONS AND INCORPORATION BY REFERENCE..................  1
      Section 1.1  Definitions.............................................  1
      Section 1.2  Other Definitions.......................................  7
      Section 1.3  Incorporation by Reference of Trust Indenture Act.......  8
      Section 1.4  Rules of Construction...................................  8

ARTICLE 2.     THE NOTES...................................................  9
      Section 2.1  Form and Dating.........................................  9
      Section 2.2  Execution and Authentication............................ 11
      Section 2.3  Registrar, Paying Agent and Conversion Agent............ 11
      Section 2.4  Paying Agent to Hold Money in Trust..................... 12
      Section 2.5  Holder Lists............................................ 12
      Section 2.6  Transfer and Exchange................................... 13
      Section 2.7  Replacement Notes....................................... 19
      Section 2.8  Outstanding Notes....................................... 20
      Section 2.9  Treasury Notes.......................................... 21
      Section 2.10 Temporary Notes......................................... 21
      Section 2.11 Cancellation............................................ 22
      Section 2.12 Defaulted Interest...................................... 22
      Section 2.13 Deposit of Moneys....................................... 23

ARTICLE 3.     REDEMPTION.................................................. 23
      Section 3.1  Notices to Trustee...................................... 23
      Section 3.2  Selection of Notes to be Redeemed....................... 23
      Section 3.3  Notice of Redemption.................................... 24
      Section 3.4  Effect of Notice of Redemption; Definition of 
                   Redemption Price ........................................25
      Section 3.5  Deposit of Redemption Price............................. 25
      Section 3.6  Notes Redeemed in Part.................................. 25

ARTICLE 4.     COVENANTS................................................... 26
      Section 4.1  Payment of Notes........................................ 26
      Section 4.2  Stay, Extension and Usury Laws.......................... 26
      Section 4.3  Continued Existence..................................... 26
      Section 4.4  Reports................................................. 27
      Section 4.5  Taxes................................................... 27
      Section 4.6  Change of Control....................................... 27
      Section 4.7  Limitation on Dividend Restrictions Affecting 
                   Subsidiaries ........................................... 30
      Section 4.8  Limitation on Line of Business.......................... 30
      Section 4.9  Limitation on Restricted Payments....................... 30



                                       -i-


   3


      Section 4.10 Limitation on Transactions with Related Persons......... 31
      Section 4.11 Compliance Certificate.................................. 32
      Section 4.12 Further Assurance to the Trustee........................ 33

ARTICLE 5.     SUCCESSORS.................................................. 33
      Section 5.1  When Company May Merge or Sell Assets................... 33
      Section 5.2  Successor Substituted................................... 34

ARTICLE 6.     DEFAULTS AND REMEDIES....................................... 34
      Section 6.1  Events of Default....................................... 34
      Section 6.2  Acceleration............................................ 36
      Section 6.3  Other Remedies.......................................... 36
      Section 6.4  Waiver of Existing and Past Defaults.................... 36
      Section 6.5  Control by Majority..................................... 37
      Section 6.6  Limitation on Suits..................................... 37
      Section 6.7  Rights of Holders to Receive Payment.................... 38
      Section 6.8  Collection Suit by Trustee.............................. 38
      Section 6.9  Trustee May File Proofs of Claim........................ 38
      Section 6.10 Priorities.............................................. 38
      Section 6.11 Undertaking for Costs................................... 39

ARTICLE 7.     TRUSTEE..................................................... 39
      Section 7.1  Duties of Trustee....................................... 39
      Section 7.2  Rights of Trustee....................................... 40
      Section 7.3  Individual Rights of Trustee............................ 41
      Section 7.4  Trustee's Disclaimer.................................... 41
      Section 7.5  Notice of Defaults...................................... 41
      Section 7.6  Reports by Trustee to Holders........................... 41
      Section 7.7  Compensation and Indemnity.............................. 42
      Section 7.8  Replacement of Trustee.................................. 43
      Section 7.9  Successor Trustee by Merger............................. 44
      Section 7.10 Eligibility; Disqualification........................... 44
      Section 7.11 Preferential Collection of Claims Against Company....... 44

ARTICLE 8.     DISCHARGE OF INDENTURE...................................... 44
      Section 8.1  Termination of Company's Obligations.................... 44
      Section 8.2  Application of Trust Money.............................. 46
      Section 8.3  Repayment to Company.................................... 46
      Section 8.4  Reinstatement........................................... 46

ARTICLE 9.     AMENDMENTS.................................................. 47
      Section 9.1  Without Consent of Holders.............................. 47
      Section 9.2  With Consent of Holders................................. 47
      Section 9.3  Compliance with Trust Indenture Act..................... 49
      Section 9.4  Revocation and Effect of Consents....................... 49



                                      -ii-


   4


      Section 9.5   Notation on or Exchange of Notes........................ 49
      Section 9.6   Trustee Protected....................................... 50

ARTICLE 10.    CONVERSION................................................... 50
      Section 10.1  Conversion Privilege.................................... 50
      Section 10.2  Conversion Procedure.................................... 50
      Section 10.3  Cash Payments in Lieu of Fractional Shares.............. 51
      Section 10.4  Adjustment of Conversion Price.......................... 52
      Section 10.5  Effect of Reclassification, Consolidation, Merger 
                    or Sale ................................................ 57
      Section 10.6  Taxes on Shares Issued.................................. 57
      Section 10.7  Reservation of Shares; Shares to be Fully Paid; 
                    Compliance with Government Requirements; Listing of 
                    Common Stock ........................................... 58
      Section 10.8  Responsibility of Trustee Requirements.................. 58
      Section 10.9  Notice to Holders Prior to Certain Actions.............. 59

ARTICLE 11.    SUBORDINATION................................................ 60
      Section 11.1  Agreement to Subordinate................................ 60
      Section 11.2  Payment Over of Proceeds Upon Dissolution, Etc.......... 60
      Section 11.3  Prior Payment to Senior Indebtedness Upon 
                    Acceleration of Notes................................... 61
      Section 11.4  No Payment When Senior Indebtedness in Default.......... 61
      Section 11.5  Payment Permitted If No Default......................... 62
      Section 11.6  Subrogation to Rights of Holders of Senior Indebtedness. 62
      Section 11.7  Provisions Solely to Define Relative Rights............. 63
      Section 11.8  Trustee to Effectuate Subordination..................... 63
      Section 11.9  No Waiver of Subordination Provisions................... 63
      Section 11.10 Notice to Trustee....................................... 64
      Section 11.11 Reliance on Judicial Order or Certificate of 
                    Liquidating Agent ...................................... 64
      Section 11.12 Trustee Not Fiduciary for Holders of Senior 
                    Indebtedness ........................................... 65
      Section 11.13 Rights of Trustee as Holder of Senior Indebtedness; 
                    Preservation of Trustee's Rights........................ 65
      Section 11.14 Article Applicable to Paying Agents..................... 65
      Section 11.15 Certain Conversions Deemed Payment...................... 65

ARTICLE 12.    MEETINGS OF HOLDERS.......................................... 66
      Section 12.1  Action by Holders....................................... 66
      Section 12.2  Purposes for Which Meetings May Be Called............... 66
      Section 12.3  Manner of Calling Meetings.............................. 67
      Section 12.4  Call of Meetings by the Company or Holders.............. 67
      Section 12.5  Who May Attend and Vote at Meetings..................... 67
      Section 12.6  Regulations May be Made by Trustee; Conduct of 
                    the Meeting; Voting Rights; Adjournment................. 67
      Section 12.7  Voting at the Meeting and Record to be Kept............. 68
      Section 12.8  Exercise of Rights of Trustee or Holders May Not 
                    Be Hindered or Delayed by Call of Meeting............... 69



                                      -iii-


   5

      Section 12.9  Communication by Holders with Other Holders............ 69

ARTICLE 13.    MISCELLANEOUS............................................... 69
      Section 13.1  Trust Indenture Act Controls........................... 69
      Section 13.2  Notices................................................ 69
      Section 13.3  Certificate and Opinion as to Conditions Precedent..... 71
      Section 13.4  Statements Required in Certificate or Opinion 
                    of Counsel ............................................ 71
      Section 13.5  Rules by Trustee and Agents............................ 72
      Section 13.6  Legal Holidays......................................... 72
      Section 13.7  No Recourse Against Others............................. 72
      Section 13.8  Counterparts........................................... 72
      Section 13.9  Governing Law.......................................... 72
      Section 13.10 No Adverse Interpretation of Other Agreements.......... 72
      Section 13.11 Successors............................................. 73
      Section 13.12 Severability........................................... 73
      Section 13.13 Table of Contents, Headings, Etc....................... 73


EXHIBITS

Exhibit A - Form of Note
Exhibit B - Transferee Letter of Representation




                                     -iv-
   6

      INDENTURE dated as of March 26, 1997 between Hybridon, Inc., a Delaware
corporation, and State Street Bank and Trust Company, as trustee.

      Each party agrees as follows for the benefit of the other party and for
the equal and ratable benefit of the registered holders of the Company's 9%
Convertible Subordinated Notes due April 1, 2004 (the "Notes"):


                                   ARTICLE 1.

                   DEFINITIONS AND INCORPORATION BY REFERENCE


SECTION 1.1    DEFINITIONS.
- -----------    -----------

      "AFFILIATE" of a Person means (i) any other Person which, directly or
indirectly, is in control of, is controlled by or is under common control with
such specified Person. For the purpose of this definition, "control" of a Person
means the power, directly or indirectly, to direct or cause the direction of the
management and policies of such Person, whether by ownership of voting
securities, by contract or otherwise, and "CONTROLLING" or "CONTROLLED" have
corresponding meanings.

      "AGENT" means any Registrar, Paying Agent or Conversion Agent.

      "BOARD OF DIRECTORS" means the Board of Directors of the Company or any
duly authorized committee thereof, except that, for purposes of the definitions
of "CHANGE OF CONTROL" and "CONTINUING DIRECTORS," "BOARD OF DIRECTORS" means
only the Board of Directors of the Company.

      "BUSINESS DAY" means any day other than a Saturday, Sunday or other day on
which banking institutions in the city of New York, New York or Boston,
Massachusetts are required or authorized by law or other governmental action to
be closed.

      "CAPITAL STOCK" of any Person means the Common Stock or Preferred Stock of
such Person. Unless otherwise stated herein or the context otherwise requires,
"CAPITAL STOCK" means Capital Stock of the Company.

      "CHANGE OF CONTROL" means the occurrence of any of the following events
after the date of this Indenture: (i) any Person (including, without limitation,
any "person" or "group" within the meaning of Section 13(d) or 14(d) of the
Exchange Act) becomes the direct or indirect beneficial owner of shares of
Capital Stock representing greater than 50% of the combined voting power of all
outstanding shares of Capital Stock entitled to vote in the election of
directors under ordinary circumstances; (ii) the Company consolidates with or
merges into any other Person and the outstanding Common Stock is changed or
exchanged as a result (except for any merger or consolidation in which the
stockholders of the Company shall continue to hold




   7


shares of Capital Stock representing greater than 50% of the combined voting
power of the Capital Stock of the surviving entity and members of the Board of
Directors immediately prior to such merger or consolidation comprise a majority
of the board of directors of the surviving entity immediately after such merger
or consolidation), (iii) sale, transfer or other disposition of all or
substantially all of the collective assets of the Company and its Subsidiaries
in a single transaction or series of related transactions, (iv) at any time
Continuing Directors cease to constitute a majority of the Board of Directors
then in office; or (v) on any day the Company makes any distribution or
distributions of cash, Property or securities (other than regular quarterly
dividends, Common Stock, Preferred Stock which is substantially equivalent to
Common Stock or rights to acquire Common Stock or Preferred Stock which is
substantially equivalent to the Common Stock) to holders of Common Stock, or the
Company or any of its Subsidiaries purchases or otherwise acquires Common Stock,
and the sum of the Fair Market Value of such distribution or purchase on the
date the same is made, plus the Fair Market Value, when made, of all other such
distributions and purchases which have occurred during the 12-month period
ending on such date, in each case expressed as a percentage of the aggregate
Current Market Price of all the shares of Common Stock outstanding at the close
of business on the last Trading Day prior to the date of each such distribution
or purchase, exceeds 50%.

      "COMMON STOCK" of any Person other than the Company means the common
equity (however designated), including, without limitation, common stock or
partnership or membership interests of, or participations or interests in such
Person (or equivalents thereof). "COMMON STOCK" of the Company means the Common
Stock, par value $.001 per share, of the Company, any successor class or classes
of common equity (however designated) of the Company into or for which such
Common Stock may hereafter be converted, exchanged or reclassified and any class
or classes of common equity (however designated) of the Company which may be
distributed or issued with respect to such Common Stock or successor class of
classes to holders thereof generally. Unless otherwise stated herein or the
context requires otherwise, "COMMON STOCK" means Common Stock of the Company.

      "COMPANY" means Hybridon, Inc., a Delaware corporation, until a successor
replaces it in accordance with the applicable provisions of this Indenture and,
thereafter, "COMPANY" shall mean such successor.

      "CONTINUING DIRECTORS" means any member of the Board of Directors who (i)
is a member of the Board of Directors on the date hereof or (ii) was nominated
for election or elected to the Board of Directors with the affirmative vote of
at least two-thirds of such members and members of the Board of Directors who
were previously so nominated or elected.

      "CORPORATE TRUST OFFICE" of the Trustee means the principal office at
which the Trustee conducts its corporate business, initially at Two
International Place, 4th Floor, Boston, Massachusetts 02110.

      "CURRENT MARKET PRICE" means, when used with respect to any security as of
any date, the last sale price, regular way, or, in case no such sale takes place
on such date, the average of the closing bid and asked prices, regular way, of
such security in either case as reported for




                                        2

   8


consolidated transactions on the New York Stock Exchange or, if such security is
not listed or admitted to trading on the New York Stock Exchange, as reported
for consolidated transactions with respect to securities listed on the principal
national securities exchange on which such security is listed or admitted to
trading or, if such security is not listed or admitted to trading on any
national securities exchange, as reported on the Nasdaq National Market, or, if
such security is not listed or admitted to trading on the Nasdaq National
Market, as reported on the Nasdaq SmallCap Market, or if such security is not
listed or admitted to trading on any national securities exchange or the Nasdaq
National Market or the Nasdaq SmallCap Market, the average of the high bid and
low asked prices of such security in the over-the-counter market as reported by
the National Association of Securities Dealers, Inc. Automated Quotations System
or such other system then in use or, if such security is not quoted by any such
organization, the average of the closing bid and asked prices of such security
furnished by a New York Stock Exchange member firm selected by the Company. If
such security is not quoted by any such organization and no such New York Stock
Exchange member firm is able to provide such prices, the Current Market Price of
such security shall be the Fair Market Value thereof.

      "DEFAULT" means any event which is, or with the passage of time or the
giving of notice or both would be, an Event of Default.

      "DEPOSITARY" means, with respect to the Notes issued in global form, the
Trustee and any successor entity thereto or such other Person as appointed by
the Company from time to time in accordance with the provisions of this
Indenture.

      "DESIGNATED TRANSACTIONS" means those transactions identified by the
Company as related party transactions in filings with the Commission made prior
to the date of this Indenture; provided, however, the amendment or modification
of the terms of any such transaction by the Company after the date of the most
recent filing by the Company with the Commission prior to the date of this
Indenture shall be deemed to be new transactions for purposes of this Indenture.

      "EXCHANGE ACT" means the Securities Exchange Act of 1934, as amended, and
the rules and regulations promulgated thereunder.

      "FAIR MARKET VALUE" means, at any date as to any asset, Property or right
(including, without limitation, Capital Stock of any Person, evidences of
indebtedness or other securities, but excluding cash), the fair market value of
such item as determined in good faith by the Board of Directors, whose
determination shall be conclusive; provided, however, that such determination is
described in an Officers' Certificate filed with the Trustee and that, if there
is a Current Market Price for such item on such date, "FAIR MARKET VALUE" means
such Current Market Price (without giving effect to the last sentence of the
definition thereof).

      "GAAP" means, as of any date, generally accepted accounting principles in
the United States and does not include any interpretations or regulations that
have been proposed but that have not become effective.

      "HOLDER" means a Person in whose name a Note is registered on the 
Register.





                                        3
   9



      "INDEPENDENT DIRECTORS" means directors that (i) are not 5% or greater
stockholders of the Company or the designees of any such stockholder; (ii) are
not officers or employees of the Company, any of its Subsidiaries or of a
stockholder referred to above in clause (i); (iii) are not Related Persons; and
(iv) do not have relationships that, in the opinion of the Board of Directors,
would interfere with their exercise of independent judgment in carrying out the
responsibilities of the directors.

      "INDENTURE" means this Indenture, as amended or supplemented from time to 
time.

      "INTEREST PAYMENT DATE" means April 1 and October 1 of each year,
commencing October 1, 1997.

      "INVESTMENT" means, with respect to any Person, all investments by such
Person in other Persons (including Affiliates) in the form of direct or indirect
loans (including guarantees of indebtedness or other obligations), advances or
capital contributions, purchases or other acquisitions for consideration of
indebtedness, equity interests or other securities, together with all other
items that are or would be classified as investments on a balance sheet prepared
in accordance with GAAP.

      "JUNIOR SECURITIES" means (a) shares of any and all classes of Capital
Stock of the Company and (b) securities of the Company which are subordinated in
right of payment to Senior Indebtedness at the time of issuance or delivery of
such securities to substantially the same extent as, or to a greater extent
than, the Notes are so subordinated as provided in Article 11.

      "OFFICER" means, with respect to any Person, the Chairman of the Board,
the Chief Executive Officer, the President, the Chief Operating Officer, the
Chief Financial Officer, the Treasurer, any Assistant Treasurer, the Controller,
the Secretary, any Assistant Secretary or any Vice President of such Person.

      "OFFICERS' CERTIFICATE" means a certificate signed on behalf of the
Company by two Officers, one of whom must be the Chairman of the Board, the
President, the Treasurer or a Vice-President of the Company, that meets the
requirements of Sections 13.3 and 13.4; provided, however, that for purposes of
Section 4.11, "Officers' Certificate" means a certificate signed on behalf of
the Company by the principal executive officer, principal financial officer or
principal accounting officer of the Company.

      "OPINION OF COUNSEL" means a written opinion from legal counsel who is
reasonably acceptable to the Trustee and that meets the requirements of Sections
13.3 and 13.4. The counsel may be an employee of or counsel to the Company or to
the Trustee.

      "PERSON" means any individual, corporation, partnership, association,
trust or any other entity or organization, including a government or political
subdivision or any agency or instrumentality thereof.




                                        4


   10


      "PREFERRED STOCK" of any Person means the class or classes of equity,
ownership or participation interests (however designated) in such Person,
including, without limitation, stock, share, partnership and membership
interests, which are preferred as to the payment of dividends or distributions
by, or as to the distribution of assets upon any voluntary or involuntary
liquidation or dissolution of, such Person (or equivalents thereof) over
interests of any other class of interests of such Person. Unless otherwise
stated herein or the context otherwise requires, "PREFERRED STOCK" means
Preferred Stock of the Company.

      "PRINCIPAL" of a debt security means the principal of the security plus
the premium, if any, on the security. "PRINCIPAL" shall include, with respect to
the Notes, the redemption price, if any, payable thereon.

      "PROPERTY" of any Person means any and all types of real, personal,
tangible, intangible or mixed property owned by such Person whether or not
included on the most recent consolidated balance sheet of such Person in
accordance with GAAP.

      "QUALIFIED STOCK" means Capital Stock of the Company which is not, and
which is not convertible into or exercisable or exchangeable for Capital Stock
which is, subject to repurchase or redemption at the option of the holder or
mandatorily by the Company prior to December 31, 2004 or exchangeable or
convertible into debt securities of the Company or any of its Subsidiaries at
the option of the holder or mandatorily prior to December 31, 2004.

      "RELATED PERSON" means an individual related to an officer, director or,
to the Company's knowledge, employee of the Company or any of its Affiliates
which relation is by blood, marriage or adoption and not more remote than first
cousin.

      "REPRESENTATIVE" means the indenture trustee or other trustee, agent or
representative for an issue of Senior Indebtedness.

      "SEC" means the Securities and Exchange Commission.

      "SECURITIES ACT" means the Securities Act of 1933, as amended, and the
rules and regulations promulgated thereunder.

      "SENIOR INDEBTEDNESS" means the principal of (and premium, if any) and
accrued interest on (including all interest accruing subsequent to the
commencement of any bankruptcy or similar proceeding, whether or not a claim for
post-petition interest is allowable as a claim in any such proceeding) (a)
indebtedness of the Company (including indebtedness of other Persons guaranteed
by the Company), other than the Notes, outstanding on the date of this Indenture
which is (i) for money borrowed or (ii) evidenced by a note, debenture or
similar instrument given in connection with the acquisition of any business,
Property or assets, (b) obligations of the Company, whether outstanding on the
date of this Indenture or hereafter created, incurred or assumed, as lessee
under leases required to be capitalized on the balance sheet of the lessee under
GAAP and leases of Property or assets made as part of any sale and leaseback
transaction to which the Company is a party, (c) all reimbursement obligations
and other liabilities



                                        5


   11


(contingent or otherwise) with respect to letters of credit, bank guarantees or
bankers' acceptances, (d) amendments, renewals, extensions, modifications and
refundings of any such indebtedness or obligation and (e) indebtedness of the
Company (including indebtedness of other Persons guaranteed by the Company)
created, incurred or assumed after the date of this Indenture which is (i) for
money borrowed or (ii) evidenced by a note, debenture or similar instrument
given in connection with the acquisition of any business, Property or assets and
amendments, renewals, extensions, modifications and refundings thereof, if the
instrument creating or evidencing such indebtedness provides by its terms that
such indebtedness or obligation is senior in right of payment to the Notes (all
of which indebtedness will have the benefit of the subordination provisions of
Article 11); provided, however, that indebtedness of the Company (including
indebtedness of other Persons guaranteed by the Company) created, incurred or
assumed after the date of this Indenture which is (i) for money borrowed or (ii)
evidenced by a note, debenture or similar instrument and which, in either case,
by its terms is convertible or exchangeable into Capital Stock, and amendments,
renewals, extensions, modifications and refundings thereof, will rank pari passu
with the Notes, unless the instruments creating or evidencing such indebtedness
provide by their terms that such indebtedness is junior in right of payment to
the Notes. "SENIOR INDEBTEDNESS" shall not include indebtedness or amounts owed
(except to banks or other financial institutions) for compensation to employees,
or for goods or materials purchased or services utilized, in the ordinary course
of business of the Company or of any other Person from whom such indebtedness or
amount was assumed or for whom such indebtedness was guaranteed.

      "SUBSIDIARY" of a Person on any date means any other Person of whom such
Person owns, directly or indirectly through a Subsidiary or Subsidiaries of such
Person, Capital Stock with voting power, acting independently and under ordinary
circumstances, entitling such Person to elect a majority of the board of
directors or other governing body of such other Person. Unless otherwise stated
herein or the context otherwise requires, "SUBSIDIARY" means a Subsidiary of the
Company.

      "TIA" or "TRUST INDENTURE ACT OF 1939" means the Trust Indenture Act of
1939 (U.S. Code ss.ss. 77aaa-77bbbb) as amended and as in effect on the date of
this Indenture; provided, however, that if the TIA is amended after such date,
"TIA" or "TRUST INDENTURE ACT OF 1939" means, to the extent required by any such
amendments, the TIA as so amended.

      "TRADING DAY" means (i) if the applicable security is listed or admitted
for trading on a national security exchange, a day on which such exchange is
open for business, (ii) if the applicable security is quoted on the Nasdaq Stock
Market, a day on which trades may be made thereon or (iii) if the applicable
security is not so listed, admitted for trading or quoted, any Business Day.

      "TRANSFER RESTRICTED SECURITIES" means Notes that bear or are required to
bear the legend set forth in Section 2.6(g) hereof.




                                        6


   12


      "TRUSTEE" means the party identified in the title of this Indenture as
trustee until a successor replaces it in accordance with the applicable
provisions of this Indenture and, thereafter, "TRUSTEE" means such successor.

      "TRUST OFFICER" means any officer or corporate trust officer or assistant
corporate trust officer of the Trustee assigned by the Trustee to administer its
corporate trust matters.

      "UNRESTRICTED SUBSIDIARIES" means any Subsidiaries of the Company which
(i) are not wholly-owned by the Company, (ii) are designated as Unrestricted
Subsidiaries by the Board of Directors (as evidenced by minutes of a meeting or
written consent of directors) and (iii) at the time of any Investment by the
Company in any such Subsidiary, in the aggregate hold or comprise less than 20%
of the Company's assets as shown on the Company's consolidated balance sheet
prepared in accordance with GAAP as at the time of such Investment.

      "U.S. GOVERNMENT OBLIGATIONS" means non-callable (i) direct obligations
(or certificates representing an ownership interest in such obligations) of the
United States for which its full faith and credit are pledged and (ii)
obligations of a Person controlled or supervised by, and acting as an agency or
instrumentality of, the United States, the payment of which is unconditionally
guaranteed as a full faith and credit obligation of the United States.


SECTION 1.2    OTHER DEFINITIONS.
- -----------    -----------------

      TERM                                                  DEFINED IN SECTION
      ----                                                  ------------------

      "Agent Members"......................................................2.1
      "Aggregate Consideration"...........................................10.4
      "Bankruptcy Law".....................................................6.1
      "Change of Control Date".............................................4.6
      "Change of Control Notice"...........................................4.6
      "Change of Control Offer"............................................4.6
      "Change of Control Payment"..........................................4.6
      "Change of Control Payment Date".....................................4.6
      "Code"..............................................................10.4
      "Conversion Agent"...................................................2.3
      "Conversion Price"..................................................10.1
      "Custodian"..........................................................6.1
      "Definitive Securities"..............................................2.1
      "DTC"...............................................................10.4
      "Equity Securities".................................................10.4
      "Event of Default"...................................................6.1
      "Expiration Time"...................................................10.4
      "Global Security"....................................................2.1
      "Notice of Default"..................................................6.1
      "Paying Agent".......................................................2.3





                                       7

   13


      "Purchase Agreement".................................................2.1
      "Purchased Shares"..................................................10.4
      "Register"...........................................................2.3
      "Registrar"..........................................................2.3
      "Restricted Payment".................................................4.9
      "Rule 144A"..........................................................2.1
      "Significant Subsidiary".............................................6.1
      "Trigger Event".....................................................10.4


      SECTION 1.3    INCORPORATION BY REFERENCE OF TRUST INDENTURE ACT.
      -----------    -------------------------------------------------

      This Indenture is subject to the mandatory provisions of the TIA, which
are incorporated by reference in and made a part of this Indenture. Such
provisions shall apply to this Indenture at all times, notwithstanding that at
any time or from time to time this Indenture is not required to be qualified
under the TIA.

      The following TIA terms used in this Indenture have the following
meanings:

          "Commission" means the SEC;

          "indenture securities" means the Notes;

          "indenture security holder" means a Holder;

          "indenture to be qualified" means this Indenture;

          "indenture trustee" or "institutional trustee" means the Trustee; and

          "obligor" on the Notes means the Company and any successor obligor on
          the Notes.

      All other terms used in this Indenture that are defined by the TIA,
defined by TIA reference to another statute or defined by SEC rule under the TIA
and not otherwise defined herein have the meanings so assigned to them.


SECTION 1.4    RULES OF CONSTRUCTION.
- -----------    ---------------------

      Unless the context otherwise requires or unless otherwise stated herein:

          (1)  a term has the meaning assigned to it;

          (2)  an accounting term not otherwise defined has the meaning assigned
               to it in accordance with GAAP;




                                        8


   14



          (3)  "or" is not exclusive;

          (4)  words in the singular include the plural, and in the plural
               include the singular;

          (5)  references to sections of or rules under the Securities Act, the
               Exchange Act or the TIA shall be deemed to include substitute,
               replacement or successor sections or rules;

          (6)  references to Sections or Articles mean Sections or Articles of
               this Indenture; and

          (7)  solely for purposes of this Indenture and the Notes, a
               determination, approval or other action by the Board of Directors
               shall not be deemed to have been made, given or taken unless it
               is set forth in a written resolution or resolutions (or
               comparable written instrument) duly adopted thereby.


                                   ARTICLE 2.

                                    THE NOTES


SECTION 2.1    FORM AND DATING.
- -----------    ---------------

     The Notes and the Trustee's certificate of authentication shall be
substantially in the form of Exhibit A which is hereby incorporated in and
expressly made a part of this Indenture. The Notes may have notations, legends
or endorsements required by law, stock exchange rule, agreements to which the
Company is subject, if any, or usage (provided that any such notation, legend or
endorsement is in a form acceptable to the Company). Each Note shall be dated
the date of its authentication. The terms of the Notes set forth in Exhibit A
are part of the terms of this Indenture. The Notes are general unsecured
obligations of the Company limited to $60,000,000 in the aggregate principal
amount, subject to Section 2.7.

     (a)  GLOBAL SECURITIES. The Notes are being offered and sold by the Company
pursuant to a Purchase Agreement, dated concurrently herewith, between the
Company and Forum Capital Markets L.P. (the "Purchase Agreement").

     Notes offered and sold to a "qualified institutional buyer" (as defined in
Rule 144A under the Securities Act ("Rule 144A")) in reliance on Rule 144A as
provided in the Purchase Agreement, shall be issued initially in the form of one
or more permanent global securities in definitive, fully registered form without
interest coupons and with the Global Securities Legend and, unless removed in
accordance with Section 2.6(g), the Restricted Securities Legend set forth in
Exhibit A hereto (each, a "Global Security"), which shall be deposited on behalf
of the





                                        9


   15


purchasers of the Notes represented thereby with the Trustee, at its Corporate
Trust Office, as custodian for the Depositary, and registered in the name of the
Depositary or a nominee of the Depositary, duly executed by the Company and
authenticated by the Trustee as hereinafter provided. The aggregate principal
amount of the Global Securities may from time to time be increased or decreased
by adjustments made on the records of the Trustee and the Depositary or its
nominee as hereinafter provided.

     (b)  BOOK-ENTRY PROVISIONS. This Section 2.1(b) shall apply only to any
Global Security deposited with or on behalf of the Depositary.

     The Company shall execute and the Trustee shall, in accordance with this
Section 2.1(b), authenticate and deliver initially one or more Global Securities
that (i) shall be registered in the name of the Depositary for such Global
Security or Global Securities or the nominee of the Depositary and (ii) shall be
delivered by the Trustee to the Depositary or pursuant to the Depositary's
instructions or held by the Trustee as custodian for the Depositary.

     Members of, or participants in, the Depositary ("Agent Members") shall have
no rights under this Indenture with respect to any Global Security held on their
behalf by the Depositary or by the Trustee as the custodian of the Depositary or
under such Global Security, and the Depositary may be treated by the Company,
the Trustee and any agent of the Company or the Trustee as the absolute owner of
such Global Security for all purposes whatsoever. Notwithstanding the foregoing,
nothing herein shall prevent the Company, the Trustee or any agent of the
Company or the Trustee from giving effect to any written certification, proxy or
other authorization furnished by the Depositary or impair, as between the
Depositary and its Agent Members, the operation of customary practices of the
Depositary governing the exercise of the rights of a holder of a beneficial
interest in any Global Security.

     (c)  CERTIFICATED SECURITIES. Except as provided in Section 2.10, owners of
beneficial interests in Global Securities will not be entitled to receive
physical delivery of certificated Notes. Notes offered and sold to Persons who
are not "qualified institutional buyers" shall be issued in certificated Notes
in definitive, fully registered form without interest coupons, with the
Restricted Securities Legend and, if such Person is an institutional "accredited
investor" (as defined in Rule 501(a)(1), (2), (3) or (7) under the Securities
Act), the Institutional Accredited Investor Legend, but without the Schedule of
Exchanges of Global Security for Definitive Securities, set forth in Exhibit A
hereto ("Definitive Securities"); provided, however, that upon transfer of such
Definitive Securities to a "qualified institutional buyer," such Definitive
Securities will, unless the Global Security has previously been exchanged, be
exchanged for an interest in a Global Security pursuant to the provisions of
Section 2.6 and provided that any such certificate may be initially issued in a
temporary global form, to be promptly re-registered as provided in this Section
2.1(c).

     After a transfer of any Notes pursuant to an effective registration
statement under the Securities Act with respect to the Notes, all requirements
pertaining to legends on such Notes will cease to apply, the requirements
requiring any such Notes issued to certain Holders to be issued in global form
will cease to apply, and a certificated Note without legends will be



                                       10


   16


available to the transferee of the Holder of such Notes upon exchange of such
transferring Holder's certificated Notes or directions to transfer such Holder's
interest in the Global Security, as applicable.


SECTION 2.2    EXECUTION AND AUTHENTICATION.
- -----------    ----------------------------

      Two Officers shall sign the Notes for the Company by manual or facsimile
signature. The Company's seal shall be reproduced on the Notes and may be in
facsimile form.

      Any Note bearing the manual or facsimile signature of an individual shall
be valid notwithstanding that such individual ceased to be an Officer prior to
authentication of the Note or ceased to hold the office of Company ascribed to
such individual on the Note.

      A Note shall not be valid until authenticated by the manual signature of
the Trustee. The signature shall be conclusive evidence, and the only evidence,
that the Note has been authenticated under this Indenture.

      The Trustee shall authenticate Notes for original issue up to the
aggregate principal amount stated in Paragraph 4 of the Notes, upon delivery of
(i) a written order of the Company signed by an Officer directing the Trustee to
authenticate the Notes and (ii) an Officers' Certificate certifying that all
conditions precedent to the issuance of the Notes contained herein have been
complied with. The aggregate principal amount of Notes outstanding at any time
may not exceed such amount, except as provided in Section 2.7.

      The Trustee may appoint an authenticating agent upon the approval and at
the expense of the Company to authenticate Notes. Unless limited by the terms of
such appointment, an authenticating agent shall be authorized to authenticate
Notes at such times and upon such conditions as the Trustee is so authorized.
Each reference in this Indenture to authentication by the Trustee includes
authentication by such agent.


SECTION 2.3    REGISTRAR, PAYING AGENT AND CONVERSION AGENT.
- -----------    --------------------------------------------

      The Company shall maintain in the City of New York, New York or the City
of Boston, Massachusetts an office or agency where Notes may be presented for
registration of transfer or for exchange (the "REGISTRAR"), an office or agency
where Notes may be presented for payment (the "PAYING AGENT") and an office or
agency where the Notes may be presented for conversion (the "CONVERSION AGENT").
The Registrar shall keep a register of the Notes (the "REGISTER") and of their
transfer and exchange. The Company may appoint one or more co-registrars and one
or more additional paying agents upon the reasonable approval of the other
Registrar or Registrars or Paying Agent or Paying Agents, as the case may be,
and at the expense of the Company. The term "REGISTRAR" includes any
co-registrar or co-registrars and the term "PAYING AGENT" includes any
additional paying agent or paying agents. The Company may change any Paying
Agent, Conversion Agent or Registrar without notice to any Holder. The Company
shall



                                       11


   17


promptly notify the Trustee in writing of the name and address of any Agent not
a party to this Indenture. The Company or any Subsidiary may act as Paying Agent
(except for purposes specified in Sections 2.8 and 4.1), Conversion Agent or
Registrar. If the Company fails to appoint or maintain itself or another Person
as Registrar, Conversion Agent or Paying Agent, the Trustee shall act as such
and shall be entitled to appropriate compensation therefor pursuant to Section
7.7.

      The Company shall enter into an appropriate agency agreement with any
Agent not a party to this Indenture, which shall incorporate the terms of the
TIA. The agreement shall implement the provisions of this Indenture that relate
to such Agent. The Company shall notify the Trustee of the name and address of
any such Agent.

      The Company initially appoints the office of the Trustee at the Corporate
Trust Office, and through it the offices of its agent, State Street Bank and
Trust Company, N.A., 61 Broadway, Concourse Level, New York, New York 10006, as
the offices or agencies for each of the purposes designated in this Section 2.3
to act as Registrar, Paying Agent and Conversion Agent with respect to the
Notes.


SECTION 2.4    PAYING AGENT TO HOLD MONEY IN TRUST.
- -----------    -----------------------------------

      The Company shall require each Paying Agent (other than the Trustee) to
agree in writing that the Paying Agent will hold in trust for the benefit of
Holders or the Trustee all money held by the Paying Agent for the payment of
Principal or repurchase price, if any, of or interest on the Notes, and will
notify the Trustee of any default by the Company in making any such payment.
While any such default continues, the Trustee may require a Paying Agent to pay
all money held by it to the Trustee and account for any money disbursed by it.
The Company at any time may require a Paying Agent to pay all money held by it
to the Trustee and account for any money disbursed by it. Upon payment over to
the Trustee, the Paying Agent (if other than the Company or a Subsidiary of the
Company) shall have no further liability for the money delivered to the Trustee.
If the Company or an Affiliate of the Company acts as Paying Agent, it shall
segregate and hold in a separate trust fund for the benefit of the Holders all
money held by it as Paying Agent. Upon any bankruptcy or reorganization
proceedings relating to the Company, the Trustee shall serve as Paying Agent for
the Notes.


SECTION 2.5    HOLDER LISTS.
- -----------    ------------

      The Trustee shall preserve in as current a form as is reasonably
practicable the most recent list available to it of the names and addresses of
Holders. If the Trustee is not the Registrar, the Company shall furnish or the
Company shall cause the Registrar to furnish to the Trustee at least ten
Business Days before each Interest Payment Date, and at such other times as the
Trustee may request in writing within five Business Days after such request, a
list in such form and as of such date as the Trustee may reasonably require, and
upon which the Trustee



                                       12


   18


may conclusively rely, of the names and addresses of, and principal amount of
Notes held by, the Holders.


SECTION 2.6    TRANSFER AND EXCHANGE.
- -----------    ---------------------

          (a)  TRANSFER AND EXCHANGE OF DEFINITIVE SECURITIES. When Definitive
Securities are presented to the Registrar with the request:

               (x)  to register the transfer of the Definitive Securities; or

               (y)  to exchange such Definitive Securities for an equal
                    principal amount of Definitive Securities of other
                    authorized denominations,

the Registrar shall register the transfer or make the exchange as requested if
its requirements for such transactions are met and subject to compliance with
applicable securities laws; provided, however, that the Definitive Securities
presented or surrendered for register of transfer or exchange:

               i)   shall be duly endorsed or accompanied by a written
                    instruction of transfer in form and substance satisfactory
                    to the Registrar duly executed by the Holder thereof or by
                    his or her attorney, duly authorized in writing; and

               ii)  in the case of Transfer Restricted Securities that are
                    Definitive Securities, shall be accompanied by the following
                    additional information and documents, as applicable:

                    (A)  if such Transfer Restricted Security is being delivered
                         to the Registrar by a Holder for registration in the
                         name of such Holder, without transfer, a certification
                         from such Holder to that effect (in the form set forth
                         on the reverse of the Notes); or

                    (B)  if such Transfer Restricted Security is being
                         transferred to the Company or a "qualified
                         institutional buyer" (as defined in Rule 144A) in
                         accordance with Rule 144A, a certification to that
                         effect (in the form set forth on the reverse of the
                         Notes); or

                    (C)  if such Transfer Restricted Securities are being
                         transferred (w) pursuant to an exemption from
                         registration in accordance with Rule 144 or Regulation
                         S under the Securities Act; or (x) to an institutional
                         "accredited investor" within the meaning of Rule
                         501(a)(1), (2), (3) or




                                       13

   19


                        (7) under the Securities Act that is acquiring the 
                        security for its own account, or for the account of 
                        such an institutional accredited investor, in each case 
                        in a minimum principal amount of Notes of $100,000 for
                        investment purposes and not with a view to, or for
                        offer or sale in connection with, any distribution in
                        violation of the Securities Act; or (y) in reliance on
                        another exemption from the registration requirements of
                        the Securities Act: (i) a certification to that effect
                        (in the form set forth on the reverse of the Notes),
                        (ii) if the Company, Trustee or Registrar so requests,
                        an Opinion of Counsel reasonably acceptable to the
                        Company, Trustee and Registrar to the effect that such
                        transfer is in compliance with the Securities Act and
                        (iii) in the case of clause (x), a signed letter in     
                        substantially the form of Exhibit B hereto.

          (b)  RESTRICTIONS ON TRANSFER OF A DEFINITIVE SECURITY FOR A
BENEFICIAL INTEREST IN A GLOBAL SECURITY. A Definitive Security may not be
exchanged for a beneficial interest in a Global Security except upon
satisfaction of the requirements set forth below and subject to compliance with
applicable securities laws. Upon receipt by the Trustee of a Definitive
Security, duly endorsed or accompanied by appropriate instruments of transfer,
in form satisfactory to the Trustee, together with:

               i)   if such Definitive Security is a Transfer Restricted
                    Security, certification, substantially in the form of
                    Exhibit B hereto, that such Definitive Security is being
                    transferred to a "qualified institutional buyer" (as defined
                    in Rule 144A) in accordance with Rule 144A; and

               ii)  whether or not such Definitive Security is a Transfer
                    Restricted Security, written instructions directing the
                    Trustee to make, or to direct the Notes Custodian to make,
                    an endorsement on the Global Security to reflect an increase
                    in the aggregate principal amount of the Notes represented
                    by the Global Security,

then the Trustee shall cancel such Definitive Security in accordance with
Section 2.11 hereof and cause, or direct the Notes Custodian to cause, in
accordance with the standing instructions and procedures existing between the
Depositary and the Notes Custodian, the aggregate principal amount of Notes
represented by the Global Security to be increased accordingly. If no Global
Security is then outstanding, the Company shall arrange for the execution and
delivery of an agreement with the Depositary upon customary terms reasonably
satisfactory to the Trustee, and shall issue and the Trustee shall authenticate
a new Global Security in the appropriate principal amount.

          (c)  TRANSFER AND EXCHANGE OF GLOBAL SECURITY. The transfer and
exchange of a Global Security or beneficial interests therein shall be effected
through the Depositary in




                                       14


   20


accordance with this Indenture (including the restrictions on transfer set forth
herein) and the procedures of the Depositary therefor and subject to compliance
with applicable securities laws.

          (d)  TRANSFER OF A BENEFICIAL INTEREST IN A GLOBAL SECURITY FOR A
               DEFINITIVE SECURITY.

               i)   Any Person having a beneficial interest in a Global Security
                    that is being exchanged or transferred pursuant to an
                    effective registration statement under the Securities Act or
                    pursuant to clause (A), (B) or (C) below may upon request,
                    and if accompanied by the information specified below,
                    exchange such beneficial interest for a Definitive Security
                    of the same aggregate principal amount subject to compliance
                    with applicable securities laws. Upon receipt by the Trustee
                    of written instructions or such other form of instructions
                    as is customary for the Depositary, from the Depositary, or
                    its nominee on behalf of any Person having a beneficial
                    interest in a Global Security, and upon receipt by the
                    Trustee of a written order or such other form of
                    instructions, and, in the case of a Transfer Restricted
                    Security only, the following additional information and
                    documents (all of which may be submitted by facsimile):

                    (A)  if such beneficial interest is being transferred to the
                         Person designated by the Depositary as being the
                         beneficial owner, a certification from such Person to
                         that effect (in the form set forth on the reverse of
                         the Notes); or

                    (B)  if such beneficial interest is being transferred to a
                         "qualified institutional buyer" (as defined in Rule
                         144A) in accordance with Rule 144A, a certification to
                         that effect from the transferor (in the form set forth
                         on the reverse of the Notes); or

                    (C)  if such beneficial interest is being transferred (w)
                         pursuant to an exemption from registration in
                         accordance with Rule 144 or Regulation S under the
                         Securities Act; or (x) to an institutional "accredited
                         investor" within the meaning of Rule 501(a)(1), (2),
                         (3) or (7) under the Securities Act that is acquiring
                         the security for its own account, or for the account of
                         such an institutional accredited investor, in each case
                         in a minimum principal amount of Notes of $100,000 for
                         investment purposes and not with a view to, or for
                         offer or sale in connection with, any distribution in
                         violation of the Securities Act; or (y) in reliance on
                         another exemption from the registration requirements of
                         the Securities Act: (i) a certification to that effect
                         from the transferee or transferor (in the form set
                         forth on the reverse of the Notes), (ii) if the
                         Company, Trustee or Registrar so requests, an Opinion
                         of Counsel from the transferee or transferor reasonably
                         acceptable to the Company and to the Registrar to the
                         effect that such transfer is in



                                       15


   21


                         compliance with the Securities Act, and (iii) in the
                         case of clause (x), a signed letter in substantially
                         the form of Exhibit B hereto,

                    then the Trustee or the Notes Custodian, at the direction of
                    the Trustee, will cause, in accordance with the standing
                    instructions and procedures existing between the Depositary
                    and the Notes Custodian, the aggregate principal amount of
                    the Global Security to be reduced on its books and records
                    and, following such reduction, the Company will execute and,
                    upon receipt of written instructions from the Company, the
                    Trustee will authenticate and deliver to the transferee a
                    Definitive Security in the appropriate principal amount.

               ii)  Definitive Notes issued in exchange for a beneficial
                    interest in a Global Security pursuant to this Section
                    2.6(d) shall be registered in such names and in such
                    authorized denominations as the Depositary, pursuant to
                    instructions from the Agent Members or otherwise, shall
                    instruct the Trustee. The Trustee shall deliver such
                    Definitive Securities to the Persons in whose names such
                    Notes are so registered.

          (e)  RESTRICTIONS ON TRANSFER AND EXCHANGE OF GLOBAL SECURITY.
Notwithstanding any other provisions of this Indenture (other than the
provisions set forth in Section 2.6(f)), a Global Security may not be
transferred as a whole or in part except by the Depositary to a nominee of the
Depositary or by a nominee of the Depositary to the Depositary or another
nominee of the Depositary or by the Depositary or any such nominee to a
successor Depositary or a nominee of such successor Depositary.


          (f)  AUTHENTICATION OF DEFINITIVE SECURITIES IN ABSENCE OF DEPOSITARY.
If at any time:

               i)   the Depositary notifies the Company that the Depositary is
                    unwilling or unable to continue as Depositary for the Global
                    Securities and a successor Depositary for the Global
                    Securities is not appointed by the Company within 90 days
                    after delivery of such notice; or

               ii)  the Company, at its sole discretion, notifies the Trustee in
                    writing that it elects to cause the issuance of Definitive
                    Securities under this Indenture,

then the Company will execute, and the Trustee, upon receipt of an Officers'
Certificate, in accordance with Section 2.2, requesting the authentication and
delivery of Definitive Securities, will authenticate and deliver Definitive
Securities, in an aggregate principal amount equal to the principal amount of
the Global Securities, in exchange for such Global Securities.

          (g)  LEGENDS.




                                       16


   22


               i)   Except as permitted by the following paragraph (ii), each
                    Note certificate evidencing the Global Securities and the
                    Definitive Securities (and all Notes issued in exchange
                    therefor or in substitution thereof and all Common Stock
                    issued upon conversion thereof) shall bear a legend in
                    substantially the following form:

               "THIS NOTE (OR ITS PREDECESSOR) HAS NOT BEEN REGISTERED UNDER THE
               SECURITIES ACT OF 1933 (THE "SECURITIES ACT"), OR ANY STATE
               SECURITIES LAWS. NEITHER THIS NOTE NOR ANY INTEREST OR
               PARTICIPATION HEREIN MAY BE OFFERED, SOLD, PLEDGED, HYPOTHECATED
               OR OTHERWISE TRANSFERRED IN THE ABSENCE OF SUCH REGISTRATION OR
               UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO,
               REGISTRATION. EACH PURCHASER OF THIS NOTE IS HEREBY NOTIFIED THAT
               THE SELLER OF THIS NOTE MAY BE RELYING ON THE EXEMPTION FROM THE
               PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED BY RULE
               144A THEREUNDER.

               "THE HOLDER OF THIS NOTE AGREES FOR THE BENEFIT OF THE COMPANY
               THAT (A) THIS NOTE MAY BE OFFERED, RESOLD, PLEDGED OR OTHERWISE
               TRANSFERRED, ONLY (I) TO A PERSON WHOM THE SELLER REASONABLY
               BELIEVES IS A QUALIFIED INSTITUTIONAL BUYER (AS DEFINED IN RULE
               144A UNDER THE SECURITIES ACT) IN A TRANSACTION MEETING THE
               REQUIREMENTS OF RULE 144A, (II) IN AN OFFSHORE TRANSACTION IN
               ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT, (III)
               PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE
               SECURITIES ACT, (IV) TO THE COMPANY OR (V) PURSUANT TO ANY OTHER
               AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE
               SECURITIES ACT, IN EACH OF CASES (I) THROUGH (V) IN ACCORDANCE
               WITH ANY APPLICABLE SECURITIES LAWS OF ANY STATE OF THE UNITED
               STATES AND (B) THE HOLDER WILL, AND EACH SUBSEQUENT HOLDER IS
               REQUIRED TO, NOTIFY ANY PURCHASER OF THIS NOTE FROM IT OF THE
               RESALE RESTRICTIONS REFERRED TO IN (A) ABOVE."

               ii)  Upon any sale or transfer of a Transfer Restricted Security
                    (including any Transfer Restricted Security represented by a
                    Global Security) pursuant to Rule 144 under the Securities
                    Act or an effective registration statement under the
                    Securities Act:

                    (A)  in the case of any Transfer Restricted Security that is
                         a Definitive Security, the Registrar shall permit the
                         Holder thereof (unless such Holder is an Affiliate of
                         the Company) to exchange such Transfer



                                       17


   23


                         Restricted Security for a Definitive Security that does
                         not bear the legends set forth above and rescind any
                         restriction on the transfer of such Transfer Restricted
                         Security; and

                    (B)  any such Transfer Restricted Security represented by a
                         Global Security shall not be subject to the provisions
                         set forth in (i) above (such sales or transfers being
                         subject only to the provisions of Section 2.6(e));
                         provided, however, that with respect to any request for
                         an exchange of a Transfer Restricted Security that is
                         represented by a Global Security for a Definitive
                         Security that does not bear a legend, which request is
                         made in reliance upon Rule 144 under the Securities
                         Act, the Holder thereof shall certify in writing to the
                         Registrar that such request is being made pursuant to
                         Rule 144 under the Securities Act (such certification
                         to be in the form set forth on the reverse of the
                         Notes).

          (h)  CANCELLATION AND/OR ADJUSTMENT OF GLOBAL SECURITY. At such time
               as all beneficial interests in a Global Security have either been
               exchanged for Definitive Securities, redeemed, repurchased or
               cancelled, such Global Security shall be returned to or retained
               and cancelled by the Trustee in accordance with Section 2.11. At
               any time prior to such cancellation, if any beneficial interest
               in a Global Security is exchanged for Definitive Securities,
               redeemed, repurchased or cancelled, the principal amount of Notes
               represented by such Global Security shall be reduced accordingly
               and the books and records of the Trustee or the Notes Custodian
               shall be marked, by the Trustee or the Notes Custodian, at the
               direction of the Trustee, to reflect such reduction.

          (i)  OBLIGATIONS WITH RESPECT TO TRANSFERS AND EXCHANGES OF DEFINITIVE
               SECURITIES.

               i)    To permit registrations of transfers and exchanges, the
                     Company shall execute and the Trustee shall authenticate
                     Definitive Securities and a Global Security at the
                     Registrar's request.

              (ii)   No service charge shall be made for any registration of
                     transfer or exchange, but the Company may require payment
                     of a sum sufficient to cover any transfer tax, assessments
                     or similar governmental charge payable in connection
                     therewith.

              (iii)  The Registrar or co-registrar shall not be required to
                     register the transfer of or exchange of (a) any Definitive
                     Security selected for redemption in whole or in part
                     pursuant to Article 3, except the unredeemed portion of any
                     Definitive Security being redeemed in part, or (b) any Note
                     during the 15 day period preceding the mailing of a notice
                     of redemption or an offer to repurchase or redeem Notes or
                     the 15 day period preceding an Interest Payment Date.




                                       18


   24


              (iv)   Prior to the due presentation for registration of transfer
                     of any Note, the Company, the Trustee, the Paying Agent,
                     the Registrar or any co- registrar may deem and treat the
                     Person in whose name a Note is registered as the absolute
                     owner of such Note for the purpose of receiving payment of
                     Principal of and interest on such Note and for all other
                     purposes whatsoever, whether or not such Note is overdue,
                     and none of the Company, the Trustee, the Paying Agent, the
                     Registrar or any co-registrar shall be affected by notice
                     to the contrary.

              (v)    All Notes issued upon any transfer or exchange pursuant to
                     the terms of this Indenture shall evidence the same debt
                     and shall be entitled to the same benefits under this
                     Indenture as the Notes surrendered upon such transfer or
                     exchange.

       (j)    NO OBLIGATION OF THE TRUSTEE.

              (i)    The Trustee shall have no responsibility or obligation to
                     any beneficial owner of a Global Security, a member of, or
                     a participant in the Depositary or other Person with
                     respect to the accuracy of the records of the Depositary or
                     its nominee or of any participant or member thereof, with
                     respect to any ownership interest in the Notes or with
                     respect to the delivery to any participant, member,
                     beneficial owner or other Person (other than the
                     Depositary) of any notice (including any notice of
                     redemption) or the payment of any amount, under or with
                     respect to such Notes. All notices and communications to be
                     given to the Holders and all payments to be made to Holders
                     under the Notes shall be given or made only to or upon the
                     order of the registered Holders (which shall be the
                     Depositary or its nominee in the case of a Global
                     Security). The rights of beneficial owners in any Global
                     Security shall be exercised only through the Depositary
                     subject to the applicable rules and procedures of the
                     Depositary. The Trustee may rely and shall be fully
                     protected in relying upon information furnished by the
                     Depositary with respect to its members, participants and
                     any beneficial owners.

              (ii)   The Trustee shall have no obligation or duty to monitor,
                     determine or inquire as to compliance with any restrictions
                     on transfer imposed under this Indenture or under
                     applicable law with respect to any transfer of any interest
                     in any Note (including any transfers between or among the
                     Agent Members or beneficial owners in any Global Security)
                     other than to require delivery of such certificates and
                     other documentation or evidence as are expressly required
                     by, and to do so if and when expressly required by, the
                     terms of this Indenture, and to examine the same to
                     determine substantial compliance as to form with the
                     express requirements hereof.






                                     19


   25


SECTION 2.7    REPLACEMENT NOTES.
- -----------    -----------------

      Upon surrender of a mutilated Note at the office or agency of the
Registrar, the Company shall execute, and the Trustee shall authenticate and
deliver, a replacement Note in the name of the Holder of such mutilated Note, of
like principal amount and dated the date of such mutilated Note.

      Upon surrender of written notice by a Holder or a Holder's attorney duly
authorized in writing at the office or agency of the Registrar that a Note has
been lost, destroyed or wrongfully taken, the Company shall execute, and the
Trustee shall authenticate and deliver, a replacement Note in the name of such
Holder, of like principal amount and dated the date of such lost, destroyed or
wrongfully taken Note; provided, however, that, unless such requirement is
waived by the Company, such notice shall be accompanied by an indemnity or
indemnity bond from an acceptable issuer that is sufficient in the judgment of
the Trustee and the Company to protect the Company, the Trustee, any Agent and
any authenticating agent from any loss which any of them may suffer by reason of
such Note's replacement.

      The Company may charge the Holder for its expenses in replacing a Note.

      Every replacement Note shall be an obligation of the Company and shall be
entitled to all benefits of this Indenture equally and proportionately with all
other Notes duly issued hereunder.


SECTION 2.8    OUTSTANDING NOTES.
- -----------    -----------------

      The Notes outstanding at any time are all the Notes authenticated by the
Trustee except for those cancelled by it, those delivered to it for
cancellation, those reductions in the interest in the Global Security effected
by the Trustee hereunder and those described in this Section 2.8 as not
outstanding. Except as set forth in Section 2.9, a Note does not cease to be
outstanding because the Company or an Affiliate of the Company holds the Note.

      If a Note is replaced pursuant to Section 2.7, it ceases to be outstanding
unless the Trustee receives proof satisfactory to it that the replaced Note is
held by a holder in due course.

      If the principal amount of any Note is considered paid under Section 4.1,
it ceases to be outstanding and interest on it ceases to accrue.

      If the Paying Agent (other than the Company, any Subsidiary or an
Affiliate of any thereof) segregates and holds in trust, in accordance with this
Indenture, on a redemption date or maturity date money sufficient to redeem or
pay Notes payable on that date, and is not prohibited from paying such money to
the Holders thereof pursuant to the terms of this Indenture, then on and after
such redemption date or maturity date such Notes shall be deemed to be no longer
outstanding and shall cease to accrue interest.




                                       20


   26



SECTION 2.9    TREASURY NOTES.
- -----------    --------------

      In determining whether the Holders of the required aggregate principal
amount of Notes have concurred in any direction, waiver or consent, Notes owned
by the Company or by any Affiliate of the Company shall be considered as though
not outstanding, except that for the purposes of determining whether the Trustee
shall be protected in relying on any such direction, waiver or consent, only
Notes as to which a Trust Officer of the Trustee knows are so owned shall be so
disregarded.


SECTION 2.10    TEMPORARY NOTES.
- ------------    ---------------

       (a)    Until definitive Notes are ready for delivery, the Company may
prepare and execute and the Trustee shall authenticate and deliver temporary
Notes upon a written order of the Company signed by an Officer and delivered to
a Trust Officer. Temporary Notes shall be substantially in the form of
definitive Notes but may have variations that the Company considers appropriate
for temporary Notes. If temporary Notes are issued, the Company shall, without
unreasonable delay, prepare definitive Notes which may be exchanged for
temporary Notes.

       After the preparation of definitive Notes, the temporary Notes shall be
exchangeable for definitive Notes upon surrender of the temporary Notes at the
office or agency of the Registrar, without charge to Holders. Upon surrender for
cancellation of one or more temporary Notes, the Company shall execute and the
Trustee upon a written order of the Company signed by an Officer shall
authenticate and deliver in exchange therefor a like principal amount of
definitive Notes of authorized denominations. Until so exchanged, the temporary
Notes shall in all respects be entitled to the same benefits under this
Indenture as definitive Notes.

       (b)    A Global Security deposited with the Depositary or with the
Trustee as custodian for the Depositary pursuant to Section 2.1 shall be
transferred to the beneficial owners thereof only if such transfer complies with
Section 2.6 and (i) the Depositary notifies the Company that it is unwilling or
unable to continue as Depositary for such Global Security or if at any time such
Depositary ceases to be a "clearing agency" registered under the Exchange Act
and a successor Depositary is not appointed by the Company within 90 days after
such notice or (ii) an Event of Default has occurred and is continuing.

       (c)    Any Global Security that is transferable to the beneficial owners
thereof pursuant to this Section 2.10 shall be surrendered by the Depositary to
the Trustee, to be so transferred, in whole or from time to time in part,
without charge, and the Trustee shall authenticate and deliver, upon such
transfer of each portion of such Global Security, an equal aggregate principal
amount of Notes of authorized denominations. Any portion of a Global Security
transferred pursuant to this Section shall be executed, authenticated and
delivered only in denominations of $1,000 and any integral multiple thereof and
registered in such names as the Depositary shall direct. Any Note delivered in
exchange for an interest in the Global Security shall, except as otherwise
provided by Section 2.6(b), bear the restricted securities legend set forth in
Exhibit A hereto.



                                       21


   27



       (d)    Subject to the provisions of Section 2.10(c), the registered
Holder of a Global Security may grant proxies and otherwise authorize any
Person, including Agent Members and Persons that may hold interests through
Agent Members, to take any action which a Holder is entitled to take under this
Indenture or the Notes.

       (e)    In the event of the occurrence of either of the events specified
in Section 2.10(b), the Company will promptly make available to the Trustee, at
the Company's expense, a reasonable supply of certificated Notes in definitive,
fully registered form without interest coupons.


SECTION 2.11    CANCELLATION.
- ------------    ------------

       The Company at any time may deliver Notes to the Trustee for
cancellation. The Registrar, Conversion Agent and Paying Agent shall forward to
the Trustee any Notes surrendered to them for registration of transfer,
exchange, conversion or payment. The Trustee shall promptly cancel and destroy
(in accordance with the standard document destruction policies of the Trustee)
all Notes so delivered and certify to the Company their destruction unless by a
written order signed by an Officer, the Company shall direct that cancelled
Notes be returned to it. The Company may not issue new Notes to replace Notes
that have matured or been converted or redeemed.


SECTION 2.12    DEFAULTED INTEREST.
- ------------    ------------------

       If the Company defaults in a payment of interest on the Notes, the
Company shall pay defaulted interest (plus interest on such defaulted interest,
to the extent lawful, at the rate borne by this Note) in any lawful manner. The
Company shall pay the defaulted interest to the Persons who are Holders on a
subsequent special record date. The Company shall fix or cause to be fixed (or
upon the Company's failure to do so the Trustee shall fix) any such special
record date and payment date to the reasonable satisfaction of the Trustee,
which specified record date shall not be less than 10 days prior to the payment
date for such defaulted interest, and shall promptly mail or cause to be mailed
to each Holder a notice that states the special record date, the payment date
and the amount of defaulted interest to be paid. The Company shall notify the
Trustee in writing of the amount of defaulted interest proposed to be paid and
the date of the proposed payment, and at the same time the Company shall deposit
with the Trustee an amount of money equal to the aggregate amount proposed to be
paid with respect to such defaulted interest or shall make arrangements
reasonably satisfactory to the Trustee for such deposit prior to the date of the
proposed payment, which money when so deposited shall be held in trust for the
benefit of the Person entitled to such defaulted interest as provided in this
Section 2.12.





                                       22


   28


SECTION 2.13     DEPOSIT OF MONEYS.
- ------------     -----------------

       Prior to 10:00 a.m., New York City time, on each Interest Payment Date
and the maturity date, the Company shall deposit with the Paying Agent in
immediately available funds money sufficient to make cash payments, if any, due
on such Interest Payment Date or maturity date, as the case may be, in a timely
manner which permits the Paying Agent to remit payment to the Holders on such
Interest Payment Date or maturity date, as the case may be.


                                   ARTICLE 3.

                                   REDEMPTION


SECTION 3.1    NOTICES TO TRUSTEE.
- -----------    ------------------

       If the Company elects to redeem Notes pursuant to the optional redemption
provisions of Paragraph 5 of the Notes, it shall notify the Trustee in writing
of the redemption date, the principal amount of Notes to be redeemed and the
redemption price at least 15 days prior to mailing any notice of redemption to
the Holders (unless the Trustee consents to a shorter period). Such notice shall
be in the form of an Officers' Certificate from the Company and will state that
such redemption will comply with the conditions herein.

       If less than all the Notes are to be redeemed, the record date relating
to such redemption shall be selected by the Company and given to the Trustee,
which record date shall be not less than 15 days after the date of notice to the
Trustee.


SECTION 3.2    SELECTION OF NOTES TO BE REDEEMED.
- -----------    ---------------------------------

       If less than all the Notes are to be redeemed, the Trustee shall select
the Notes to be redeemed in compliance with the requirements of the principal
national securities exchange, if any, on which the Notes are quoted or listed or
admitted to trading or, if the Notes are not so quoted or listed or admitted to
trading, on a pro rata basis, by lot or by such other method that complies with
applicable legal requirements and that the Trustee considers fair and
appropriate. The Trustee shall make the selection not more than 60 days and not
less than 30 days before the redemption date from Notes outstanding and not
previously called for redemption. The Trustee may select for redemption portions
of the principal amount of Notes that have denominations larger than $1,000. The
Trustee will make the selection from Notes outstanding and not previously called
for redemption. Notes and portions thereof selected by the Trustee shall be in
amounts of $1,000 or integral multiples of $1,000. If less than all of the Notes
are to be redeemed and a Note is converted in accordance with Article 10 after
the date on which notice of redemption is given pursuant to Section 3.3 and
prior to the time and date specified in Section 3.5, such Note shall, for
purposes of determining the amount of such Notes which have been redeemed, be
deemed to have been redeemed. Provisions of this Indenture that apply to Notes



                                       23


   29


called for redemption also apply to portions of Notes called for redemption. The
Trustee shall notify the Company promptly of the Notes or portions of Notes to
be called for redemption.


SECTION 3.3    NOTICE OF REDEMPTION.
- -----------    --------------------

       At least 30 days but not more than 60 days before a redemption date, the
Company or, upon written notice to the Trustee by the Company, the Trustee shall
give a notice of redemption to the Holders.

      The notice shall identify the Notes to be redeemed and shall state:

              (a)    the redemption date;

              (b)    the redemption price;

              (c)    the Conversion Price;

              (d)    the name and address of the Paying Agent and Conversion
       Agent;

              (e)    that Notes called for redemption may be converted at any
       time before the close of business on the Business Day immediately
       preceding the redemption date in accordance with Article 10;

              (f)    that Holders who want to convert Notes must satisfy the
       requirements in Paragraph 8 of the Notes;

              (g)    that Notes called for redemption must be surrendered to the
       Paying Agent to collect the redemption price;

              (h)    the CUSIP number of the Notes;

              (i)    if fewer than all of the outstanding Notes are to be
       redeemed, the certificate numbers and principal amounts of the particular
       Notes to be redeemed;

              (j)    if any Note is being redeemed in part, that, after the
       redemption date, upon surrender of such Note, a new Note or Notes in
       principal amount equal to the unredeemed portion will be issued; and

              (k)    that unless the Company defaults in making such redemption
       payment or the Paying Agent is prohibited from making such redemption
       payment pursuant to the terms of this Indenture, interest on Notes called
       for redemption ceases to accrue on and after the redemption date.





                                       24


   30


       If the Trustee gives such notice of redemption, it shall do so in the
Company's name and at the Company's expense and the Company shall provide the
Trustee with the information required to give such notice of redemption.


SECTION 3.4    EFFECT OF NOTICE OF REDEMPTION; DEFINITION OF REDEMPTION PRICE.
- -----------    --------------------------------------------------------------

       Notice of redemption given in accordance with Sections 3.3 and 13.2 to
each Holder shall be deemed to have been duly given, whether or not any
particular Holder receives such notice. Once notice of redemption is so mailed,
Notes called for redemption become due and payable on the redemption date at the
redemption price set forth in the Notes. A notice of redemption may not be
conditional. Upon surrender to the Trustee or the Paying Agent, such Notes
called for redemption shall be paid at the redemption price. References in this
Indenture to the "redemption price" mean the redemption price set forth in the
Notes plus the interest payable as provided in the Notes on Notes called for
redemption.


SECTION 3.5    DEPOSIT OF REDEMPTION PRICE.
- -----------    ---------------------------

       On or before 10:00 a.m., New York City time, on any redemption date, the
Company shall deposit with the Trustee or with the Paying Agent immediately
available funds sufficient to pay the redemption price of all Notes to be
redeemed on that date other than Notes or portions of Notes called for
redemption which prior thereto have been delivered by the Company to the Trustee
for cancellation or have been converted; provided, however, that any such
deposit shall be a payment with respect to the Notes on such date and shall be
subject to the provisions of Article 11 and shall be permitted on such date only
if payment would be permitted on such date under Article 11. The Trustee or the
Paying Agent shall return to the Company any money not required for the purpose
of paying such redemption price.


SECTION 3.6    NOTES REDEEMED IN PART.
- -----------    ----------------------

       Upon surrender of a Note that is redeemed in part, the Company shall
issue and the Trustee shall authenticate for the Holder at the expense of the
Company a new Note equal in principal amount to the unredeemed portion of the
Note surrendered.




                                       25


   31


                                   ARTICLE 4.

                                    COVENANTS


SECTION 4.1    PAYMENT OF NOTES.
- -----------    ----------------

       The Company shall pay the Principal and repurchase price, if any, of and
interest on the Notes on the dates and in the manner provided in the Notes and
this Indenture. Principal and interest shall be considered paid on the date due
if the Paying Agent (other than the Company or a Subsidiary) on that date holds
money in accordance with this Indenture designated for and sufficient to pay in
cash all Principal and interest then due and the Paying Agent is not prohibited
from paying such money to Holders on that date pursuant to the terms of this
Indenture.

       To the extent lawful, the Company shall pay interest (including
post-petition interest in any proceeding under any Bankruptcy Law) on (i)
overdue Principal and repurchase price, if any, of the Notes at the rate borne
by the Notes and (ii) overdue installments of interest at the same rate.


SECTION 4.2    STAY, EXTENSION AND USURY LAWS.
- -----------    ------------------------------

       The Company covenants (to the extent that it may lawfully do so) that it
will not at any time insist upon, plead, or in any manner whatsoever claim or
take the benefit or advantage of, any stay, extension or usury law wherever
enacted, now or at any time hereafter in force, which may affect the covenants
or the performance of this Indenture; and the Company (to the extent it may
lawfully do so) hereby expressly waives all benefit or advantage of any such
law, and covenants that it will not, by resort to any such law, hinder, delay or
impede the execution of any power herein granted to the Trustee, but will suffer
and permit the execution of every such power as though no such law has been
enacted.


SECTION 4.3    CONTINUED EXISTENCE.
- -----------    -------------------

       Subject to Article 5, the Company will do or cause to be done all things
necessary to preserve and keep in full force and effect its existence as a
corporation and the corporate existence of the Subsidiaries and will refrain or
cause the Subsidiaries to refrain from taking any action that would cause its
corporate existence or the corporate existence of any of the Subsidiaries to
cease, including without limitation any action that would result in the
liquidation, winding up or dissolution of it or any of the Subsidiaries;
provided, however, that the Company shall not be required to preserve the
existence of any Subsidiary if the Board of Directors shall determine that the
preservation thereof is no longer desirable in the conduct of the business of
the Company and the Subsidiaries and that the loss thereof to the Company taken
as a whole is not disadvantageous in any material respect to the Holders.




                                       26


   32



SECTION 4.4    REPORTS.
- -----------    -------

       (a)    The Company shall file with the Trustee copies of all reports and
other information and documents that the Company is required to file with the
SEC pursuant to the Exchange Act. Each such report or other information or
document shall be filed with the Trustee within 15 days after filing of such
report or other information or document with the SEC. The Company will mail or
cause to be mailed to all Holders copies of all of (a) its annual reports to
stockholders and (b) quarterly reports to stockholders which are mailed to its
institutional stockholders.

       (b)    If the Company is at any time no longer subject to the reporting
requirements of Section 13 or 15(d) of the Exchange Act, the Company will
prepare (i) for the first three quarters of each fiscal year of the Company,
quarterly financial statements substantially equivalent to the financial
statements required to be included in a report on Form 10-Q under the Exchange
Act, and (ii) annually, complete audited consolidated financial statements,
including, but not limited to, a balance sheet, a statement of operations, a
statement of stockholders' equity and all appropriate notes. All such financial
statements will be prepared in accordance with GAAP, except for changes with
which the Company's independent accountants concur and except that quarterly
financial statements may be subject to year-end adjustments. The Company will
file or cause to be filed with the Trustee and will mail or cause to be mailed
to the Holders a copy of such financial statements within 50 days after the end
of each of the first three quarters of each fiscal year of the Company and
within 95 days after the close of each fiscal year of the Company, respectively.
Notwithstanding the foregoing, if the Company is no longer subject to such
reporting requirements by reason of the acquisition of Capital Stock by, or
merger or consolidation of the Company with, a Person which is subject to such
reporting requirements or a Subsidiary of such a Person and such Person has
unconditionally and irrevocably guaranteed payment in full when due of all
amounts payable with respect to the Notes, then the Company need not prepare,
file or mail the financial statements described in this Section 4.4(b);
provided, however, that such Person complies with Section 4.4(a) as if
references therein to the Company were references to such Person.


SECTION 4.5    TAXES.
- -----------    -----

       The Company shall, and shall cause each of the Subsidiaries to, pay or
discharge prior to delinquency all taxes, assessments and governmental levies,
except as contested in good faith and by appropriate proceedings.


SECTION 4.6    CHANGE OF CONTROL.
- -----------    -----------------

       (a)    In the event of a Change of Control, the Company shall give or
cause to be given written notice in the form of an Officers' Certificate (the
"CHANGE OF CONTROL NOTICE") to all Holders, the Trustee and the Paying Agent of
such event and shall make an offer to purchase (as the same may be extended in
accordance with applicable law, the "CHANGE OF CONTROL OFFER")



                                       27


   33


all then outstanding Notes at a purchase price equal to 150% of the principal
amount thereof plus accrued and unpaid interest thereon to the Change of Control
Payment Date. The Change of Control Notice shall be given in accordance with
Section 13.2 and the Change of Control Offer shall be made not more than 30 days
following the date of the Change of Control (the "CHANGE OF CONTROL DATE"),
unless the Company has previously given a notice of optional redemption by the
Company of all of the Notes in accordance with this Indenture. The Change of
Control Notice shall set forth:

              (i) a statement that a Change of Control has occurred and, unless
              the Notes are subject to a notice of optional redemption described
              above, that the Company is offering to repurchase all of the
              outstanding Notes;

              (ii) a brief description of such Change of Control and, to the
              extent readily available to the Company, information with respect
              to pro forma historical consolidated income, cash flow and
              capitalization of the Company after giving effect to such Change
              of Control and such other financial information relating to the
              Company with respect to such Change of Control as the Company may,
              in its sole discretion, deem relevant to a decision whether to
              convert or hold Notes or tender Notes in connection with such
              Change of Control Offer;

              (iii) the repurchase price (the "CHANGE OF CONTROL PAYMENT");

              (iv) the expiration date of the Change of Control Offer, which
              shall be no earlier than 30 days nor later than 60 days from the
              date the Change of Control Notice is mailed;

              (v) the date such purchase shall be effected, which shall be no
              later than 30 days after the expiration date of the Change of
              Control Offer (the "CHANGE OF CONTROL PAYMENT DATE");

              (vi) a statement that any Notes not accepted for payment pursuant
              to the Change of Control Offer shall continue to accrue interest;

              (vii) a statement that unless the Company defaults in the payment
              of the Change of Control Payment, all Notes or portions thereof
              accepted for payment pursuant to the Change of Control Offer shall
              cease to accrue interest on and after the Change of Control
              Payment Date;

              (viii) the Conversion Price as then in effect;

              (ix) the name and address of the Paying Agent and the Conversion
              Agent;

              (x) a statement that Notes (duly endorsed for transfer to the
              Company), together with the form of "Option of Holder to Elect
              Repurchase" thereon completed and signed, must be surrendered to
              the Paying Agent prior to the




                                       28


   34


              expiration of the Change of Control Offer to collect the Change of
              Control Payment; and

              (xi) any other information required by applicable law to be
              included therein and any other procedures that a Holder must
              follow in order to have Notes repurchased.

       (b)    The Change of Control Offer shall remain open until the close of
business on the expiration date of the Change of Control Offer. Each Holder
shall have the right to withdraw his tender in accordance with applicable rules
promulgated by the SEC under the Exchange Act.

       (c)    In the event that the Company is required to make a Change of
Control Offer, the Company will comply with any applicable securities laws and
regulations, including, to the extent applicable, Section 14(e) of, and Rule
14e-1 and any other tender offer rules under, the Exchange Act which may then be
applicable in connection with any offer by the Company to purchase Notes at the
option of the Holders; provided that in event such laws and regulations conflict
with any of the provisions hereof, such laws and regulations shall supersede
such provisions.

       (d)    On the Change of Control Payment Date, the Company shall, to the
extent lawful:

              (i) accept for payment Notes or portions thereof tendered pursuant
              to the Change of Control Offer;

              (ii) deposit with the Paying Agent in immediately available funds
              an amount equal to the Change of Control Payment with respect to
              all Notes or portions thereof so accepted; and

              (iii) deliver or cause to be delivered to the Trustee the Notes so
              accepted together with an Officers' Certificate stating the Notes
              or portions thereof tendered to the Company.

       (e)    The Paying Agent shall promptly (but in any case not later than
five Business Days after the Change of Control Payment Date) mail to each Holder
of Notes so accepted payment in an amount equal to the Change of Control Payment
for such Notes, and the Trustee shall promptly authenticate and mail to each
Holder a new Note equal in principal amount to any unpurchased portion of the
Notes surrendered by such Holder, if any; provided, that each such new Note
shall be in principal amount of $1,000 or an integral multiple thereof. The
Company shall publicly announce the results of all repurchases pursuant to this
Section 4.6 on or as soon as practicable after the Change of Control Payment
Date.






                                       29


   35


SECTION 4.7    LIMITATION ON DIVIDEND RESTRICTIONS AFFECTING SUBSIDIARIES.
- -----------    ----------------------------------------------------------

       The Company shall not, and shall not permit any of its Subsidiaries to,
create or otherwise cause or suffer to exist or become effective any encumbrance
or restriction of any kind on the ability of any Subsidiary other than
Unrestricted Subsidiaries to (a) pay to the Company dividends or make to the
Company any other distribution on its Capital Stock, (b) pay any debt owed to
the Company or any of the Subsidiaries, (c) make loans or advances to the
Company or any of the Subsidiaries or (d) transfer any of its property or assets
to the Company or any of the Subsidiaries, other than such encumbrances or
restrictions existing or created under or by reason of (i) applicable law, (ii)
this Indenture, (iii) covenants or restrictions contained in any instrument
governing debt of the Company or any of the Subsidiaries existing on the date of
this Indenture or hereafter, provided that in the absence of a default under any
such loan documents, no such restriction shall prevent a Subsidiary from paying
dividends or otherwise distributing funds to the Company in amounts sufficient
to enable the Company to make interest and principal payments on the Notes as
and when due, (including pursuant to any Change of Control Offer), (iv)
customary provisions restricting subletting, assignment and transfer of any
lease governing a leasehold interest of the Company or any of the Subsidiaries
or in any license or other agreement entered into in the ordinary course of
business, (v) any agreement governing debt of a Person acquired by the Company
or any of the Subsidiaries in existence at the time of such acquisition (but not
created in connection with or in contemplation thereof), which encumbrances or
restrictions are not applicable to any Person, or the property or assets of any
Person, other than the Person, or the property or assets of the Person, so
acquired, or (vi) any restriction with respect to a Subsidiary imposed pursuant
to an agreement entered into in accordance with the terms of this Indenture for
the sale or disposition of Capital Stock or property or assets of such
Subsidiary, pending the closing of such sale or disposition.


SECTION 4.8    LIMITATION ON LINE OF BUSINESS.
- -----------    ------------------------------

       For so long as the Notes are outstanding, the Company and its
Subsidiaries will engage solely in the manufacturing, marketing, research,
development and sale of products or services in or related to the pharmaceutical
or biotechnology industries.


SECTION 4.9    LIMITATION ON RESTRICTED PAYMENTS.
- -----------    ---------------------------------

       The Company shall not, and shall not permit any of its Subsidiaries to,
directly or indirectly, (i) declare or pay any distribution or dividend on or in
respect of any class or series of its Capital Stock (except dividends or
distributions payable by wholly-owned Subsidiaries of the Company and dividends
and distributions payable in Qualified Stock of the Company or in options,
warrants or other rights to purchase Qualified Stock of the Company); or (ii)
purchase, repurchase, prepay, redeem, defease or otherwise acquire or retire for
value (other than in Qualified Stock of the Company or in options, warrants or
other rights to purchase Qualified Stock of the Company) any Capital Stock of
the Company or any of its Subsidiaries (other than a wholly-owned Subsidiary of
the Company), except for the repurchase by the Company of any




                                       30


   36


shares of Common Stock held by employees, directors or officers of, or
consultants or advisors to, the Company or any of its Subsidiaries pursuant to
the terms of any stock restrictions, stock repurchase or similar agreement at a
price per share that is less than 95% of the then Current Market Price of the
Common Stock (any such prohibited declaration, payment, distribution, purchase,
repurchase, prepayment, redemption, defeasance or other acquisition or
retirement or investment referred to in clauses (i) or (ii) above being
hereinafter referred to as a "Restricted Payment"), unless at the time of and
after giving effect to such proposed Restricted Payment (the value of such
payment, if other than cash, as determined by the Board of Directors, including
the affirmative vote of a majority of the Independent Directors, whose
determination shall be conclusive and evidenced by a resolution of the Board of
Directors) (A) no Event of Default (and no event that, after notice or lapse of
time or both, would become an Event of Default) shall have occurred and be
continuing and (B) (I) the value of such Restricted Payment, together with all
other Restricted Payments made during the fiscal year in which such Restricted
Payment is to be made, does not exceed 50% of the Company's consolidated net
income with respect to the immediately preceding fiscal year or (II) the Current
Market Price of the Common Stock is at least $14.025 for each of the 10 Trading
Days preceding the approval by the Board of Directors of such Restricted Payment
and the Company's market capitalization at the time of such approval (defined as
the average Current Market Price of the Common Stock for the ten Trading Day
period preceding such approval multiplied by the number of outstanding shares of
Common Stock at such time) is at least 400% of the Company's outstanding debt
(as shown on the Company's consolidated balance sheet) immediately prior to and
immediately after such Restricted Payment and all Restricted Payments under this
clause (II) do not exceed $5.0 million in any fiscal year of the Company.

       Not later than the date of making any Restricted Payment, the Company
shall deliver to the Trustee an Officers' Certificate stating that such
Restricted Payment is permitted and setting forth the basis upon which the
calculations required by this Section 4.9 were computed, which calculations may
by based upon the Company's latest available financial statements.


SECTION 4.10     LIMITATION ON TRANSACTIONS WITH RELATED PERSONS.
- ------------     -----------------------------------------------

       The Company shall not, and shall not permit any of its Subsidiaries to,
directly or indirectly, enter into any transaction or series of related
transactions (including, without limitation, the sale, purchase, exchange or
lease of assets, property or services) with (a) any beneficial owner of 5% or
more of the outstanding voting securities of the Company (determined in
accordance with Section 13(d) of the Exchange Act) at the time of such
transaction, (b) any officer, director or employee of the Company, or any of its
Subsidiaries or any such beneficial owner of 5% or more of the outstanding
voting securities of the Company as described in clause (a) above or (c) any
Related Person, unless such transaction or series of related transactions (A) is
on terms that are no less favorable to the Company or any such Subsidiary, as
the case may be, than would be available in a comparable transaction with an
unrelated third party or (B)(x) if such transaction or series of related
transactions involve aggregate payments in excess of $60,000, the Company
delivers an Officers' Certificate to the Trustee certifying that such
transaction complies with clause (A) above and such transaction or series of
related transactions




                                       31


   37


is approved by a majority of the Independent Directors or (y) if such
transaction or series of related transactions involve aggregate payments in
excess of $1.0 million, the Company obtains an opinion as to the fairness to the
Company or such Subsidiary from a financial point of view issued by an
investment banking firm, appraisal firm or accounting firm, in each case of
national standing. Notwithstanding the foregoing, the provisions of this Section
4.9 shall not apply to (i) any transaction entered into between the Company and
its Subsidiaries (but excluding transactions with any Subsidiary of which more
than 5% of the outstanding voting securities (as determined in accordance with
Section 13(d) under the Exchange Act) are beneficially owned by Persons who are
(a) officers, directors or employees of the Company or any of its Subsidiaries
or any beneficial owner of 5% or more of the outstanding voting securities of
the Company (as determined in accordance with Section 13(d) under the Exchange
Act) at the time of such transaction, (b) a beneficial owner of 5% or more of
the outstanding voting securities of the Company (as determined in accordance
with Section 13(d) under the Exchange Act) or (c) Related Persons), (ii) the
payment of compensation and provision of benefits to officers and employees of
the Company and loans and advances made in the ordinary course of business, or
any issuance of securities, or other payments, awards or grants in cash,
securities or otherwise (including the grant of stock options or similar rights
to officers, employees and directors of the Company or any Subsidiary) pursuant
to, or the funding of, employment arrangements, stock options and stock
ownership plans or other benefit plans approved by a majority of the Independent
Directors; any Designated Transactions and (iv) transactions with any Person who
is a Director of the Company or any of its Subsidiaries and who is not (a) the
beneficial owner of 5% or more of the outstanding voting securities of the
Company (as determined in accordance with Section 13(d) under the Exchange Act)
or (b) an officer or employee of the Company or any of its Subsidiaries or any
such beneficial owner of 5% or more of the outstanding voting securities of the
Company at the time of such transaction.


SECTION 4.11    COMPLIANCE CERTIFICATE.
- ------------    ----------------------

       The Company shall deliver to the Trustee, within 120 days after the end
of each fiscal year of the Company, an Officers' Certificate stating that a
review of the activities of the Company and the Subsidiaries during the
preceding fiscal year has been made under the supervision of the signing Officer
with a view to determining whether the Company has kept, observed, performed and
fulfilled its obligations under this Indenture and further stating, as to such
Officer, that to the best of his or her knowledge the Company has kept,
observed, performed and fulfilled each and every covenant and condition
contained in this Indenture and is not in default in the performance or
observance of any of the terms, provisions and conditions hereof (or, if a
Default or Event of Default shall have occurred, describing all such Defaults or
Event of Default of which he or she may have knowledge and what action the
Company is taking or proposes to take with respect thereto), and that, to the
best of his or her knowledge, no event has occurred and remains in existence by
reason of which payments on account of the Principal of or interest on the Notes
are prohibited.





                                       32


   38


SECTION 4.12    FURTHER ASSURANCE TO THE TRUSTEE.
- ------------    --------------------------------

       The Company shall, upon reasonable request of the Trustee, execute and
deliver such further instruments and do such further acts as may be reasonably
necessary or proper to carry out more effectively the provisions of this
Indenture.


                                   ARTICLE 5.

                                   SUCCESSORS


SECTION 5.1    WHEN COMPANY MAY MERGE OR SELL ASSETS.
- -----------    -------------------------------------

       The Company shall not consolidate with or merge into, or sell, lease,
convey or otherwise dispose of all or substantially all of its assets to, any
Person in a single transaction or series of related transactions, without the
consent of Holders of the majority in aggregate principal amount of Notes then
outstanding, unless:

       (a)    the Company is the continuing corporation or the Person formed by
or surviving any such consolidation or merger (if other than the Company), or to
which such sale, lease, conveyance or other disposition of assets shall have
been made, is organized and existing under the laws of the United States, any
state thereof or the District of Columbia and such Person (if other than the
Company) expressly assumes by supplemental indenture executed and delivered to
the Trustee and in a form reasonably satisfactory to the Trustee, all the
obligations of the Company under the Notes and this Indenture, including,
without limitation, conversion rights in accordance with Article 10;

       (b)    immediately before and immediately after giving effect to the
transaction no Event of Default, and no event which, after notice or lapse of
time, or both, would become an Event of Default, shall have occurred and be
continuing;

       (c)    immediately after giving effect to such transaction, the Notes and
this Indenture (as supplemented by any such supplemental indenture) will be
valid and enforceable obligations of the Company or such successor; and

       (d)    the Company shall have delivered to the Trustee an Officers'
Certificate and an Opinion of Counsel, each stating that such proposed
transaction and such supplemental indenture do not conflict with the applicable
provisions of this Indenture and, with respect to such Officers' Certificate
only, that all conditions precedent herein provided for relating to such
transaction have been satisfied.






                                       33


   39


SECTION 5.2    SUCCESSOR SUBSTITUTED.
- -----------    ---------------------

       Upon any consolidation or merger, or any sale, lease, conveyance or other
disposition of all or substantially all of the assets of the Company in
accordance with Section 5.1, the Person formed by such consolidation or into or
with which the Company is merged or to which such sale, lease, conveyance or
other disposition is made shall succeed to, and be substituted for, and may
exercise every right and power of, the Company under this Indenture with the
same effect as if such successor Person has been named as the Company herein;
provided, however that in the case of a sale, lease, conveyance or other
disposition the Company shall not be released from the obligation to pay the
Principal of and interest on the Notes.


                                   ARTICLE 6.

                              DEFAULTS AND REMEDIES


SECTION 6.1    EVENTS OF DEFAULT.
- -----------    -----------------

      The following shall constitute an "EVENT OF DEFAULT":

              (a)    failure to pay any Principal or repurchase price, if any,
of any Note when due and payable, whether at maturity, upon redemption, upon a
Change of Control Offer or otherwise, whether or not such payment is prohibited
by the subordination provisions of this Indenture;

              (b)    failure to pay any interest on any Note when due and
payable, which failure continues for ten days, whether or not such payment is
prohibited by the subordination provisions of this Indenture;

              (c)    failure to perform the other covenants of the Company in
this Indenture, which failure continues for 60 days after written notice as
provided in the last paragraph of this Section 6.1;

              (d)    a default occurs (after giving effect to any applicable
grace periods or any extension of any maturity date) in the payment when due of
Principal of, or an acceleration of, any indebtedness for money borrowed by the
Company or any of its Subsidiaries (other than an Unrestricted Subsidiary which
is not a Significant Subsidiary and provided there is no recourse against the
Company or any other Subsidiary with respect to the obligations of such
Unrestricted Subsidiary arising as a result of such default) in excess of $2
million, individually or in the aggregate, if such indebtedness is not
discharged, or such acceleration is not annulled, within 30 days after written
notice as provided in the last paragraph of this Section 6.1;

              (e)    the Company or any of its Significant Subsidiaries,
pursuant to or within the meaning of any Bankruptcy Law:






                                       34


   40



                     (i)    commences a voluntary case,

                     (ii)   consents to the entry of an order for relief against
              it in an involuntary case,

                     (iii)  consents to the appointment of a Custodian of it or
              for all or substantially all of its property, and such Custodian
              is not discharged within 30 days,

                     (iv)   makes a general assignment for the benefit of its
              creditors, or

                     (v)    admits in writing that it is generally unable to pay
              its debts as the same become due;

                     (f)    a court of competent jurisdiction enters an order or
              decree under any Bankruptcy Law that:

                     (i)    is for relief in an involuntary case against the
              Company or any Significant Subsidiary,

                     (ii)   appoints a Custodian of the Company or any
              Significant Subsidiary or for all or substantially all of the
              property of the Company or any Significant Subsidiary, or

                     (iii)  orders the liquidation of the Company or any
              Significant Subsidiary,

and, in each case, the order or decree remains unstayed and in effect for 60
consecutive days.

       The term "BANKRUPTCY LAW" means Title 11 of the U.S. Code or any similar
federal, foreign or state law for the relief of debtors. The term "CUSTODIAN"
means any receiver, trustee, assignee, liquidator, examiner or similar official
under any Bankruptcy Law. The term "SIGNIFICANT SUBSIDIARY" has the same meaning
as significant subsidiary has under Regulation S- X under the Securities Act as
in effect on the date hereof.

       A Default under clause (c) of this Section 6.1 (other than a Default
under Section 5.1, which Default shall be an Event of Default with the notice
but without the passage of time specified in clause (c) of this Section 6.1) or
clause (d) of this Section 6.1 shall not be an Event of Default until (i) the
Trustee shall have notified the Company, or the Holders of at least 25% in
aggregate principal amount of the Notes then outstanding shall have notified the
Company and the Trustee, of the Default and (ii) the Company shall have failed
to cure the Default under such clause (c) within 60 days after receipt of the
notice or under such clause (d) within 10 days after receipt of the notice,
respectively. Any such notice must specify the Default, demand that it be
remedied and state that the notice is a "NOTICE OF DEFAULT."





                                       35


   41



SECTION 6.2     ACCELERATION.
- -----------     ------------

       If an Event of Default (other than an Event of Default specified in
clauses (e) and (f) of Section 6.1) occurs and is continuing, the Trustee (by
notice to the Company), or the Holders of at least 25% in aggregate principal
amount of the Notes then outstanding (by notice to the Company and the Trustee),
may declare the unpaid Principal of and accrued interest on all the Notes then
outstanding to be due and payable. Upon any such declaration, such Principal and
accrued interest shall be due and payable immediately. If an Event of Default
specified in clause (e) or (f) of Section 6.1 occurs, such an amount shall ipso
facto become and be immediately due and payable without any declaration or other
act on the part of the Trustee or any Holder. The Holders of a majority in
aggregate principal amount of the Notes then outstanding by written notice to
the Trustee may rescind an acceleration and its consequences if (a) the Company
has paid or deposited with the Trustee a sum sufficient to pay (i) all overdue
interest on all Notes then outstanding and (ii) the Principal or repurchase
price, if any, of the Notes then outstanding which have become due otherwise
than by such declaration of acceleration and accrued interest thereon at a rate
borne by the Notes and (b) the rescission would not conflict with any judgment
or decree and if all existing Events of Default have been cured or waived except
nonpayment of Principal or interest that has become due solely because of the
acceleration. No such recision shall affect any subsequent Default or impair any
right consequent thereto.


SECTION 6.3    OTHER REMEDIES.
- -----------    --------------

       If an Event of Default occurs and is continuing, the Trustee may pursue
any remedy available under applicable law to collect the payment of Principal or
repurchase price, if any, of or interest on the Notes or to enforce the
performance of any provision of the Notes or this Indenture.

       The Trustee may maintain a proceeding even if it does not possess any of
the Notes or does not produce any of them in the proceeding. A delay or omission
by the Trustee or any Holder in exercising any right or remedy accruing upon an
Event of Default shall not impair the right or remedy or constitute a waiver of
or acquiescence in the Event of Default. All remedies are cumulative to the
extent permitted by law.


SECTION 6.4    WAIVER OF EXISTING AND PAST DEFAULTS.
- -----------    ------------------------------------

       The Holders of a majority in aggregate principal amount of the Notes then
outstanding held by Persons who are not Affiliates of the Company by written
notice to the Trustee may waive an existing Default or Event of Default and its
consequences, except (i) a continuing Default or Event of Default in the payment
of the Principal of or the interest on any Note or (ii) a Default or Event of
Default with respect to a provision that under Section 9.2 cannot be amended
without the consent of each Holder affected. Upon any such waiver, such Default
shall cease to exist and any Event of Default arising therefrom shall be deemed
to have been cured



                                       36


   42


for every purpose of this Indenture; but no such waiver shall extend to any
subsequent or other Default or impair any right consequent thereon.


SECTION 6.5    CONTROL BY MAJORITY.
- -----------    -------------------

       Notwithstanding anything contained in Section 6.3 to the contrary, the
Holders of a majority in aggregate principal amount of the Notes then
outstanding may direct the time, method and place of conducting any proceeding
for any remedy available to the Trustee or exercising any trust or power
conferred on it; provided, however, that the Trustee may refuse to follow any
direction that conflicts with applicable law or this Indenture or that the
Trustee determines is unduly prejudicial to the rights of other Holders or would
involve the Trustee in personal liability; provided further, however, that the
Trustee may take any other action deemed proper by the Trustee which is not
inconsistent with such direction.

       Prior to taking any action or following any direction pursuant to this
Article 6, the Trustee shall be entitled to request indemnification from the
requesting Holders satisfactory to it in its sole discretion against any loss or
expense caused by taking such action or following such direction. If the Trustee
makes such request, it shall be entitled to delay taking such action or
following such direction until it has received such indemnification.


SECTION 6.6    LIMITATION ON SUITS.
- -----------    -------------------

       A Holder may pursue a remedy with respect to this Indenture or the Notes
only if:

              (a)    the Holder gives to the Trustee notice of a continuing
       Event of Default;

              (b)    the Holders of at least 25% in aggregate principal amount
       of the Notes then outstanding make a written request to the Trustee to
       pursue the remedy;

              (c)    such Holder or Holders offer to the Trustee indemnity
       satisfactory to the Trustee against any loss, liability or expense;

              (d)    the Trustee does not comply with the request within 60 days
       after receipt of the request and the offer of indemnity; and

              (e)    during such 60-day period the Holders of a majority in
       aggregate principal amount of the Notes then outstanding do not give the
       Trustee a direction inconsistent with the request.

A Holder may not use this Indenture to prejudice the rights of another Holder or
to obtain a preference or priority over another Holder.






                                       37


   43


SECTION 6.7    RIGHTS OF HOLDERS TO RECEIVE PAYMENT.
- -----------    ------------------------------------

       Notwithstanding any other provision of this Indenture, the right of any
Holder of a Note to receive payment of Principal or repurchase price, if any, of
and interest on such Note, on or after the respective due dates expressed in the
Note, or to bring suit for the enforcement of any such payment on or after such
respective dates, shall not be impaired or affected without the consent of such
Holder.

       Notwithstanding any other provision of this Indenture, the right of any
Holder of a Note to bring suit for the enforcement of the right to convert such
Note shall not be impaired or affected without the consent of such Holder.


SECTION 6.8    COLLECTION SUIT BY TRUSTEE.
- -----------    --------------------------

       If an Event of Default specified in Section 6.1(a) or 6.1(b) occurs and
is continuing, the Trustee may recover judgment in its own name and as trustee
of an express trust against the Company for the whole amount of Principal or
repurchase price, if any, of and interest accrued on the Notes and interest on
overdue Principal or repurchase price, if any, of and accrued interest on the
Notes and for such further amount as shall be sufficient to cover the costs and,
to the extent lawful, expenses of collection, including the reasonable
compensation, expenses, disbursements and advances of the Trustee, its agents
and its counsel.


SECTION 6.9    TRUSTEE MAY FILE PROOFS OF CLAIM.
- -----------    --------------------------------

       The Trustee may file such proofs of claim and other papers or documents
as may be necessary or advisable in order to have the claims of the Trustee and
the Holders allowed in any judicial proceedings relative to the Company, its
creditors or its property. Except as provided in this Indenture, nothing
contained herein shall be deemed to authorize the Trustee to authorize or
consent to or accept or adopt on behalf of any Holder any plan of
reorganization, arrangement, adjustment or composition affecting the Notes or
the rights of any Holder or to authorize the Trustee to vote with respect to the
claim of any Holder in any such proceeding.


SECTION 6.10    PRIORITIES.
- ------------    ----------

       If the Trustee collects any money pursuant to this Article 6, it shall
pay out the money in the following order:

      First:   to the Trustee for amounts due under Section 6.8 or 7.7;

      Second:  to holders of Senior Indebtedness to the extent required by
               Article 11;





                                       38


   44


      Third:   to Holders for amounts due and unpaid on the Notes for Principal
               and interest, ratably, without preference or priority of any
               kind, according to the amounts due and payable on the Notes for
               Principal and interest, respectively; and

      Fourth:  to the Company or to such party as a court of competent
               jurisdiction shall direct.

     The Trustee may fix a record date and payment date for any payment to
Holders and, if it does so, will give prompt prior written notice thereof to the
Registrar.

     At least 15 days before any such record date, the Trustee shall give or
cause to be given to each Holder a notice that states such record date, such
payment date and the amount to be paid.


SECTION 6.11    UNDERTAKING FOR COSTS.
- ------------    ---------------------

     In any suit for the enforcement of any right or remedy under this Indenture
or in any suit against the Trustee for any action taken or omitted by it as a
Trustee, a court in its discretion may require the filing by any party litigant
in the suit of an undertaking to pay the costs of the suit, and the court in its
discretion may assess reasonable costs, including reasonable attorneys' fees,
against any party litigant in the suit, having due regard to the merits and good
faith of the claims or defenses made by the party litigant. This Section 6.11
does not apply to a suit by the Trustee, a suit by a Holder pursuant to Section
6.7, or a suit by Holders of more than 10% in aggregate principal amount of the
then outstanding Notes or any suit for the enforcement of the right to convert
any Note in accordance with Article 10.


                                   ARTICLE 7.

                                     TRUSTEE


SECTION 7.1    DUTIES OF TRUSTEE.
- -----------    -----------------

       (a)    If an Event of Default has occurred and is continuing, the Trustee
              shall exercise such of the rights and powers vested in it by this
              Indenture, and use the same degree of care and skill in their
              exercise, as a prudent person would exercise or use under the
              circumstances in the conduct of such person's own affairs.

       (b)    Except during the continuance of an Event of Default:

              (i)    The Trustee need perform only those duties that are
       specifically set forth in this Indenture or the TIA and no others; and





                                       39


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              (ii)   in the absence of negligence, willful misconduct or bad
       faith on its part, the Trustee may conclusively rely, as to the truth of
       the statements and the correctness of the opinions expressed therein,
       upon certificates or opinions furnished to the Trustee and conforming to
       the requirements of this Indenture. However, the Trustee shall examine
       the certificates and opinions to determine whether or not they conform to
       the requirements of this Indenture, but the Trustee need not verify the
       contents thereof.

       (c)    The Trustee may not be relieved from liability for its own
negligent action, its own negligent failure to act, or its own willful
misconduct, except that:

              (i)    this Section 7.1(c) does not limit the effect of Section
       7.1(b);

              (ii)   the Trustee shall not be liable for any error of judgment
       made in good faith by a Trust Officer, unless it is proved that the
       Trustee was negligent in ascertaining the pertinent facts; and

              (iii)  the Trustee shall not be liable with respect to any action
       it takes or omits to take in good faith in accordance with a direction
       received by it pursuant to Section 6.5.

       (d)    Every provision of this Indenture that in any way relates to the
Trustee is subject to the provisions of the TIA and Sections 7.1(a), 7.1(b),
7.1(c) and 7.1(e).

       (e)    The Trustee may refuse to perform any duty or exercise any right
or power hereunder unless it receives indemnity satisfactory to it against any
loss, liability or expense.

       (f)    The Trustee shall not be liable for interest on any money received
by it hereunder, except as the Trustee may agree in writing with the Company.
Money held by the Trustee in trust hereunder need not be segregated from other
funds, except to the extent required by law.


SECTION 7.2    RIGHTS OF TRUSTEE.
- -----------    -----------------

       (a)    The Trustee may conclusively rely on any document believed by it
to be genuine and to have been signed or presented by the proper Person. The
Trustee need not investigate any fact or matter stated in the document, but the
Trustee, in its discretion, may make such further inquiry or investigation into
such facts or matters to the extent reasonably deemed necessary by it.

       (b)    Before the Trustee acts or refrains from acting pursuant to the
terms of this Indenture or otherwise, it may require an Officers' Certificate or
an Opinion of Counsel, or both. The Trustee shall not be liable for any action
it takes or omits to take in good faith in reliance on such Officers'
Certificate or Opinion of Counsel.




                                       40


   46


       (c)    The Trustee may act through agents and attorneys and shall not be
responsible for the willful misconduct or gross negligence of any agents and
attorneys appointed with due care.

       (d)    Subject to the provisions of Section 7.1(c), the Trustee shall not
be liable for any action it takes or omits to take in good faith which it
believes to be authorized or within its rights or powers conferred by this
Indenture.


SECTION 7.3    INDIVIDUAL RIGHTS OF TRUSTEE.
- -----------    ----------------------------

       The Trustee in its individual or any other capacity may become the owner
or pledgee of Notes and may otherwise deal with the Company or any Affiliate of
the Company with the same rights it would have if it were not Trustee. Any Agent
may do the same with like rights. However, the Trustee is subject to and must
comply with Sections 7.10 and 7.11.


SECTION 7.4    TRUSTEE'S DISCLAIMER.
- -----------    --------------------

       The Trustee makes no representation as to the validity or adequacy of
this Indenture or the Notes, it shall not be accountable for the Company's use
of the proceeds from the Notes, and it shall not be responsible for any
statement of the Company in this Indenture or any statement in the Notes other
than its authentication.


SECTION 7.5    NOTICE OF DEFAULTS.
- ----------    -------------------

       If a Default or Event of Default occurs and is continuing and if it is
actually known to the Trustee, the Trustee shall mail to the Company and each
Holder a notice of the Default or Event of Default within 90 days after it
occurs, unless such Default or Event of Default shall have been cured or waived.
Except in the case of a Default or Event of Default in payment on any Note under
Section 6.1(a) or 6.1(b), the Trustee may withhold the notice if and so long as
a committee of its Trust Officers in good faith determines that withholding the
notice is in the best interests of Holders.


SECTION 7.6    REPORTS BY TRUSTEE TO HOLDERS.
- -----------    -----------------------------

       Within 60 days after each May 15, commencing, May 15, 1997, the Trustee
shall mail to the Company and each Holder, at the Company's expense, a brief
report dated as of such reporting date that complies with TIA [Section]313(a)
(but if no event described in TIA [Section]313(a) has occurred within the 12
months preceding the reporting date, no report need be transmitted). The Trustee
also shall comply with TIA [Section]313(b)(2) to the extent applicable. The
Trustee shall also transmit by mail all reports as required by TIA
[Section]313(c).



                                       41


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       Provided that this Indenture shall have been qualified under the TIA, a
copy of each report at the time of its mailing to Holders shall be filed with
the SEC and each stock exchange or market on which the Notes are listed or
admitted to trading. The Company shall promptly notify the Trustee when the
Notes are listed on any stock exchange or admitted to trading on any market and
of any delisting thereof.


SECTION 7.7    COMPENSATION AND INDEMNITY.
- -----------    --------------------------

       The Company shall pay to the Trustee (in its capacities as Trustee,
Conversion Agent, Paying Agent and Registrar) from time to time such
compensation as may be agreed in writing between the Company and the Trustee for
its services hereunder. The Trustee's compensation shall not be (to the extent
permitted by law) limited by any law on compensation of a trustee of an express
trust. The Company shall reimburse the Trustee upon request for all reasonable
out-of-pocket expenses incurred by it in accordance with any provision of this
Indenture. Such expenses may include the reasonable compensation and
out-of-pocket expenses of the Trustee's agents and counsel, except such
disbursements, advances and expenses as may be attributable to its negligence,
willful misconduct or bad faith. Any "float" earned on any money disbursed
hereunder shall be considered additional compensation to the Trustee.

       The Company shall indemnify the Trustee (in its capacity as Trustee,
Conversion Agent, Paying Agent and Registrar) and each of its officers,
directors, employees, attorneys-in-fact and agents for, and hold each of such
Persons harmless against, any claim, demand, expense (including, but not limited
to, reasonable disbursements and expenses of the Trustee's agents and counsel),
loss or liability incurred by any of them without negligence, willful misconduct
or bad faith on such Person's part, arising out of or in connection with the
administration of this trust and the rights or duties of the Trustee hereunder,
including the reasonable costs and expenses of such Person's defense against any
claim or liability in connection with the exercise or performance of any of the
Trustee's powers or duties hereunder. The Trustee shall notify the Company
promptly of any claim asserted against the Trustee for which it may seek
indemnity. The Company shall defend the claim and the Trustee shall provide
reasonable cooperation at the Company's expense in the defense. The Trustee may
engage separate counsel at its own expense and participate in the defense,
provided that the Company shall bear the reasonable expenses of such separate
counsel which is reasonably acceptable to the Company if the defendants
regarding such claim include both the Trustee and the Company and the Company
and the Trustee shall have been advised in writing by the Trustee's separate
counsel that representation of the Trustee and the Company would be
inappropriate under applicable standards of professional responsibility due to
actual or potential differing interests between them. The Company need not
reimburse any expense or indemnify against any loss or liability to the extent
incurred by the Trustee through its negligence, bad faith or willful misconduct.
The Company need not pay for any settlement made without its consent, which
consent shall not be unreasonable withheld.

       The Company's payment obligations pursuant to this Section 7.7 shall
survive the discharge of this Indenture. When the Trustee incurs expenses or
renders services after an Event




                                       42


   48


of Default specified in Section 6.1(e) or 6.1(f) occurs, the expenses and the
compensation for the services are intended to constitute expenses of
administration under any Bankruptcy Law.


SECTION 7.8    REPLACEMENT OF TRUSTEE.
- -----------    ----------------------

       A resignation or removal of the Trustee and appointment of a successor
Trustee shall become effective only upon the successor Trustee's acceptance of
appointment as provided in this Section 7.8.

       The Trustee may resign by so notifying the Company in writing at least 30
days prior to the date of the proposed resignation; provided, however, that no
such resignation shall be effective until a successor Trustee has accepted its
appointment pursuant to this Section 7.8. The Holders of a majority in aggregate
principal amount of the then outstanding Notes may remove the Trustee by so
notifying the Trustee and the Company. The Company shall remove the Trustee if:

              (a)    the Trustee fails to comply with Section 7.10;

              (b)    the Trustee is adjudged a bankrupt or an insolvent or an
       order for relief is entered with respect to the Trustee under any
       Bankruptcy Law;

              (c)    a Custodian or public officer takes charge of the Trustee
       or its property; or

              (d)    the Trustee otherwise becomes incapable of acting.

       If the Trustee resigns or is removed or if a vacancy exists in the office
of Trustee for any reason, the Company shall promptly appoint a successor
Trustee.

       If a successor Trustee is not appointed or does not take office within 30
days after the retiring Trustee resigns or is removed, the retiring Trustee, the
Company or the Holders of at least 10% in aggregate principal amount of the then
outstanding Notes may petition any court of competent jurisdiction for the
appointment of a successor Trustee.

       If the Trustee fails to comply with Section 7.10, any Holder may petition
any court of competent jurisdiction for the removal of the Trustee and the
appointment of a successor Trustee.

       A successor Trustee shall deliver a written acceptance of its appointment
to the retiring Trustee and to the Company. Thereupon the resignation or removal
of the retiring Trustee shall become effective, and the successor Trustee shall
have all the rights, powers and duties of the Trustee under this Indenture. The
successor Trustee shall mail a notice of its succession to the Holders. The
retiring Trustee shall promptly transfer all property held by it as Trustee to
the successor Trustee upon payment of all amounts due it hereunder.
Notwithstanding the



                                       43


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replacement of the Trustee pursuant to this Section 7.8, the Company's
obligations under Section 7.7 shall continue for the benefit of the retiring
Trustee with respect to expenses and liabilities incurred by it prior to such
replacement.


SECTION 7.9    SUCCESSOR TRUSTEE BY MERGER.
- -----------    ---------------------------

      Except as otherwise provided in Section 7.8(a) or 7.8(d), if the Trustee
consolidates, merges or converts into, or transfers all or substantially all of
its corporate trust business to, another corporation, the successor corporation
without any further act shall be the successor Trustee.


SECTION 7.10    ELIGIBILITY; DISQUALIFICATION.
- ------------    -----------------------------

       This Indenture shall always have a Trustee who satisfies the requirements
of TIA ss. 310(a). The Trustee shall always have a combined capital and surplus
as stated in its most recent published annual report of condition of at least
$100 million. The Trustee shall comply with TIA ss. 310(b). In the event the
Trustee shall cease to be eligible in accordance with this Section 7.10, the
Trustee shall resign immediately in the manner and with the effect specified in
Section 7.8.


SECTION 7.11    PREFERENTIAL COLLECTION OF CLAIMS AGAINST COMPANY.
- ------------    -------------------------------------------------

       The Trustee shall comply with TIA ss. 311(a), excluding any creditor
relationship listed in TIA ss. 311(b). A Trustee who has resigned or been
removed shall be subject to TIA ss. 311(a) to the extent indicated therein.


                                   ARTICLE 8.

                             DISCHARGE OF INDENTURE


SECTION 8.1    TERMINATION OF COMPANY'S OBLIGATIONS.
- -----------    ------------------------------------

       This Indenture shall cease to be of further effect (except that the
Company's obligations under Section 7.7 and 8.3 shall survive) when all
outstanding Notes theretofore authenticated and issued (other than destroyed,
lost or stolen Notes which have been replaced or paid) have been delivered to
the Trustee for cancellation and the Company has paid all sums payable
hereunder. In addition, the Company shall be discharged from all of its
obligations under Section 2.13 and Sections 4.3 through 4.12 while the Notes
remain outstanding if all outstanding Notes will become due and payable at their
scheduled maturity within one year and the following conditions have been
satisfied:




                                       44


   50



       (a)    the Company has deposited, or caused to be deposited, irrevocably
with the Trustee as trust funds specifically pledged as security for, and
dedicated solely for, such purpose, (i) money in an amount, (ii) non-callable
U.S. Government Obligations which through the payment of Principal and interest
in accordance with their terms (without the reinvestment of such interest or
Principal) will provide not later than one day before the due date of any
payment money in an amount, or (iii) a combination thereof, sufficient with
respect to clauses (ii) and (iii) in the opinion of a nationally recognized firm
of independent public accountants expressed in a written certification thereof
delivered to the Trustee at or prior to the time of such deposit, to pay the
Principal and discharge each installment of interest on the outstanding Notes.

       (b)    no Default or Event of Default with respect to the Notes has
occurred and is continuing on the date of such deposit or shall occur as a
result of such deposit or at any time during the period ending on the 91st day
after the date of such deposit, as evidenced to the Trustee by an Officer's
Certificate delivered to the Trustee concurrently with such deposit.

       (c)    such defeasance does not result in a breach or violation of, or
constitute a default under, any other agreement or instrument to which the
Company is a party or by which it is bound, and is not prohibited by Article 11,
as evidenced to the Trustee by an Officers' Certificate delivered to the Trustee
concurrently with such deposit.

       (d)    the Company has delivered to the Trustee a private Internal
Revenue Service ruling or an Opinion of Counsel that Holders will not recognize
income, gain or loss for federal income tax purposes as a result of such
deposit, defeasance and discharge and will be subject to federal income tax on
the same amount, in the same manner, and at the same times, as would have been
the case if such deposit, defeasance and discharge had not occurred.

       (e)    the Company has delivered to the Trustee an Opinion of Counsel to
the effect that the deposit shall not result in the Company, the Trustee or the
trust being deemed to be an "investment company" under the Investment Company
Act of 1940, as amended.

       (f)    91 days pass after the deposit is made and during such 91 day
period no event of Default specified in Section 6.1(e) or (f) shall occur and be
continuing at the end of such period.

       (g)    the Company has delivered to the Trustee an Officers' Certificate
and an Opinion of Counsel, each stating that such deposit, defeasance and
discharge does not conflict with the applicable provisions of this Indenture.

       (h)    the Company has delivered to the Trustee an Officers' Certificate
stating that all conditions precedent under this Indenture relating to such
deposit, defeasance and discharge have been complied with.

Notwithstanding the foregoing, the Company's obligations to pay Principal and
interest on the Notes shall continue until the Internal Revenue Service ruling
or Opinion of Counsel referred to in clause (d) above is provided. If the
Company exercises such option to discharge such




                                       45


   51


provisions of the Indenture, payment of the Notes may not be accelerated because
of an event of default specified in Sections 6.1(c) with respect to the failure
to perform any of the covenants set forth in Section 2.13 and Section 4.3
through 4.12, or Section 6.1(d).

       After a deposit made pursuant to this Section 8.1, the Trustee upon
request shall acknowledge in writing the discharge of the Company's obligations
specified above under this Indenture.


SECTION 8.2    APPLICATION OF TRUST MONEY.
- -----------    --------------------------

       The Trustee shall hold in trust money or U.S. Government Obligations
deposited with it pursuant to Section 8.1. It shall apply the deposited money
and the money from U.S. Government Obligations through the Paying Agent and in
accordance with this Indenture to the payment of Principal and interest on the
Notes. Money and securities so held in trust are not subject to Article 11.


SECTION 8.3    REPAYMENT TO COMPANY.
- -----------    --------------------

       The Trustee and the Paying Agent shall promptly pay to the Company upon
request any excess money or securities held by them at any time.

       The Trustee and the Paying Agent shall pay to the Company upon written
request by the Company any money held by them for the payment of Principal,
repurchase price or interest that remains unclaimed for one year after the date
upon which such payment shall have become due; provided, however, that the
Company shall have first caused notice of such payment to the Company to be
mailed to each Holder entitled thereto no less than 30 days prior to such
payment. After payment to the Company, Holders entitled to the money must look
to the Company for payment as general creditors unless an applicable abandoned
property law designates another Person.


SECTION 8.4    REINSTATEMENT.
- -----------    -------------

       If the Trustee or Paying Agent is unable to apply any money in accordance
with Section 8.2 by reason of any order or judgment of any court or governmental
authority enjoining, restraining or otherwise prohibiting such application, the
Company's obligations under this Indenture and the Notes shall be revived and
reinstated as though no deposit had occurred pursuant to Section 8.1 until such
time as the Trustee or Paying Agent is permitted to apply all such money in
accordance with Section 8.2; provided, however that if the Company makes any
payment of interest on or Principal of any Note following the reinstatement of
its obligations, the Company shall be subrogated to the rights of the Holders of
such Notes to receive such payment from the money held by the Trustee or Paying
Agent.




                                       46


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                                   ARTICLE 9.

                                   AMENDMENTS


SECTION 9.1    WITHOUT CONSENT OF HOLDERS.
- -----------    --------------------------

       The Company and the Trustee may amend this Indenture or the Notes without
the consent of any Holder:

              (a)    to cure any ambiguity, defect or inconsistency; provided
       such amendment does not adversely affect the rights of any Holder;

              (b)    to comply with Section 5.1 or 10.5;

              (c)    to provide for uncertificated Notes in addition to or in
       lieu of certificated Notes;

              (d)    to add to the covenants of the Company such further
       covenants, restrictions, conditions or provisions for the protection of
       the Holders, and to make the occurrence, or the occurrence and
       continuance, of a default in any such additional covenants, restrictions,
       conditions or provisions an Event of Default permitting the enforcement
       of all or any of the several remedies provided in this Indenture or in
       the Notes as herein set forth;

              (e)    to make any change that does not adversely affect the
       rights hereunder of any Holder; or

              (f)    to comply with requirements of the SEC in order to effect
       or maintain the qualification of this Indenture under the TIA;

provided, however, that, in each case, the Company has delivered to the Trustee
an Officers' Certificate stating that such amendment complies with the
provisions of this Section 9.1 and an Opinion of Counsel stating that adoption
of such amendment does not conflict with the provisions of this Section 9.1.


SECTION 9.2    WITH CONSENT OF HOLDERS.
- -----------    -----------------------

       Subject to the provisions of Sections 6.4 and 6.7, the Company and the
Trustee may amend or modify this Indenture or the Notes with the written consent
of the Holders of at least a majority in aggregate principal amount of the then
outstanding Notes, and the Holders of a majority in aggregate principal amount
of the Notes then outstanding may waive compliance in a particular instance by
the Company with any provision of this Indenture or the Notes; provided,
however, that, without the consent of each Holder affected, an amendment,





                                       47


   53


modification or waiver under this Section 9.2 may not (with respect to any Notes
held by a nonconsenting Holder):

              (a)    change the stated maturity of, or any installment of
       interest on, or waive a default in the payment of Principal or repurchase
       price, if any, of or interest on any Note;

              (b)    reduce the principal amount of any Note or reduce the rate
       or extend the time of payment of interest on any Note;

              (c)    increase the Conversion Price (other than in connection
       with a combination described in Section 10.4(a)(iii));

              (d)    change the place or currency of payment of Principal or
       repurchase price, if any, of or interest on any Note;

              (e)    impair the right to institute suit for the enforcement of
       any payment on or with respect to any Note;

              (f)    adversely affect the right to exchange or convert Notes;

              (g)    reduce the percentage of the aggregate principal amount of
       outstanding Notes, the consent of the Holders of which is necessary to
       amend this Section 9.2, consent to a merger, consolidation or conveyance,
       sale, transfer or lease of assets as described in Section 5.1 or modify
       or amend any other provision of this Indenture;

              (h)    reduce the percentage of the aggregate principal amount of
       outstanding Notes, the consent of the Holders of which is necessary for
       waiver of compliance with certain provisions of this Indenture or for
       waiver of certain defaults;

              (i)    modify the provisions of this Indenture with respect to the
       subordination of the Notes in a manner adverse to the Holders;

              (j)    except as otherwise permitted under Article 5, consent to
       the assignment or transfer by the Company of any of its rights and
       obligations under this Indenture; or

              (k)    modify the provisions of this Indenture with respect to the
       obligation of the Company to repurchase Notes in a manner adverse to the
       Holders.

       To secure a consent of the Holders under this Section 9.2, it shall not
be necessary for the Holders to approve the particular form of any proposed
amendment or waiver, but it shall be sufficient if such consent approves the
substance thereof.

       After an amendment or waiver under this Section 9.2 becomes effective,
the Company shall mail to Holders a notice briefly describing the amendment or
waiver. Any failure of the




                                       48


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Company to mail such notices, or any defect therein, shall not, however, in any
way, impair or affect the validity of any such amendment or waiver.


SECTION 9.3    COMPLIANCE WITH TRUST INDENTURE ACT.
- -----------    -----------------------------------

       Every amendment to this Indenture or the Notes shall be set forth in a
supplemental indenture that complies with the TIA as then in effect.


SECTION 9.4    REVOCATION AND EFFECT OF CONSENTS.
- -----------    ---------------------------------

       Until an amendment, supplemental indenture or waiver becomes effective, a
consent to it by a Holder of a Note is a continuing consent by such Holder and
every subsequent Holder of a Note or portion of a Note that evidences the same
debt as such consenting Holder's Note, even if notation of the consent is not
made on any Note. However, prior to becoming effective, any such Holder or
subsequent Holder may revoke the consent as to its Notes or a portion thereof if
the Trustee receives written notice of revocation before the consent of Holders
of the requisite aggregate principal amount of Notes then outstanding has been
obtained and not revoked.

       The Company may, but shall not be obligated to, fix a record date
pursuant to Section 12.1 for the purpose of determining the Holders entitled to
consent to any amendment or waiver. If a record date is fixed, then
notwithstanding the provisions of the immediately preceding paragraph, those
Persons who were Holders at such record date (or their duly designated proxies),
and only those Persons, shall be entitled to consent to such amendment or waiver
or to revoke any consent previously given, whether or not such Persons continue
to be Holders after such record date. No consent shall be valid or effective for
more than 90 days after such record date unless consents from Holders of the
principal amount of Notes required hereunder for such amendment or waiver to be
effective shall have also been given and not revoked within such 90-day period.

       After an amendment or waiver becomes effective it shall bind every
Holder, unless it is of the type described in any of clauses (a) through (k) of
Section 9.2. In such case, the amendment or waiver shall bind each Holder of a
Note who has consented to it and every subsequent Holder of a Note that
evidences the same debt as the consenting Holder's Note.


SECTION 9.5    NOTATION ON OR EXCHANGE OF NOTES.
- -----------    --------------------------------

       The Trustee (in accordance with the written direction of the Company) may
(at the Company's expense) place an appropriate notation about an amendment,
supplement or waiver on any Note thereafter authenticated. The Company in
exchange for all Notes may issue and the Trustee shall authenticate new Notes
that reflect the amendment or waiver. Failure to make





                                       49


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the appropriate notation or issue a new Note shall not affect the validity and
effect of such amendment, supplement or waiver.


SECTION 9.6    TRUSTEE PROTECTED.
- -----------    -----------------

       The Trustee shall sign all supplemental indentures authorized by this
Indenture, except that the Trustee need not sign any supplemental indenture that
adversely affects its rights. In signing or refusing to sign such supplemental
indenture, the Trustee shall be entitled to receive an Officers' Certificate and
Opinion of Counsel to the effect that such supplemental indenture is authorized
or permitted by this Indenture and will be valid and binding on the Company in
accordance with its terms.

                                   ARTICLE 10.

                                   CONVERSION


SECTION 10.1    CONVERSION PRIVILEGE.
- ------------    --------------------

       Each Holder may, at such Holder's option, at any time prior to the close
of business on April 1, 2004, unless earlier redeemed or repurchased, convert
such Holder's Notes, in whole or in part (in denominations of $1,000 or
multiples thereof), at 100% of the principal amount so converted, into shares of
Common Stock at a conversion price per share equal to $7.0125, as such
conversion price may be adjusted from time to time in accordance with this
Article 10 (the "CONVERSION PRICE").


SECTION 10.2    CONVERSION PROCEDURE.
- ------------    --------------------

       To convert a Note, the Holder thereof must (1) complete and sign the
"Form of Election to Convert" thereon (unless such Holder is The Depository
Trust Company ("DTC") or its nominee, in which case the customary procedures of
DTC will apply), (2) surrender such Note to the Conversion Agent, (3) furnish
appropriate endorsements and transfer documents if required by the Registrar or
the Conversion Agent and (4) pay any transfer or similar tax if required by
Section 10.6. The Company's delivery to the Holder of a fixed number of shares
of Common Stock (and any cash in lieu of fractional shares of Common Stock into
which such Note is converted) shall be deemed to satisfy the Company's
obligation to pay the principal amount of such Note and, except as provided in
the next two sentences, all accrued interest on such Note. Prior to April 1,
2000, a Holder who surrenders such Note for conversion (including a Note which
has been called for redemption and even if a Change of Control Offer has been
made) will be paid promptly after such conversion interest accrued but not paid
from the most recent date on which interest has been paid or, if no interest has
been paid, from the date of original issuance of such Note through the date of
such conversion. In addition, if such Note (including a Note which has been
called for redemption and even if a Change of Control





                                       50


   56


Offer has been made) is converted after a regular interest payment record date
and prior to the related Interest Payment Date (regardless of whether such
conversion occurs before or after April 1, 2000), the full interest installment
on such Note scheduled to be paid on such Interest Payment Date shall be payable
on such Interest Payment Date to the Holder of record at the close of business
on such record date.

       As promptly as practicable after the surrender of a Note in compliance
with this Section 10.2, the Company shall issue and deliver at the office or
agency of the Registrar or the Conversion Agent to such Holder, or on such
Holder's written order, a certificate or certificates for the full number of
whole shares of Common Stock issuable upon the conversion of such Note in
accordance with the provisions of this Article 10 and a check or cash with
respect to any fractional share of Common Stock arising upon such conversion as
provided in Section 10.3. In case any Note of a denomination greater than $1,000
shall be surrendered for partial conversion, then, subject to Article 2, the
Company shall execute and the Trustee shall authenticate and deliver to the
Holder of the Note so surrendered, without charge to such Holder, a new Note or
Notes in authorized denominations in an aggregate principal amount equal to the
unconverted portion of the surrendered Note.

       Each conversion shall be deemed to have been effected on the date on
which such Note shall have been surrendered in compliance with this Section
10.2, and the Person in whose name any certificate or certificates for shares of
Common Stock shall be issuable upon such conversion shall be deemed to have
become on said date the holder of record of the shares of Common Stock
represented thereby for all purposes; provided, however, that no surrender of a
Note on any date when the stock transfer books of the Company shall be closed
shall be effective to constitute the Person or Persons entitled to receive such
shares upon such conversion as the record holder or holders of such shares on
such date, but such surrender shall be effective to constitute the Person or
Persons entitled to receive such shares as the record holder or holders thereof
for all purposes at the close of business on the next succeeding day on which
such stock transfer books are open and, in any such case, such conversion shall
be at the Conversion Price in effect on the date on which such Note shall have
been surrendered.

       If the last day on which a Note may be converted is not a Business Day,
the Note may be surrendered to that Conversion Agent on the next succeeding
Business Day.

       Provisions of this Indenture that apply to conversion of all of a Note
also apply to conversion of a portion of such Note.


SECTION 10.3    CASH PAYMENTS IN LIEU OF FRACTIONAL SHARES.
- ------------    ------------------------------------------

      No fractional shares of Common Stock or scrip representing fractional
shares of Common Stock shall be issued upon conversion of Notes. If more than
one Note shall be surrendered for conversion at one time by the same Holder, the
full number of whole shares of Common Stock which shall be issuable upon
conversion shall be computed on the basis of the aggregate principal amount of
Notes (or specified portions thereof to the extent permitted hereby) so




                                       51


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surrendered. If any fractional share of Common Stock would be issuable upon the
conversion of any Note or Notes, the Company shall make an adjustment therefor
in cash at the Current Market Price of the Common Stock as of the close of
business on the Business Day prior to such conversion.


SECTION 10.4    ADJUSTMENT OF CONVERSION PRICE.
- ------------    ------------------------------

       (a)    If the Company shall (i) pay a dividend or other distribution, in
Common Stock, on any class of Capital Stock of the Company, (ii) subdivide the
outstanding Common Stock into a greater number of shares by any means or (iii)
combine the outstanding Common Stock into a smaller number of shares by any
means (including, without limitation, a reverse stock split), then in each such
case the Conversion Price in effect immediately prior thereto shall be adjusted
so that the Holder of any Note thereafter surrendered for conversion shall be
entitled to receive the number of shares of Common Stock that such Holder would
have owned or have been entitled to receive upon the happening of such event had
such Note been converted immediately prior to the relevant record date or, if
there is no such record date, the effective date of such event. An adjustment
made pursuant to this Section 10.4(a) shall become effective immediately after
the record date for the determination of stockholders entitled to receive such
dividend or distribution and shall become effective immediately after the
effective date of such subdivision or combination, as the case may be.

       (b)    If the Company shall (i) issue or distribute (at a price per share
less than the Current Market Price per share of such Capital Stock on the date
of such issuance or distribution) Capital Stock generally to holders of Common
Stock or to holders of any class or series of Capital Stock which is convertible
into or exchangeable or exercisable for Common Stock (excluding an issuance or
distribution of Common Stock described in Section 10.4(a)) or (ii) issue or
distribute generally to such holders rights, warrants, options or convertible or
exchangeable securities entitling the holder thereof to subscribe for, purchase,
convert into or exchange for Capital Stock at a price per share less than the
Current Market Price per share of such Capital Stock on the date of issuance or
distribution, then, in each such case, at the earliest of (A) the date the
Company enters into a firm contract for such issuance or distribution, (B) the
record date for the determination of stockholders entitled to receive any such
Capital Stock or any such rights, warrants, options or convertible or
exchangeable securities or (C) the date of actual issuance or distribution of
any such Capital Stock or any such rights, warrants, options or convertible or
exchangeable securities, the Conversion Price shall be reduced by multiplying
the Conversion Price in effect immediately prior to such earliest date by:

       (x) if such Capital Stock is Common Stock, a fraction the numerator of
       which is the number of shares of Common Stock outstanding on such
       earliest date plus the number of shares of Common Stock which could be
       purchased at the Current Market Price per share of Common Stock on the
       date of such issuance or distribution with the aggregate consideration
       (based on the Fair Market Value thereof) received or receivable by the
       Company either (A) in connection with such issuance or distribution or
       (B) upon the conversion, exchange, purchase or subscription of all such
       rights, warrants, options or





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       convertible or exchangeable securities (the "AGGREGATE CONSIDERATION"),
       and the denominator of which is the number of shares of Common Stock
       outstanding on such earliest date plus the number of shares of Common
       Stock to be so issued or distributed or to be issued upon the conversion,
       exchange, purchase or subscription of all such rights, warrants, options
       or convertible or exchangeable securities; or

       (y) if such Capital Stock is other than Common Stock, a fraction the
       numerator of which is the Current Market Price per share of Common Stock
       on such earliest date minus an amount equal to (A) the difference between
       (1) the Current Market Price per share of such Capital Stock multiplied
       by the number of shares of such Capital Stock to be so issued and (2) the
       Aggregate Consideration, divided by (B) the number of shares of Common
       Stock outstanding on such date, and the denominator of which is the
       Current Market Price per share of Common Stock on such earliest date.

Such adjustment shall be made successively whenever any such Capital Stock,
rights, warrants, options or convertible or exchangeable securities are so
issued or distributed. In determining whether any rights, warrants, options or
convertible or exchangeable securities entitle the holders thereof to subscribe
for, purchase, convert into or exchange for shares of such Capital Stock at less
than such Current Market Price, there shall be taken into account the Fair
Market Value of any consideration received or receivable by the Company for such
rights, warrants, options or convertible or exchangeable securities. If any
right, warrant, option or convertible or exchangeable securities, the issuance
of which resulted in an adjustment in the Conversion Price pursuant to this
Section 10.4(b), shall expire and shall not have been exercised, the Conversion
Price shall immediately upon such expiration be recomputed to the Conversion
Price which would have been in effect if such right, warrant, option or
convertible or exchangeable securities had never been distributed or issued.
Notwithstanding anything contained in this paragraph to the contrary, (i) the
issuance of Capital Stock upon the exercise of such rights, warrants or options
or the conversion or exchange of such convertible or exchangeable securities
will not cause an adjustment in the Conversion Price if no such adjustment would
have been required at the time such right, warrant, option or convertible or
exchangeable security was issued or distributed; provided, however, that, if the
consideration payable upon such exercise, conversion or exchange and/or the
Capital Stock receivable thereupon are changed after the time of the issuance or
distribution of such right, warrant, option or convertible or exchangeable
security, then such change shall be deemed to be the expiration thereof without
having been exercised and the issuance or distribution of new options, rights,
warrants or convertible or exchangeable securities and (ii) the issuance of
convertible preferred stock of the Company as a dividend on convertible
preferred stock of the Company will not cause an adjustment in the Conversion
Price if no such adjustment would have been required at the time such underlying
convertible preferred stock was issued (or as a result of any subsequent
modification to the terms thereof) and the conversion provisions of such
convertible stock so issued as a dividend are the same as in such underlying
convertible preferred stock.

       Notwithstanding anything contained in this Indenture to the contrary,
options, rights or warrants issued or distributed by the Company, including
options, rights or warrants distributed prior to the date of this Indenture, to
holders of Common Stock generally which, until the




                                       53


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occurrence of a specified event or events (a "TRIGGER EVENT"), (i) are deemed to
be transferred with Common Stock, (ii) are not exercisable and (iii) are also
issued on a pro rata basis with respect to future issuances of Common Stock,
shall be deemed not to have been issued or distributed for purposes of this
Section 10.4 (and no adjustment to the Conversion Price under this Section 10.4
will be required) until the occurrence of the earliest Trigger Event. Upon the
occurrence of a Trigger Event, such options, rights or warrants shall continue
to be deemed not to have been issued or distributed for purposes of this Section
10.4 (and no adjustment to the Conversion Price under this Section 10.4 will be
required) if and for so long as each Holder who thereafter converts such
Holder's Notes shall be entitled to receive upon such conversion, in addition to
the shares of Common Stock issuable upon such conversion, a number of such
options, rights or warrants, as the case may be, equal to the number of options,
rights or warrants to which a holder of the number of shares of Common Stock
equal to the number of shares of Common Stock issuable upon conversion of such
Holder's Notes is entitled to receive at the time of such conversion in
accordance with the terms and provisions of and applicable to such options,
rights or warrants. Upon the expiration of any such options, rights or warrants
or at such time, if any, as a Holder is not entitled to receive such options,
rights or warrants upon conversion of such Holder's Notes, an adjustment (if any
is required) to the Conversion Price shall be made in accordance with this
Section 10.4(b) with respect to the issuance of all such options, rights and
warrants as of the date of issuance thereof, but subject to the provisions of
the preceding paragraph. If any such option, right or warrant, including any
such options, rights or warrants distributed prior to the date of this
Indenture, are subject to events, upon the occurrence of which such options,
rights or warrants become exercisable to purchase different securities,
evidences of indebtedness, cash, Properties or other assets or different amounts
thereof, then, subject to the preceding provisions of this paragraph, the date
of the occurrence of any and each such event shall be deemed to be the date of
distribution and record date with respect to new options, rights or warrants
with such new purchase rights (and a termination or expiration of the existing
options, rights or warrants without exercise thereof). In addition, in the event
of any distribution (or deemed distribution) of options, rights or warrants, or
any Trigger Event or other event of the type described in the preceding
sentence, that required (or would have required but for the provisions of
Section 10.4(e) or this paragraph) an adjustment to the Conversion Price under
this Section 10.4 and such options, rights or warrants shall thereafter have
been redeemed or repurchased without having been exercised, then the Conversion
Price shall be adjusted upon such redemption or repurchase to give effect to
such distribution, Trigger Event or other event, as the case may be, as though
it had instead been a cash distribution, equal on a per share basis to the
result of the aggregate redemption or repurchase price received by holders of
such options, rights or warrants divided by the number of shares of Common Stock
outstanding as of the date of such repurchase or redemption, made to holders of
Common Stock generally as of the date of such redemption or repurchase.

       Notwithstanding anything contained in this Section 10.4(b) to the
contrary, no adjustment shall be made in the Conversion Price pursuant to this
Section 10.4(b) with respect to the issuance of Common Stock or options or other
rights to purchase Common Stock pursuant to any employee stock purchase, bonus,
award, grant, option or ownership plan (including, without limitation, an
employee stock ownership plan which is part of an employee benefit plan
qualified under Section 401 of the Internal Revenue Code of 1986, as amended
(the "CODE"), an employee




                                       54


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stock option or incentive stock option plan qualified under Section 422 of the
Code and a restricted stock plan), including the issuance of Common Stock upon
the exercise of such options; provided, that, for purposes of this paragraph,
the term "employee" includes directors, consultants and advisors and the term
"plan" means a plan, program or arrangement in which 5 or more Persons are
eligible to participate (or, if only directors or outside directors of the
Company are eligible to participate and there are fewer than 5 such directors or
outside directors, as the case may be, in which all of such directors or outside
directors, as the case may be, are eligible to participate).

       (c)    If the Company shall pay or distribute, as a dividend or
otherwise, generally to holders of Common Stock or any class or series of
Capital Stock which is convertible into or exercisable or exchangeable for
Common Stock any assets, Properties or rights (including, without limitation,
evidences of indebtedness of the Company, any Subsidiary or any other Person,
cash or Capital Stock or other securities of the Company, any Subsidiary or any
other Person, but excluding payments and distributions as described in Section
10.4(a) or 10.4(b), dividends and distributions in connection with the
liquidation, dissolution or winding up of the Company in its entirety and
distributions consisting solely of cash described in Section 10.4(d)), then in
each such case the Conversion Price shall be reduced by multiplying the
Conversion Price in effect immediately prior to the date of such payment or
distribution by a fraction, the numerator of which is the Current Market Price
per share of Common Stock on the record date for the determination of
stockholders entitled to receive such payment or distribution less the Fair
Market Value per share on such record date of the assets, Properties or rights
so paid or distributed, and the denominator of which is the Current Market Price
per share of Common Stock on such record date. Such adjustment shall become
effective immediately after such record date. For purposes of this Section
10.4(c), such Fair Market Value per share shall equal the aggregate Fair Market
Value on such record date of the assets, Properties or rights so paid or
distributed divided by the number of shares of Common Stock outstanding on such
record date.

       (d)    If the Company shall, by dividend or otherwise, make a
distribution (other than in connection with the liquidation, dissolution or
winding up of the Company in its entirety), generally to holders of Common Stock
or any class or series of Capital Stock which is convertible into or exercisable
or exchangeable for Common Stock, consisting solely of cash where (x) the sum of
(i) the aggregate amount of such cash plus (ii) the aggregate amount of all cash
so distributed (by dividend or otherwise) to such holders within the 12-month
period ending on the record date for determining stockholders entitled to
receive such distribution with respect to which no adjustment has been made to
the Conversion Price pursuant to this Section 10.4(d) exceeds (y) 10% of the
result of the multiplication of (1) the Current Market Price per share of Common
Stock on such record date times (2) the number of shares of Common Stock
outstanding on such record date, then the Conversion Price shall be reduced,
effective immediately prior to the opening of business on the day following such
record date, by multiplying the Conversion Price in effect immediately prior to
the close of business on the day prior to such record date by a fraction, the
numerator of which is the Current Market Price per share of Common Stock on such
record date less the aggregate amount of cash per share so distributed and the
denominator of which is such Current Market Price; provided, however, that,



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if the aggregate amount of cash per share is equal to or greater than such
Current Market Price, then, in lieu of the foregoing adjustment, adequate
provision shall be made so that each Holder shall have the right to receive upon
conversion (with respect to each share of Common Stock issued upon such
conversion and in addition to the Common Stock issuable upon conversion) the
aggregate amount of cash per share such Holder would have received had such
Holder's Note been converted immediately prior to such record date. In no event
shall the Conversion Price be increased pursuant to this Section 10.4(d);
provided, however, that if such distribution is not so made, the Conversion
Price shall be adjusted to be the Conversion Price which would have been in
effect if such distribution had not been declared. For purposes of this
paragraph of this Section 10.4(d), such aggregate amount of cash per share shall
equal such sum divided by the number of shares of Common Stock outstanding on
such record date.

       (e)    The provisions of this Section 10.4 shall similarly apply to all
successive events of the type described in this Section 10.4. Notwithstanding
anything contained herein to the contrary, no adjustment in the Conversion Price
shall be required unless such adjustment would require an increase or decrease
of at least 1% in the Conversion Price then in effect; provided, however, that
any adjustments which by reason of this Section 10.4(e) are not required to be
made shall be carried forward and taken into account in any subsequent
adjustment. All calculations under this Article 10 shall be made by the Company
and shall be made to the nearest cent or to the nearest one hundredth of a
share, as the case may be, and the Trustee shall be entitled to rely
conclusively thereon. Notwithstanding anything contained in this Section 10.4 to
the contrary, the Company shall be entitled to make such reductions in the
Conversion Price, in addition to those required by this Section 10.4, as it in
its discretion shall determine to be advisable in order that any stock
dividends, subdivision of shares, distribution of rights to purchase stock or
securities, or distribution of securities convertible into or exchangeable for
stock hereafter made by the Company to its stockholders shall not be taxable.
Except as provided in this Article 10, no adjustment in the Conversion Price
will be made for the issuance of Common Stock or any securities convertible into
or exchangeable for Common Stock or carrying the right to purchase Common Stock
or any securities so convertible or exchangeable.

       (f)    Whenever the Conversion Price is adjusted as provided herein, the
Company shall promptly file with the Trustee and any Conversion Agent other than
the Trustee an Officers' Certificate setting forth the Conversion Price in
effect after such adjustment and setting forth a brief statement of the facts
requiring such adjustment. Promptly after delivery of such Officers'
Certificate, the Company shall give or cause to be given to each Holder a notice
of such adjustment of the Conversion Price setting forth the adjusted Conversion
Price and the date on which such adjustment becomes effective.

       (g)    Notwithstanding anything contained herein to the contrary, in any
case in which this Section 10.4 provides that an adjustment in the Conversion
Price shall become effective immediately after a record date for an event, the
Company may defer until the occurrence of such event (i) issuing to the Holder
of any Note converted after such record date and before the occurrence of such
event the additional shares of Common Stock issuable upon such conversion by
reason of the adjustment required by such event over and above the number of
shares of Common Stock issuable upon such conversion before giving effect to
such adjustment and (ii)




                                       56


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paying to such Holder any amount in cash in lieu of any fractional share of
Common Stock pursuant to Section 10.3.


SECTION 10.5    EFFECT OF RECLASSIFICATION, CONSOLIDATION, MERGER OR SALE.
- ------------    ---------------------------------------------------------

       In the event of (i) any reclassification (including, without limitation,
a reclassification effected by means of an exchange or tender offer by the
Company or any Subsidiary) or change of outstanding Common Stock (other than a
change in par value, or from par value to no par value, or from no par value to
par value, or as a result of a subdivision or combination), (ii) any
consolidation, merger or combination of the Company with another corporation as
a result of which holders of Common Stock shall be entitled to receive
securities or other Property (including cash) with respect to or in exchange for
Common Stock or (iii) any sale or conveyance of the Property of the Company as,
or substantially as, an entirety to any other corporation as a result of which
holders of Common Stock shall be entitled to receive securities or other
Property (including cash) with respect to or in exchange for Common Stock, then
the Company or the successor or purchasing corporation, as the case may be,
shall enter into a supplemental indenture providing that each Note shall be
convertible into the kind and amount of securities or other Property (including
cash) receivable upon such reclassification, change, consolidation, merger,
combination, sale or conveyance which the Holder of such Note would have
received if such Note had been converted immediately prior to such
reclassification, change, consolidation, merger, combination, sale or
conveyance. Such supplemental indenture shall provide for adjustments which
shall be as nearly equivalent as may be practicable to the adjustments provided
for in this Article 10.

       Whenever a supplemental indenture is entered into as provided herein, the
Company shall promptly file with the Trustee and any Conversion Agent other than
the Trustee an Officers' Certificate setting forth a brief statement of the
facts requiring such supplemental indenture. Promptly after delivery of such
Officers' Certificate, the Company shall give or cause to be given to each
Holder a notice of the execution of such supplemental indenture.

       The provisions of this Section 10.5 shall similarly apply to all
successive events of the type described in this Section 10.5.


SECTION 10.6    TAXES ON SHARES ISSUED.
- ------------    ----------------------

       The issuance of a certificate or certificates on conversions of Notes
shall be made without charge to the Holders of such Notes for any tax or charge
with respect to the issuance thereof. The Company shall not, however, be
required to pay any tax or charge which may be payable with respect to any
transfer involved in the issuance and delivery of a certificate or certificates
in any name other than that of the Holders of such Notes, and the Company shall
not be required to issue or deliver any such certificate or certificates unless
and until the Person or Persons requesting the issuance thereof shall have paid
to the Company the amount of such tax or charge





                                       57


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or shall have established to the satisfaction of the Company that such tax or
charge has been paid.


SECTION 10.7    RESERVATION OF SHARES; SHARES TO BE FULLY PAID; COMPLIANCE WITH
- ------------    ---------------------------------------------------------------
                GOVERNMENT REQUIREMENTS; LISTING OF COMMON STOCK.
                ------------------------------------------------

       The Company shall reserve, out of its authorized but unissued Common
Stock or its Common Stock held in treasury, sufficient shares of Common Stock to
provide for the conversion of all of the Notes that are outstanding from time to
time.

       Before taking any action which would cause an adjustment reducing the
Conversion Price below the then par value, if any, of the Common Stock issuable
upon conversion of Notes, the Company will take all corporate action which may,
in the opinion of its counsel, be necessary in order that the Company may
validly and legally issue Common Stock at such adjusted Conversion Price.

       The Company covenants that all Common Stock which may be issued upon
conversion of Notes will, upon issuance, be duly authorized, validly issued,
fully paid and nonassessable and free from all taxes, liens and charges with
respect to the Company's issuance and delivery thereof.

       The Company covenants that if any Common Stock issued or delivered upon
conversion of Notes hereunder require registration with or approval of any
governmental authority under any applicable federal or state law (excluding
federal or state securities laws) before such Common Stock may be lawfully
issued, the Company will in good faith and as expeditiously as possible endeavor
to secure such registration or approval, as the case may be.

       The Company covenants that it will not take any action which would cause
the exemption from the registration requirement of Section 5 of the Securities
Act afforded by Section 3(a)(9) of the Securities Act to be unavailable with
respect to the issuance and delivery of Common Stock upon the conversion of
Notes in accordance with this Indenture.


SECTION 10.8    RESPONSIBILITY OF TRUSTEE REQUIREMENTS.
- ------------    --------------------------------------

       The Trustee and any other Conversion Agent shall not at any time be under
any duty or responsibility to any Holder to determine whether any fact exists
which may require any adjustment of the Conversion Price or other adjustment, or
with respect to the nature, extent or calculation of any such adjustment when
made, or with respect to the method employed, or herein or in any supplemental
indenture provided to be employed, in making any such adjustment, or with
respect to the correctness thereof. The Trustee and any other Conversion Agent
shall not be accountable with respect to the validity, value, kind or amount of
any item at any time issued or delivered upon the conversion of any Note, and
neither the Trustee nor any other Conversion Agent makes any representations
with respect thereto. Subject to Section 7.1,



                                       58


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neither the Trustee nor any Conversion Agent shall be responsible for any
failure of the Company to issue, transfer or deliver any item upon the surrender
of any Note for conversion or to comply with any of the duties, responsibilities
or covenants of the Company contained in this Article 10. Without limiting the
generality of the foregoing, neither the Trustee nor any Conversion Agent shall
be under any responsibility to determine the correctness of any provisions
contained in any supplemental indenture entered into pursuant to Section 10.5,
but, subject to the provisions of Section 7.1, may accept as conclusive evidence
of the correctness of any such provisions, and shall be protected in relying
upon, the Officers' Certificate with respect thereto.


SECTION 10.9    NOTICE TO HOLDERS PRIOR TO CERTAIN ACTIONS.
- ------------    ------------------------------------------

      In the event that:

       (a)    the Company shall declare or authorize any event which could
reasonably be anticipated to result in an adjustment in the Conversion Price
under Section 10.4 or require the execution of a supplemental indenture under
Section 10.5; or

       (b)    the Company shall authorize the granting to the holders of Common
Stock generally of rights, options or warrants to subscribe for or purchase any
shares of any class or series of Capital Stock of the Company or any Subsidiary
or any other rights, options or warrants, the reclassification of Common Stock
(other than a subdivision or combination of outstanding Common Stock, or a
change in par value, or from par value to no par value, or from no par value to
par value), the combination, consolidation or merger of the Company for which
approval of any stockholders of the Company is required, the sale or transfer of
all or substantially all of the assets of the Company or the voluntary or
involuntary dissolution, liquidation or winding-up of the Company in whole or in
part;

then, in each such case, the Company shall file or cause to be filed with the
Trustee and shall give or cause to be given to each Holder, as promptly as
possible but in any event at least 15 days prior to the applicable date
hereinafter specified, a notice stating the date on which a record is to be
taken for the purpose of determining the holders of outstanding Common Stock
entitled to participate in such event, the date on which such event is expected
to become effective or occur and the date on which it is expected that holders
of outstanding Common Stock of record shall be entitled to surrender their
shares, or receive any items, in connection with such event. Failure to give
such notice, or any defect therein, shall not affect the legality or validity of
such event.





                                       59


   65


                                   ARTICLE 11.

                                  SUBORDINATION


SECTION 11.1    AGREEMENT TO SUBORDINATE.
- ------------    ------------------------

       The Company covenants and agrees, and each Holder, by such Holder's
acceptance of a Note, likewise covenants and agrees, that, to the extent and in
the manner hereinafter set forth in this Article 11, the indebtedness
represented by the Notes and the payment of the Principal and repurchase price,
if any, of and interest on each and all of the Notes are hereby expressly made
subordinate and subject in right of payment to the prior payment in full of all
Senior Indebtedness.

       No provision of this Article 11 shall prevent the occurrence of any
Default or Event of Default hereunder.


SECTION 11.2    PAYMENT OVER OF PROCEEDS UPON DISSOLUTION, ETC.
- ------------    ----------------------------------------------

       In the event of (a) any insolvency or bankruptcy case or proceeding, or
any receivership, liquidation, reorganization or other similar case or
proceeding in connection therewith, relative to the Company or to its creditors,
as such, or to its assets, or (b) any liquidation, dissolution or other
winding-up of the Company, whether voluntary or involuntary and whether or not
involving insolvency or bankruptcy, or (c) any assignment for the benefit of
creditors or any other marshalling of assets and liabilities of the Company,
then and in any such event the holders of Senior Indebtedness shall be entitled
to receive payment in full of all amounts due or to become due on or with
respect to all Senior Indebtedness, or provision shall be made for such payment
in money or money's worth, before the Holders are entitled to receive any
payment on account of Principal or repurchase price, if any, of or interest on
the Notes, and to that end the holders of Senior Indebtedness shall be entitled
to receive, for application to the payment thereof, any payment or distribution
of any kind or character, whether in cash, property or securities, which may be
payable or deliverable with respect to the Notes in any such case, proceeding,
liquidation, dissolution or other winding up or event.

       In the event that, notwithstanding the foregoing provisions of this
Section 11.2, the Trustee or any Holder shall have received any payment or
distribution of assets of the Company of any kind or character, whether in cash,
property or securities, before all Senior Indebtedness is paid in full or
payment thereof provided for, then and in such event such payment or
distribution shall be held in trust by such recipient and shall be paid over or
delivered forthwith to the trustee in bankruptcy, receiver, liquidating trustee,
custodian, assignee, agent or other Person making payment or distribution of
assets of the Company for application in the form received to the payment of all
Senior Indebtedness remaining unpaid, to the extent necessary to pay all Senior
Indebtedness in full, after giving effect to any concurrent payment or
distribution to or for the holders of Senior Indebtedness.




                                       60


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       The consolidation of the Company with, or the merger of the Company into,
another Person or the liquidation or dissolution of the Company following the
conveyance or transfer of its properties and assets substantially as an entirety
to another Person upon the terms and conditions set forth in Article 5 shall not
be deemed a dissolution, winding-up, liquidation, reorganization, assignment for
the benefit of creditors or marshalling of assets and liabilities of the Company
for the purposes of this Section 11.2 if the Person formed by such consolidation
or into which the Company is merged or the Person which acquires by conveyance
or transfer such properties and assets substantially as an entirety, as the case
may be, shall, as a part of such consolidation, merger, conveyance or transfer,
comply with the conditions set forth in Article 5.


SECTION 11.3    PRIOR PAYMENT TO SENIOR INDEBTEDNESS UPON ACCELERATION OF NOTES.
- ------------    ---------------------------------------------------------------

       In the event that any Notes are declared due and payable before their
stated maturity, then and in such event the holders of Senior Indebtedness
outstanding at the time such Notes so become due and payable shall be entitled
to receive payment in full of all amounts due or to become due on or with
respect to such Senior Indebtedness, or provision shall be made for such payment
in money or money's worth, before the Holders are entitled to receive any
payment by the Company on account of the Principal or repurchase price, if any,
of or interest on the Notes or on account of the purchase or other acquisition
of Notes.

       In the event that, notwithstanding the foregoing, the Company shall make
any payment to the Trustee or to any Holder prohibited by the foregoing
provision of this Section 11.3, then and in such event such payment shall be
held in trust by such recipient and shall be paid over and delivered forthwith
to the Company in the form received.

       The provisions of this Section 11.3 shall not apply to any payment with
respect to which Section 11.2 would be applicable.


SECTION 11.4    NO PAYMENT WHEN SENIOR INDEBTEDNESS IN DEFAULT.
- ------------    ----------------------------------------------

       (a)    In the event and during the continuation of any default in the
payment of principal of or interest on any Senior Indebtedness beyond any
applicable grace period with respect thereto, or in the event that any event of
default with respect to any Senior Indebtedness shall have occurred and be
continuing (or would arise by reason of a payment required hereunder by the
Company with respect to the Principal or repurchase price, if any, of or
interest on the Notes) permitting the holders of such Senior Indebtedness (or a
trustee on behalf of the holders thereof) to declare such Senior Indebtedness
due and payable prior to the date on which it would otherwise have become due
and payable, unless and until such event of default shall have been cured or
waived or shall have ceased to exist or the Company and the Trustee shall have
received written notice from the Representative of the Senior Indebtedness with
respect to which such event of default relates approving payment on the Notes,
then no payment shall be made by the Company with respect to the Principal or
repurchase price, if any, of or



                                       61


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interest on the Notes or to acquire any of the Notes; provided that no such
default will prevent any payment on, or with respect to, the Notes for more than
120 days unless the maturity of such Senior Indebtedness has been accelerated.
Not more than one such 120 day delay may be made in any consecutive 360 day
period with respect to a covenant default, irrespective of the number of
defaults with respect to Senior Indebtedness during such period.

       In the event that, notwithstanding the foregoing, the Company shall make
any payment to the Trustee or to any Holder prohibited by the foregoing
provision of this Section 11.4, then and in such event such payment shall be
held in trust by such recipient and shall be paid over and delivered forthwith
to the Company in the form received.

       The provisions of this Section 11.4 shall not apply to any payment with
respect to which Section 11.2 would be applicable.


SECTION 11.5    PAYMENT PERMITTED IF NO DEFAULT.
- ------------    -------------------------------

       Nothing contained in this Article 11 or elsewhere in this Indenture or in
any of the Notes shall prevent (a) the Company, at any time except when any of
the conditions described in Section 11.2, 11.3 or 11.4 exist, from making
payments at any time of Principal or repurchase price, if any, of or interest on
the Notes or (b) the application by the Trustee of any money deposited with it
hereunder to the payment of or on account of the Principal or repurchase price,
if any, of or interest on the Notes or the retention of any such payment by the
Holders, except if, at the time of the application by the Trustee, any of the
conditions described in Section 11.2, 11.3 or 11.4 exist; provided that the
Trustee shall have no responsibility to refrain from so applying such money
unless it shall have actual knowledge of the existence of such condition.


SECTION 11.6    SUBROGATION TO RIGHTS OF HOLDERS OF SENIOR INDEBTEDNESS.
- ------------    -------------------------------------------------------

       Subject to the payment in full of all Senior Indebtedness, the Holders
shall be subrogated to the extent of the payments or distributions made to the
holders of such Senior Indebtedness pursuant to the provisions of this Article
11 (equally and ratably with the holders of all indebtedness of the Company
which is not Senior Indebtedness and which is entitled to like rights of
subrogation) to the rights of the holders of such Senior Indebtedness to receive
payments and distributions of cash, property and securities applicable to the
Senior Indebtedness until the Principal or repurchase price, if any, of and
interest on the Notes shall be paid in full. For purposes of such subrogation,
no payments or distributions to the holders of Senior Indebtedness of any cash,
property or securities to which the Holders or the Trustee would be entitled
except for the provisions of this Article, and no payments over pursuant to the
provisions of this Article to the holders of Senior Indebtedness by Holders or
the Trustee, shall, as among the Company, its creditors other than holders of
Senior Indebtedness and the Holders be deemed to be a payment or distribution by
the Company to or on account of Senior Indebtedness.





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SECTION 11.7     PROVISIONS SOLELY TO DEFINE RELATIVE RIGHTS.
- ------------     -------------------------------------------

       The provisions of this Article 11 are and are intended solely for the
purpose of defining the relative rights of the Holders on the one hand and the
holders of Senior Indebtedness on the other hand. Nothing contained in this
Article 11 or elsewhere in this Indenture or in the Notes is intended to or
shall: (a) impair, as among the Company, its creditors other than holders of
Senior Indebtedness and the Holders, the obligation of the Company, which is
absolute and unconditional (and which, subject to the rights under this Article
11 of the holders of Senior Indebtedness, is intended to rank equally with all
other general obligations of the Company), to pay to the Holders the Principal
or repurchase price, if any, of and interest on the Notes as and when the same
shall become due and payable in accordance with their terms; or (b) affect the
relative rights against the Company of the Holders and creditors of the Company
other than the holders of Senior Indebtedness; or (c) prevent the Trustee or any
Holder from exercising all remedies otherwise permitted by applicable law upon
default under this Indenture, subject to the rights, if any, under this Article
11 of the holders of Senior Indebtedness to receive cash, property and
securities otherwise payable or deliverable to the Trustee or such Holder.


SECTION 11.8    TRUSTEE TO EFFECTUATE SUBORDINATION.
- ------------    -----------------------------------

       Each Holder of a Note by acceptance thereof authorizes and directs the
Trustee on such Holder's behalf to take such action as may be necessary or
appropriate to effectuate the subordination provided in this Article 11 and
appoints the Trustee as such Holder's attorney-in-fact for any and all such
purposes.


SECTION 11.9    NO WAIVER OF SUBORDINATION PROVISIONS.
- ------------    -------------------------------------

       No right of any present or future holder of any Senior Indebtedness to
enforce subordination as herein provided shall at any time in any way be
prejudiced or impaired by any act or failure to act by the Company or by any act
or failure to act, in good faith, by any such holder, or by any non-compliance
by the Company with the terms, provisions and covenants of this Indenture,
regardless of any knowledge thereof any such holder may have or be otherwise
charged with.

       Without in any way limiting the generality of the foregoing paragraph,
the holders of Senior Indebtedness may, at any time and from time to time,
without the consent of or notice to the Trustee or the Holders, without
incurring responsibility to the Holders and without impairing or releasing the
subordination provided in this Article 11 or the obligations hereunder of the
Holders to the holders of Senior Indebtedness, do any one or more of the
following: (i) change the manner, place or terms of payment or extend the time
of payment of, or renew or alter, Senior Indebtedness, or otherwise amend or
supplement in any manner Senior Indebtedness or any instrument evidencing the
same or any agreement under which Senior Indebtedness is outstanding; (ii) sell,
exchange, release or otherwise deal with any property pledged, mortgaged or
otherwise securing Senior Indebtedness; (iii) release any Person liable in any
manner for the




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collection of Senior Indebtedness; and (iv) exercise or refrain from exercising
any rights against the Company and any other Person.


SECTION 11.10   NOTICE TO TRUSTEE.
- -------------   -----------------

       The Company shall give prompt written notice to the Trustee of any fact
known to the Company which would prohibit the making of any payment to or by the
Trustee with respect to the Notes. Notwithstanding the provisions of this
Article 11 or any other provision of this Indenture, the Trustee shall not be
charged with knowledge of the existence of any facts which would prohibit the
making of any payment to or by the Trustee with respect to the Notes, unless and
until the Trustee shall have received written notice thereof from the Company or
a holder of Senior Indebtedness or from any Representative therefor, and, prior
to the receipt of any such written notice, the Trustee, subject to the
provisions of Section 7.1, shall be entitled in all respects to assume that no
such facts exist; the fact that the Trustee may so rely does not relieve the
Holders of their obligations under Section 11.3 to hold in trust any payments
received in contravention of Sections 11.2, 11.3 or 11.4.

       Subject to the provisions of Section 7.1, the Trustee shall be entitled
to rely on the delivery to it of a written notice by a Person representing
himself to be a holder of Senior Indebtedness (or a Representative therefor) to
establish that such notice has been given by a holder of Senior Indebtedness (or
a Representative therefor). In the event that the Trustee determines in good
faith that further evidence is required with respect to the right of any Person
as a holder of Senior Indebtedness to participate in any payment or distribution
pursuant to this Article 11, the Trustee may request such Person to furnish
evidence to the reasonable satisfaction of the Trustee as to the amount of
Senior Indebtedness held by such Person, the extent to which such Person is
entitled to participate in such payment or distribution and any other facts
pertinent to the rights of such Person under this Article 11, and if such
evidence is not furnished, the Trustee may defer any payment to such Person
pending judicial determination as to the right of such Person to receive such
payment.


SECTION 11.11   RELIANCE ON JUDICIAL ORDER OR CERTIFICATE OF LIQUIDATING AGENT.
- -------------   --------------------------------------------------------------

      Upon any payment or distribution of assets of the Company referred to in
this Article 11, the Trustee, subject to the provisions of Section 7.1, and the
Holders shall be entitled to rely upon any order or decree entered by any court
of competent jurisdiction in which such insolvency, bankruptcy, receivership,
liquidation, reorganization, dissolution, winding-up or similar case or
proceeding is pending, or a certificate of the trustee in bankruptcy, receiver,
liquidating trustee, custodian, assignee for the benefit of creditors, agent or
other Person making such payment or distribution, delivered to the Trustee or to
the Holders, for the purpose of ascertaining the Persons entitled to participate
in such payment or distribution, the holders of the Senior Indebtedness and
other indebtedness of the Company, the amount thereof or payable thereon, the
amount or amounts paid or distributed thereon and all other facts pertinent
thereto or to this Article 11.



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SECTION 11.12    TRUSTEE NOT FIDUCIARY FOR HOLDERS OF SENIOR INDEBTEDNESS.
- -------------    --------------------------------------------------------

       The Trustee shall not be deemed to owe any fiduciary duty to, or be
subject to any implied covenants or obligations in favor of, the holders of
Senior Indebtedness and shall not be liable to any such holders if it shall in
good faith mistakenly pay over or distribute to Holders or to the Company or to
any other Person cash, property or securities to which any holders of Senior
Indebtedness shall be entitled by virtue of this Article 11 or otherwise.


SECTION 11.13    RIGHTS OF TRUSTEE AS HOLDER OF SENIOR INDEBTEDNESS;
- -------------    ---------------------------------------------------
                 PRESERVATION OF TRUSTEE'S RIGHTS.
                 --------------------------------

       The Trustee in its individual capacity shall be entitled to all the
rights set forth in this Article 11 with respect to any Senior Indebtedness
which may at any time be held by it, to the same extent as any other holder of
Senior Indebtedness, and nothing in this Indenture shall deprive the Trustee of
any of its rights as such holder.


SECTION 11.14    ARTICLE APPLICABLE TO PAYING AGENTS.
- -------------    -----------------------------------

       In case at any time any Paying Agent other than the Trustee shall have
been appointed by the Company and be then acting hereunder, the term "TRUSTEE"
as used in this Article 11 shall in such case (unless the context otherwise
requires) be construed as extending to and including such Paying Agent within
its meaning as fully for all intents and purposes as if such Paying Agent were
named in this Article 11 in addition to or in place of the Trustee; provided,
however, that Section 11.13 shall not apply to the Company or any Affiliate of
the Company if it or such Affiliate acts as Paying Agent.


SECTION 11.15    CERTAIN CONVERSIONS DEEMED PAYMENT.
- -------------    ----------------------------------

       For the purposes of this Article 11 only, (a) the issuance and delivery
of Junior Securities upon conversion of Notes in accordance with Article 10
shall not be deemed to constitute a payment or distribution on account of the
Principal or repurchase price, if any, of or interest on Notes or on account of
the purchase or other acquisition of Notes and (b) the payment, issuance or
delivery of cash, property or securities (other than Junior Securities) upon
conversion of a Note shall be deemed to constitute payment on account of the
Principal of such Note. Nothing contained in this Article 11 or elsewhere in
this Indenture or in the Notes is intended to or shall impair, as among the
Company, its creditors other than holders of Senior Indebtedness and the
Holders, the right, which is absolute and unconditional, of a Holder to convert
any Note in accordance with Article 10.





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                                   ARTICLE 12.

                               MEETINGS OF HOLDERS


SECTION 12.1     ACTION BY HOLDERS.
- ------------     -----------------

       Whenever in this Indenture it is provided that the Holders of a specified
percentage in aggregate principal amount of the Notes may take any action
(including the making of any demand or request, the giving of any notice,
consent or waiver or the taking of any other action), the fact that at the time
of taking any such action, the Holders of such specified percentage have joined
therein may be evidenced (a) by any instrument or any number of instruments of
similar tenor executed by Holders in person or by proxy appointed in writing or
(b) by the record of the Holders voting in favor thereof at any meeting of
Holders called and held in accordance with the provisions of this Article 12.
Whenever the Company or the Trustee solicits the taking of action by the
Holders, the Company or the Trustee may fix in advance of such solicitation a
date as the record date for determining Holders entitled to take such action. If
a record date is fixed, those and only those Persons who are Holders at the
record date so fixed, or their proxies, shall be entitled to take such action
regardless of whether they are Holders at the time of such action.


SECTION 12.2    PURPOSES FOR WHICH MEETINGS MAY BE CALLED.
- ------------    -----------------------------------------

       A meeting of Holders may be called at any time and from time to time
pursuant to the provisions of this Article 12 for any of the following purposes:

              (a)    to give any notice to the Company, or the Trustee, or to
       give any directions to the Trustee, or to waive or to consent to the
       waiving of any Default hereunder and its consequences, or to take any
       other action authorized to be taken by Holders pursuant to any of the
       provisions of Article 6;

              (b)    to remove the Trustee or to appoint a successor Trustee
       pursuant to the provisions of Article 7;

              (c)    to consent to the execution of an indenture or indentures
       supplemental hereto pursuant to Section 9.2; or

              (d)    to take any other action (i) authorized to be taken by or
       on behalf of the Holders of any specified aggregate principal amount of
       the Notes under any other provision of this Indenture, or authorized or
       permitted by law or (ii) which the Trustee deems necessary or appropriate
       in connection with the administration of this Indenture.





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SECTION 12.3    MANNER OF CALLING MEETINGS.
- ------------    --------------------------

       The Trustee may at any time call a meeting of Holders to take any action
specified in Section 12.2, to be held at such time and at such place in the City
of New York, New York or such other place as the Trustee shall determine. Notice
of every meeting of Holders, setting forth the time and place of such meeting
and in general terms the action proposed to be taken at such meeting, shall be
given by the Trustee, to the Company and to each Holder not less than 10 nor
more than 60 days prior to the date fixed for such meeting.

       Any meeting of Holders shall be valid without notice if the Holders of
all Notes then outstanding are present in person or by proxy, or if notice is
waived before or after the meeting by all of the Holders and if the Company and
the Trustee are either present by duly authorized representatives or have,
before or after the meeting, waived notice.


SECTION 12.4    CALL OF MEETINGS BY THE COMPANY OR HOLDERS.
- ------------    ------------------------------------------

       In case at any time the Company or the Holders of not less than 10% in
aggregate principal amount of the Notes then outstanding, shall have requested
the Trustee to call a meeting of Holders to take any action specified in Section
12.2, by written request setting forth in reasonable detail the action proposed
to be taken at the meeting, and the Trustee shall not have given the notice of
such meeting within 20 days after receipt of such request, then the Company or
the Holders of Notes in the amount above specified may determine the time and
place in the City of New York, New York or the City of Boston, Massachusetts for
such meeting and may call such meeting for the purpose of taking such action, by
giving or causing to be given notice thereof as provided in Section 12.3.


SECTION 12.5    WHO MAY ATTEND AND VOTE AT MEETINGS.
- ------------    -----------------------------------

       To be entitled to vote at any meeting of Holders, a person shall be (a) a
Holder on the record date for such meeting or, if there is no such record date,
on the date of such meeting or (b) a Person appointed by an instrument in
writing as proxy for one or more of such Holders. The only Persons who shall be
entitled to be present or to speak at any meeting of Holders shall be the
Persons entitled to vote at such meeting and their counsel and any
representatives of the Trustee and its counsel and any representatives of the
Company and its counsel.


SECTION 12.6    REGULATIONS MAY BE MADE BY TRUSTEE; CONDUCT OF THE MEETING;
- ------------    -----------------------------------------------------------
                VOTING RIGHTS; ADJOURNMENT.
                --------------------------

       Notwithstanding any other provision of this Indenture, the Trustee may
make such reasonable regulations as it may deem advisable for any meeting of
Holders, in regard to proof of the holding of Notes and of the appointment of
proxies, and in regard to the appointment and duties of inspectors of votes, the
submission and examination of proxies, certificates and other




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evidence of the right to vote, and such other matters concerning the conduct of
the meeting as it shall deem appropriate.

       The Trustee shall, by an instrument in writing, appoint a temporary
chairman of the meeting, unless the meeting shall have been called by the
Company or by Holders as provided in Section 12.4, in which case the Company or
the Holders calling the meeting, as the case may be, shall in like manner
appoint a temporary chairman. A permanent chairman and a permanent secretary of
the meeting shall be elected by vote of the Holders of a majority in principal
amount of the Notes represented at the meeting and entitled to vote.

       At any meeting each Holder or proxy shall be entitled to one vote for
each $1,000 principal amount of Notes held or represented by such Holder or
proxy, as the case may be; provided, however, that no vote shall be cast or
counted at any meeting with respect to any Notes challenged as not outstanding
and ruled by the chairman of the meeting to be not outstanding. The chairman of
the meeting shall have no right to vote other than by virtue of Notes held by
such chairman or instruments in writing as aforesaid duly designating such
chairman as the proxy to vote on behalf of other Holders. At any meeting of
Holders, the presence (in person or by proxy) of Persons holding or representing
a majority in aggregate principal amount of the Notes then outstanding shall be
sufficient for a quorum. Any meeting of Holders duly called pursuant to the
provisions of Section 12.3 or 12.4 may be adjourned from time to time by vote of
the Holders of a majority in aggregate principal amount of the Notes represented
at the meeting and entitled to vote, and the meeting may be held as so adjourned
without further notice.


SECTION 12.7   VOTING AT THE MEETING AND RECORD TO BE KEPT.
- ------------   -------------------------------------------

       The vote upon any resolution submitted to any meeting of Holders shall be
by written ballots on which shall be subscribed the signatures of the Holders or
of their representatives by proxy and the principal amount of the Notes voted by
the ballot. The permanent chairman of the meeting shall appoint two inspectors
of votes, who shall count all votes cast at the meeting for or against any
resolution and who shall make and file with the secretary of the meeting their
verified written reports in duplicate of all votes cast at the meeting. A record
in duplicate of the proceedings of each meeting of Holders shall be prepared by
the secretary of the meeting and there shall be attached to such record the
original reports of the inspectors of votes on any vote by ballot taken thereat
and affidavits by one or more Persons having knowledge of the facts, setting
forth a copy of the notice of the meeting and showing that such notice was given
as provided in Section 12.3 or 12.4. The record shall be signed and verified by
the affidavits of the permanent chairman and the secretary of the meeting and
one of the duplicates shall be delivered to the Company and the other to the
Trustee to be preserved by the Trustee, the latter to have attached thereto the
ballots voted at the meeting.

       Any record so signed and verified shall be conclusive evidence of the
matters therein stated.




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SECTION 12.8     EXERCISE OF RIGHTS OF TRUSTEE OR HOLDERS MAY NOT BE HINDERED 
- ------------     ------------------------------------------------------------ 
                 OR DELAYED BY CALL OF MEETING.
                 -----------------------------

       Nothing contained in this Article 12 shall be deemed or construed to
authorize or permit, by reason of any call of a meeting of Holders or any rights
expressly or impliedly conferred hereunder to make such call, any hindrance or
delay in the exercise of any right or rights conferred upon or reserved to the
Trustee or to the Holders under any of the provisions of this Indenture or of
the Notes.


SECTION 12.9    COMMUNICATION BY HOLDERS WITH OTHER HOLDERS.
- ------------    -------------------------------------------

       Holders may communicate pursuant to TIA ss. 312(b) with other Holders
with respect to their rights under this Indenture or the Notes. The Company, the
Trustee, the Registrar and anyone else shall have the protection of TIA ss.
312(c).


                                   ARTICLE 13.

                                  MISCELLANEOUS


SECTION 13.1    TRUST INDENTURE ACT CONTROLS.
- ------------    ----------------------------

       If any provision of this Indenture limits, qualifies or conflicts with
another provision which is required or deemed to be included in this Indenture
by the TIA, the required or deemed provision shall control.


SECTION 13.2     NOTICES.
- ------------     -------

       Any notice or communication by the Company or the Trustee to the other
shall be deemed to have been duly given if given in writing and delivered in
person or mailed by first-class mail (registered or certified, return receipt
requested), telecopier or overnight air courier guaranteeing next day delivery
addressed as follows:

      if to the Company:

                   Hybridon, Inc.
                   620 Memorial Drive
                   Cambridge, Massachusetts 02139
                   Fax No.: (617) 528-7113
                   Attention: President





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                   with a copy to:

                   David E. Redlick, Esq.
                   Hale & Dorr LLP
                   60 State Street
                   Boston, Massachusetts 02109
                   Fax No.: (617) 526-5000

      if to the Trustee:

                   State Street Bank and Trust Company
                   Corporate Trust Department
                   Two International Place - 4th Floor
                   Boston, Massachusetts 02110
                   Fax No. (617) 644-5365:
                   Attention: Eric Donaghey

                   with a copy to:

                   Ripley E. Hastings, Esq.
                   Peabody and Arnold
                   50 Rowes Wharf
                   Boston, Massachusetts 02110
                   Fax No.: (617) 951-2125

The Company or the Trustee by notice to the other may designate additional or
different addresses for subsequent notices or communications.

      All notices and communications (other than those sent to Holders) shall be
deemed to have been duly given: at the time delivered by hand, if personally
delivered; five Business Days after being deposited in the mail, postage
prepaid, if mailed; when receipt acknowledged, if telecopied; and the next
Business Day after timely delivery to the courier, if sent by overnight air
courier guaranteeing next day delivery.

      Any notice or communication to a Holder shall be in writing and shall be
mailed by first class mail, certified or registered, return receipt requested,
or by overnight air courier guaranteeing next day delivery to its last address
shown on the Register. Any notice or communication shall also be so mailed to
any Person described in TIA ss. 313(c), to the extent required by the TIA.
Failure to mail a notice or communication to a Holder or any defect in it shall
not affect its sufficiency with respect to other Holders.

      If a notice or communication is given in the manner provided above within
the time prescribed, it shall be deemed to have been duly given, whether or not
received by the addressee.




                                       70


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       If the Company mails a notice or communication to Holders, it shall mail
a copy to the Trustee and each Agent at the same time.


SECTION 13.3    CERTIFICATE AND OPINION AS TO CONDITIONS PRECEDENT.
- ------------    --------------------------------------------------

       Upon any request or application by the Company to the Trustee to take any
action under this Indenture, the Company shall furnish to the Trustee:

              (a)    an Officers' Certificate stating that, in the opinion of
       the signers, all conditions precedent, if any, provided for in this
       Indenture relating to the proposed action have been complied with; and

              (b)    at the Trustee's request, an Opinion of Counsel stating
       that, in the opinion of such counsel, the proposed action does not
       conflict with this Indenture.


SECTION 13.4    STATEMENTS REQUIRED IN CERTIFICATE OR OPINION OF COUNSEL.
- ------------    --------------------------------------------------------

       Each Officers' Certificate or Opinion of Counsel with respect to
compliance or conflicts with a condition or covenant in this Indenture shall
include:

              (a)    a statement that each Person executing such Officers'
       Certificate or Opinion of Counsel has read such covenant or condition;

              (b)    a brief statement as to the nature and scope of the
       examination or investigation upon which the statements or opinions
       contained in such Officers' Certificate or Opinion of Counsel are based;

              (c)    a statement that, in the opinion of each such Person, such
       examination or investigation has been made as is necessary to enable it
       to express an informed opinion as to whether or not such covenant or
       condition has been complied with or whether the proposed action is not in
       conflict with this Indenture, as the case may be; and

              (d)    a statement as to whether or not, in the opinion of such
       Person, such condition or covenant has been complied with or such action
       does not conflict with this Indenture, as the case may be; provided,
       however, that an Opinion of Counsel may be based, insofar as it relates
       to factual matters, on a certificate or certificates of public officials,
       a legal opinion of counsel employed by the Company or a Subsidiary or a
       certificate of or representations by an Officer or Officers unless
       counsel rendering such Opinion of Counsel actually knows that such
       certificate, legal opinion or representation is erroneous.






                                      71

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SECTION 13.5     RULES BY TRUSTEE AND AGENTS.
- ------------     ---------------------------

       The Trustee may make reasonable rules for action by or at a meeting of
Holders. The Registrar, Paying Agent or Conversion Agent may make reasonable
rules and set reasonable requirements for its functions.


SECTION 13.6     LEGAL HOLIDAYS.
- ------------     --------------

       If a payment date is not a Business Day at a place of payment, payment
may be made at such place of payment on the next succeeding Business Day, and no
additional interest shall accrue for the intervening period.


SECTION 13.7     NO RECOURSE AGAINST OTHERS.
- ------------     --------------------------

      A director, officer, employee or stockholder, as such, of the Company
shall not have any liability for any obligations of the Company under the Notes
or this Indenture or for any claim based on, with respect to or by reason of
such obligations or their creation including with respect to any certificate
delivered thereunder or hereunder. Each Holder by accepting a Note waives and
releases all such liability. The waiver and release contained in this Section
13.7 are part of the consideration for the Company's issuance of the Notes.


SECTION 13.8     COUNTERPARTS.
- ------------     ------------

       This Indenture may be executed in any number of counterparts and by the
parties hereto in separate counterparts, each of which when so executed shall be
deemed to be an original and all of which taken together shall constitute one
and the same agreement.


SECTION 13.9     GOVERNING LAW.
- ------------     -------------


       THE INTERNAL LAWS OF THE STATE OF NEW YORK SHALL GOVERN THIS INDENTURE
AND THE NOTES, WITHOUT REGARD TO THE CONFLICT OF LAWS PROVISIONS THEREOF.


SECTION 13.10    NO ADVERSE INTERPRETATION OF OTHER AGREEMENTS.
- -------------    ---------------------------------------------

       This Indenture may not be used to interpret another indenture, loan or
debt agreement of the Company or a Subsidiary. Any such indenture, loan or debt
agreement may not be used to interpret this Indenture.






                                       72


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SECTION 13.11     SUCCESSORS.
- -------------     ----------

       All agreements of the Company in this Indenture and the Notes shall bind
its successors. All agreements of the Trustee in this Indenture shall bind its
successors.


SECTION 13.12     SEVERABILITY.
- -------------     ------------

       In case any provision of this Indenture or in the Notes shall be invalid,
illegal or unenforceable, the validity, legality and enforceability of the
remaining provisions shall not in any way be affected or impaired thereby.


SECTION 13.13     TABLE OF CONTENTS, HEADINGS, ETC.
- -------------     --------------------------------

       The Table of Contents and headings of the Articles and Sections have been
inserted for convenience of reference only, are not to be considered a part
hereof and shall in no way modify or restrict any of the terms or provisions
hereof.


       IN WITNESS WHEREOF, the parties hereto have caused this Indenture to be
executed as of the day and year first above written.




                              HYBRIDON, INC.


                              By:  /s/  E. Andrews Grinstead, III
                                 ---------------------------------------------
                                   Name:  E. Andrews Grinstead, III
                                   Title:  Chairman, President and Chief
                                           Executive Officer 


                              STATE STREET BANK AND TRUST COMPANY


                              By:  /s/  Eric J. Donaghey
                                 ---------------------------------------------
                                   Name:  Eric J. Donaghey
                                   Title:  Assistant Vice President

















                                      73


   79


                                                                       EXHIBIT A
                                 [Face of Note]

                                 HYBRIDON, INC.

                   9% CONVERTIBLE SUBORDINATED NOTES DUE 2004


                           [Global Securities Legend]

      UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF
THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION ("DTC"), TO THE COMPANY OR
ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE
ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR SUCH OTHER NAME AS IS
REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO
CEDE & CO., OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED
REPRESENTATIVE OF DTC) ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR
OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER
HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.

      TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE,
BUT NOT IN PART, TO NOMINEES OF DTC OR TO A SUCCESSOR THEREOF OR SUCH
SUCCESSOR'S NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE
LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS SET FORTH IN THE
INDENTURE REFERRED TO ON THE REVERSE HEREOF.

                         [Restricted Securities Legend]

      THIS NOTE (OR ITS PREDECESSOR) HAS NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933 (THE "SECURITIES ACT"), OR ANY STATE SECURITIES LAWS.
NEITHER THIS NOTE NOR ANY INTEREST OR PARTICIPATION HEREIN MAY BE OFFERED, SOLD,
PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED IN THE ABSENCE OF SUCH
REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO,
REGISTRATION. EACH PURCHASER OF THIS NOTE IS HEREBY NOTIFIED THAT THE SELLER OF
THIS NOTE MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF
THE SECURITIES ACT PROVIDED BY RULE 144A THEREUNDER.

      THE HOLDER OF THIS NOTE AGREES FOR THE BENEFIT OF THE COMPANY THAT (A)
THIS NOTE MAY BE OFFERED, RESOLD, PLEDGED OR OTHERWISE TRANSFERRED, ONLY (I) TO
A PERSON WHOM THE SELLER REASONABLY BELIEVES IS A QUALIFIED INSTITUTIONAL BUYER
(AS DEFINED IN RULE 144A UNDER THE SECURITIES ACT) IN A TRANSACTION MEETING THE
REQUIREMENTS OF RULE 144A, (II) IN AN OFFSHORE TRANSACTION IN ACCORDANCE WITH
REGULATION S UNDER THE SECURITIES ACT, (III) PURSUANT TO AN EFFECTIVE
REGISTRATION STATEMENT UNDER THE SECURITIES ACT, (IV) TO THE COMPANY OR (V)
PURSUANT TO ANY OTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF
THE SECURITIES ACT, IN EACH OF CASES (I) THROUGH (V) IN ACCORDANCE WITH ANY
APPLICABLE SECURITIES LAWS OF ANY STATE OF THE UNITED STATES AND (B) THE HOLDER
WILL, AND EACH SUBSEQUENT HOLDER IS REQUIRED TO, NOTIFY ANY PURCHASER OF THIS
NOTE FROM IT OF THE RESALE RESTRICTIONS REFERRED TO IN (A) ABOVE.



                                       A-1


   80


                   [Institutional Accredited Investor Legend]

     IN CONNECTION WITH ANY TRANSFER OF THIS NOTE, THE HOLDER WILL DELIVER TO
THE REGISTRAR AND TRANSFER AGENT SUCH CERTIFICATES AND OTHER INFORMATION AS SUCH
TRANSFER AGENT MAY REASONABLY REQUIRE TO CONFIRM THAT THE TRANSFER COMPLIES WITH
THE FOREGOING RESTRICTIONS.



                                                           CUSIP No.__________

No._________                                                    $_____________


     Hybridon, Inc. promises to pay to ______________________________________
______________  or registered assigns, the principal sum of___________________
________ Dollars on April 1, 2004.

     Interest Payment Dates:  April 1 and October 1, commencing October 1, 1997.

     Record Dates:  March 15 and September 15.

     Reference is made to the further provisions of this Note set forth on the
reverse hereof, which further provisions shall for all purposes have the same
effect as if set forth at this place.


                                          HYBRIDON, INC.


                                          By:
                                             ----------------------------------
                                             President
     
                                            (SEAL)

                                          ATTEST:


                                          By:
                                             ----------------------------------
                                             Secretary

Authentication:

This is one of the Notes referred to
in the within-mentioned Indenture:

STATE STREET BANK AND TRUST COMPANY,
as Trustee


By:
   ---------------------------- 
   Authorized Signature

Dated:
      -------------------------

  




                                       A-2


   81


                                 [Reverse Side]


      Capitalized terms used herein without definition shall have the meanings
ascribed to them in the Indenture dated as of March 26, 1997 between Hybridon,
Inc., a Delaware corporation, and State Street Bank and Trust Company, as
trustee, as amended from time to time in accordance with its terms (the
"Indenture").

       1.     INTEREST.

              (a) The Company shall pay interest on the outstanding principal
amount of this Note at the rate of 9% per annum from the date of original
issuance of any Notes under the Indenture until maturity. The Company will pay
interest semi-annually on April 1 and October 1 of each year commencing October
1, 1997, or if any such day is not a Business Day, on the next succeeding
Business Day. Interest on the Notes will accrue from the most recent date on
which interest has been paid or, if no interest has been paid, from the date of
original issuance of any Notes under the Indenture; provided, however, that if
there is no existing Default in the payment of interest and this Note is
authenticated between a record date shown on the face hereof and the next
succeeding Interest Payment Date, interest shall accrue from such next
succeeding Interest Payment Date. Interest will be computed on the basis of a
360-day year of twelve 30-day months.

              (b) To the extent lawful, the Company shall pay interest
(including post-petition interest in any proceeding under any Bankruptcy Law) on
(i) overdue Principal or repurchase price, if any, of the Notes at the rate
borne by the Notes and (ii) overdue installments of interest on the Notes at the
rate borne by the Notes.

       2.     METHOD OF PAYMENT. The Company will pay interest (except defaulted
interest) on the Notes to those persons who are Holders at the close of business
on the record date shown on the face hereof next preceding the applicable
Interest Payment Date (even if such Notes are cancelled after such record date
and on or before such Interest Payment Date), except as provided in Section 10.2
of the Indenture. Defaulted interest shall be paid to Holders as of a special
record date established for purposes of determining the Holders entitled
thereto. The Notes will be payable as to Principal, repurchase price, if any,
and interest at the office or agency of the Company maintained for such purpose
within or without the City and State of New York, as set forth in the Indenture,
or, at the option of the Company, payment of interest may be made by check
mailed to the Holders at their addresses set forth in the Register, and provided
that payment by wire transfer of immediately available funds will be required
with respect to Principal of and interest on the Global Security. Such payment
shall be in the currency of the United States of America which at the time of
payment is legal tender for payment of public and private debts.

       3.     PAYING AGENT, REGISTRAR AND CONVERSION AGENT. Initially, the
Trustee will act as Paying Agent, Registrar and Conversion Agent. The Company
may change any Paying Agent, Registrar or Conversion Agent without notice to any
Holder. The Company or any Subsidiary may act in any such capacity.

       4.     INDENTURE. The Company issued the Notes under the Indenture. The
terms of the Notes include those stated in the Indenture and those made part of
the Indenture by reference to the Trust Indenture Act of 1939. The Notes are
subject to all such terms, and Holders are referred to the Indenture and the
Trust Indenture Act of 1939 for a statement of such terms. The Notes are general
unsecured obligations of the Company limited to $60,000,000 in aggregate
principal amount, subject to Section 2.7 of the Indenture.

       5.     OPTIONAL REDEMPTION BY THE COMPANY. The Notes are not subject to
redemption at the option of the Company prior to April 1, 2000. Thereafter, the
Notes will be redeemable at any time prior to maturity at the option of the
Company, in whole or in part from time to time, upon not less than 30 days' nor
more than 60 days' prior notice to the Holders at the redemption prices
(expressed as percentages of principal amount) set forth below, in each case
together with accrued but unpaid interest, if any, up to but not including the
redemption date:




                                       A-3


   82
AFTER APRIL 1, PERCENTAGE -------------- ---------- 2000 104.5 2001 103.0 2002 101.5 2003 100.0
provided that from April 1, 2000 to March 31, 2001 the Notes may not be redeemed unless the Current Market Price of the Common Stock equals or exceeds 150% of the Conversion Price for a period of at least 20 out of 30 consecutive trading days and the Notes are redeemed within 60 days after any such trading period. 6. MANDATORY REDEMPTION. Except as set forth in paragraph 7 below, the Company shall not be required to make mandatory redemptions with respect to the Notes. 7. REPURCHASE AT THE OPTION OF HOLDER. Upon a Change of Control, the Company shall offer to repurchase all then outstanding Notes at a repurchase price equal to 150% of the principal amount thereof, plus accrued and unpaid interest to the Change of Control Payment Date, if any. Within 30 days after a Change of Control, the Company shall mail a notice to each Holder setting forth the procedures governing the Change of Control Offer as required by the Indenture. A Holder may tender or refrain from tendering all or any portion of such Holder's Notes, at such Holder's discretion, by completing and signing the form entitled "Option of Holder to Elect Repurchase" below and delivering such form, together with the Notes with respect to which the repurchase right is being exercised, duly endorsed for transfer to the Company, to the Paying Agent. Any partial tender of Notes must be made in an integral multiple of $1,000. 8. CONVERSION. To convert a Note, the Holder thereof must (i) complete and sign the "Form of Election to Convert" below (unless such Holder is DTC, in which case the customary procedures of DTC will apply), (ii) surrender such Note to the Conversion Agent, (iii) furnish appropriate endorsements and transfer documents if required by the Registrar or the Conversion Agent and (iv) pay any transfer or similar tax if required by Section 10.6 of the Indenture. Prior to April 1, 2000, a Holder who surrenders this Note for conversion (even if this Note has been called for redemption or a Change of Control Offer has been made) will be paid promptly after such conversion interest accrued but not paid from the most recent date on which interest has been paid or, if no interest has been paid, from the date of original issuance of this Note through the date of such conversion. In addition, if this Note (even if this Note has been called for redemption or a Change of Control Offer has been made) is converted after a regular interest payment record date and prior to the related Interest Payment Date (regardless of whether such conversion occurs before or after April 1, 2000), the full interest installment on this Note scheduled to be paid on such Interest Payment Date shall be payable on such Interest Payment Date to the Holder of this Note at the close of business on such record date. No fractional shares of Common Stock will be issued upon conversion, but an adjustment in cash will be made, as provided in the Indenture, with respect to any fractional share which would otherwise be issuable upon conversion. A Holder is not entitled to any rights of a holder of Common Stock until such Holder has converted its Notes into Common Stock as provided in the Indenture. 9. SUBORDINATION. The Notes are subordinated to Senior Indebtedness. To the extent provided in the Indenture, Senior Indebtedness must be paid before the Notes may be paid. The Company agrees, and each Holder by accepting a Note agrees, to the subordination provisions contained in the Indenture and authorizes the Trustee to give effect to such provisions, and each Holder appoints the Trustee its attorney-in-fact for any and all such purposes. 10. DENOMINATIONS, TRANSFER, EXCHANGE. The Notes are in registered form without coupons in denominations of $1,000 and integral multiples of $1,000. A Holder may transfer or exchange Notes as provided in the Indenture. The Registrar may require a Holder, among other things, to furnish appropriate endorsements and transfer documents and to pay any taxes and fees required by law or permitted by the Indenture. The Registrar need not register the exchange or transfer of any Notes (or portion thereof) during the 15 day period (or shorter) preceding the mailing of a notice of redemption or any Notes (or portion thereof) with respect to which a repurchase A-4 83 election has been tendered and not withdrawn by the Holder thereof in accordance with Section 4.6 of the Indenture. 11. PERSONS DEEMED OWNERS. The registered Holder of a Note may be treated as its owner for all purposes. 12. AMENDMENTS AND WAIVERS. Subject to certain exceptions for which the consent of each Holder is required, the Indenture or the Notes may be amended with the consent of the Holders of at least a majority in aggregate principal amount of the Notes then outstanding and any existing Default (except a payment default) may be waived with the consent of the Holders of at least a majority in aggregate principal amount of the Notes then outstanding. Without the consent of any Holder, the Company and the Trustee may amend or supplement the Indenture or the Notes to (i) cure any ambiguity, defect or inconsistency, provided that such amendment does not in the opinion of the Trustee adversely affect the rights of any Holder, (ii) provide for uncertificated Notes in addition to or in lieu of certificated Notes, (iii) comply with Sections 5.1 and 10.5 of the Indenture, (iv) make any change that does not adversely affect the rights of any Holder, (v) comply with requirements of the SEC in order to effect or maintain the qualification of the Indenture under the TIA and (vi) add to the covenants of the Company. 13. DEFAULTS AND REMEDIES. Events of Default include: (a) failure to pay any Principal or repurchase price, if any, of any Note when due and payable, whether at maturity, upon redemption, upon a Change of Control Offer or otherwise, whether or not such payment is prohibited by the subordination provisions of the Indenture; (b) failure to pay any interest on any Note when due and payable, which failure continues for ten days, whether or not such payment is prohibited by the subordination provisions of the Indenture; (c) failure to perform the other covenants of the Company in the Indenture, which failure continues for 60 days after written notice as provided in the Indenture; (d) default in payment when due of Principal of, or acceleration of, any indebtedness for money borrowed by the Company or any Subsidiary (other than an Unrestricted Subsidiary which is not a Significant Subsidiary and provided there is no recourse against the Company or any other Subsidiary with respect to the obligations of such Unrestricted Subsidiary arising as a result of such default) in excess of $2 million, individually or in the aggregate, if such indebtedness is not discharged, or such acceleration is not annulled, within 30 days after written notice as provided in the Indenture; and (e) certain events of bankruptcy, insolvency or reorganization of the Company or any Significant Subsidiary. If an Event of Default shall occur and be continuing, the Trustee or the Holders of at least 25% in aggregate principal amount of the then outstanding Notes may accelerate the maturity of all Notes, except that in the case of an Event of Default arising from certain events of bankruptcy or insolvency, all outstanding Notes shall immediately so accelerate. The Trustee may require indemnity satisfactory to it before it enforces the Indenture or the Notes at the request or direction of any of the Holders. Subject to certain limitations, the Holders of a majority in aggregate principal amount of the outstanding Notes will have the right to direct the time, method and place of conducting any proceeding for any remedy available to the Trustee or exercising any trust or power conferred on the Trustee. The Company must furnish an annual compliance certificate to the Trustee. 14. TRUSTEE DEALINGS WITH COMPANY. The Trustee, in its individual or any other capacity, may make loans to, accept deposits from and perform services for the Company or its Affiliates, and may otherwise deal with the Company or its Affiliates, as if were not Trustee; provided, however, that if the Trustee acquires any conflicting interest as described in the Trust Indenture Act of 1939, it must eliminate such conflict or resign. 15. NO RECOURSE AGAINST OTHERS. A director, officer, employee, incorporator or stockholder of the Company, as such, shall not have any liability for any obligations of the Company under the Notes or the Indenture or for any claim based on, with respect to, or by reason of, such obligations or their creation. Each Holder by accepting a Note waives and releases all such liability. The waiver and release contained in Article 13 of the Indenture are part of the consideration for the Company's issuance of the Notes. 16. AUTHENTICATION. This Note shall not be valid until authenticated by the manual signature of the Trustee or an authenticating agent. A-5 84 17. ABBREVIATIONS. Customary abbreviations may be used in the name of a Holder or an assignee, such as: TEN COM (=tenants in common), TEN ENT (=tenants by the entireties), JT TEN (=joint tenants with right of survivorship and not as tenants in common), CUST (=Custodian), and U/G/M/A (=Uniform Gifts to Minors Act). 18. ADDITIONAL RIGHTS OF HOLDERS OF TRANSFER RESTRICTED SECURITIES. In addition to the rights provided to Holders of Notes under the Indenture, Holders of Transfer Restricted Securities shall have all the rights set forth in the Registration Rights Agreement dated as of the date hereof between the Company and Forum Capital Markets L.P. as representative of the Holders of Notes. The Company will furnish to any Holder upon written request and without charge a copy of the Indenture and such Registration Rights Agreement. Requests may be made to: Hybridon, Inc. 620 Memorial Drive Cambridge, Massachusetts 02139 Attn: President A-6 85 SCHEDULE OF EXCHANGES OF GLOBAL SECURITY FOR DEFINITIVE SECURITIES The following exchanges of this Global Security for Definitive Securities have been made:
Amount of Principal Amount decrease in Amount of increase of this Global Signature of Principal Amount in Principal Security following authorized officer of this Global Amount of this such decrease or of Trustee or Notes Date of Exchange Security Global Security increase) Custodian - -----------------------------------------------------------------------------------------------
A-7 86 FORM OF ELECTION TO CONVERT I (we) hereby irrevocably exercise the option to convert this Note, or the portion below designated, into shares of Common Stock in accordance with the terms of the Indenture referred to in this Note, and direct that the shares issuable and deliverable upon conversion, together with any check in payment for fractional shares, be issued in the name of and delivered to the undersigned registered Holder hereof, unless a different name has been indicated below. If shares are to be issued in the name of a Person other than the undersigned, the undersigned will pay all transfer taxes payable with respect thereto. Portion of this Note to be converted (if partial conversion, $1,000 or an integral multiple thereof): $______________ Signature:___________________________________ (exactly as your name appears on the face of this Note) Name:_______________________________________ Title:______________________________________ Address:____________________________________ Phone No.:__________________________________ Date:_______________________________________ If shares are to be issued and registered in the name of a Person other than the undersigned, please print the name and address, including zip code, and social security or other taxpayer identification number of such Person below. Name: ________________________________________ Address:______________________________________ TIN/Social Security No:_______________________ Signature Guaranteed (if Common Stock to be issued to other than registered holders): By: ___________________________________ This signature shall be guaranteed by an eligible guarantor institution (a bank or trust company having an office or correspondent in the United States or a broker or dealer which is a member of a registered securities exchange or the National Association of Securities Dealers, Inc.) with membership in an approved signature guaranty medallion program pursuant to SEC Rule 17Ad-15. A-8 87 ASSIGNMENT FORM (I) or (we) assign and transfer this Note to ________________________________________________________________________________ (Insert assignee's social security or tax I.D. no.) ________________________________________________________________________________ ________________________________________________________________________________ ________________________________________________________________________________ (Print or type assignee's name, address and zip code) and irrevocably appoint _________________________________________________ agent to transfer this Note on the Register. The agent may substitute another to act for him. Date:_________ Signature:__________________________________ (exactly as your name appears on the face of this Note) Name:_______________________________________ Title:______________________________________ Address:____________________________________ Phone No.:__________________________________ Date:_______________________________________ Signature Guaranteed: By:_____________________________________ This signature shall be guaranteed by an eligible guarantor institution (a bank or trust company having an office or correspondent in the United States or a broker or dealer which is a member of a registered securities exchange or the National Association of Securities Dealers, Inc.) with membership in an approved signature guaranty medallion program pursuant to SEC Rule 17Ad-15. ====================================== [THE FOLLOWING IS APPLICABLE ONLY IF A RESTRICTED SECURITIES LEGEND APPEARS ON THE FACT OF THIS NOTE] In connection with any transfer or exchange of any of the Notes evidenced by this certificate occurring prior to the date that is two years after the later of the date of original issuance of such Notes and the last date, if any, on which such Notes were owned by the Company or any Affiliate of the Company, the undersigned confirms that such Notes are being: [CONTINUED ON NEXT PAGE] A-9 88 CHECK ONE BOX BELOW: [ ] (1) acquired for the undersigned's own account, without transfer (in satisfaction of Section 2.6(a)(ii)(A) or Section 2.6(d)(i)(A) of the Indenture; or [ ] (2) transferred to the Company; or [ ] (3) transferred pursuant to and in compliance with Rule 144A under the Securities Act of 1933; or [ ] (4) transferred pursuant to and in compliance with Regulation S under the Securities Act of 1933; or [ ] (5) transferred to an institutional "accredited investor" (as defined in Rule 501(a)(1), (2), (3) or (7) under the Securities Act of 1933), that has furnished to the Company and the Trustee a signed letter containing certain representations and agreements (the form of which letter appears as Exhibit C to the Indenture); or [ ] (6) transferred pursuant to another available exemption from the registration requirements of the Securities Act of 1933. Unless one of the boxes is checked, the Trustee will refuse to register any of the Notes evidenced by this certificate in the name of any Person other than the registered holder thereof; provided, however, that if box (4), (5) or (6) is checked, the Company, Trustee or Registrar may require, prior to registering any such transfer of the Notes, in their sole discretion, such legal opinions, certifications and other information as the Company, Trustee or Registrar has reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject to, the registration requirements of the Securities Act of 1933, including but not limited to the exemption provided by Rule 144 under such Act. Your Name:________________________________________ (exactly as your name appears on the face of this Note) By:_______________________________________________ Title:____________________________________________ Date:_____________________________________________ Signature Guaranteed: By:______________________________________ This signature shall be guaranteed by an eligible guarantor institution (a bank or trust company having an office or correspondent in the United States or a broker or dealer which is a member of a registered securities exchange or the National Association of Securities Dealers, Inc.) with membership in an approved signature guaranty medallion program pursuant to SEC Rule 17Ad-15. A-10 89 OPTION OF HOLDER TO ELECT REPURCHASE To elect to have all or part of this Note repurchased by the Company pursuant to Section 4.6 of the Indenture in connection with a Change of Control Offer, state the amount you elect to have repurchased (if all, write "ALL"): $_____________________. Your Name:________________________________________ (exactly as your name appears on the face of this Note) By:_______________________________________________ Title:____________________________________________ Date:_____________________________________________ Signature Guaranteed: By:______________________________________ This signature shall be guaranteed by an eligible guarantor institution (a bank or trust company having an office or correspondent in the United States or a broker or dealer which is a member of a registered securities exchange or the National Association of Securities Dealers, Inc.) with membership in an approved signature guaranty medallion program pursuant to SEC Rule 17Ad-15. A-11 90 EXHIBIT B TRANSFEREE LETTER OF REPRESENTATION Hybridon, Inc. c/o State Street Bank and Trust Company Corporate Trust Department Two International Place - 4th Floor Boston, Massachusetts 02110 Attention: Eric Donoghy Dear Sirs: This Certificate is delivered to request a transfer of $__________________ principal amount of the 9% Convertible Subordinated Notes due 2004 (the "Notes") of Hybridon, Inc. (the "Company"). Upon transfer, the Notes would be registered in the name of the new beneficial owner as follows: Name:________________________________________________________ Address:_____________________________________________________ Taxpayer ID Number:__________________________________________ The undersigned represents and warrant to you that: 1. We are an institutional "accredited investor" (as defined in Rule 501(a)(1), (2), (3) or (7) under the Securities Act of 1933, as amended (the "Securities Act")) purchasing for our own account or for the account of such an institutional "accredited investor," and we are acquiring the Notes not with a view to, or for offer or sale in connection with, any distribution in violation of the Securities Act. We have such knowledge and experience in financial business matters as to be capable of evaluating the merits and risk of our investment in the Notes and invest in or purchase securities similar to the Notes in the normal course of our business. We and any accounts for which we are acting are each able to bear the economic risk of our or its investment. 2. We understand that the Notes have not been registered under the Securities Act and, unless so registered, may not be sold except as permitted in the following sentence. We agree on our own behalf and on behalf of any investor account for which we are purchasing Notes to offer, sell or otherwise transfer such Notes prior to the date which is two years after the later of the date of original issue and the last date on which the Company or any affiliate of the Company was the owner of such Notes (or any predecessor thereto) (the "Resale Restriction Termination Date"), unless as of such date we are an affiliate of the Company inn which case the Resale Restriction Termination Date shall be the date three months after we cease to be an affiliate of the Company, only (a) so long as the Notes are eligible for resale pursuant to Rule 144A un the Securities Act, to a person we reasonably believe is a qualified institutional buyer, as defined in Rule 144A under the Securities Act (a "QIB") in a transaction complying with the requirements of Rule 144A, (b) in an offshore transaction in accordance with Regulation S under the Securities Act, (c) pursuant to a registration statement which has been declared effective under the Securities Act, (d) to the Company, (e) to an institutional "accredited investor" within the meaning of Rule 501(a)(1), (2), (3) or (7) under the Securities Act that is purchasing for its own account or for the account of such an institutional "accredited investor," in each case in a minimum principal amount of Notes of $250,000 or (f) pursuant to any other available exemption from the registration requirements of the Securities Act, subject in each of the foregoing cases to any requirement of law that the disposition of our property or the property of such investor B-1 91 account or accounts be at all times within our or their control and in compliance with any applicable state securities laws. The foregoing restrictions on resale will not apply subsequent to the Resale Restriction Termination Date. If any resale or other transfer of the Notes is proposed to be made pursuant to clause (e) above prior to the Resale Restriction Termination Date, the transferor shall deliver a letter from the transferee substantially in the form of this letter to the Company and the Trustee, which shall provide, among other things, that the transferee is an institutional "accredited investor" within the meaning of Rule 501(a)(1), (2), (3) or (7) under the Securities Act and that it is acquiring such Notes for investment purposes and not for distribution in violation of the Securities Act. Each purchaser acknowledges that the Company and the Trustee reserve the right prior to any offer, sale or other transfer prior to the Resale Termination Date of the Notes pursuant to clause (b), (e) or (f) above, to require the delivery of an opinion of counsel, certifications and/or other information satisfactory to the Company and the Trustee. TRANSFEREE:____________________________________________ BY:____________________________________________________ B-2
   1

                                                                  EXHIBIT 10.1

- --------------------------------------------------------------------------------

                                 HYBRIDON, INC.

                                       AND

                           FORUM CAPITAL MARKETS L.P.


                                  -------------


                          REGISTRATION RIGHTS AGREEMENT



                           Dated as of March 26, 1997


- --------------------------------------------------------------------------------





   2




                          REGISTRATION RIGHTS AGREEMENT
                          -----------------------------


     THIS AGREEMENT is made as of March 26, 1997, by and between Hybridon, Inc.,
a Delaware corporation (the "Company"), and Forum Capital Markets L.P., (the
"Initial Purchaser"). The Company proposes to issue and sell to the Initial
Purchaser, upon the terms set forth in a purchase agreement dated concurrently
herewith (the "Purchase Agreement"), up to $60,000,000 aggregate principal
amount of its 9% Convertible Subordinated Notes due 2004 (the "Notes"). The
Notes are convertible into Common Stock (as defined herein) as provided in the
Notes and the Indenture (as defined herein). As an inducement to the Initial
Purchaser to enter into the Purchase Agreement and in satisfaction of a
condition to the Initial Purchaser's obligations thereunder, the Company agrees
with the Initial Purchaser, for the benefit of the Initial Purchaser and the
other Holders (as defined herein), as follows:

     1. Definitions.
        -----------
     As used in this Agreement, the following capitalized terms shall have the
following meanings:

     "ACT" means the Securities Act of 1933, as amended from time to time.

     "CLOSING DATE" has the meaning set forth in the Purchase Agreement.

     "COMMON STOCK" means the Common Stock, par value $.001 per share, of the
Company, or any successor class thereto, issuable upon conversion of the Notes.

     "COMMISSION" means the Securities and Exchange Commission.

     "DAMAGES PAYMENT DATE" means April 1 and October 1 in each year.

     "EFFECTIVENESS PERIOD" has the meaning set forth in Section 2 hereof.

     "EXCHANGE ACT" means the Securities Exchange Act of 1934, as amended from
time to time.

     "HOLDERS" means Persons owning Transfer Restricted Securities.

     "INDENTURE" means the Indenture, to be dated the date hereof, between the
Company and State Street Bank and Trust Company or other comparable entity
selected by the Company, as trustee (the "TRUSTEE"), pursuant to which the Notes
are to be issued, as such Indenture is amended or supplemented from time to time
in accordance with the terms thereof.

     "LIQUIDATED DAMAGES" has the meaning set forth in Section 4 hereof.


   3


     "OPTION CLOSING DATE" has the meaning set forth in the Purchase Agreement.

     "PERSON" means an individual, partnership, corporation, limited liability
company, trust or unincorporated organization, or a government or agency or
political subdivision thereof.

     "PROSPECTUS" means the prospectus included in the Shelf Registration
Statement, as amended or supplemented by any prospectus supplement and by all
other amendments thereto, including post-effective amendments, and all material
incorporated by reference into such Prospectus.

     "RECORD HOLDER" means with respect to any Damages Payment Date relating to
the Notes, each Person who is a holder of Notes on the record date with respect
to the interest payment on the Notes due on such date and with respect to any
Damages Payment Date relating to the Common Stock, each Person who is a holder
of Common Stock on March 15 with respect to an April 1 Damages Payment Date and
on September 15 with respect to an October 1 Damages Payment Date.

     "REGISTRATION DEFAULT" has the meaning set forth in Section 4 hereof.

     "SHELF REGISTRATION STATEMENT" has the meaning set forth in Section 2
hereof.

     "TIA" means the Trust Indenture Act of 1939 (15 U.S.C. Section
77aaa-77bbbb) as in effect on the date of the Indenture.

     "TRANSFER RESTRICTED SECURITIES" means each Note and, if such Note has been
converted, each share of Common Stock issued in connection with such conversion,
until the earlier of (a) the date on which such Note or share of Common Stock,
as applicable, has been effectively registered under the Act and disposed of
pursuant to and in accordance with an effective Shelf Registration Statement,
(b) the date on which such Note or share of Common Stock, as applicable, is
distributed to the public pursuant to Rule 144 or any other applicable exemption
under the Act without additional restriction upon public resale or (c) at such
time as such Note or share of Common Stock, as applicable, may be sold by a
Holder under Rule 144(k).

     "UNDERWRITTEN OFFERING" means a registration in which securities of the
Company are sold to an underwriter for re-offering to the public.

     2. SHELF REGISTRATION. The Company shall use its reasonable best efforts to
file a registration statement with the Commission within 60 days after the
Closing Date relating to the offer and sale of the Transfer Restricted
Securities by Holders from time to time pursuant to Rule 415 under the Act and
in accordance with the methods of distribution set forth therein, which
registration statement may be substituted for by one or more subsequent
registration statements each relating to the offer and sale of the Transfer
Restricted Securities by Holders from time to time (as in effect from time to
time, the "Shelf Registration Statement"), and the Company shall use its
reasonable best efforts to cause such Shelf Registration Statement to be
declared effective by the Commission within 120 days after the 


                                       2


   4


Closing Date, provided, however, that the Company may delay such filing or
effectiveness under the circumstances and during the periods described in
Section 3 hereof. In addition, the Company shall use its reasonable best efforts
to keep the Shelf Registration Statement continuously effective, supplemented
and amended for a period (the "Effectiveness Period") of not less than two years
following the later of the Closing Date or any Option Closing Date or such
shorter period that will terminate when all the Notes and shares of Common Stock
covered by the Shelf Registration Statement cease to be Transfer Restricted
Securities.

     3. Delay Periods; Suspension of Sales.
        ----------------------------------

          (a) If at any time prior to the expiration of the Effectiveness
Period, counsel to the Company (which counsel shall be experienced in securities
laws matters) has determined in good faith that it is reasonable to conclude
that the filing of the Shelf Registration Statement or the compliance by the
Company with its disclosure obligations in connection with the Shelf
Registration Statement may require the disclosure of information which the Board
of Directors of the Company has identified as material and which the Board of
Directors has determined that the Company has a bona fide business purpose for
preserving as confidential, then the Company may delay the filing or the
effectiveness of the Shelf Registration Statement (if not then filed or
effective, as applicable) and shall not be required to maintain the
effectiveness thereof or amend or supplement the Shelf Registration Statement
for a period (an "Information Delay Period") expiring three business days after
the earlier to occur of (A) the date on which such material information is
disclosed to the public or ceases to be material or the Company is able to so
comply with its disclosure obligations and Commission requirements or (B) 45
days after the Company notifies the Holders of such good faith determination.
There shall not be more than four Information Delay Periods during the
Effectiveness Period, and there shall not be two Information Delay Periods
during any contiguous 135 day period.

          (b) If at any time prior to the expiration of the Effectiveness
Period, the Company is advised by a nationally recognized investment banking
firm selected by the Company that, in such firm's written reasonable opinion
addressed to the Company (a copy of which shall be delivered to each Holder of
Transfer Restricted Securities registered under the Shelf Registration
Statement), sales of Common Stock pursuant to the Shelf Registration Statement
at such time would materially adversely affect any immediately planned
underwritten public equity financing by the Company of at least $5 million, the
Company shall not be required to maintain the effectiveness of the Shelf
Registration Statement or amend or supplement the Shelf Registration Statement
for a period (a "Transaction Delay Period") commencing on the date of pricing of
such equity financing and expiring three business days after the earliest to
occur of (i) the abandonment of such financing or (ii) 90 days after the
completion of such financing. There shall not be more than two Transaction Delay
Periods during the Effectiveness Period.

          (c) A Transaction Delay Period and an Information Delay Period are
hereinafter collectively referred to as "Delay Periods" or a "Delay Period." The
Company will give prompt written notice, in the manner prescribed by Section
10(b) hereof, to each Holder of each Delay Period. Such notice shall be given
(i) in the case of a Transaction Delay Period, at least 20 days in advance of
the commencement of such Delay Period and 


                                       3


   5


(ii) in the case of an Information Delay Period, as soon as practicable after
the Board of Directors makes the determination referenced in Section 3(a). Such
notice shall state to the extent, if any, as is practicable, an estimate of the
duration of such Delay Period. Each Holder, by his acceptance of any Transfer
Restricted Securities, agrees that (i) upon receipt of such notice of an
Information Delay Period it will forthwith discontinue disposition of Transfer
Restricted Securities pursuant to the Shelf Registration Statement, (ii) upon
receipt of such notice of a Transaction Delay Period it will forthwith
discontinue disposition of the Common Stock pursuant to the Shelf Registration
Statement and (iii) in either such case, will not deliver any prospectus forming
a part of the Shelf Registration Statement in connection with any sale of
Transfer Restricted Securities or Common Stock, as applicable until the
expiration of such Delay Period.

         4. LIQUIDATED DAMAGES. Except as may be permitted by Section 3, if (i)
the Shelf Registration Statement is not filed with the Commission within 60 days
after the Closing Date, (ii) the Shelf Registration Statement has not been
declared effective by the Commission within 120 days after the Closing Date (the
"Effectiveness Target Date"), or (iii) at any time prior to the second
anniversary of the later of the Closing Date or any Option Closing Date, the
Shelf Registration Statement is filed and declared effective but shall
thereafter cease to be effective (other than as a result of the effectiveness of
a successor registration statement) and such effectiveness is not restored
within 75 days thereafter (each such event referred to in clauses (i) through
(iii), a "Registration Default"), the Company will pay liquidated damages
("Liquidated Damages") to each Holder who has complied with its obligations
under this Agreement. During the first 90-day period immediately following the
occurrence of such Registration Default, the amount of such Liquidated Damages
shall equal $.05 per week per $1,000 principal amount of Notes and, if
applicable, $.0005 per week per share of Common Stock constituting Transfer
Restricted Securities registered under the Shelf Registration Statement (subject
to adjustment in the event of stock splits, stock consolidations, stock
dividends and the like). Upon each subsequent 90-day period following the
occurrence of such Registration Default, the amount of the Liquidated Damages
shall increase by an additional $.05 per week per $1,000 principal amount of
Notes and $.0005 per week per share of Common Stock constituting Transfer
Restricted Securities registered under the Shelf Registration Statement (subject
to adjustment as set forth above); provided, however, the maximum amount of the
Liquidated Damages shall be $.20 per week per $1,000 principal amount of Notes
and $.002 per week per share of Common Stock constituting Transfer Restricted
Securities registered under the Shelf Registration Statement (subject to
adjustment as set forth above). All accrued Liquidated Damages shall be paid by
the Company to Record Holders entitled thereto on the next succeeding Damages
Payment Date by wire transfer of immediately available funds or by federal funds
check. Following the cure of all Registration Defaults, the accrual of
Liquidated Damages will cease, but any Liquidated Damages accrued through the
date of cure shall be paid to Record Holders on the next succeeding Damages
Payment Date. If the Registration Defaults described in either of clauses (i) or
(ii) above arose solely because the applicable Holder or Holders failed to
provide the Company with certain information within 20 business days after
request therefor pursuant to Section 5(m), Liquidated Damages in respect thereof
will not begin to accrue until five business days after such information has
been provided to the Company.


                                       4


   6


                  All of the Company's obligations set forth in the preceding
paragraph which are outstanding with respect to any Transfer Restricted Security
at the time such security ceases to be a Transfer Restricted Security shall
survive until such time as all such obligations with respect to such security
shall have been satisfied in full.

     5. Registration Procedures.
        -----------------------
          In connection with the Shelf Registration Statement and any 
Prospectus required by this Agreement to permit the sale or resale of Transfer
Restricted Securities, the following provisions shall apply:

          (a) The Company shall furnish to each Holder, promptly after filing
thereof with the Commission, a copy of the Shelf Registration Statement and each
amendment thereto or each amendment or supplement to the Prospectus included
therein.

          (b) The Company shall take such action as may be reasonably necessary
so that (i) the Shelf Registration Statement and any amendment thereto and any
Prospectus forming a part thereof and any supplement or amendment thereto
complies in all material respects with the Act and the rules and regulations
thereunder, (ii) the Shelf Registration and any amendment thereto (in either
case, other than with respect to written information furnished to the Company by
or on behalf of any Holder specifically for inclusion therein) does not contain
an untrue statement of a material fact or omit to state a material fact required
to be stated therein or necessary to make any statement therein not misleading
and (iii) the Prospectus and any supplement thereto (in either case, other than
with respect to such information from Holders), does not include an untrue
statement of a material fact or omit to state a material fact necessary in order
to make the statements therein, in light of the circumstances under which they
were made, not misleading.

          (c) The Company shall promptly advise the Holders of Transfer
Restricted Securities registered under the Shelf Registration Statement (which
advice pursuant to clauses (ii) - (iv) shall be accompanied by an instruction to
suspend the use of the Prospectus until the requisite changes have been made)
and, if requested by such Persons, shall confirm such advice in writing:

               (i) when the Shelf Registration Statement and any amendment
          thereto has been filed with the Commission and when the Shelf
          Registration Statement or any post-effective amendment thereto has
          become effective;

               (ii) of any request by the Commission for amendments to the Shelf
          Registration Statement or amendments or supplements to the Prospectus
          or for additional information relating thereto;

               (iii) of the issuance by the Commission of any stop order
          suspending the effectiveness of the Shelf Registration Statement or of
          the suspension by any state securities commission of the qualification
          of the Transfer Restricted Securities for offering or sale in any
          jurisdiction, or the initiation of any proceeding for any of the
          preceding purposes; and


                                       5


   7


               (iv) of the happening of any event that requires the making of
          any changes in the Shelf Registration Statement or the Prospectus so
          that, as of such date, the Shelf Registration Statement and the
          Prospectus do not contain an untrue statement of a material fact and
          do not omit to state a material fact required to be stated therein or
          necessary to make the statements therein (in the case of the
          Prospectus, in light of the circumstances under which they were made)
          not misleading.

          (d) If at any time the Commission shall issue any stop order
suspending the effectiveness of the Shelf Registration Statement, or any state
securities commission or other regulatory authority shall issue an order
suspending the qualification or exemption from qualification of the Transfer
Restricted Securities under state securities or Blue Sky laws, the Company shall
use its reasonable best efforts to obtain the withdrawal or lifting of such
order at the earliest possible time.

          (e) The Company shall furnish to each Holder of Transfer Restricted
Securities included under the Shelf Registration Statement, without charge, at
least one copy of the Shelf Registration Statement and each post-effective
amendment thereto, including all financial statements and schedules, documents
incorporated by reference therein and, if the Holder so requests in writing, all
exhibits (including exhibits incorporated therein by reference).

          (f) The Company shall, during the Effectiveness Period, deliver to
each Holder of Transfer Restricted Securities included under the Shelf
Registration Statement, without charge, such reasonable number of copies of the
Prospectus (including each preliminary prospectus) included in the Shelf
Registration Statement and any amendment or supplement thereto as such Holder
may reasonably request to facilitate the public sale or other disposition of the
Transfer Restricted Securities by the selling Holder.

          (g) Prior to any public offering pursuant to the Shelf Registration
Statement, the Company shall use its reasonable best efforts to register or
qualify or cooperate with the Holders of Transfer Restricted Securities
registered thereunder, the underwriter(s), if any, and their respective counsel
in connection with the registration and qualification of such Transfer
Restricted Securities under the securities or Blue Sky laws of such
jurisdictions as such Holders or underwriters reasonably request in writing and
do any and all other acts or things reasonably necessary or advisable to enable
the offer and sale in such jurisdictions of such Transfer Restricted Securities;
provided, however, that the Company will not be required to qualify generally to
do business in any jurisdiction where it is not then so qualified or to take any
action that would subject it to general service of process or to taxation in any
jurisdiction where it is not then so subject.

          (h) The Company shall cooperate with the Holders and the
underwriter(s), if any, to facilitate the timely preparation and delivery of
certificates representing Transfer Restricted Securities to be sold under the
Shelf Registration Statement, free of any restrictive legends and in such
denominations and registered in such names as the Holders or the underwriter(s),
if any, may reasonably request in connection with the sales of Transfer
Restricted Securities pursuant to the Shelf Registration Statement.


                                       6




   8


          (i) Upon the occurrence of any event contemplated by Section 5(c)(ii)
- - (iv), and subject to the provisions of Section 3, the Company shall file (and
use its reasonable best efforts to have declared effective as soon as possible)
a post-effective amendment to the Shelf Registration Statement or an amendment
or supplement to the Prospectus or file any other required document so that, as
thereafter delivered to the purchasers of Transfer Restricted Securities
registered under the Shelf Registration Statement, the Prospectus will not
contain an untrue statement of a material fact or omit to state any material
fact necessary to make the statements therein in light of the circumstances
under which they were made not misleading. Each Holder of Transfer Restricted
Securities registered under the Shelf Registration Statement agrees by
acquisition of such Transfer Restricted Securities that, upon receipt of any
notice from the Company of the existence of any fact of the kind described in
Section 5(c)(ii) - (iv) hereof, such Holder will forthwith discontinue
disposition of Transfer Restricted Securities pursuant to the Shelf Registration
Statement until such Holder receives copies of the supplemented or amended
Prospectus contemplated by this Section 5(i), or until such Holder is advised in
writing by the Company that the use of the Prospectus may be resumed, and such
Holder has received copies of any additional or supplemental filings which are
incorporated by reference in the Prospectus. If so directed by the Company, each
Holder will deliver to the Company (at the Company's expense) all copies, other
than permanent file copies then in such Holder's possession, of the Prospectus
covering such Transfer Restricted Securities current at the time of receipt of
such notice.

          (j) The Company shall provide CUSIP numbers for all Transfer
Restricted Securities registered under the Shelf Registration Statement, in the
event of and at the time of any distribution thereof to Holders, not later than
the effective date of the Shelf Registration Statement and provide the Trustee
and the transfer agent for the Common Stock with printed certificates for such
Transfer Restricted Securities which are in a form eligible for deposit with The
Depository Trust Company.

          (k) The Company shall use its reasonable best efforts to comply with
all applicable rules and regulations of the Commission, and make generally
available to its security holders or otherwise provide in accordance with
Section 11(a) of the Act, as soon as practicable after the effective date of the
Shelf Registration Statement an earnings statement satisfying the provisions of
Section 11(a) of the Act.

          (l) The Company shall cause the Indenture to be qualified under the
TIA in a timely manner not later than the effective date of the Shelf
Registration Statement, and, in connection therewith, cooperate with the Trustee
and the Holders of Notes to effect such changes to the Indenture as may be
required for such Indenture to be so qualified in accordance with the terms of
the TIA.

          (m) The Company may require each Holder of Transfer Restricted
Securities to be registered under the Shelf Registration Statement to furnish to
the Company such information regarding such Holder and the distribution of such
Holder's securities thereunder as the Company may from time to time reasonably
require for inclusion in the Shelf Registration Statement and the Company may
exclude from such registration the 


                                       7




   9


Transfer Restricted Securities of any Holder that fails to furnish such
information within a reasonable time after receiving such request.

          (n) The Company shall, if requested by the Holders of Transfer
Restricted Securities being sold in an Underwritten Offering or the
underwriter(s) thereof, promptly incorporate in the Shelf Registration Statement
or Prospectus, pursuant to a supplement or post-effective amendment, if
necessary, such information relating to the plan of distribution of the Transfer
Restricted Securities, information with respect to the principal amount of
Transfer Restricted Securities being sold to such underwriter(s), the purchase
price being paid therefor and with respect to any other terms of the offering of
the Transfer Restricted Securities to be sold in such offering as such
underwriters and Holders reasonably agree should be included therein and to
which the Company does not reasonably object; and shall make all required
filings of such Prospectus supplement or post-effective amendment as soon as
practicable after the Company is notified of the matters to be incorporated in
such Prospectus supplement or post-effective amendment. Notwithstanding the
foregoing, any Delay Period resulting from such supplement or amendment shall
not constitute a Delay Period under Section 3, and the Company shall not be
liable under Section 4, in connection with such delay or amendment.

          (o) The Company shall enter into such customary agreements (including
an underwriting agreement in customary form, if applicable) and take all such
other reasonable and appropriate actions in order to expedite or facilitate the
disposition in an Underwritten Offering of the Transfer Restricted Securities
pursuant to the Shelf Registration Statement, and in connection therewith, the
Company shall (1) make such representations and warranties to the underwriter(s)
in form, substance and scope as are customarily made by issuers to underwriters
in comparable underwritten offerings; (2) obtain opinions of counsel to the
Company and updates thereof (which counsel and opinions (in form, scope and
substance) shall be reasonably satisfactory to such underwriters) addressed to
each such underwriter covering such matters as are customarily covered in
opinions requested in underwritten offerings; (3) if and to the extent permitted
by Statement of Auditing Standards No. 72, obtain comfort letters and updates
thereof from the Company's independent certified public accountants addressed to
the underwriters requesting the same, such letters to be in customary form and
covering matters of the type customarily covered in comfort letters in
connection with comparable underwritten offerings; (4) set forth in full or
incorporate by reference in the underwriting agreement the indemnification
provisions and procedures of Section 6 hereof with respect to all parties to be
indemnified pursuant to said Section; and (5) deliver such documents and
certificates as may be reasonably requested by such underwriters to evidence
compliance with Section 5(i) and with any customary conditions contained in the
underwriting agreement or other agreement entered into by the Company pursuant
to this Section 5(o). The foregoing actions set forth in clauses (1), (2), (3)
and (5) of this Section 5(o) shall be performed at each closing under any
underwriting or similar agreement as and to the extent required thereunder.

          (p) The Company shall make available at reasonable times for
inspection by the Holders of the Transfer Restricted Securities, any underwriter
participating in any disposition pursuant to the Shelf Registration Statement,
and any attorney or accountant retained by any such Holders or underwriters, all
financial and other records, pertinent


                                       8




   10


corporate documents and properties of the Company and its subsidiaries; and
cause the Company's officers, directors and employees to supply all information
reasonably requested by any such Holder, underwriter, attorney or accountant in
connection with the Shelf Registration Statement subsequent to the filing
thereof as is customary for similar due diligence examinations; provided,
however, that any information that is designated in writing by the Company, in
good faith, as confidential at the time of delivery of such information shall be
kept confidential by such Holders or any such underwriter, attorney or
accountant, unless (i) such disclosure is required to be made in connection with
a court proceeding or required by law (provided that the disclosing party
provides prior written notice to the Company and cooperates with the Company, at
the Company's expense, to take reasonable and lawful actions to avoid and/or
minimize the extent of such disclosure) or (ii) such information becomes
available to the public other than through a wrongful act by such Person; and
provided, further that the foregoing inspection and information gathering shall,
to the greatest extent possible, be coordinated on behalf of the Holders and the
other parties entitled thereto by one counsel designated by and on behalf of
such Holders and other parties.

          (q) The Company shall use its reasonable best efforts, subject to any
applicable rules thereto, to cause all Common Stock included among the Transfer
Restricted Securities to be listed on each securities exchange on which the
Common Stock is listed and, if requested by the Holders of a majority of in
aggregate principal amount of Notes, and if the Common Stock is then listed on
the American Stock Exchange or the New York Stock Exchange, to also list the
Notes registered under the Shelf Registration Statement on such exchange.

     6. Registration Expenses.
        ---------------------

          (a) Except as otherwise provided in Section 7, the Company shall bear
all expenses incurred in connection with the performance of or compliance with
its obligations under Sections 2, 4 and 5 hereof, including without limitation
all registration and filing fees, fees and expenses of compliance with
securities or blue sky laws, printing expenses, messenger and delivery expenses
and fees and disbursements of counsel for the Company and all independent
certified public accountants, and other persons retained by the Company (all
such expenses being herein called "Registration Expenses"). Registration
Expenses shall also include the Company's internal expenses (including, without
limitation, all salaries and expenses of its officers and employees performing
legal or accounting duties), the expense of any annual audit or quarterly
review, the expense of any liability insurance and the expenses and fees for
listing the securities to be registered on each securities exchange on which
similar securities issued by the Company are then listed or on the Nasdaq Stock
Market. The Company will reimburse the Holders for the reasonable fees and
disbursements (not to exceed $15,000 in the aggregate) of one firm of attorneys
chosen by the Holders of a majority in aggregate principal amount of the Notes
to be sold pursuant to the Shelf Registration Statement to act as counsel
therefor in connection therewith.

          (b) Each Holder will pay any discounts and commissions incurred upon
the sale of securities by it under the Shelf Registration Statement.


                                       9




   11


     7. Indemnification and Contribution.
        --------------------------------
          (a) The Company agrees to indemnify and hold harmless each Holder (for
purposes of this Section 7, "Holder" shall include the officers, directors,
partners, employees and agents, and each Person, if any, who controls any Holder
("controlling person") within the meaning of Section 15 of the Securities Act or
Section 20(a) of the Exchange Act, from and against any and all losses, claims,
damages, expenses or liabilities, joint or several (and actions, proceedings,
suits and litigation in respect thereof), whatsoever, as the same are incurred,
to which such Holder or any such controlling Person may become subject, under
the Securities Act, the Exchange Act or any other statute or at common law or
otherwise insofar as such losses, claims, damages, expenses or liabilities arise
out of or are based upon any untrue statement or alleged untrue statement of a
material fact contained in the Shelf Registration Statement, or any preliminary
Prospectus or Prospectus (as from time to time amended and supplemented) or
arise out of or are based upon the omission or alleged omission therefrom of a
material fact required to be stated therein or necessary to make the statements
therein (with respect to any preliminary Prospectus or Prospectus, in the light
of the circumstances under which they were made), not misleading; provided,
however, that the Company shall not be liable in any such case to the extent
that any such loss, claim, damage, expense or liability arises out of or is
based upon any untrue statement or alleged untrue statement or omission or
alleged omission made in the Registration Statement, or any preliminary
Prospectus or Prospectus or any such amendment or supplement in reliance upon
and in conformity with written information furnished to the Company by or on
behalf of any such Holder specifically for inclusion therein and provided,
further, that the Company shall not be liable to any such Holder under the
indemnity agreement in this subsection (a) (i) with respect to any preliminary
Prospectus or Prospectus (if such Prospectus has then been amended or
supplemented) to the extent that any such loss, liability, claim, damage or
expense of such Holder arises out of a sale of Transfer Restricted Securities by
such Holder to a Person to whom there was not sent or given, at or prior to the
written confirmation of such sale, a copy of the Prospectus (or of the
Prospectus as then amended or supplemented) if the Company has previously
furnished copies thereof to such Holder a reasonable time in advance and the
loss, liability, claim, damage or expense of such Holder results from an untrue
statement or alleged untrue statement or omission or alleged omission of a
material fact contained in the preliminary Prospectus (or the Prospectus) which
was corrected in the Prospectus (or the Prospectus as amended or supplemented)
or (ii) to the extent that any such loss, claim, damage, expense or liability
arises out of or is based upon any action or failure to act by such Holder that
is found in a final judicial determination (or a settlement tantamount thereto)
to constitute bad faith, willful misconduct or gross negligence on the part of
such Holder. The indemnity agreement in this subsection (a) shall be in addition
to any liability which the Company may have at common law or otherwise.

          The Company also agrees to indemnify or contribute to losses of, as
provided in Section 7(d), any underwriters of Transfer Restricted Securities
registered under the Shelf Registration Statement, their officers and directors
and each Person, if any, who controls any such underwriter (within the meaning
of the Act) on substantially the same basis as that of the indemnification of
the Holders provided in this Section 7(a) and shall, if requested by any Holder,
enter into an underwriting agreement reflecting such agreement, as provided in
Section 5(o) hereof.


                                       10



   12


          (b) Each Holder agrees to indemnify and hold harmless the Company,
each of its directors, each of its officers and each other Person, if any, who
controls the Company within the meaning of the Securities Act, to the same
extent as the foregoing indemnity from the Company to the Holders, but only with
respect to statements or omissions, if any, made in conformity with information
relating to such Holder furnished in writing by such Holder specifically for use
in the Shelf Registration Statement in the Registration Statement, or any
preliminary Prospectus or the Prospectus or any amendment thereof or supplement
thereto; provided, however, that the obligation to indemnify will be individual
to each Holder and will be limited to the amount of net proceeds received by
such Holder from the sale of Transfer Restricted Securities pursuant to the
Shelf Registration Statement.

          (c) Promptly after receipt by an indemnified party under this Section
7 of notice of the commencement of any action, suit or proceeding, such
indemnified party shall, if a claim in respect thereof is to be made against one
or more indemnifying parties under this Section 7, notify each party against
whom indemnification is to be sought in writing of the commencement thereof (but
the failure to notify an indemnifying party shall not relieve it from any
liability which it may have under Sections 7(a) or (b) unless and to the extent
that it has been prejudiced in a material respect by such failure or from the
forfeiture of substantial rights and defenses). In case any such action, suit or
proceeding is brought against any indemnified party, and it notifies an
indemnifying party or parties of the commencement thereof, the indemnifying
party or parties will be entitled to participate therein, and to the extent it
may elect by written notice delivered to the indemnified party promptly after
receiving the aforesaid notice from such indemnified party, to assume the
defense thereof with counsel reasonably satisfactory to such indemnified party,
which may be the same counsel as counsel to the indemnifying party.
Notwithstanding the foregoing, the indemnified party or parties shall have the
right to employ its or their own counsel in any such case but the fees and
expenses of such counsel shall be at the expense of such indemnified party or
parties unless (i) the employment of such counsel shall have been authorized in
writing by the indemnifying parties in connection with the defense of such
action at the expense of the indemnifying party, (ii) the indemnifying parties
shall not have employed counsel reasonably satisfactory to such indemnified
party to take charge of the defense of such action within a reasonable time
after notice of commencement of the action or (iii) such indemnified party or
parties shall have reasonably concluded, after consultation with counsel to such
indemnified party or parties, that a conflict of interest exists which makes
representation by counsel chosen by the indemnifying party not advisable (in
which case the indemnifying parties shall not have the right to direct the
defense of such action on behalf of the indemnified party or parties), in any of
which events such fees and expenses of one additional counsel shall be borne by
the indemnifying parties. In no event shall the indemnifying parties be liable
for fees and expenses of more than one counsel (in addition to any local
counsel) separate from their own counsel for all indemnified parties in
connection with any one action or separate but similar or related actions in the
same jurisdiction arising out of the same general allegations or circumstances.
Anything in this Section 7 to the contrary notwithstanding, an indemnifying
party shall not be liable for any settlement of any claim or action effected
without its written consent.

          (d) In order to provide for just and equitable contribution in any
case in which (i) an indemnified party makes claim for indemnification pursuant
to this Section 7,


                                       11


   13



but it is judicially determined (by the entry of a final judgment or decree by a
court of competent jurisdiction and the expiration of time to appeal or the
denial of the last right of appeal) that such indemnification may not be
enforced in such case notwithstanding the fact that the express provisions of
this Section 7 provide for indemnification in such case, or (ii) contribution
under the Securities Act may be required, then each indemnifying party, in lieu
of indemnifying such indemnified party, shall contribute to the amount paid as a
result of such losses, claims, damages, expenses or liabilities (or actions,
suits, proceedings or litigation in respect thereof) in such proportion as is
appropriate to reflect the relative fault of each of the contributing parties,
on the one hand, and the party to be indemnified, on the other hand, in
connection with the statements or omissions that resulted in such losses,
claims, damages, expenses or liabilities, as well as any other relevant
equitable considerations. Relative fault shall be determined by reference to,
among other things, whether the untrue or alleged untrue statement of a material
fact or the omission or alleged omission to state a material fact relates to
information supplied by the Company or by a Holder, and the parties' relative
intent, knowledge, access to information and opportunity to correct or prevent
such untrue statement or omission. The amount paid or payable by an indemnified
party as a result of the losses, claims, damages, expenses or liabilities (or
actions, suits, proceedings or litigation in respect thereof) referred to above
in this subsection (d) shall be deemed to include any legal or other expenses
reasonably incurred by such indemnified party in connection with investigating,
preparing or defending any such action, claim, suit, proceeding or litigation.
Notwithstanding the provisions of this subsection (d), no Holder shall be
required to contribute any amount in excess of the amount by which the total
price at which the Transfer Restricted Securities sold by such indemnifying
party and distributed to the public were offered to the public exceeds the
amount of any damages that such indemnifying party has otherwise been required
to pay by reason of such untrue or alleged untrue statement or omission or
alleged omission. No Person guilty of fraudulent misrepresentation (within the
meaning of Section 12(f) of the Securities Act) shall be entitled to
contribution from any Person who was not guilty of such fraudulent
misrepresentation. For purposes of this Section 7, each Person, if any, who
controls the Company within the meaning of the Securities Act, each executive
officer of the Company and each director of the Company shall have the same
rights to contribution as the Company, subject in each case to this subsection
(d). Any party entitled to contribution will, promptly after receipt of notice
of commencement of any action, suit, proceeding or litigation against such party
in respect to which a claim for contribution may be made against another party
or parties under this subsection (d), notify such party or parties from whom
contribution may be sought, but the omission so to notify such party or parties
shall not relieve the party or parties from whom contribution may be sought from
any obligation it or they may have hereunder or otherwise than under this
subsection (d), or to the extent that such party or parties were not adversely
affected by such omission. The contribution agreement set forth above shall be
in addition to any liabilities which any indemnifying party may have at common
law or otherwise.

     8. RULES 144 AND 144A. The Company shall use commercially reasonable
efforts to file the reports required to be filed by it under the Act and the
Exchange Act in a timely manner and, if at any time the Company is not required
to file such reports, it will, upon the written request of any Holder of
Transfer Restricted Securities, make publicly available other information so
long as necessary to permit sales of such Holder's securities pursuant to Rules


                                       12


   14


144 and 144A. The Company covenants that it will take such further action as any
Holder of Transfer Restricted Securities may reasonably request, all to the
extent required from time to time, to enable such Holder to sell securities
without registration under the Act within the limitation of the exemptions
provided by Rules 144 and 144A (including the requirements of Rule 144A(d)(4)).

     9. UNDERWRITTEN REGISTRATIONS. If any of the Transfer Restricted Securities
included under the Shelf Registration Statement are to be sold in an
underwritten offering, the investment banker or investment bankers and manager
or managers that will administer the offering will be selected by the Holders of
a majority of the shares of Common Stock included among such Transfer Restricted
Securities (calculated as if all of the then outstanding Notes were converted
into Common Stock at the time of such selection), provided, however, that such
managing underwriters shall be reasonably satisfactory to the Company and the
Company shall not be obligated to arrange for more than one underwritten
offering during the Effectiveness Period.

     No Person may participate in any underwritten registration hereunder unless
such Person (i) agrees to sell such Person's Transfer Restricted Securities on
the basis reasonably provided in any underwriting arrangements approved by the
Persons entitled hereunder to approve such arrangements, (ii) completes and
executes all questionnaires, powers of attorney, indemnities, underwriting
agreements, lock-up letters and other documents reasonably required under the
terms of such underwriting arrangements and (iii) at least 20% of the
outstanding Transfer Restricted Securities are included in such underwritten
offering. The Holders participating in any underwritten offering shall be
responsible for any expenses customarily borne by selling securityholders,
including underwriting discounts and commissions and fees and expenses of
counsel to the selling securityholders.

     10. Miscellaneous.
         -------------

          (a) AMENDMENTS AND WAIVERS. The provisions of this Agreement may not
be amended, modified or supplemented, and waivers or consents to departures from
the provisions hereof may not be given, unless the Company has obtained the
written consent of Holders of a majority of the Common Stock issued or issuable
upon conversion of the Notes (calculated as if all of the then outstanding Notes
were converted into Common Stock at the time of such consent). Notwithstanding
the foregoing, a waiver or consent to depart from the provisions hereof with
respect to a matter that relates exclusively to the rights of the Holders of
Transfer Restricted Securities being sold pursuant to the Shelf Registration
Statement and that does not directly or indirectly affect the rights of other
Holders may be given by Holders of a majority of the shares of Common Stock
included among such Transfer Restricted Securities.

          (b) NOTICES. All notices and other communications provided for or
permitted hereunder shall be made in writing by hand-delivery, first-class mail,
telex, telecopier, or air courier guaranteeing overnight delivery:


                                       13


   15


               (1) if to a Holder, at the address of such Holder maintained by
          the Registrar under the Indenture;

               (2) if to the Initial Purchaser, at the address set forth in the
          Purchase Agreement;

               (3) if to the Company, at its address set forth in the Purchase
          Agreement;

or to such other addresses as the recipient party has specified to the sending
party by prior written notice to the sending party.

          All such notices and communications shall be deemed to have been duly
given: when delivered by hand, if personally delivered; one business day after
being delivered to a next-day air courier; five business days after being
deposited in the mail; when answered back, if faxed; and when receipt is
acknowledged by the recipient's telecopier machine, if telecopied.

          (c) REMEDIES. In the event of a breach by the Company or by a Holder
of any of their respective obligations under this Agreement, each Holder or the
Company, as the case may be, in addition to being entitled to exercise all
rights granted by law, including recovery of damages, will be entitled to
specific performance of its rights under this Agreement. The Company and each
Holder agree that monetary damages would not be adequate compensation for any
loss incurred by reason of a breach by it of any of the provisions of this
Agreement and hereby further agrees that, in the event of any action for
specific performance in respect of such breach, it shall waive the defense that
a remedy at law would be adequate.

          (d) SEVERABILITY. The remedies provided herein are cumulative and not
exclusive of any remedies provided by law. If any term, provision, covenant or
restriction of this Agreement is held by a court of competent jurisdiction to be
invalid, illegal, void or unenforceable, the remainder of the terms, provisions,
covenants and restrictions set forth herein shall remain in full force and
effect and shall in no way be affected, impaired or invalidated and the parties
hereto shall use their reasonable efforts to find and employ an alternative
means to achieve the same or substantially the same result as that contemplated
by such term, provision, covenant or restriction. It is hereby stipulated and
declared to be the intention of the parties that they would have executed the
remaining terms, provisions, covenants and restrictions without including any of
such that may be hereafter declared invalid, illegal, void or unenforceable.

          (e) NO INCONSISTENT AGREEMENTS. The Company will not hereafter enter
into any agreement with respect to its securities which is inconsistent with or
violates the rights granted to the Holders in this Agreement.

          (f) SUCCESSORS AND ASSIGNS. All covenants and agreements in this
Agreement by or on behalf of any of the parties hereto will bind and inure to
the benefit of their respective heirs, executors, administrators, successors,
legal representatives and assigns.


                                       14


   16


In addition, whether or not any express assignment has been made, the provisions
of this Agreement which are for the benefit of Holders are also for the benefit
of, and enforceable by, any subsequent Holder.

          (g) COUNTERPARTS. This Agreement may be executed simultaneously in two
or more counterparts, any one of which need not contain the signatures of more
than one party, but all such counterparts taken together will constitute one and
the same Agreement.

          (h) DESCRIPTIVE HEADINGS. The descriptive headings of this Agreement
are inserted for convenience only and do not constitute a part of this
Agreement.

          (i) GOVERNING LAW. All questions concerning the construction, validity
and interpretation of this Agreement shall be governed by and construed in
accordance with the domestic laws of the State of New York, without giving
effect to any choice of law or conflict of law provision or rule (whether of the
State of New York or any other jurisdiction) that would cause the application of
the laws of any jurisdiction other than the State of New York.

     IN WITNESS WHEREOF, the parties have executed this Registration Rights
Agreement as of the date first written above.

                          HYBRIDON, INC.


                          By: /s/ E. Andrews Grinstead, III
                             ---------------------------------

                          Its: Chairman, President and Chief Executive Officer
                              ------------------------------------------------




                          Acting on behalf of itself and as the representative
                          of the Holders:

                          FORUM CAPITAL MARKETS L.P.


                          By: /s/ C. Keith Hartley
                             --------------------------------- 
                          Name:  C. Keith Hartley
                          Title:  Senior Managing Director





                                       15

   1
                                                                  Exhibit 10.2

- --------------------------------------------------------------------------------

                                 HYBRIDON, INC.

                                       AND

                           FORUM CAPITAL MARKETS L.P.



                                   ----------



                               INITIAL PURCHASER'S
                                WARRANT AGREEMENT








                           Dated as of March 26, 1997




- --------------------------------------------------------------------------------


   2


     INITIAL PURCHASER'S WARRANT AGREEMENT, dated as of March 26, 1997 by and
between HYBRIDON, INC., a Delaware corporation (the "Company"), and FORUM
CAPITAL MARKETS L.P. (the "Initial Purchaser").


                              W I T N E S S E T H:
                              - - - - - - - - - -


     WHEREAS, the Company proposes to issue to the Initial Purchaser warrants
("Warrants") to purchase up to 427,807 shares of Common Stock, par value $.001
per share, of the Company (the "Common Stock"); and

     WHEREAS, the Initial Purchaser has agreed, pursuant to the purchase
agreement dated March 26, 1997 between the Initial Purchaser and the Company
(the "Purchase Agreement"), to act as the Initial Purchaser in connection with
the Company's proposed offering (the "Offering") of up to $60,000,000 aggregate
principal amount of 9% Convertible Subordinated Notes due 2004 (the "Notes");
and

     WHEREAS, the Warrants to be issued pursuant to this Agreement will be
issued on the Closing Date (as such term is defined in the Purchase Agreement)
by the Company to the Initial Purchaser in consideration for, and as part of the
Initial Purchaser's compensation in connection with, the Initial Purchaser
acting as such pursuant to the Purchase Agreement;

     NOW, THEREFORE, in consideration of the premises hereof, the payment by the
Initial Purchaser to the Company of an aggregate of $42.78, the agreements
herein set forth and other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties hereto agree as
follows:

     1. Grant.
        -----

     (a) The Initial Purchaser is hereby granted the right pursuant to the
Warrants to purchase, at any time from April 2, 1998 until 5:30 p.m., New York
time, on April 2, 2002 (the "Expiration Date"), up to 427,807 shares of Common
Stock (subject to adjustment as provided in Section 8 hereof and cancellation
pursuant to Sections 1(b) and 1(c) hereof) at an exercise price (subject to
adjustment as provided in Section 8 hereof), of $7.0125 per share subject to the
terms and conditions of this Agreement. Any Warrant that is not exercised on or
prior to the Expiration Date shall be void, and all rights hereunder shall
cease.

     (b) Notwithstanding the provisions of Section 1(a) hereof, the Company
shall hold in escrow Warrant Certificates (as defined below) with respect to
Warrants to purchase up to 71,301 shares of Common Stock, which Warrant
Certificates shall be released to the Initial Purchaser at each Option Closing
(as such term is defined in the Purchase Agreement), if any. At each Option
Closing there shall be released to the Initial Purchaser Warrant Certificates
representing that portion of such Warrants equivalent to the ratio which the
aggregate principal amount of Notes purchased at such Option Closing bears to
$10,000,000. Any Warrants held in escrow on June 9, 1997 pursuant to this
Section 1(b) shall be cancelled and terminated.

     (c) Notwithstanding the provisions of Section 1(a) hereof, if during the
effectiveness of a registration statement filed pursuant to Section 7.2(a)
hereof any Warrant Securities are sold under such registration statement, then,
within 10 days after learning of such sale, the Company will give notice of such
sale to each Holder of then outstanding Warrants. If such notice is given, all
Warrants outstanding on the date such registration statement is terminated or
withdrawn in accordance with Section 7.3 hereof shall be cancelled and
terminated on such date.

     2. WARRANT CERTIFICATES. The warrant certificates delivered and to be
delivered pursuant to this Agreement (the "Warrant Certificates") shall be in
the form set forth in Exhibit A attached hereto and made a part hereof, with
such appropriate insertions, omissions, substitutions and other variations as
required or permitted by this Agreement. Notwithstanding the foregoing, in the
event that any provision of the Warrant Certificates conflicts with or are
inconsistent with the terms of this Agreement, the terms of this Agreement shall
supersede the provisions in the Warrant Certificates.


   3


     3. EXERCISE OF WARRANT. The Warrants initially are exercisable at an
initial exercise price per share of Common Stock set forth in Section 6 hereof
(subject to adjustment as provided in Section 8 hereof) payable by certified or
official bank check. Upon surrender of a Warrant Certificate with a duly
executed Election to Purchase (in the form of Annex A to the Warrant
Certificate) together with payment of the Exercise Price (as hereinafter
defined) for the Common Stock purchased at the Company's principal offices
(presently located at 620 Memorial Drive, Cambridge, Massachusetts 02139), the
registered holder of a Warrant Certificate ("Holder") shall be entitled to
receive a certificate or certificates for the Common Stock so purchased. The
purchase rights represented by each Warrant Certificate are exercisable at the
option of the Holder thereof, in whole or in part (but not as to fractional
shares of Common Stock underlying the Warrants). In the case of the purchase of
less than all the Common Stock purchasable under any Warrant Certificate, the
Company shall cancel said Warrant Certificate upon the surrender thereof and
shall execute and deliver a new Warrant Certificate of like tenor for the
balance of the Common Stock purchasable thereunder.

     4. ISSUANCE OF CERTIFICATES. Upon the exercise of the Warrants, the
issuance of certificates for the total number of whole shares of Common Stock
for which such Warrants were exercised shall be made forthwith (and in any event
within five business days thereafter) without charge to the Holder thereof
including, without limitation, any stock transfer or similar tax which may be
payable in respect of the issuance thereof, and such certificates shall (subject
to the provisions of Sections 5 and 7 hereof) be issued in the name of, or in
such names as may be directed by, the Holder thereof; provided, however, that
the Company shall not be required to pay any tax which may be payable in respect
of any transfer involved in the issuance and delivery of any such certificates
in a name other than that of the Holder, and the Company shall not be required
to issue or deliver such certificates unless or until the person or persons
requesting the issuance thereof shall have paid to the Company the amount of
such tax or shall have established to the satisfaction of the Company that such
tax has been paid.

     The Warrant Certificates shall be executed on behalf of the Company, by the
manual or facsimile signature of the then present Chairman or Vice Chairman of
the Board of Directors or President or Vice President of the Company under its
corporate seal reproduced thereon and by the manual or facsimile signature of
the then present Treasurer or Assistant Treasurer or Secretary or Assistant
Secretary of the Company. Warrant Certificates shall be dated the date of
execution by the Company upon initial issuance, division, exchange, substitution
or transfer. Certificates representing the Common Stock issuable upon exercise
of the Warrants (and/or other securities, property or rights issuable upon
exercise of Warrants) shall be dated the date on which the Company receives the
Election to Purchase, Warrant Certificate and payment of the Exercise Price
(regardless of when executed).

     5. RESTRICTION ON TRANSFER OF WARRANTS. The Holder of a Warrant
Certificate, by acceptance thereof, covenants and agrees that (a) the Warrants
represented by such Warrant Certificate and the shares of Common Stock issuable
upon exercise of such Warrants (the "Warrant Securities") are being acquired as
an investment and not with a view to, nor for sale in connection with, the
distribution thereof; nor with any present intention of distributing or selling
the same, except as may be permitted under applicable securities laws. The
Warrants and the Warrant Shares have not been registered under the Securities
Act of 1933, as amended (the "Securities Act"), or any state securities law and
any transfer of the Warrants and the Warrant Shares may only be made upon such
registration or pursuant to an exemption from registration thereunder and, if
required by the Company in connection with any transfer pursuant to such an
exemption from registration, conditioned upon receipt by the Company of an
opinion of counsel, reasonably satisfactory to counsel to the issuer, that such
an exemption is available for such transfer. Upon exercise, in part or in whole,
of the Warrants, certificates representing the Common Stock issuable upon
exercise of the Warrants (and/or other securities, property or rights issuable
upon exercise of Warrants) shall bear the following legend:

     The securities represented by this certificate have not been registered
     under the Securities Act of 1933, as amended (the "Securities Act"), and
     may not be offered or sold except pursuant to (i) an effective registration
     statement under the Securities Act or (ii) an exemption from registration
     under the Securities Act, of an opinion of counsel, reasonably satisfactory
     to counsel to the issuer, is delivered that such an exemption is available
     for such transfer.


                                      -2-


   4


Any assignment shall be effected by a duly executed assignment in the form of
Annex B to the Warrant Certificate and shall be subject to the provisions of
this Section 5 and Section 9 hereof.

     6. EXERCISE PRICE. The initial exercise price of each Warrant shall be
$7.0125 per share of Common Stock. The adjusted exercise price of each Warrant
shall be the price which shall result from time to time from any and all
adjustments of the initial exercise price in accordance with the provisions of
Section 8 hereof. The term "Exercise Price" herein shall mean the initial
exercise price or, after the first adjustment hereunder, the adjusted exercise
price.

     7. Registration Rights.
        -------------------

     7.1 PIGGYBACK REGISTRATION. The Company shall use its reasonable best
efforts to include the Common Stock issued or issuable upon exercise of the
Warrants (the "Warrant Securities") in the shelf registration statement (the
"Shelf Registration Statement") to be filed under the Securities Act pursuant to
the Registration Rights Agreement between the Company and the Initial Purchaser
dated concurrently herewith. If, at any time commencing after the date on which
the Shelf Registration Statement is terminated or withdrawn and expiring seven
years after the date hereof, the Company proposes to register any of its
securities under the Securities Act (other than pursuant to Form S-4, Form S-8
or any successor form of limited purpose and other than any registration
statement covering only securities proposed to be issued in exchange for
securities or assets of another corporation), it will give written notice by
registered mail, at least 20 days prior to the filing of each such registration
statement, to the Holders of the Warrants or Warrant Securities of its intention
to do so. If the Holders of the Warrants and/or Warrant Securities notify the
Company within 20 days after receipt of any such notice of its or their desire
to include any of their respective Warrant Securities in such proposed
registration statement, the Company shall afford each of such Holders the
opportunity to have such Warrant Securities registered under such registration
statement. In connection with any offering under this Section 7.1 involving a
firm commitment underwriting of Common Stock, the Company shall not be required
to include any Warrant Securities in such underwriting unless the Holders
thereof accept the terms of the underwriting agreement related thereto as agreed
upon between the Company and/or the holders of securities of the Company who
have initiated such offering pursuant to demand registration rights held by them
and the underwriter(s) of such offering. If such offering is an underwritten
offering and in the opinion of the managing underwriter(s) of such offering the
registration of all, or part of, shares of Common Stock ("Incidental Shares")
which the Holders have requested to be included pursuant to this Section 7.1
and/or which other holders of shares of Common Stock or other securities of the
Company entitled to include shares of Common Stock in such registration (other
than, if such registration is initiated by the demand of holders of specified
securities of the Company, for securities of such holders ("Initiating
Stockholders"), have requested to be included would materially and adversely
affect such public offering, then the Company shall be required to include in
the underwriting only that number of such shares, if any, which the managing
underwriter(s) believe(s) may be sold without causing such adverse effect. If
the number of Warrant Securities to be included in the underwriting in
accordance with the foregoing is less than the total number of shares which the
Holders have requested be included, then (i) the party or parties initiating the
registration (i.e., the Company or the Initiating Stockholders) shall be
entitled to include all shares that they have requested to be registered and
(ii) the Holders who have requested registration and other holders of shares of
Common Stock or other securities of the Company entitled to include shares of
Common Stock in such registration on a parity with the Holders (i.e., all
holders of such securities other than the Initiating Stockholders, who shall be
entitled to include the total number of shares they have requested as provided
in clause (i), or those persons who have registration rights expressly
subordinated to the Holders) shall participate in the underwriting pro rata
based upon their total ownership of shares of Common Stock of the Company.

     Notwithstanding the provisions of this Section 7.1, the Company shall have
the right at any time after it shall have given written notice pursuant to this
Section 7.1 (irrespective of whether a written request for inclusion of any such
Warrant Securities shall have been made) to elect not to file any such proposed
registration statement or to withdraw the same after the filing but prior to the
effective date thereof.


                                      -3-


   5


     7.2 Demand Registration.
         -------------------

     (a) At any time commencing on the date the Shelf Registration Statement is
terminated or withdrawn and expiring seven years after the date hereof, the
Holders of the Warrants and/or Warrant Securities representing a Majority (as
hereinafter defined) of such securities shall have the right (which right is in
addition to the registration rights under Section 7.1 hereof), exercisable by
written notice to the Company, to require the Company to use its best efforts to
prepare and file with the Securities and Exchange Commission (the "Commission"),
on one occasion only, a registration statement on such form selected by the
Company as it is then eligible to use and such other documents, including a
prospectus, as may be necessary in the opinion of both counsel for the Company
and counsel for the Holders, in order to comply with the provisions of the
Securities Act, so as to permit a public offering and sale of their Warrant
Securities for six consecutive months (subject to the provisions of Section
7.2(d) below) by any such Holders and any other Holders of the Warrants and/or
Warrant Securities who notify the Company of their decision to join therein
within 10 days after receiving notice from the Company pursuant to Section
7.2(b) below.

     (b) The Company covenants and agrees to give written notice of any
registration request under this Section 7.2 to all Holders of the Warrants
and/or the Warrant Securities within 10 days from the date of the receipt of any
such registration request.

     (c) [Intentionally omitted]

     (d) Notwithstanding the provisions of Sections 7.2(a) and (c), if at any
time during which the Company is obligated to maintain the effectiveness of a
registration statement pursuant to such Sections counsel to the Company (which
counsel shall be experienced in securities matters) has determined in good faith
it is reasonable to conclude that the filing of such registration statement or
the compliance by the Company with its disclosure obligations thereunder may
require the disclosure of material information which the Board of Directors of
the Company has identified as material and which the Board of Directors has
determined the Company has a bona fide business purpose for preserving as
confidential, then the Company may delay the filing or the effectiveness of such
registration statement (if not then filed or effective, as appropriate) and
shall not be required to maintain the effectiveness thereof or amend or
supplement the registration statement for a period expiring three business days
after the earlier to occur of (i) the date on which such information is
disclosed to the public or ceases to be material or the Company is so able to
comply with its disclosure obligations or (ii) 45 days after the Company
notifies the Holders of such good faith determination. There shall not be more
than two such delay periods with respect to any registration pursuant to Section
7.2(a), and the period such registration statement is required to be kept
effective by the Company shall be increased by the period of any such delay
period. Notice of any such delay period and of the termination thereof will be
promptly delivered by the Company to each Holder and shall be maintained in
confidence by each such Holder.

     7.3 COVENANTS WITH RESPECT TO REGISTRATION. In connection with any
registration under Section 7.1 or 7.2 hereof, as applicable, the Company
covenants and agrees as follows:

     (a) In connection with any registration under Section 7.2, the Company
shall use its best efforts to file a registration statement as soon as
practicable, but in any event within 90 days after receipt of any demand
therefor, shall use its best efforts to have such registration statement
declared effective at the earliest possible time and shall furnish each Holder
desiring to sell Warrant Securities such number of prospectuses as shall
reasonably be requested; provided, however, that the Company shall not be
obligated to effect such registration under the Securities Act except in
accordance with the following provisions:

          (i) the Company shall not be obligated to use its best efforts to file
     and cause to become effective any registration statement for a period of up
     to 90 days if at the time of such request any other registration statement
     pursuant to which shares of Common Stock of the Company are to be or were
     sold has been filed with the Commission and not withdrawn or has been
     declared effective within the prior 60 days; and


                                      -4-


   6


          (ii) the Company may delay the filing or effectiveness of the
     registration statement for a period of up to 90 days after the date of a
     request for registration if at the time of such request the Company is
     engaged in a firm commitment underwritten public offering of Common Stock
     in which the Holders may include their Warrant Securities pursuant to
     Section 7.1 hereof.

     (b) The Company shall pay all costs, fees and expenses in connection with
all registration statements filed pursuant to Sections 7.1 and 7.2(a) hereof
(excluding fees and expenses of Holders' counsel and any underwriting or selling
commissions), including, without limitation, the Company's legal and accounting
fees, printing expenses and blue sky fees and expenses. If the Company shall
fail to comply with the provisions of Section 7.3(a) hereof, the Company shall,
in addition to any other equitable or other relief available to such Holders,
extend the Exercise Period by such number of days as shall equal the delay
caused by the Company's failure and be liable for any or all incidental, special
and consequential damages sustained by such Holders.

     (c) The Company shall furnish to each Holder, promptly after filing thereof
with the Commission, a copy of the registration statement filed pursuant to
Section 7.1 or 7.2 (a "Registration Statement") and each amendment thereto or
each amendment or supplement to the prospectus included therein (the
"Prospectus").

     (d) The Company shall take such action as may be reasonably necessary so
that (i) the Registration Statement and any amendment thereto and any Prospectus
forming a part thereof and any supplement or amendment thereto complies in all
material respects with the Securities Act and the rules and regulations
thereunder, (ii) the Registration Statement and any amendment thereto (in either
case, other than with respect to written information furnished to the Company by
or on behalf of any Holder specifically for inclusion therein) does not contain
an untrue statement of a material fact or omit to state a material fact required
to be stated therein or necessary to make any statement therein not misleading
and (iii) the Prospectus and any supplement thereto (in either case, other than
with respect to such information from Holders), does not include an untrue
statement of a material fact or omit to state a material fact necessary in order
to make the statements therein, in light of the circumstances under which they
were made, not misleading.

     (e) The Company shall promptly advise the Holders of Warrant Securities
registered under the Registration Statement (which advice pursuant to clauses
(ii) - (iv) shall be accompanied by an instruction to suspend the use of the
Prospectus until the requisite changes have been made) and, if requested by such
persons, shall confirm such advice in writing:

          (i) when the Registration Statement and any amendment thereto has been
     filed with the Commission and when the Registration Statement or any
     post-effective amendment thereto has become effective;

          (ii) of any request by the Commission for amendments to the
     Registration Statement or amendments or supplements to the Prospectus or
     for additional information relating thereto;

          (iii) of the issuance by the Commission of any stop order suspending
     the effectiveness of the Registration Statement or of the suspension by any
     state securities commission of the qualification of the Warrant Securities
     for offering or sale in any jurisdiction, or the initiation of any
     proceeding for any of the preceding purposes; and

          (iv) of the happening of any event that requires the making of any
     changes in the Registration Statement or the Prospectus so that, as of such
     date, the Registration Statement and the Prospectus do not contain an
     untrue statement of a material fact and do not omit to state a material
     fact required to be stated therein or necessary to make the statements
     therein (in the case of the Prospectus, in light of the circumstances under
     which they were made) not misleading.

     (f) If at any time the Commission shall issue any stop order suspending the
effectiveness of the Registration Statement, or any state securities commission
or other regulatory authority shall issue an order 


                                      -5-


   7


suspending the qualification or exemption from qualification of the Warrant
Securities under state securities or Blue Sky laws, the Company shall use its
reasonable best efforts to obtain the withdrawal or lifting of such order at the
earliest possible time.

     (g) The Company shall furnish to each Holder of Warrant Securities included
under the Registration Statement, without charge, at least one copy of the
Registration Statement and each post-effective amendment thereto, including all
financial statements and schedules, documents incorporated by reference therein
and, if the Holder so requests in writing, all exhibits (including exhibits
incorporated therein by reference).

     (h) The Company shall, during the period the Company is obligated to
maintain the effectiveness of a Registration Statement under Section 7.2 hereof,
deliver to each Holder of Warrant Securities included under the Registration
Statement, without charge, such reasonable number of copies of the Prospectus
(including each preliminary prospectus) included in the Registration Statement
and any amendment or supplement thereto as such Holder may reasonably request to
facilitate the public sale or other disposition of the Warrant Securities by the
selling Holder.

     (i) Prior to any public offering pursuant to the Registration Statement,
the Company shall use its reasonable best efforts to register or qualify or
cooperate with the Holders of Warrant Securities registered thereunder, the
underwriter(s), if any, and their respective counsel in connection with the
registration and qualification of such Warrant Securities under the securities
or Blue Sky laws of such jurisdictions as such Holders or underwriters
reasonably request in writing and do any and all other acts or things reasonably
necessary or advisable to enable the offer and sale in such jurisdictions of
such Warrant Securities; provided, however, that the Company will not be
required to qualify generally to do business in any jurisdiction where it is not
then so qualified or to take any action that would subject it to general service
of process or to taxation in any jurisdiction where it is not then so subject.

     (j) The Company shall cooperate with the Holders and the underwriter(s), if
any, to facilitate the timely preparation and delivery of certificates
representing Warrant Securities to be sold under the Registration Statement,
free of any restrictive legends and in such denominations and registered in such
names as the Holders or the underwriter(s), if any, may reasonably request in
connection with the sales of Warrant Securities pursuant to the Registration
Statement.

     (k) Upon the occurrence of any event contemplated by Section 7(e)(ii) -
(iv) hereof, the Company shall file (and use its reasonable best efforts to have
declared effective as soon as possible) a post-effective amendment to the
Registration Statement or an amendment or supplement to the Prospectus or file
any other required document so that, as thereafter delivered to the purchasers
of Warrant Securities registered under the Registration Statement, the
Prospectus will not contain an untrue statement of a material fact or omit to
state any material fact necessary to make the statements therein in light of the
circumstances under which they were made not misleading. Each Holder of Warrant
Securities registered under the Registration Statement agrees by acquisition of
such Warrant Securities that, upon receipt of any notice from the Company of the
existence of any fact of the kind described in Section 7(e)(ii) - (iv) hereof,
such Holder will forthwith discontinue disposition of Warrant Securities
pursuant to the Registration Statement until such Holder receives copies of the
supplemented or amended Prospectus contemplated by this Section 7(k), or until
such Holder is advised in writing by the Company that the use of the Prospectus
may be resumed, and such Holder has received copies of any additional or
supplemental filings which are incorporated by reference in the Prospectus. If
so directed by the Company, each Holder will deliver to the Company (at the
Company's expense) all copies, other than permanent file copies then in such
Holder's possession, of the Prospectus covering such Warrant Securities current
at the time of receipt of such notice.

     (l) The Company shall use its reasonable best efforts to comply with all
applicable rules and regulations of the Commission, and make generally available
to its security holders or otherwise provide in accordance with Section 11(a) of
the Act, as soon as practicable after the effective date of the Registration
Statement an earnings statement satisfying the provisions of Section 11(a) of
the Act.


                                      -6-


   8


     (m) The Company may require each Holder of Warrant Securities to be
registered under the Registration Statement to furnish to the Company such
information regarding such Holder and the distribution of such Holder's
securities thereunder as the Company may from time to time reasonably require
for inclusion in the Registration Statement and the Company may exclude from
such registration the Warrant Securities of any Holder that fails to furnish
such information within a reasonable time after receiving such request.

     (n) With respect an offering pursuant to Section 7.2 only, the Company
shall, if requested by the Holders of Warrant Securities being sold in an
underwritten offering or the underwriter(s) thereof, promptly incorporate in the
Registration Statement or Prospectus, pursuant to a supplement or post-effective
amendment, if necessary, such information relating to the plan of distribution
of the Warrant Securities, information with respect to the principal amount of
Warrant Securities being sold to such underwriter(s), the purchase price being
paid therefor and with respect to any other terms of the offering of the Warrant
Securities to be sold in such offering as such underwriters and Holders
reasonably agree should be included therein and to which the Company does not
reasonably object; and shall make all required filings of such Prospectus
supplement or post-effective amendment as soon as practicable after the Company
is notified of the matters to be incorporated in such Prospectus supplement or
post-effective amendment. Notwithstanding the foregoing, any delay period
resulting from such supplement or amendment shall not constitute a delay period
under Section 7.2(d) hereof.

     (o) With respect an offering pursuant to Section 7.2 only, the Company
shall enter into such customary agreements (including an underwriting agreement
in customary form, if applicable) and take all such other reasonable and
appropriate actions in order to expedite or facilitate the disposition of the
Warrant Securities in an underwritten offering pursuant to the Registration
Statement, and in connection therewith, the Company shall (1) make such
representations and warranties to the underwriter(s), if any, in form, substance
and scope as are customarily made by issuers to underwriters in comparable
underwritten offerings; (2) obtain opinions of counsel to the Company and
updates thereof (which counsel and opinions (in form, scope and substance) shall
be reasonably satisfactory to such underwriters) addressed to each such
underwriter covering such matters as are customarily covered in opinions
requested in underwritten offerings; (3) if and to the extent permitted by
Statement of Auditing Standards No. 72, obtain comfort letters and updates
thereof from the Company's independent certified public accountants addressed to
the underwriters requesting the same, such letters to be in customary form and
covering matters of the type customarily covered in comfort letters in
connection with primary underwritten offerings; (4) set forth in full or
incorporate by reference in the underwriting agreement the indemnification
provisions and procedures of Section 6 hereof with respect to all parties to be
indemnified pursuant to said Section; and (5) deliver such documents and
certificates as may be reasonably requested by such underwriters to evidence
compliance with Section 5(i) and with any customary conditions contained in the
underwriting agreement or other agreement entered into by the Company pursuant
to this Section 7(o). The foregoing actions set forth in clauses (1), (2), (3)
and (5) of this Section 5(o) shall be performed at each closing under any
underwriting or similar agreement as and to the extent required thereunder.

     (p) With respect an offering pursuant to Section 7.2 only, the Company
shall make available at reasonable times for inspection by the Holders of the
Warrant Securities, any underwriter participating in any disposition pursuant to
the Registration Statement, and any attorney or accountant retained by any such
Holders or underwriters, all financial and other records, pertinent corporate
documents and properties of the Company and its subsidiaries; and cause the
Company's officers, directors and employees to supply all information reasonably
requested by any such Holder, underwriter, attorney or accountant in connection
with the Registration Statement subsequent to the filing thereof as is customary
for similar due diligence examinations; provided, however, that any information
that is designated in writing by the Company, in good faith, as confidential at
the time of delivery of such information shall be kept confidential by such
Holders or any such underwriter, attorney or accountant, unless (i) such
disclosure is required to be in connection with a court proceeding or required
by law (provided that the disclosing party provides prior written notice to the
Company and cooperates with the Company, at the Company's expense, to take
reasonable and lawful actions to avoid and/or minimize the extent of such
disclosure) or (ii) such information becomes available to the public other than
through a wrongful act by such Person; and provided, further that the foregoing
inspection and information gathering shall, to the greatest extent possible, be
coordinated on behalf of the Holders and the other parties entitled thereto by
one counsel designated by and on behalf of such Holders and other parties.


                                      -7-

   9


     (q) The Company shall use its reasonable best efforts, subject to any
applicable rules thereto, to cause all Common Stock included among the Warrant
Securities to be listed on each securities exchange on which the Common Stock is
listed.

     (r) Nothing contained in this Agreement shall be construed as requiring the
Holders to exercise their Warrants prior to the initial filing of any
Registration Statement or the effectiveness thereof; provided, however, no
Holder of Warrants with respect to which the underlying Warrant Securities are
registered under an effective registration statement filed pursuant to Section
7.2 hereof may exercise such Holder's Warrants in part instead of in whole.

     (s) The Company may permit the inclusion of any securities other than
Warrant Securities to be included in any Registration Statement filed pursuant
to Section 7.2(a) hereof provided that viz. a viz. the Holders, the holders of
such other securities shall have no greater right to include their shares in
such registration statement than Holders have to include their shares in an
offering by Initiating Stockholders pursuant to Section 7.1 hereof and provided
further that, viz. a viz. such other holders, the Holders have rights no less
than Initiating Stockholders have in relation to the Holders to include all of
their shares in such a registration statement pursuant to Section 7.1 hereof.

     (t) For purposes of this Agreement, the term "Majority" in reference to the
Holders of Warrants and/or Warrant Securities shall mean the Holders of Warrants
and/or Warrant Securities who, assuming the immediate exercise of all of the
outstanding Warrants for Common Stock, would hold in excess of fifty percent
(50%) of the Common Stock then issued or issuable pursuant to Warrants that (i)
are not held by the Company, an affiliate or officer thereof or any of their
respective affiliates, members of their family or persons acting as their
nominees or in conjunction therewith or (ii) have not been resold to the public
pursuant to a Registration Statement filed with the Commission under the
Securities Act.

     (u) Indemnification and Contribution.
         --------------------------------

     (1) The Company agrees to indemnify and hold harmless each Holder (for
purposes of this Section 7(u), "Holder" shall include the officers, directors,
partners, employees and agents, and each person, if any, who controls any Holder
("controlling person") within the meaning of Section 15 of the Securities Act or
Section 20(a) of the Exchange Act, from and against any and all losses, claims,
damages, expenses or liabilities, joint or several (and actions, proceedings,
suits and litigation in respect thereof), whatsoever, as the same are incurred,
to which such Holder or any such controlling person may become subject, under
the Securities Act, the Exchange Act or any other statute or at common law or
otherwise insofar as such losses, claims, damages, expenses or liabilities arise
out of or are based upon any untrue statement or alleged untrue statement of a
material fact contained in the Registration Statement, or any preliminary
Prospectus or Prospectus (as from time to time amended and supplemented) or
arise out of or are based upon the omission or alleged omission therefrom of a
material fact required to be stated therein or necessary to make the statements
therein (with respect to any preliminary Prospectus or Prospectus, in the light
of the circumstances under which they were made), not misleading; provided,
however, that the Company shall not be liable in any such case to the extent
that any such loss, claim, damage, expense or liability arises out of or is
based upon any untrue statement or alleged untrue statement or omission or
alleged omission made in the Registration Statement, or any preliminary
Prospectus or Prospectus or any such amendment or supplement in reliance upon
and in conformity with written information furnished to the Company by or on
behalf of any such Holder specifically for inclusion therein and provided,
further, that the Company shall not be liable to any such Holder under the
indemnity agreement in this subsection (1) (i) with respect to any preliminary
Prospectus or Prospectus (if such Prospectus has then been amended or
supplemented) to the extent that any such loss, liability, claim, damage or
expense of such Holder arises out of a sale of Warrant Securities by such Holder
to a person to whom there was not sent or given, at or prior to the written
confirmation of such sale, a copy of the Prospectus (or of the Prospectus as
then amended or supplemented) if the Company has previously furnished copies
thereof to such Holder a reasonable time in advance and the loss, liability,
claim, damage or expense of such Holder results from an untrue statement or
alleged untrue statement or omission or alleged omission of a material fact
contained in the preliminary Prospectus (or the Prospectus) which was corrected
in the Prospectus (or the Prospectus as amended or supplemented) or (ii) to the
extent that any such loss, claim, damage, expense or liability arises out of


                                      -8-

   10

or is based upon any action or failure to act by such Holder that is found in a
final judicial determination (or a settlement tantamount thereto) to constitute
bad faith, willful misconduct or gross negligence on the part of such Holder.
The indemnity agreement in this subsection (1) shall be in addition to any
liability which the Company may have at common law or otherwise.

     The Company also agrees to indemnify or contribute to losses of, as
provided in Section 7(u)(4), any underwriters of Warrant Securities registered
under the Registration Statement, their officers and directors and each person,
if any, who controls any such underwriter (within the meaning of the Act) on
substantially the same basis as that of the indemnification of the Holders
provided in this Section 7(u)(1) and shall, if requested by any Holder, enter
into an underwriting agreement reflecting such agreement, as provided in Section
7(o) hereof.

     (2) Each Holder agrees to indemnify and hold harmless the Company, each of
its directors, each of its officers and each other person, if any, who controls
the Company within the meaning of the Securities Act, to the same extent as the
foregoing indemnity from the Company to the Holders, but only with respect to
statements or omissions, if any, made in conformity with information relating to
such Holder furnished in writing by such Holder specifically for use in the
Registration Statement in the Registration Statement, or any preliminary
Prospectus or the Prospectus or any amendment thereof or supplement thereto;
provided, however, that the obligation to indemnify will be individual to each
Holder and will be limited to the amount of net proceeds received by such Holder
from the sale of Warrant Securities pursuant to the Registration Statement.

     (3) Promptly after receipt by an indemnified party under this Section 7(u)
of notice of the commencement of any action, suit or proceeding, such
indemnified party shall, if a claim in respect thereof is to be made against one
or more indemnifying parties under this Section 7(u), notify each party against
whom indemnification is to be sought in writing of the commencement thereof (but
the failure to notify an indemnifying party shall not relieve it from any
liability which it may have under Sections 7(u)(1) or (2) unless and to the
extent that it has been prejudiced in a material respect by such failure or from
the forfeiture of substantial rights and defenses). In case any such action,
suit or proceeding is brought against any indemnified party, and it notifies an
indemnifying party or parties of the commencement thereof, the indemnifying
party or parties will be entitled to participate therein, and to the extent it
may elect by written notice delivered to the indemnified party promptly after
receiving the aforesaid notice from such indemnified party, to assume the
defense thereof with counsel reasonably satisfactory to such indemnified party,
which may be the same counsel as counsel to the indemnifying party.
Notwithstanding the foregoing, the indemnified party or parties shall have the
right to employ its or their own counsel in any such case but the fees and
expenses of such counsel shall be at the expense of such indemnified party or
parties unless (i) the employment of such counsel shall have been authorized in
writing by the indemnifying parties in connection with the defense of such
action at the expense of the indemnifying party, (ii) the indemnifying parties
shall not have employed counsel reasonably satisfactory to such indemnified
party to take charge of the defense of such action within a reasonable time
after notice of commencement of the action or (iii) such indemnified party or
parties shall have reasonably concluded, after consultation with counsel to such
indemnified party or parties, that a conflict of interest exists which makes
representation by counsel chosen by the indemnifying party not advisable (in
which case the indemnifying parties shall not have the right to direct the
defense of such action on behalf of the indemnified party or parties), in any of
which events such fees and expenses of one additional counsel shall be borne by
the indemnifying parties. In no event shall the indemnifying parties be liable
for fees and expenses of more than one counsel (in addition to any local
counsel) separate from their own counsel for all indemnified parties in
connection with any one action or separate but similar or related actions in the
same jurisdiction arising out of the same general allegations or circumstances.
Anything in this Section 7 to the contrary notwithstanding, an indemnifying
party shall not be liable for any settlement of any claim or action effected
without its written consent.

     (4) In order to provide for just and equitable contribution in any case in
which (i) an indemnified party makes claim for indemnification pursuant to this
Section 7(u), but it is judicially determined (by the entry of a final judgment
or decree by a court of competent jurisdiction and the expiration of time to
appeal or the denial of the last right of appeal) that such indemnification may
not be enforced in such case notwithstanding the fact that the express
provisions of this Section 7(u) provide for indemnification in such case, or
(ii) contribution under the Securities Act may be required, then each
indemnifying party, in lieu of indemnifying such indemnified


                                      -9-


   11


party, shall contribute to the amount paid as a result of such losses, claims,
damages, expenses or liabilities (or actions, suits, proceedings or litigation
in respect thereof) in such proportion as is appropriate to reflect the relative
fault of each of the contributing parties, on the one hand, and the party to be
indemnified, on the other hand, in connection with the statements or omissions
that resulted in such losses, claims, damages, expenses or liabilities, as well
as any other relevant equitable considerations. Relative fault shall be
determined by reference to, among other things, whether the untrue or alleged
untrue statement of a material fact or the omission or alleged omission to state
a material fact relates to information supplied by the Company or by a Holder,
and the parties' relative intent, knowledge, access to information and
opportunity to correct or prevent such untrue statement or omission. The amount
paid or payable by an indemnified party as a result of the losses, claims,
damages, expenses or liabilities (or actions, suits, proceedings or litigation
in respect thereof) referred to above in this subsection (4) shall be deemed to
include any legal or other expenses reasonably incurred by such indemnified
party in connection with investigating, preparing or defending any such action,
claim, suit, proceeding or litigation. Notwithstanding the provisions of this
subsection (4), no Holder shall be required to contribute any amount in excess
of the amount by which the total price at which the Warrant Securities sold by
such indemnifying party and distributed to the public were offered to the public
exceeds the amount of any damages that such indemnifying party has otherwise
been required to pay by reason of such untrue or alleged untrue statement or
omission or alleged omission. No person guilty of fraudulent misrepresentation
(within the meaning of Section 12(f) of the Securities Act) shall be entitled to
contribution from any person who was not guilty of such fraudulent
misrepresentation. For purposes of this Section 7, each person, if any, who
controls the Company within the meaning of the Securities Act, each executive
officer of the Company and each director of the Company shall have the same
rights to contribution as the Company, subject in each case to this subsection
(4). Any party entitled to contribution will, promptly after receipt of notice
of commencement of any action, suit, proceeding or litigation against such party
in respect to which a claim for contribution may be made against another party
or parties under this subsection (4), notify such party or parties from whom
contribution may be sought, but the omission so to notify such party or parties
shall not relieve the party or parties from whom contribution may be sought from
any obligation it or they may have hereunder or otherwise than under this
subsection (4), or to the extent that such party or parties were not adversely
affected by such omission. The contribution agreement set forth above shall be
in addition to any liabilities which any indemnifying party may have at common
law or otherwise.

     (v) Notwithstanding the foregoing provisions of this Section 7.3, no
registration rights shall be extended pursuant to this Section 7 with respect to
any Warrant Securities (i) which have been sold pursuant to and in accordance
with an effective Registration Statement, (ii) sold in accordance with Rule 144
under the Securities Act or (iii) eligible for sale under Rule 144(k) under the
Securities Act.

     8. Adjustments to Exercise Price and Number of Securities.
        ------------------------------------------------------

     8.1 Adjustments.
         -----------

     (a) In the event that the Company shall subdivide its outstanding shares of
Common Stock into a greater number of shares or combine its outstanding shares
of Common Stock into a smaller number of shares, the Exercise Price in effect
immediately prior thereto shall be forthwith proportionately decreased in the
case of a subdivision or increased in the case of a combination. An adjustment
made pursuant to this Section 8.1(a) shall become effective immediately after
the record date for the determination of stockholders entitled to receive such
dividend or distribution and shall become effective immediately after the date
of such subdivision or combination, as the case may be.

     (b) In the event that the Company shall (i) issue or distribute (for no
consideration or at a price per share less than the Current Market Price (as
defined below) per share on the date of such issuance or distribution shares of
any class of capital stock of the Company (such shares being hereafter referred
to as "Capital Stock") generally to holders of Common Stock or to holders of any
class or series of Capital Stock which is convertible into or exchangeable or
exercisable for Common Stock (excluding an issuance or distribution of Common
Stock described in Section 8.1(a)) or (ii) issue or distribute generally to
such holders rights, warrants, options or convertible or exchangeable securities
entitling the holder thereof to subscribe for, purchase, convert into or
exchange for Capital Stock at a price per share less than the Current Market
Price per share of such Capital Stock


                                      -10-


   12


on the date of such issuance or distribution, then, in each such case, at the
earliest of (A) the date the Company enters into a firm contract for such
issuance or distribution, (B) the record date for the determination of
stockholders entitled to receive any such Capital Stock or any such rights,
warrants, options or convertible or exchangeable securities or (C) the date of
actual issuance or distribution of any such Capital Stock or any such rights,
warrants, options or convertible or exchangeable securities, the Exercise Price
shall be reduced by multiplying the Exercise Price in effect immediately prior
to such earliest date by:

          (x) if such Capital Stock is Common Stock, a fraction the numerator of
          which is the number of shares of Common Stock outstanding on such
          earliest date plus the number of shares of Common Stock which could be
          purchased at the Current Market Price per share of Common Stock on the
          date of such issuance or distribution with the aggregate consideration
          (based on the fair market value thereof as determined by the Board of
          Directors, whose determination shall be conclusive and described in a
          certificate provided to each Holder) received or receivable by the
          Company either (A) in connection with such issuance or distribution or
          (B) upon the conversion, exchange, purchase or subscription of all
          such rights, warrants, options or convertible or exchangeable
          securities (the "Aggregate Consideration"), and the denominator of
          which is the number of shares of Common Stock outstanding on such
          earliest date plus the number of shares of Common Stock to be so
          issued or distributed or to be issued upon the conversion, exchange,
          purchase or subscription of all such rights, warrants, options or
          convertible or exchangeable securities; or

          (y) if such Capital Stock is other than Common Stock, a fraction the
          numerator of which is the Current Market Price per share of Common
          Stock on such earliest date minus an amount equal to (A) the sum of
          (1) the Current Market Price per share of such Capital Stock
          multiplied by the number of shares of such Capital Stock to be so
          issued minus (2) the Aggregate Consideration, divided by (B) the
          number of shares of Common Stock outstanding on such date, and the
          denominator of which is the Current Market Price per share of Common
          Stock on such earliest date.

Such adjustment shall be made successively whenever any such Capital Stock,
rights, warrants, options or convertible or exchangeable securities are so
issued or distributed. In determining whether any rights, warrants, options or
convertible or exchangeable securities entitle the holders thereof to subscribe
for, purchase, convert into or exchange for shares of such Capital Stock at less
than such Current Market Price, there shall be taken into account the fair
market value (as determined by the Board of Directors, whose determination shall
be conclusive and described in a certificate provided to each Holder) of any
consideration received or receivable by the Company for such rights, warrants,
options or convertible or exchangeable securities. If any right, warrant, option
or convertible or exchangeable securities, the issuance of which resulted in an
adjustment in the Exercise Price pursuant to this Section 8.1(b), shall expire
and shall not have been exercised, the Exercise Price shall immediately upon
such expiration be recomputed to the Exercise Price which would have been in
effect if such right, warrant, option or convertible or exchangeable securities
had never been distributed or issued. Notwithstanding anything contained in this
paragraph to the contrary, the issuance of Capital Stock upon the exercise of
such rights, warrants or options or the conversion or exchange of such
convertible or exchangeable securities will not cause an adjustment in the
Exercise Price if no such adjustment would have been required at the time such
right, warrant, option or convertible or exchangeable security was issued or
distributed; provided, however, that, if the consideration payable upon such
exercise, conversion or exchange and/or the Capital Stock receivable thereupon
are changed after the time of the issuance or distribution of such right,
warrant, option or convertible or exchangeable security, then such change shall
be deemed to be the expiration thereof without having been exercised and the
issuance or distribution of new options, rights, warrants or convertible or
exchangeable securities.

     Notwithstanding anything contained in this Agreement to the contrary,
options, rights or warrants issued or distributed by the Company, including
options, rights or warrants distributed prior to the date of this Agreement, to
holders of Common Stock generally which, until the occurrence of a specified
event or events (a "Trigger Event"), (i) are deemed to be transferred with
Common Stock, (ii) are not exercisable and (iii) are also issued on a pro rata
basis with respect to future issuances of Common Stock, shall be deemed not to
have been issued or distributed for purposes of this Section 8.1(b) (and no
adjustment to the Exercise Price under this Section


                                      -11-


   13


8.1(b) will be required) until the occurrence of the earliest Trigger Event.
Upon the occurrence of a Trigger Event, such options, rights or warrants shall
continue to be deemed not to have been issued or distributed for purposes of
this Section 8.1(b) (and no adjustment to the Conversion Price under this
Section 8.1(b) will be required) if and for so long as each Holder who
thereafter exercises such Holder's Warrants shall be entitled to receive upon
such exercise, in addition to the shares of Common Stock issuable upon such
conversion, a number of such options, rights or warrants, as the case may be,
equal to the number of options, rights or warrants to which a holder of the
number of shares of Common Stock equal to the number of shares of Common Stock
issuable upon exercise of such Holder's Warrants is entitled to receive at the
time of such exercise in accordance with the terms and provisions of and
applicable to such options, rights or warrants. Upon the expiration of any such
options, rights or warrants or at such time, if any, as a Holder is not entitled
to receive such options, rights or warrants upon exercise of such Holder's
Warrants, an adjustment (if any is required) to the Conversion Price shall be
made in accordance with this Section 8.1(b) with respect to the issuance of all
such options, rights and warrants as of the date of issuance thereof, but
subject to the provisions of the preceding paragraph. If any such option, right
or warrant, including any such options, rights or warrants distributed prior to
the date of this Agreement, are subject to events, upon the occurrence of which
such options, rights or warrants become exercisable to purchase different
securities, evidences of indebtedness, cash, properties or other assets or
different amounts thereof, then, subject to the preceding provisions of this
paragraph, the date of the occurrence of any and each such event shall be deemed
to be the date of distribution and record date with respect to new options,
rights or warrants with such new purchase rights (and a termination or
expiration of the existing options, rights or warrants without exercise
thereof). In addition, in the event of any distribution (or deemed distribution)
of options, rights or warrants, or any Trigger Event or other event of the type
described in the preceding sentence, that required (or would have required but
for the provisions of Section 8.3 or this paragraph) an adjustment to the
Exercise Price under this Section 8.1(b) and such options, rights or warrants
shall thereafter have been redeemed or repurchased without having been
exercised, then the Exercise Price shall be adjusted upon such redemption or
repurchase to give effect to such distribution, Trigger Event or other event, as
the case may be, as though it had instead been a cash distribution, equal on a
per share basis to the result of the aggregate redemption or repurchase price
received by holders of such options, rights or warrants divided by the number of
shares of Common Stock outstanding as of the date of such repurchase or
redemption, made to holders of Common Stock generally as of the date of such
redemption or repurchase.

     Notwithstanding anything contained in this Section 8.1(b) to the contrary,
no adjustment shall be made in the Exercise Price pursuant to this Section
8.1(b) with respect to the issuance of Common Stock or options or other rights
to purchase Common Stock pursuant to any employee stock purchase, bonus, award,
grant, option or ownership plan (including, without limitation, an employee
stock ownership plan which is part of an employee benefit plan qualified under
Section 401 of the Internal Revenue Code of 1986, as amended (the "Code"), an
employee stock option or incentive stock option plan qualified under Section 422
of the Code and a restricted stock plan), including the issuance of Common Stock
upon the exercise of such options; provided, that, for purposes of this
paragraph, the term "employee" includes directors, consultants and advisors and
the term "plan" means a plan, program or arrangement in which 5 or more persons
are eligible to participate (or, if only directors of the Company are eligible
to participate and there are fewer than 5 such directors, in which all of such
directors are eligible to participate).

     (c) If the Company shall pay or distribute, as a dividend or otherwise,
generally to holders of Common Stock or any class or series of Capital Stock
which is convertible into or exercisable or exchangeable for Common Stock any
assets, properties or rights (including, without limitation, evidences of
indebtedness of the Company, any subsidiary or any other person or entity, cash
or Capital Stock or other securities of the Company, any subsidiary or any other
person or entity, but excluding payments and distributions as described in
Section 8.1(a) or 8.1(b), dividends and distributions in connection with the
liquidation, dissolution or winding up of the Company in its entirety and
distributions consisting solely of cash described in Section 8.1(d)), then in
each such case the Exercise Price shall be reduced by multiplying the Exercise
Price in effect immediately prior to the date of such payment or distribution by
a fraction, the numerator of which is the Current Market Price per share of
Common Stock on the record date for the determination of stockholders entitled
to receive such payment or distribution less the fair market value (as
determined by the Board of Directors, whose determination shall be conclusive
and described in a certificate provided to each Holder) on such record date of
the assets or evidences of indebtedness so distributed attributable to one share
of Common Stock (the amount so attributable equaling the aggregate fair


                                      -12-


   14


market value of such indebtedness or assets, as so determined by the Board of
Directors, divided by the number of shares of Common Stock outstanding on such
record date), and the denominator shall be the Current Market Price per share of
Common Stock on such record date. Such adjustment shall become effective
immediately after the record date for the determination of shareholders entitled
to receive such distribution.

     (d) If the Company shall, by dividend or otherwise, make a distribution
(other than in connection with the liquidation, dissolution or winding up of the
Company in its entirety), generally to holders of Common Stock or any class or
series of Capital Stock which is convertible into or exercisable or exchangeable
for Common Stock, consisting solely of cash where (x) the sum of (i) the
aggregate amount of such cash plus (ii) the aggregate amount of all cash so
distributed (by dividend or otherwise) to such holders within the 12-month
period ending on the record date for determining stockholders entitled to
receive such distribution with respect to which no adjustment has been made to
the Exercise Price pursuant to this Section 8.1(d) exceeds (y) 10% of the result
of the multiplication of (1) the Current Market Price per share of Common Stock
on such record date times (2) the number of shares of Common Stock outstanding
on such record date, then the Exercise Price shall be reduced, effective
immediately prior to the opening of business on the day following such record
date, by multiplying the Exercise Price in effect immediately prior to the close
of business on the day prior to such record date by a fraction, the numerator of
which is the Current Market Price per share of Common Stock on such record date
less the aggregate amount of cash per share so distributed and the denominator
of which is such Current Market Price; provided, however, that, if the aggregate
amount of cash per share is equal to or greater than such Current Market Price,
then, in lieu of the foregoing adjustment, adequate provision shall be made so
that each Holder shall have the right to receive upon conversion (with respect
to each share of Common Stock issued upon such conversion and in addition to the
Common Stock issuable upon conversion) the aggregate amount of cash per share
such Holder would have received had such Holder's Warrants been exercised
immediately prior to such record date. In no event shall the Exercise Price be
increased pursuant to this Section 8.1(d); provided, however, that if such
distribution is not so made, the Exercise Price shall be adjusted to be the
Exercise Price which would have been in effect if such distribution had not been
declared. For purposes of this paragraph of this Section 8.1(d), such aggregate
amount of cash per share shall equal such sum divided by the number of shares of
Common Stock outstanding on such record date.

     (e) Anything in this Section 8 to the contrary notwithstanding, the Company
shall be entitled to make such reductions in the Exercise Price, in addition to
those required by this Section 8.1, as it in its discretion shall determine to
be advisable.

     (f) For purposes of this Agreement, "Current Market Price" means, when used
with respect to any security as of any date, the last sale price, regular way,
or, in case no such sale takes place on such date, the average of the closing
bid and asked prices, regular way, in either case as reported for consolidated
transactions on the Nasdaq National Market system or, if the security is not
listed or admitted to trading on the Nasdaq National Market system, as reported
for consolidated transactions with respect to such security listed on the
principal national securities exchange on which such security is listed or
admitted to trading or, if the security is not listed or admitted to trading on
any national securities exchange, the last quoted price or, if not so quoted,
the average of the high bid and low asked prices in the over-the-counter market,
as reported by the National Association of Securities Dealers, Inc. Automated
Quotations System or such other system then in use or, if the security is not
quoted by any such organization, the average of the closing bid and asked prices
furnished by a New York Stock Exchange member firm selected by the Company.
"Current Market Price" means, when used with respect to a security as to which
none of the above-mentioned prices are available and with respect to any
property other than a security, as of any date, the market value of such
security or property on such date as determined by the Board of Directors of the
Company in good faith, which shall be entitled to rely for such purposes on the
advice of any firm of investment bankers or appraisers having familiarity with
such property.

     8.2 MERGER OR CONSOLIDATION. In the event of (i) any reclassification
(including, without limitation, a reclassification effected by means of an
exchange or tender offer by the Company or any Subsidiary) or change of
outstanding Common Stock (other than a change in par value, or from par value to
no par value, or from no par value to par value, or as a result of a subdivision
or combination), (ii) any consolidation, merger or combination of the Company
with another corporation as a result of which holders of Common Stock shall be


                                      -13-


   15


entitled to receive securities or other assets (including cash) with respect to
or in exchange for Common Stock or (iii) any sale or conveyance of the assets of
the Company as, or substantially as, an entirety to any other corporation as a
result of which holders of Common Stock shall be entitled to receive securities
or other assets (including cash) with respect to or in exchange for Common
Stock, then the Company or the successor or purchasing corporation, as the case
may be, shall execute and deliver to the Holder upon surrender of the Warrant
Certificate held by such Holder a supplemental warrant agreement providing that
the holder of each Warrant then outstanding or to be outstanding shall have the
right thereafter (until the expiration of such Warrant) to receive, upon full
exercise of such Warrant, the kind and amount of shares of stock and/or other
securities and/or property receivable upon such consolidation or merger, by a
holder of the number of shares of Common Stock for which such Warrant might have
been exercised immediately prior to such consolidation or merger. Such
supplemental warrant agreement shall provide for adjustments which shall be as
nearly equivalent as practicable to the adjustments provided for in this Section
8. The above provision of this subsection shall similarly apply to successive
consolidations or mergers.

     8.3 NO ADJUSTMENT OF EXERCISE PRICE IN CERTAIN CASES. No adjustment of the
Exercise Price shall be made if the amount of said adjustment shall be less than
two cents (2(cent)) per Warrant Security, provided, however, that in such case
any adjustment that would otherwise be required then to be made shall be carried
forward and shall be made at the time of and together with the next subsequent
adjustment which, together with any adjustment so carried forward, shall amount
to at least two cents (2(cent)) per Warrant Security.

     8.4 ADJUSTMENT IN NUMBER OF SECURITIES. Upon each adjustment of the
Exercise Price pursuant to the provisions of Section 8.1(a) or (b), the number
of shares of Common Stock issuable upon exercise at the adjusted Exercise Price
of each Warrant shall be adjusted to the nearest full amount by multiplying a
number equal to the Exercise Price in effect immediately prior to such
adjustment by the number of shares of Common Stock issuable upon exercise of
Warrants immediately prior to such adjustment and dividing the product so
obtained by the adjusted Exercise Price.

     8.5 CERTIFICATE OF ADJUSTMENT. After each adjustment of the Exercise Price
or the amount of Warrant Securities purchasable upon exercise of Warrants
pursuant to this Section 8, the Company will promptly prepare a certificate
signed by the Chairman or President, and by the Treasurer or an Assistant
Treasurer or the Secretary or an Assistant Secretary, of the Company setting
forth: (i) the Exercise Price, as so adjusted; (ii) the amount of Warrant
Securities purchasable upon exercise of each Warrant after such adjustment; and
(iii) a brief statement of the facts accounting for such adjustment. The Company
will promptly file such certificate with its records and cause a brief summary
thereof to be sent by ordinary first class mail to each Holder at his or her
last address as it shall appear on the registry books of the Company.

     8.6 VALIDITY OF WARRANT CERTIFICATE. Irrespective of any adjustments or
changes in the Exercise Price or the amount of Warrant Securities purchasable
upon exercise of Warrants, Warrant Certificates theretofore and thereafter
issued shall continue to express the Exercise Price per share and the amount of
Warrant Securities purchasable thereunder as of the date such Warrant
Certificates were originally issued; provided, the Holders shall be entitled to
exercise Warrants represented by such Warrant Certificates after giving effect
to each such adjustment and change, and such Warrant Certificate shall be deemed
to incorporate each such adjustment and change as if new Warrant Certificates
reflecting each such adjustment and change had been issued to the Holders.

     9. Exchange, Replacement and Transfer of Warrant Certificates.
        ----------------------------------------------------------

     (a) Each Warrant Certificate is exchangeable, without expense, and subject
to the provisions of Section 5 and 9(c), upon the surrender thereof by the
Holder at the principal executive office of the Company, for a new Warrant
Certificate of like tenor and date representing in the aggregate the right to
purchase the same number of Warrant Securities in such denominations as shall be
designated by the Holder thereof at the time of such surrender.

     (b) Upon receipt by the Company of evidence reasonably satisfactory to it
of the loss, theft, destruction or mutilation of any Warrant Certificate, and,
in case of loss, theft or destruction, of indemnity or security reasonably
satisfactory to it, and reimbursement to the Company of all reasonable expenses
incidental


                                      -14-


   16


thereto, and upon surrender and cancellation of such Warrant Certificates, if
mutilated, the Company will make and deliver a new Warrant Certificate of like
tenor in lieu thereof.

     (c) The Company will maintain a register containing the name and address of
the Holder of each Warrant Certificate. Any Holder may change its or his address
as shown on the warrant register by written notice to the Company requesting
such change. Subject to the provisions of Section 5 hereof, the Warrants and all
rights thereunder are transferrable, in whole and not in part, upon surrender of
the Warrant Certificates representing such Warrants with a properly executed
assignment (in the form of Exhibit B hereto) at the principal office of the
Company. Until any transfer of the Warrants is made in the warrant register, the
Company may treat the Holder of such Warrants as the absolute owner thereof for
all purposes; provided, however, that if and when the Warrant Certificate
representing such Warrants is properly assigned in blank, the Company may (but
shall not be obligated to) treat the bearer thereof as the absolute owner
thereof for all purposes, notwithstanding any notice to the contrary.

     10. ELIMINATION OF FRACTIONAL INTERESTS. The Company shall not be required
to issue certificates representing fractions of shares of Common Stock upon the
exercise of the Warrants to purchase Common Stock, nor shall it be required to
issue scrip or pay cash in lieu of fractional interests, it being the intent of
the parties that all fractional interests shall be eliminated by rounding any
fraction up to the nearest whole number of shares of Common Stock or other
securities, properties or rights.

     11. RESERVATION AND LISTING OF SECURITIES. The Company shall at all times
reserve and keep available out of its authorized capital stock, solely for the
purpose of issuance upon the exercise of the Warrants, such number of shares of
Common Stock or other securities, property or rights as shall be issuable upon
exercise thereof. The Company covenants and agrees that, upon exercise of the
Warrants and payment of the Exercise Price therefor, all shares of Common Stock
and other securities issued by the Company upon such exercise shall be duly and
validly issued, fully paid, non-assessable and not subject to the preemptive
rights of any security holder of the Company. As long as the Warrants shall be
outstanding, the Company shall use its reasonable best efforts to cause the
Common Stock issuable upon the exercise of the Warrants to be listed (subject to
official notice of issuance) on all securities exchanges on which the Common
Stock may then be listed and/or quoted on the Nasdaq Stock Market if the Common
Stock issued to the public is so quoted.

     12. NOTICES TO HOLDERS. Nothing contained in this Agreement shall be
construed as conferring upon the Holders the right to receive dividends or to
vote or to consent or to receive notice as a stockholder in respect of any
meetings of stockholders for the election of directors or any other matter or as
having any rights whatsoever as a stockholder of the Company. If, however, at
any time prior to the expiration of the Warrants and their exercise, any of the
following events shall occur:

          (a) the Company shall set a record date for the purpose of entitling
     them to receive a dividend or distribution payable otherwise than in cash,
     or a cash dividend or distribution payable otherwise than out of current or
     retained earnings, as indicated by the accounting treatment of such
     dividend or distribution on the books of the Company; or


          (b) the Company shall offer to all the holders of shares of Common
     Stock any additional shares of capital stock of the Company or securities
     convertible into or exchangeable for shares of capital stock of the
     Company, or any option, right or warrant to subscribe therefor; or

          (c) a dissolution, liquidation or winding up of the Company (other
     than in connection with a consolidation or merger) or a sale of all or
     substantially all of its property, assets and business as an entirety shall
     be proposed;

then, in any one or more of said events, the Company shall give written notice
of such event to each Holder at least 10 days prior to the date fixed as a
record date or the date of closing the transfer books for the determination of
the stockholders entitled to such dividend, distribution or offer, or entitled
to vote on such proposed dissolution, liquidation, winding up or sale. Such
notice shall specify such record date or the date of closing the transfer books,


                                      -15-


   17


as the case may be. Failure to give such notice or any defect therein shall not
affect the validity of any action taken in connection with any of the events
described in this Section 12.

     13. Notices.
         -------

     All notices, requests, consents and other communications hereunder shall be
in writing and shall be deemed to have been duly made and sent when delivered,
or mailed by registered or certified mail, return receipt requested:

               (a) If to a Holder, to the address of such Holder as shown on the
          books of the Company; or

               (b) If to the Company, to the address set forth in Section 3
          hereof or to such other address as the Company may designate by notice
          to the Holders.

     14. SUPPLEMENTS AND AMENDMENTS. The Company and the Initial Purchaser may
from time to time supplement or amend this Agreement without the approval of any
Holders (other than the Initial Purchaser) in order to cure any ambiguity, to
correct or supplement any provision contained herein which may be defective or
inconsistent with any provisions herein, or to make any other provisions in
regard to matters or questions arising hereunder which the Company and the
Initial Purchaser may deem necessary or desirable and which the Company and the
Initial Purchaser deem shall not adversely affect the interests of the Holders
in any material respect.

     15. SUCCESSORS. All the covenants and provisions of this Agreement shall be
binding upon and inure to the benefit of the Company, the Holders and their
respective successors and assigns hereunder.

     16. TERMINATION. This Agreement shall terminate at the close of business on
April 2, 2004. Notwithstanding the foregoing, the indemnification provisions of
Section 7 shall survive such termination until the close of business on April 2,
2009.

     17. GOVERNING LAW. This Agreement and each Warrant Certificate issued
hereunder shall be deemed to be a contract made under the laws of the State of
New York and for all purposes shall be construed in accordance with the laws of
said State without giving effect to the rules of said State governing the
conflicts of laws.

     18. ENTIRE AGREEMENT; MODIFICATION. This Agreement (including the Purchase
Agreement to the extent portions thereof are referred to herein) contains the
entire understanding between the parties hereto with respect to the subject
matter hereof. Except as set forth in Section 14 hereof, this Agreement may not
be modified or amended except by a writing duly signed by the party against whom
enforcement of the modification or amendment is sought.

     19. SEVERABILITY. If any provision of this Agreement shall be held to be
invalid or unenforceable, such invalidity or unenforceability shall not affect
any other provision of this Agreement.

     20. CAPTIONS. The caption headings of the Sections of this Agreement are
for convenience of reference only, and are not intended, nor should they be
construed as, a part of this Agreement and shall be given no substantive effect.

     21. BENEFITS OF THIS AGREEMENT. Nothing in this Agreement shall be
construed to give to any person, corporation or entity other than the Company
and the Initial Purchaser and any other Holders of Warrants and/or Warrant
Securities any legal or equitable right, remedy or claim under this Agreement;
and this Agreement shall be for the sole and exclusive benefit of the Company
and the Initial Purchaser and any other Holders of Warrants and/or Warrant
Securities.


                                      -16-


   18


     22. COUNTERPARTS. This Agreement may be executed in any number of
counterparts and each of such counterparts shall for all purposes be deemed to
be an original and such counterparts shall together constitute but one and the
same instrument.

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed as of the day and year first above written.


[SEAL]                                HYBRIDON, INC.


                                      By: /s/ E. Andrews Grinstead, III
                                         ---------------------------------
                                          Name: E. Andrews Grinstead, III
                                          Title: Chairman, President and Chief
Attest:                                          Executive Officer

/s/ Anthony J. Payne
- -----------------------------       
Name: Anthony J. Payne
Title: Chief Financial Officer


                                      FORUM CAPITAL MARKETS L. P.



                                      By: /s/ C. Keith Hartley
                                         ----------------------------------
                                         Name:  C. Keith Hartley
                                         Title:  Senior Managing Director


                                      -17-


   19


                                                                     EXHIBIT A



                          [FORM OF WARRANT CERTIFICATE]

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER
THE SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES ACT"), AND MAY NOT BE
OFFERED OR SOLD EXCEPT PURSUANT TO (i) AN EFFECTIVE REGISTRATION STATEMENT UNDER
THE SECURITIES ACT OR (ii) AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES
ACT, IF AN OPINION OF COUNSEL, REASONABLY SATISFACTORY TO COUNSEL FOR THE
ISSUER, IS DELIVERED THAT SUCH AN EXEMPTION IS AVAILABLE FOR SUCH TRANSFER.

THE TRANSFER OR EXCHANGE OF THE WARRANTS REPRESENTED BY THIS CERTIFICATE IS
RESTRICTED IN ACCORDANCE WITH THE WARRANT AGREEMENT REFERRED TO HEREIN.

                            EXERCISABLE ON OR BEFORE
                     5:30 P.M., NEW YORK TIME, APRIL 2, 2002

No. W-                                                                 Warrants
                                                                    ---


                               WARRANT CERTIFICATE

     This Warrant Certificate certifies that      , or registered assigns, is
the registered holder of      Warrants to purchase initially, at any time from
March   , 1998 until 5:30 p.m. New York time on April 2, 2002 (the "Expiration
Date"), up to            fully-paid and non-assessable shares of Common Stock,
par value $.001 per share (the "Common Stock"), of HYBRIDON, INC. (the
"Company"), at the initial exercise price, subject to adjustment in certain
events (the "Exercise Price"), of $7.0125 per share upon surrender of this
Warrant Certificate and payment of the Exercise Price, at an office or agency of
the Company, but subject to the conditions set forth herein and in the warrant
agreement dated as of March 26, 1997 between the Company and Forum Capital
Markets L.P. (the "Warrant Agreement"). Payment of the Exercise Price, shall be
made by certified or official bank check in New York Clearing House funds
payable to the order of the Company and upon surrender of this Warrant
Certificate.

     No Warrant may be exercised after 5:30 p.m., New York time, on the
Expiration Date, at which time all Warrants evidenced hereby, unless exercised
prior thereto, shall thereafter be void.

     The Warrants evidenced by this Warrant Certificate are part of a duly
authorized issue of Warrants issued pursuant to the Warrant Agreement, which
Warrant Agreement is hereby incorporated by reference in and made a part of this
instrument and is hereby referred to for a description of the rights, limitation
of rights, obligations, duties and immunities thereunder of the Company and the
holders (the words "holders" or "holder" meaning the registered holders or
registered holder) of the Warrants. In the event that any provision of this
Warrant Certificate conflicts with or is inconsistent with the terms of the
Warrant Agreement, the terms of the Warrant Agreement shall supersede the
provisions of this Warrant Certificate.

     The Warrant Agreement provides that upon the occurrence of certain events
the Exercise Price and the amount the type and/or number of the Company's
securities issuable hereunder may, subject to certain conditions, be adjusted.
Subject to Section 8.6 of the Warrant Agreement, in such event, the Company
will, at the request of the holder, issue a new Warrant Certificate evidencing
the adjustment in the Exercise Price and the number and/or type of securities
issuable upon the exercise of the Warrants; provided, however, that the failure
of the Company to issue such new Warrant Certificates shall not in any way
change, alter or otherwise impair the rights of the holder as set forth in the
Warrant Agreement.


                                      A-1

   20




     Upon due presentment for registration of transfer of this Warrant
Certificate at an office or agency of the Company and subject to compliance with
the terms of the Warrant Agreement, a new Warrant Certificate or Warrant
Certificates of like tenor and evidencing in the aggregate a like number of
Warrants shall be issued to the transferee(s) in exchange for this Warrant
Certificate, subject to the limitations provided herein and in the Warrant
Agreement, without any charge except for any tax or other governmental charge
imposed in connection with such transfer.

     Upon the exercise of less than all of the Warrants evidenced by this
Certificate, the Company shall forthwith issue to the holder hereof a new
Warrant Certificate representing such number of unexercised Warrants.

     The Company may deem and treat the registered holder(s) hereof as the
absolute owner(s) of this Warrant Certificate (notwithstanding any notation of
ownership or other writing hereon made by anyone), for the purpose of any
exercise hereof, and of any distribution to the holder(s) hereof, and for all
other purposes, and the Company shall not be affected by any notice to the
contrary.

     All terms used in this Warrant Certificate which are defined in the Warrant
Agreement shall have the meanings assigned to them in the Warrant Agreement.

     IN WITNESS WHEREOF, the Company has caused this Warrant Certificate to be
duly executed under its corporate seal.

Dated as of                        , 199  
            -----------------------     --

                                              HYBRIDON, INC.



[SEAL]                                        By:
                                                 ----------------------------
                                                 Name:
                                                 Title:


Attest:


- ---------------------------
Name:
Title:



                                       A-2


   21





              [FORM OF ELECTION TO PURCHASE PURSUANT TO SECTION 3]

     The undersigned hereby irrevocably elects to exercise the right,
represented by this Warrant Certificate, to purchase          shares of Common
Stock and herewith tenders in payment for such securities a certified or
official bank check payable in New York Clearing House Funds to the order of
Hybridon, Inc. in the amount of $         , all in accordance with the terms of
Section 3 of the Initial Purchaser's Warrant Agreement dated as of
March 26, 1997 between Hybridon, Inc., and Forum Capital Markets L.P. The
undersigned requests that a certificate for such securities be registered in 
the name of                whose address is                                   
and that such certificate be delivered to                 whose address is     
                                       .


Dated:                             
        -------------------  
                                Signature
                                         --------------------------------
                                (Signature must conform in all respects to
                                name of holder as specified on the face of
                                the Warrant Certificate.)


                                 ----------------------------------------
                                (Insert Social Security or Other Identifying
                                 Number of Holder)




                                      A-3


   22


                                                                       ANNEX B
                                                        TO WARRANT CERTIFICATE

                              [FORM OF ASSIGNMENT]



             (To be executed by the registered holder if such holder
                  desires to transfer the Warrant Certificate.)


     FOR VALUE RECEIVED                     hereby sells, assigns and transfers
 unto


                  (Please print name and address of transferee)

the within Warrant Certificate, together with all right, title and interest
therein, and does hereby irrevocably constitute and appoint                  
Attorney to transfer the within Warrant Certificate on the books of the within-
named Company, with full power of substitution.



Dated:              
     -------------------         Signature:
                                           ------------------------------------
                                 (Signature must conform in all respects to name
                                 of holder as specified on the face of the
                                 Warrant Certificate.)



                                 ----------------------------------------------
                                 (Insert Social Security or Other Identifying
                                 Number of Assignee)




                                      A-4


   1

                                                                  Exhibit 99.1

[LOGO:HYBRIDON]                                           [LOGO:NEWS RELEASE]

                                                                              

FOR IMMEDIATE RELEASE  Hybridon, Inc.       TEL: 617.528.7000 Fax: 617.528.7001
                       620 Memorial Drive   www.hybridon.com
                       Cambridge, MA 02139



                              Contact: Robin Hogen
                                       Vice President, Corporate Communications
                                       and Public Affairs
                                       617.528.7504



                 HYBRIDON ENTERS INTO AGREEMENT FOR THE SALE OF
                  $50 MILLION OF CONVERTIBLE SUBORDINATED NOTES

     CAMBRIDGE, MA., March 27, 1997 - Hybridon, Inc. (Nasdaq: HYBN), announced
     today that it has entered into an agreement for the sale of 9% convertible
     subordinated notes due 2004 in the original purchase amount of $50,000,000.
     The closing is expected to occur on April 2, 1997, and is subject to the
     satisfaction of certain conditions. The notes will be convertible into
     shares of common stock at a price of $ 7.0125 per share.

     Hybridon, a biopharmaceutical company headquartered in Cambridge,
     Massachusetts, is a leader in the discovery and development of novel
     genetic medicines based primarily on antisense technology. Antisense
     involves the use of synthetic segments of nucleic acid, called
     oligonucleotides, constructed through rational drug design to modulate
     protein expression by interacting at the genetic level with target
     messenger RNA.

                                      ###

     NOTE: THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
     1933, AS AMENDED. ACCORDINGLY, SUBJECT TO REGISTRATION OR CERTAIN
     EXEMPTIONS THEREFROM, THESE SECURITIES MAY NOT BE OFFERED OR SOLD DIRECTLY
     OR INDIRECTLY IN THE UNITED STATES OF AMERICA, ITS TERRITORIES OR
     POSSESSIONS.



                    Leadership in Genetic Antisense Medicine


   1

                                                                  Exhibit 99.2 

[LOGO:HYBRIDON]                                           [LOGO:NEWS RELEASE]



FOR IMMEDIATE RELEASE  Hybridon, Inc.        TEL: 617.528.7000 Fax: 617.528.7001
                       620 Memorial Drive    www.hybridon.com
                       Cambridge, MA 02139



                              Contact: Robin Hogen
                                       Vice President, Corporate Communications
                                       and Public Affairs
                                       617.528.7504





                   HYBRIDON COMPLETES $50,000,000 OFFERING OF
                         CONVERTIBLE SUBORDINATED NOTES

     CAMBRIDGE, MA., April 2, 1997 -- Hybridon, Inc. (Nasdaq: HYBN), announced
     today that it has completed its previously announced offering of 9%
     convertible subordinated notes due 2004 in the original purchase amount of
     $50,000,000. The notes are convertible into shares of common stock at a
     price of $7.0125 per share.

     Hybridon, a biopharmaceutical company, is a leader in the discovery and
     development of novel genetic medicines based primarily on antisense
     technology. Antisense involves the use of synthetic segments of nucleic
     acid, called oligonucleotides, constructed through rational drug design to
     modulate protein expression by interacting at the genetic level with target
     messenger RNA.

                                      ###

     NOTE: THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
     1933, AS AMENDED. ACCORDINGLY, SUBJECT TO REGISTRATION OR CERTAIN
     EXEMPTIONS THEREFROM, THESE SECURITIES MAY NOT BE OFFERED OR SOLD DIRECTLY
     OR INDIRECTLY IN THE UNITED STATES OF AMERICA, ITS TERRITORIES OR
     POSSESSIONS.



                    Leadership in Genetic Antisense Medicine