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1 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 --------------------- SCHEDULE 13G (Rule 13d-102) INFORMATION STATEMENT PURSUANT TO RULES 13d-1 AND 13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Hybridon, Inc. - -------------------------------------------------------------------------------- (Name of Issuer) Common Stock, $.001 par value per share - -------------------------------------------------------------------------------- (Title of Class of Securities) 44860M 10 8 ----------------------------- (CUSIP Number) 2 - ------------------------------ ----------------------------- CUSIP No. 44860M 10 8 13G Page 2 of 9 ----------- --- --- - ------------------------------ ----------------------------- - ------------------------------------------------------------------------------- 1. NAME OF REPORTING PERSONS S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSONS Medical Science Partners, L.P. - ------------------------------------------------------------------------------- 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP Not Applicable - ------------------------------------------------------------------------------- 3. SEC USE ONLY - ------------------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - ------------------------------------------------------------------------------- 5. SOLE VOTING POWER 0 Shares NUMBER OF ---------------------------------------------------- SHARES 6. SHARED VOTING POWER BENEFICIALLY OWNED BY 1,336,779 Shares EACH ---------------------------------------------------- REPORTING 7. SOLE DISPOSITIVE POWER PERSON WITH: 0 Shares ---------------------------------------------------- 8. SHARED DISPOSITIVE POWER 1,336,779 Shares - ------------------------------------------------------------------------------- 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON. 1,336,779 Shares - ------------------------------------------------------------------------------- 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES. Not Applicable - ------------------------------------------------------------------------------- 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9. 5.3% - ------------------------------------------------------------------------------- 12. TYPE OF REPORTING PERSON. PN - ------------------------------------------------------------------------------- 3 - ------------------------------ ----------------------------- CUSIP No. 44860M 10 8 13G Page 3 of 9 ----------- --- --- - ------------------------------ ----------------------------- - -------------------------------------------------------------------------------- 1. NAME OF REPORTING PERSONS S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSONS Medical Science Ventures, L.P. - -------------------------------------------------------------------------------- 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP Not Applicable - -------------------------------------------------------------------------------- 3. SEC USE ONLY - -------------------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5. SOLE VOTING POWER 0 Shares NUMBER OF ----------------------------------------------------------- SHARES 6. SHARED VOTING POWER BENEFICIALLY OWNED BY 1,336,779 Shares EACH ----------------------------------------------------------- REPORTING 7. SOLE DISPOSITIVE POWER PERSON WITH: 0 Shares ----------------------------------------------------------- 8. SHARED DISPOSITIVE POWER 1,336,779 Shares - -------------------------------------------------------------------------------- 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON. 1,336,779 Shares - -------------------------------------------------------------------------------- 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES. Not Applicable - -------------------------------------------------------------------------------- 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9. 5.3% - -------------------------------------------------------------------------------- 12. TYPE OF REPORTING PERSON. PN - -------------------------------------------------------------------------------- 4 - ------------------------------ ----------------------------- CUSIP No. 44860M 10 8 13G Page 4 of 9 ----------- --- --- - ------------------------------ ----------------------------- - -------------------------------------------------------------------------------- 1. NAME OF REPORTING PERSONS S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSONS Andre L. Lamotte - -------------------------------------------------------------------------------- 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP Not Applicable - -------------------------------------------------------------------------------- 3. SEC USE ONLY - -------------------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION United States of America - -------------------------------------------------------------------------------- 5. SOLE VOTING POWER 15,000 Shares NUMBER OF -------------------------------------------------------- SHARES 6. SHARED VOTING POWER BENEFICIALLY OWNED BY 1,542,171 Shares EACH -------------------------------------------------------- REPORTING 7. SOLE DISPOSITIVE POWER PERSON WITH: 15,000 Shares -------------------------------------------------------- 8. SHARED DISPOSITIVE POWER 1,542,171 Shares - -------------------------------------------------------------------------------- 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON. 1,557,171 Shares (Includes 1,321,779 Shares held by Medical Science Partners, L.P., the sole general partner of which is Medical Science Ventures, L.P., of which Mr. Lamotte is a general partner. Also includes 187,500 Shares held by Medical Science Partners II, L.P. and 32,892 Shares held by Medical Science II Co-Investment L.P., the sole general partner of each of which is Medical Science Ventures II, L.P., of which Mr. Lamotte is a general partner.) - -------------------------------------------------------------------------------- 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES. [ ] - -------------------------------------------------------------------------------- 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9. 6.2% - -------------------------------------------------------------------------------- 12. TYPE OF REPORTING PERSON. IN - -------------------------------------------------------------------------------- 5 - ------------------------------ ----------------------------- CUSIP No. 44860M 10 8 13G Page 5 of 9 ----------- --- --- - ------------------------------ ----------------------------- - -------------------------------------------------------------------------------- 1. NAME OF REPORTING PERSONS S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSONS Joseph F. Lovett - -------------------------------------------------------------------------------- 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP Not Applicable - -------------------------------------------------------------------------------- 3. SEC USE ONLY - -------------------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION United States of America - -------------------------------------------------------------------------------- 5. SOLE VOTING POWER 0 Shares NUMBER OF ----------------------------------------------------- SHARES 6. SHARED VOTING POWER BENEFICIALLY OWNED BY 1,542,171 Shares EACH ----------------------------------------------------- REPORTING 7. SOLE DISPOSITIVE POWER PERSON WITH: 0 Shares ----------------------------------------------------- 8. SHARED DISPOSITIVE POWER 1,542,171 Shares - -------------------------------------------------------------------------------- 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON. 1,542,171 Shares (Includes 1,321,779 Shares held by Medical Science Partners, L.P., the sole general partner of which is Medical Science Ventures, L.P., of which Mr. Lovett is a general partner. Also includes 187,500 Shares held by Medical Science Partners II, L.P. and 32,892 Shares held by Medical Science II Co-Investment L.P., the sole general partner of each of which is Medical Science Ventures II, L.P., of which Mr. Lovett is a general partner.) - -------------------------------------------------------------------------------- 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES. [ ] - -------------------------------------------------------------------------------- 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9. 6.1% - -------------------------------------------------------------------------------- 12. TYPE OF REPORTING PERSON. IN - -------------------------------------------------------------------------------- 6 - ------------------------------ ----------------------------- CUSIP No. 44860M 10 8 13G Page 6 of 9 ----------- --- --- - ------------------------------ ----------------------------- SCHEDULE 13G Item 1(a). Name of Issuer: --------------- Hybridon, Inc. Item 1(b). Address of Issuer's Principal Executive Offices: ------------------------------------------------ 620 Memorial Drive Cambridge, Massachusetts 02139 Item 2(a). Name of Person Filing: ---------------------- Andre L. Lamotte for himself and on behalf of: Medical Science Partners, L.P. Medical Science Ventures, L.P. Joseph F. Lovett Item 2(b). Address of Principal Business Office or, if None, Residence: ------------------------------------------------------------ For each reporting person the business address is: c/o Medical Science Partners, L.P. 20 William Street Suite 250 Wellesley, MA 02181 Item 2(c). Citizenship: ------------ Each of Medical Science Partners, L.P. and Medical Science Ventures, L.P. is organized under the laws of the State of Delaware. Each of Andre L. Lamotte and Joseph F. Lovett is a citizen of the United States of America. 7 - ------------------------------ ----------------------------- CUSIP No. 44860M 10 8 13G Page 7 of 9 ----------- --- --- - ------------------------------ ----------------------------- Item 2(d). Title of Class of Securities: ----------------------------- Common Stock, $.001 par value per share Item 2(e). CUSIP Number: ------------- 44860M 10 8 Item 3: Not Applicable Item 4. Ownership: ---------- (a) Amount Beneficially Owned: Medical Science Partners, L.P. holds 1,321,779 Shares. The sole general partner of Medical Science Partners, L.P. is Medical Science Ventures, L.P. The general partners of Medical Science Ventures, L.P., who share voting and investment control over the Shares held by Medical Science Partners, L.P., are: Andre L. Lamotte and Joseph F. Lovett. Messrs. Lamotte and Lovett are also general partners of Medical Science Ventures II, L.P., which is the sole general partner of each of Medical Science Partners II, L.P. and Medical Science II Co-Investment L.P. Medical Science Partners II, L.P., Medical Science II Co-Investment L.P. and Mr. Lamotte hold 187,500 Shares, 32,892 Shares and 15,000 Shares, respectively. Messrs. Lamotte and Lovett disclaim beneficial ownership of Shares held by Medical Science Partners, L.P., Medical Science Partners II, L.P. and Medical Science II Co-Investment L.P. except to the extent of their pecuniary interest therein. (b) Percent of Class: 6.2% (c) Number of shares as to which such person has: (i) sole power to vote or to direct the vote: 0 Shares; 8 - ------------------------------ ----------------------------- CUSIP No. 44860M 10 8 13G Page 8 of 9 ----------- --- --- - ------------------------------ ----------------------------- (ii) shared power to vote or to direct the vote: 1,557,171 Shares; Item 5. Ownership of Five Percent or Less of a Class: --------------------------------------------- Not Applicable Item 6. Ownership of More Than Five Percent on Behalf of Another Person: ---------------------------------------------------------------- Not Applicable Item 7. Identification and Classification of the Subsidiary which Acquired the ---------------------------------------------------------------------- Security Being Reported by the Parent Holding Company: - ------------------------------------------------------ Not Applicable Item 8. Identification and Classification of Members of the Group: ---------------------------------------------------------- Not Applicable Item 9. Notice of Dissolution of Group: ------------------------------- Not Applicable Item 10. Certification: -------------- By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired in the ordinary course of business and were not acquired for the purpose of and do not have the effect of changing or influencing the control of the issuer of such securities and were not acquired in connection with or as a participant in any transaction having such purposes or effect. 9 - ------------------------------ ----------------------------- CUSIP No. 44860M 10 8 13G Page 9 of 9 ----------- --- --- - ------------------------------ ----------------------------- SIGNATURE After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. MEDICAL SCIENCE PARTNERS, L.P. By: MEDICAL SCIENCE VENTURES, L.P. /s/ Joseph F. Lovett Date: February 11, 1997 By:___________________________ Name: Joseph F. Lovett Title: General Partner MEDICAL SCIENCE VENTURES, L.P. /s/ Joseph F. Lovett Date: February 11, 1997 By:___________________________ Name: Joseph F. Lovett Title: General Partner /s/ Andre L. Lamotte Date: February 11, 1997 ______________________________ Andre L. Lamotte /s/ Joseph F. Lovett Date: February 11, 1997 ______________________________ Joseph F. Lovett