Idera Pharmaceuticals Presents Preclinical Data on IMO-2125, its Lead Drug Candidate for Chronic Hepatitis C Virus Infection, at Liver Meeting 2009
- IMO-2125 Induces Endogenous Interferons and Other Antiviral Proteins -
“Induction of endogenous interferon-alpha and other antiviral proteins
by IMO-2125 provides a novel immunotherapy approach to the potential
treatment of chronic hepatitis C virus infection,” said
“One of our presentations today provides insights into the mechanism of
immune activation by IMO-2125 as mediated through TLR9 and the
associated interferon signaling pathways involving MyD88 and IRF7,” said
Abstract 1593: “IMO-2125, a TLR9 agonist, induces Th-1 type cytokines and interferons with potent anti-HCV activity in human peripheral blood mononuclear cells (PBMCs) and plasmacytoid dendritic cells (pDCs)”
In this study, IMO-2125 induction of cytokines was evaluated in human peripheral blood mononuclear cells (hPBMCs) and plasmacytoid dendritic cells (pDCs). The data show that IMO-2125 induced high levels of endogenous interferon-alpha along with interferon-beta, interferon-lambda, and other proteins including IP-10 and 2’-5’-OAS. These IMO-2125-induced cytokines showed potent antiviral activity in the HCV replicon assay. Antiviral activity was decreased by addition of anti-interferon-alpha antibody, but only partially which suggests that other cytokines and chemokines induced by IMO-2125 also contribute to the antiviral activity.
Abstract 1597: “Gene expression profiles induced by IMO-2125, an agonist of Toll-like receptor 9, in human peripheral blood mononuclear cells”
In this study, the mechanism of immune activation by IMO-2125 in hPBMCs was evaluated by gene expression analysis. Gene expression profiles were obtained using TLR signaling pathway microarray, IFN-alpha/beta response microarray, human innate and adaptive immune response microarray, and human Th1-Th2-Th3 response microarray. The results show that IMO-2125 mediated immune responses through TLR9 and associated interferon signaling pathways involving MyD88 and interferon regulatory factor 7 (IRF7). In addition, many type 1 interferon-response genes, interferon-inducible proteins, antiviral proteins, TLR9 signaling molecules and transcription factors were up-regulated.
The above presentations are being made by Idera scientists today at
About IMO-2125
IMO-2125 is a novel DNA-based TLR9 agonist being evaluated for the treatment of chronic HCV infection. IMO-2125 has been shown to induce endogenous interferon-alpha and other antiviral immune response proteins in preclinical models, including non-human primates. IMO-2125 is being evaluated in a phase 1 clinical trial as monotherapy in patients with chronic HCV infection who have failed to respond to previous standard of care combination therapy of ribavirin and pegylated interferon-alpha. IMO-2125 also is being evaluated in a phase 1 clinical trial in combination with ribavirin in treatment-naïve patients with chronic HCV infection.
About
Idera Forward Looking Statements
This press release contains forward-looking statements concerning
Source:
Idera Pharmaceuticals, Inc.
Kelly Luethje, 617-679-5519
kluethje@iderapharma.com
or
MacDougall
Biomedical Communications
Chris Erdman, 781-235-3060
cerdman@macbiocom.com